CN104136614B - Toll‑样受体和激动剂用于治疗癌症的用途 - Google Patents

Toll‑样受体和激动剂用于治疗癌症的用途 Download PDF

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CN104136614B
CN104136614B CN201080055226.1A CN201080055226A CN104136614B CN 104136614 B CN104136614 B CN 104136614B CN 201080055226 A CN201080055226 A CN 201080055226A CN 104136614 B CN104136614 B CN 104136614B
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flagellin
vector
tlr
cancer
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CN104136614A (zh
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A.V.古德科夫
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Panna Serra Laboratories Ltd
Park Roswell Cancer Institute
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Rosewell Park Cancer Institute
Panna Serra Laboratories Ltd
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CN201080055226.1A 2009-10-06 2010-10-06 Toll‑样受体和激动剂用于治疗癌症的用途 Expired - Fee Related CN104136614B (zh)

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US24925309P 2009-10-06 2009-10-06
US61/249,253 2009-10-06
US24959609P 2009-10-07 2009-10-07
US61/249,596 2009-10-07
PCT/US2010/051646 WO2011044246A1 (en) 2009-10-06 2010-10-06 Use of toll-like receptor and agonist for treating cancer

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CN104136614A CN104136614A (zh) 2014-11-05
CN104136614B true CN104136614B (zh) 2018-04-06

