EA021842B1 - Применение toll-подобного рецептора и агониста для лечения рака - Google Patents
Применение toll-подобного рецептора и агониста для лечения рака Download PDFInfo
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- EA021842B1 EA021842B1 EA201290140A EA201290140A EA021842B1 EA 021842 B1 EA021842 B1 EA 021842B1 EA 201290140 A EA201290140 A EA 201290140A EA 201290140 A EA201290140 A EA 201290140A EA 021842 B1 EA021842 B1 EA 021842B1
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Applications Claiming Priority (3)
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| US24925309P | 2009-10-06 | 2009-10-06 | |
| US24959609P | 2009-10-07 | 2009-10-07 | |
| PCT/US2010/051646 WO2011044246A1 (en) | 2009-10-06 | 2010-10-06 | Use of toll-like receptor and agonist for treating cancer |
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| EA201290140A1 EA201290140A1 (ru) | 2012-11-30 |
| EA021842B1 true EA021842B1 (ru) | 2015-09-30 |
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| EA201290140A EA021842B1 (ru) | 2009-10-06 | 2010-10-06 | Применение toll-подобного рецептора и агониста для лечения рака |
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| JP (2) | JP5796014B2 (https=) |
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| AU (1) | AU2010303464B2 (https=) |
| BR (1) | BR112012011331B8 (https=) |
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| IL (1) | IL219060A (https=) |
| MX (1) | MX2012004095A (https=) |
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| EP2460534A1 (en) | 2004-12-22 | 2012-06-06 | Cleveland Clinic Foundation | Flagellin related polypeptides and uses thereof |
| CN102170911B (zh) | 2008-08-01 | 2014-07-02 | 克里夫兰生物实验室公司 | 用于治疗再灌注损伤的方法 |
| WO2012097012A1 (en) | 2011-01-10 | 2012-07-19 | Cleveland Biolabs, Inc. | Use of toll-like receptor agonist for treating cancer |
| WO2014098649A1 (en) * | 2012-12-18 | 2014-06-26 | Obschestvo S Ogranichennoy Otvetstvennostyu "Panacela Labs" | Compositions and methods using toll-like receptor 5 and toll-like receptor agonist |
| WO2015080631A1 (en) * | 2013-11-27 | 2015-06-04 | Obschestvo S Ogranichennoy Otvetstvennost`Yu "Panacela Labs" | Improved expression vector for toll-like receptor and agonist and use for treating cancer |
| US10202426B2 (en) | 2014-07-30 | 2019-02-12 | Genome Protection, Inc. | Flagellin compositions and uses |
| EP3925968A3 (en) | 2014-10-07 | 2022-03-02 | Cytlimic Inc. | Hsp70-derived peptide, pharmaceutical composition for treating or preventing cancer using same, immunity inducer, and method for producing antigen-presenting cell |
| US10183056B2 (en) | 2014-10-16 | 2019-01-22 | Cleveland Biolabs, Inc. | Methods and compositions for the treatment of radiation-related disorders |
| CN113388021A (zh) | 2015-03-09 | 2021-09-14 | Cytlimic公司 | 源于gpc3的肽、使用其的医药组合物、免疫诱导剂、及抗原呈递细胞的制造方法 |
| RU2709015C2 (ru) * | 2015-04-07 | 2019-12-13 | Ситлимик Инк. | Лекарственное средство |
| KR101634380B1 (ko) | 2015-06-23 | 2016-06-28 | 한국생산기술연구원 | Tlr5 아고니스트 단백질의 생산방법 |
| CN105801709B (zh) * | 2016-04-29 | 2019-10-08 | 北京纽莱福生物科技有限公司 | CBLB502-Fc融合蛋白及其制备方法 |
| US11291718B2 (en) | 2016-10-11 | 2022-04-05 | Cytlimic Inc. | Method for treating cancer by administering a toll-like receptor agonist and LAG-3 IgG fusion protein |
| WO2018088933A1 (en) * | 2016-11-14 | 2018-05-17 | Limited Liability Company "Panacela Labs" | Anti-tumor effects of a viral vector encoding a toll-like receptor and a toll-like receptor agonist |
