EA029987B1 - Антитела к cd33 и их применение в лечении рака - Google Patents
Антитела к cd33 и их применение в лечении рака Download PDFInfo
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- EA029987B1 EA029987B1 EA201492137A EA201492137A EA029987B1 EA 029987 B1 EA029987 B1 EA 029987B1 EA 201492137 A EA201492137 A EA 201492137A EA 201492137 A EA201492137 A EA 201492137A EA 029987 B1 EA029987 B1 EA 029987B1
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- antibody
- heavy chain
- variable region
- seeg
- light chain
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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Landscapes
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| US201261649110P | 2012-05-18 | 2012-05-18 | |
| US13/804,227 US20130309223A1 (en) | 2012-05-18 | 2013-03-14 | CD33 Antibodies And Use Of Same To Treat Cancer |
| PCT/US2013/041209 WO2013173496A2 (en) | 2012-05-18 | 2013-05-15 | Cd33 antibodies and use of same to treat cancer |
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| CA2699837C (en) | 2006-12-01 | 2017-06-13 | Seattle Genetics, Inc. | Variant target binding agents and uses thereof |
| US20130309223A1 (en) | 2012-05-18 | 2013-11-21 | Seattle Genetics, Inc. | CD33 Antibodies And Use Of Same To Treat Cancer |
| NZ758050A (en) | 2013-10-15 | 2024-03-22 | Seagen Inc | Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics |
| KR102306493B1 (ko) * | 2013-11-25 | 2021-09-28 | 씨젠 인크. | 접합을 위한 ｃｈｏ 세포 배양물로부터의 항체 제조 |
| AU2014362238A1 (en) | 2013-12-13 | 2016-06-09 | Genentech, Inc. | Anti-CD33 antibodies and immunoconjugates |
| HK1231400A1 (zh) | 2014-02-11 | 2017-12-22 | Seattle Genetics, Inc. | 蛋白质的选择性还原 |
| IL309933A (en) | 2014-02-17 | 2024-03-01 | Seagen Inc | Hydrophilic antibody-drug conjugates |
| CA2944528C (en) * | 2014-04-03 | 2021-08-10 | Cellectis | Cd33 specific chimeric antigen receptors for cancer immunotherapy |
| SG10201913765YA (en) * | 2014-07-21 | 2020-03-30 | Novartis Ag | Treatment of cancer using a cd33 chimeric antigen receptor |
| AU2016212158B2 (en) | 2015-01-26 | 2021-06-03 | Allogene Therapeutics, Inc. | mAb-driven chimeric antigen receptor systems for sorting/depleting engineered immune cells |
| KR20180033502A (ko) | 2015-06-12 | 2018-04-03 | 알렉터 엘엘씨 | 항-cd33 항체 및 그의 사용 방법 |
| WO2016201389A2 (en) | 2015-06-12 | 2016-12-15 | Alector Llc | Anti-cd33 antibodies and methods of use thereof |
| TW201709932A (zh) | 2015-06-12 | 2017-03-16 | 西雅圖遺傳學公司 | Ｃｄ１２３抗體及其共軛物 |
| BR112017027498A2 (pt) * | 2015-06-30 | 2018-09-11 | Seattle Genetics Inc | anticorpo, ácido nucleico, composto, composição, e, método para tratamento de um paciente com uma doença. |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| ES2919323T3 (es) | 2015-12-04 | 2022-07-26 | Seagen Inc | Conjugados de compuestos de tubulisina cuaternizados |
| EP3442584B1 (en) | 2016-03-15 | 2021-07-28 | Seagen Inc. | Combinations of pbd-based antibody drug conjugates with bcl-2 inhibitors |
| JP7073266B2 (ja) | 2016-03-25 | 2022-05-23 | シージェン インコーポレイテッド | Ｐｅｇ化薬物リンカー及びその中間体を調製するためのプロセス |
| WO2017180768A1 (en) * | 2016-04-15 | 2017-10-19 | Seattle Genetics, Inc. | Combinations of cd33 antibody drug conjugates with hypomethylating agents |
| US11110179B2 (en) | 2016-06-03 | 2021-09-07 | Seagen Inc. | Combination of CD33 antibody drug conjugates with chemotherapeutic agents |
| EP3469001A4 (en) | 2016-06-09 | 2020-05-06 | Seattle Genetics, Inc. | COMBINATIONS OF PBD-BASED ANTIBODY CONJUGATES WITH FLT3 INHIBITORS |
| SG11201900699QA (en) | 2016-08-09 | 2019-02-27 | Seattle Genetics Inc | Drug conjugates with self-stabilizing linkers having improved physiochemical properties |
| MA46660A (fr) | 2016-10-18 | 2019-08-28 | Seattle Genetics Inc | Administration ciblée d'inhibiteurs de la voie de récupération de nicotinamide adénine dinucléotide |
| BR112019011186A2 (pt) | 2016-12-01 | 2019-10-08 | Regeneron Pharmaceuticals, Inc. | conjugado de anticorpo radiomarcado, composto, e, métodos de imageamento e para tratamento de um tumor. |
| AU2017366739B2 (en) | 2016-12-02 | 2023-11-23 | Angeles Therapeutics, Inc. | Synthetic immune receptors and methods of use thereof |
| JP7386082B2 (ja) | 2017-02-28 | 2023-11-24 | ブイオーアール バイオファーマ インコーポレーテッド | 系統特異的タンパク質の阻害のための組成物および方法 |
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| CA3057447A1 (en) * | 2017-08-03 | 2019-02-07 | Alector Llc | Anti-cd33 antibodies and methods of use thereof |
| AU2018342527B2 (en) | 2017-09-29 | 2024-06-27 | Daiichi Sankyo Company, Limited | Antibody-pyrrolobenzodiazepine derivative conjugate |
| WO2019164987A1 (en) | 2018-02-20 | 2019-08-29 | Seattle Genetics, Inc. | Hydrophobic auristatin f compounds and conjugates thereof |
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| CA3091764A1 (en) * | 2018-02-20 | 2019-08-29 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting cd33, and use thereof |
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| BR112021003016A2 (pt) * | 2018-08-31 | 2021-05-18 | Alector Llc | anticorpos isolados, ácido nucleico isolado, vetor, célula hospedeira, métodos para produzir um anticorpo e para prevenir, reduzir o risco ou tratar uma doença e composição farmacêutica |
| EP3849565A4 (en) * | 2018-09-12 | 2022-12-28 | Fred Hutchinson Cancer Research Center | REDUCTION OF CD33 EXPRESSION TO SELECTIVELY PROTECT THERAPEUTIC CELLS |
| CN112672757A (zh) * | 2018-09-25 | 2021-04-16 | 中央研究院 | 抗-唾液酸结合性免疫球蛋白样凝集素的抗体、包括该抗体的药学组合物及其用途 |
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