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Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2460534A1 (en) 2004-12-22 2012-06-06 Cleveland Clinic Foundation Flagellin related polypeptides and uses thereof
CN102170911B (zh) 2008-08-01 2014-07-02 克里夫兰生物实验室公司 用于治疗再灌注损伤的方法
WO2012097012A1 (en) 2011-01-10 2012-07-19 Cleveland Biolabs, Inc. Use of toll-like receptor agonist for treating cancer
WO2014098649A1 (en) * 2012-12-18 2014-06-26 Obschestvo S Ogranichennoy Otvetstvennostyu "Panacela Labs" Compositions and methods using toll-like receptor 5 and toll-like receptor agonist
WO2015080631A1 (en) * 2013-11-27 2015-06-04 Obschestvo S Ogranichennoy Otvetstvennost`Yu "Panacela Labs" Improved expression vector for toll-like receptor and agonist and use for treating cancer
US10202426B2 (en) 2014-07-30 2019-02-12 Genome Protection, Inc. Flagellin compositions and uses
EP3925968A3 (en) 2014-10-07 2022-03-02 Cytlimic Inc. Hsp70-derived peptide, pharmaceutical composition for treating or preventing cancer using same, immunity inducer, and method for producing antigen-presenting cell
US10183056B2 (en) 2014-10-16 2019-01-22 Cleveland Biolabs, Inc. Methods and compositions for the treatment of radiation-related disorders
CN113388021A (zh) 2015-03-09 2021-09-14 Cytlimic公司 源于gpc3的肽、使用其的医药组合物、免疫诱导剂、及抗原呈递细胞的制造方法
RU2709015C2 (ru) * 2015-04-07 2019-12-13 Ситлимик Инк. Лекарственное средство
KR101634380B1 (ko) 2015-06-23 2016-06-28 한국생산기술연구원 Tlr5 아고니스트 단백질의 생산방법
CN105801709B (zh) * 2016-04-29 2019-10-08 北京纽莱福生物科技有限公司 CBLB502-Fc融合蛋白及其制备方法
US11291718B2 (en) 2016-10-11 2022-04-05 Cytlimic Inc. Method for treating cancer by administering a toll-like receptor agonist and LAG-3 IgG fusion protein
WO2018088933A1 (en) * 2016-11-14 2018-05-17 Limited Liability Company "Panacela Labs" Anti-tumor effects of a viral vector encoding a toll-like receptor and a toll-like receptor agonist
CN113608416B (zh) * 2016-12-28 2024-07-30 Asml荷兰有限公司 量测图像与设计之间的模拟辅助的对准
WO2018210279A1 (zh) * 2017-05-16 2018-11-22 科济生物医药（上海）有限公司 Toll样受体激动剂与免疫效应细胞的联用
WO2019018768A1 (en) 2017-07-20 2019-01-24 Spogen Biotech Inc. BIOACTIVE POLYPEPTIDES FOR PLANT PROTECTION, GROWTH AND PRODUCTIVITY ENHANCEMENTS
WO2019180051A1 (en) 2018-03-19 2019-09-26 4D Pharma Research Limited Compositions comprising bacterial strains
US12440536B2 (en) 2018-05-18 2025-10-14 The University Of Hong Kong Compositions of toll-like receptor 5 (TLR5) agonist and methods of use thereof
EP3841112A1 (en) 2018-08-24 2021-06-30 Codiak BioSciences, Inc. Extracellular vesicles targeting dendritic cells and uses thereof
CA3128386A1 (en) 2019-02-04 2020-08-13 Codiak Biosciences, Inc. Membrane protein scaffolds for exosome engineering
EP3941607A1 (en) 2019-03-21 2022-01-26 Codiak BioSciences, Inc. Process for preparing extracellular vesicles
BR112021018694A2 (pt) 2019-03-21 2021-11-30 Codiak Biosciences Inc Vesículas extracelulares para distribuição de vacina
US20240108747A1 (en) 2019-03-21 2024-04-04 Lonza Sales Ag Extracellular vesicle conjugates and uses thereof
EP3994158A1 (en) 2019-07-03 2022-05-11 Codiak BioSciences, Inc. Extracellular vesicles targeting t cells and uses thereof
MX2022003570A (es) 2019-09-25 2022-07-11 Codiak Biosciences Inc Composiciones de vesícula extracelular.
US20230114434A1 (en) 2020-03-13 2023-04-13 Codiak Biosciences, Inc. Extracellular vesicles for treating neurological disorders
JP2023518414A (ja) 2020-03-20 2023-05-01 コディアック バイオサイエンシーズ， インコーポレイテッド 治療のための細胞外小胞
WO2021237100A1 (en) 2020-05-21 2021-11-25 Codiak Biosciences, Inc. Methods of targeting extracellular vesicles to lung
WO2021246666A1 (ko) * 2020-06-04 2021-12-09 가톨릭대학교 산학협력단 플라젤린으로부터 유도된 tlr5 작용제를 유효성분으로 포함하는 항암제 조성물
US20230220068A1 (en) 2020-06-05 2023-07-13 Codiak Biosciences, Inc. Anti-transferrin extracellular vesicles
WO2022066883A1 (en) 2020-09-23 2022-03-31 Codiak Biosciences, Inc. Extracellular vesicles comprising kras antigens and uses thereof
WO2022066928A2 (en) 2020-09-23 2022-03-31 Codiak Biosciences, Inc. Process for preparing extracellular vesicles
US20240082389A1 (en) 2020-09-23 2024-03-14 Lonza Sales Ag Methods of producing extracellular vesicles
WO2025196053A1 (en) * 2024-03-18 2025-09-25 Istituto Europeo Di Oncologia S.R.L. Flagellin-related peptides and uses thereof
EP4620482A1 (en) * 2024-03-18 2025-09-24 Istituto Europeo di Oncologia S.r.l. Flagellin-related peptides and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8703146B2 (en) * 2001-04-20 2014-04-22 Institute For Systems Biology Toll-like receptor 5 ligands and methods of use
EP2460534A1 (en) * 2004-12-22 2012-06-06 Cleveland Clinic Foundation Flagellin related polypeptides and uses thereof
EP2374474A1 (en) * 2005-01-19 2011-10-12 Vaxinnate Corporation Compositions comprising pathogen-associated molecular patterns and antigens and their use to stimulate an immune response
WO2009102818A1 (en) * 2008-02-11 2009-08-20 Cleveland Biolabs, Inc. Method for reducing the effects of chemotheraphy using flagellin related polypeptides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression;Andrew T. Gewirtz et al;《The Journal of Immunology》;20010815;第167卷(第4期);第1882-1885页 *

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WO2011044246A1 (en) 2011-04-14
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JP2015165821A (ja) 2015-09-24
CA2777198C (en) 2018-07-24
HK1199058A1 (en) 2015-06-19
BR112012011331A2 (pt) 2015-09-15
AU2010303464A1 (en) 2012-04-12
ZA201202500B (en) 2013-06-26
ES2457518T3 (es) 2014-04-28
MY163110A (en) 2017-08-15
CN104136614A (zh) 2014-11-05
JP2013506437A (ja) 2013-02-28
EP2486134B1 (en) 2014-01-08
IL219060A (en) 2017-02-28
US9205095B2 (en) 2015-12-08
BR112012011331B8 (pt) 2021-05-25
BR112012011331B1 (pt) 2021-03-02
IL219060A0 (en) 2012-06-28
EA201290140A1 (ru) 2012-11-30
US20120208871A1 (en) 2012-08-16
EA021842B1 (ru) 2015-09-30
AP2012006253A0 (en) 2012-06-30
MX2012004095A (es) 2012-09-12
KR20120104177A (ko) 2012-09-20
EP2486134A4 (en) 2013-02-13
AU2010303464B2 (en) 2014-05-01

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