| CN113608416B (zh) * | 2016-12-28 | 2024-07-30 | Asml荷兰有限公司 | 量测图像与设计之间的模拟辅助的对准 |
| WO2018210279A1 (zh) * | 2017-05-16 | 2018-11-22 | 科济生物医药（上海）有限公司 | Toll样受体激动剂与免疫效应细胞的联用 |
| WO2019018768A1 (en) | 2017-07-20 | 2019-01-24 | Spogen Biotech Inc. | BIOACTIVE POLYPEPTIDES FOR PLANT PROTECTION, GROWTH AND PRODUCTIVITY ENHANCEMENTS |
| WO2019180051A1 (en) | 2018-03-19 | 2019-09-26 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| US12440536B2 (en) | 2018-05-18 | 2025-10-14 | The University Of Hong Kong | Compositions of toll-like receptor 5 (TLR5) agonist and methods of use thereof |
| EP3841112A1 (en) | 2018-08-24 | 2021-06-30 | Codiak BioSciences, Inc. | Extracellular vesicles targeting dendritic cells and uses thereof |
| CA3128386A1 (en) | 2019-02-04 | 2020-08-13 | Codiak Biosciences, Inc. | Membrane protein scaffolds for exosome engineering |
| EP3941607A1 (en) | 2019-03-21 | 2022-01-26 | Codiak BioSciences, Inc. | Process for preparing extracellular vesicles |
| BR112021018694A2 (pt) | 2019-03-21 | 2021-11-30 | Codiak Biosciences Inc | Vesículas extracelulares para distribuição de vacina |
| US20240108747A1 (en) | 2019-03-21 | 2024-04-04 | Lonza Sales Ag | Extracellular vesicle conjugates and uses thereof |
| EP3994158A1 (en) | 2019-07-03 | 2022-05-11 | Codiak BioSciences, Inc. | Extracellular vesicles targeting t cells and uses thereof |
| MX2022003570A (es) | 2019-09-25 | 2022-07-11 | Codiak Biosciences Inc | Composiciones de vesícula extracelular. |
| US20230114434A1 (en) | 2020-03-13 | 2023-04-13 | Codiak Biosciences, Inc. | Extracellular vesicles for treating neurological disorders |
| JP2023518414A (ja) | 2020-03-20 | 2023-05-01 | コディアック バイオサイエンシーズ， インコーポレイテッド | 治療のための細胞外小胞 |
| WO2021237100A1 (en) | 2020-05-21 | 2021-11-25 | Codiak Biosciences, Inc. | Methods of targeting extracellular vesicles to lung |
| WO2021246666A1 (ko) * | 2020-06-04 | 2021-12-09 | 가톨릭대학교 산학협력단 | 플라젤린으로부터 유도된 tlr5 작용제를 유효성분으로 포함하는 항암제 조성물 |
| US20230220068A1 (en) | 2020-06-05 | 2023-07-13 | Codiak Biosciences, Inc. | Anti-transferrin extracellular vesicles |
| WO2022066883A1 (en) | 2020-09-23 | 2022-03-31 | Codiak Biosciences, Inc. | Extracellular vesicles comprising kras antigens and uses thereof |
| WO2022066928A2 (en) | 2020-09-23 | 2022-03-31 | Codiak Biosciences, Inc. | Process for preparing extracellular vesicles |
| US20240082389A1 (en) | 2020-09-23 | 2024-03-14 | Lonza Sales Ag | Methods of producing extracellular vesicles |
| WO2025196053A1 (en) * | 2024-03-18 | 2025-09-25 | Istituto Europeo Di Oncologia S.R.L. | Flagellin-related peptides and uses thereof |
| EP4620482A1 (en) * | 2024-03-18 | 2025-09-24 | Istituto Europeo di Oncologia S.r.l. | Flagellin-related peptides and uses thereof |
Citations (4)
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| US20050147627A1 (en) * | 2001-04-20 | 2005-07-07 | The Institute For Systems Biology | Toll-like receptor 5 ligands and methods of use |
| US20080063657A1 (en) * | 2005-01-19 | 2008-03-13 | Powell Thomas J | Compositions comprising pathogen-associated molecular patterns and antigens and methods of use thereof |
| US20090011982A1 (en) * | 2004-12-22 | 2009-01-08 | Gudkov Andrei V | Flagellin Related Polypeptides and Uses Thereof |
| US20090246303A1 (en) * | 2003-12-02 | 2009-10-01 | Gudkov Andrei V | Method for Reducing The Effects of Chemotherapy Using Flagellin Related Polypeptides |
