MX2022004335A - Biarilos como inhibidores de la dihidroorotato deshidrogenasa. - Google Patents
Biarilos como inhibidores de la dihidroorotato deshidrogenasa.Info
- Publication number
- MX2022004335A MX2022004335A MX2022004335A MX2022004335A MX2022004335A MX 2022004335 A MX2022004335 A MX 2022004335A MX 2022004335 A MX2022004335 A MX 2022004335A MX 2022004335 A MX2022004335 A MX 2022004335A MX 2022004335 A MX2022004335 A MX 2022004335A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- aryl
- dehydrogenase inhibitors
- dihydroorotate dehydrogenase
- compounds
- Prior art date
Links
- 239000003363 dihydroorotate dehydrogenase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 108010052167 Dihydroorotate Dehydrogenase Proteins 0.000 abstract 1
- 102100032823 Dihydroorotate dehydrogenase (quinone), mitochondrial Human genes 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describen compuestos, composiciones y métodos para tratar enfermedades, trastornos o afecciones médicas que son afectados por la modulación de DHODH. Tales compuestos se representan mediante la Fórmula I de la siguiente manera: Fórmula I en donde R1, R2 y R3 5 se definen en la presente descripción. (Ver Fórmula I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201962913281P | 2019-10-10 | 2019-10-10 | |
PCT/IB2020/059503 WO2021070132A1 (en) | 2019-10-10 | 2020-10-09 | Bi-aryl dihydroorotate dehydrogenase inhibitors |
Publications (1)
Publication Number | Publication Date |
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MX2022004335A true MX2022004335A (es) | 2022-07-19 |
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ID=72964759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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MX2022004335A MX2022004335A (es) | 2019-10-10 | 2020-10-09 | Biarilos como inhibidores de la dihidroorotato deshidrogenasa. |
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Country | Link |
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US (1) | US20240158414A1 (es) |
EP (1) | EP4041714B1 (es) |
JP (1) | JP2022552496A (es) |
KR (1) | KR20220083735A (es) |
CN (1) | CN114630822A (es) |
AU (1) | AU2020363021A1 (es) |
BR (1) | BR112022006846A2 (es) |
CA (1) | CA3157223A1 (es) |
ES (1) | ES2970180T3 (es) |
MX (1) | MX2022004335A (es) |
WO (1) | WO2021070132A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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EP4313150A1 (en) | 2021-03-26 | 2024-02-07 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Pyrimidine biosynthesis inhibitor combination for use in treating viral infections |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3233857B1 (en) | 2014-12-18 | 2020-03-11 | Takeda Pharmaceutical Company Limited | Solid state forms of fused heteroaromatic pyrrolidinones |
EP3265072A1 (en) * | 2015-03-04 | 2018-01-10 | Dana-Farber Cancer Institute, Inc. | Salicylate inhibitors of melk and methods of use |
JOP20190094A1 (ar) * | 2016-10-27 | 2019-04-25 | Broad Inst Inc | مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh) |
US10968216B2 (en) * | 2016-10-27 | 2021-04-06 | Bayer Aktiengesellschaft | 4,5-annulated 1,2,4-triazolones |
-
2020
- 2020-10-09 EP EP20793814.3A patent/EP4041714B1/en active Active
- 2020-10-09 BR BR112022006846A patent/BR112022006846A2/pt not_active Application Discontinuation
- 2020-10-09 AU AU2020363021A patent/AU2020363021A1/en active Pending
- 2020-10-09 WO PCT/IB2020/059503 patent/WO2021070132A1/en unknown
- 2020-10-09 US US17/767,465 patent/US20240158414A1/en active Pending
- 2020-10-09 JP JP2022521475A patent/JP2022552496A/ja active Pending
- 2020-10-09 ES ES20793814T patent/ES2970180T3/es active Active
- 2020-10-09 CA CA3157223A patent/CA3157223A1/en active Pending
- 2020-10-09 KR KR1020227015521A patent/KR20220083735A/ko unknown
- 2020-10-09 MX MX2022004335A patent/MX2022004335A/es unknown
- 2020-10-09 CN CN202080070852.1A patent/CN114630822A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2020363021A1 (en) | 2022-04-07 |
KR20220083735A (ko) | 2022-06-20 |
EP4041714A1 (en) | 2022-08-17 |
EP4041714B1 (en) | 2023-12-13 |
CN114630822A (zh) | 2022-06-14 |
CA3157223A1 (en) | 2021-04-15 |
BR112022006846A2 (pt) | 2022-07-05 |
ES2970180T3 (es) | 2024-05-27 |
JP2022552496A (ja) | 2022-12-16 |
US20240158414A1 (en) | 2024-05-16 |
WO2021070132A1 (en) | 2021-04-15 |
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