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- 2010-10-06 AU AU2010303464A patent/AU2010303464B2/en not_active Ceased
- 2010-10-06 BR BR112012011331A patent/BR112012011331B8/pt not_active IP Right Cessation
- 2010-10-06 MX MX2012004095A patent/MX2012004095A/es active IP Right Grant
- 2010-10-06 AP AP2012006253A patent/AP2012006253A0/xx unknown
- 2010-10-06 KR KR1020127008759A patent/KR20120104177A/ko not_active Ceased
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- 2010-10-06 EA EA201290140A patent/EA021842B1/ru unknown
- 2010-10-06 WO PCT/US2010/051646 patent/WO2011044246A1/en not_active Ceased
- 2010-10-06 US US13/500,552 patent/US9205095B2/en active Active
- 2010-10-06 CN CN201080055226.1A patent/CN104136614B/zh not_active Expired - Fee Related
- 2010-10-06 EP EP10822611.9A patent/EP2486134B1/en active Active
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2012
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- 2012-04-05 ZA ZA2012/02500A patent/ZA201202500B/en unknown
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| US20050147627A1 (en) * | 2001-04-20 | 2005-07-07 | The Institute For Systems Biology | Toll-like receptor 5 ligands and methods of use |
| US20090246303A1 (en) * | 2003-12-02 | 2009-10-01 | Gudkov Andrei V | Method for Reducing The Effects of Chemotherapy Using Flagellin Related Polypeptides |
| US20090011982A1 (en) * | 2004-12-22 | 2009-01-08 | Gudkov Andrei V | Flagellin Related Polypeptides and Uses Thereof |
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| GEWIRTZ et al. Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression. The Journal of Immunology, 15 August 2001, vol. 167, No 4, pp.1882-1885. Esp: abstract; pg 1882 second column, first paragraph; pg 1883 section entitled "Construction of TLR expression plasmids"; fig. 3, 4 * |
| HAWN et al. A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease. J. Exp. Med., 17 November 2003, vol. 198, No 10, pp. 1563-1572, entire document * |
| MURTHY et al. Identification of Conserved Domains in Salmonella muenchen Flagellin That Are Essential for Its Ability to Activate TLR5 and to Induce an Inflammatory Response in Vitro, J. Biol. Chem., 13 February 2004, vol. 279, No 7, pp. 5667-5675, entire document * |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP5796014B2 (ja) | 2015-10-21 |
| WO2011044246A1 (en) | 2011-04-14 |
| EP2486134A1 (en) | 2012-08-15 |
| CA2777198A1 (en) | 2011-04-14 |
| JP2015165821A (ja) | 2015-09-24 |
| CA2777198C (en) | 2018-07-24 |
| HK1199058A1 (en) | 2015-06-19 |
| BR112012011331A2 (pt) | 2015-09-15 |
| AU2010303464A1 (en) | 2012-04-12 |
| ZA201202500B (en) | 2013-06-26 |
| ES2457518T3 (es) | 2014-04-28 |
| MY163110A (en) | 2017-08-15 |
| CN104136614A (zh) | 2014-11-05 |
| JP2013506437A (ja) | 2013-02-28 |
| EP2486134B1 (en) | 2014-01-08 |
| IL219060A (en) | 2017-02-28 |
| US9205095B2 (en) | 2015-12-08 |
| BR112012011331B8 (pt) | 2021-05-25 |
| BR112012011331B1 (pt) | 2021-03-02 |
| CN104136614B (zh) | 2018-04-06 |
| IL219060A0 (en) | 2012-06-28 |
| EA201290140A1 (ru) | 2012-11-30 |
| US20120208871A1 (en) | 2012-08-16 |
| AP2012006253A0 (en) | 2012-06-30 |
| MX2012004095A (es) | 2012-09-12 |
| KR20120104177A (ko) | 2012-09-20 |
| EP2486134A4 (en) | 2013-02-13 |
| AU2010303464B2 (en) | 2014-05-01 |
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