EA008666B1 - Модифицированная реакция пикте-шпенглера и полученные с ее использованием продукты - Google Patents

Модифицированная реакция пикте-шпенглера и полученные с ее использованием продукты Download PDF

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Publication number
EA008666B1
EA008666B1 EA200500264A EA200500264A EA008666B1 EA 008666 B1 EA008666 B1 EA 008666B1 EA 200500264 A EA200500264 A EA 200500264A EA 200500264 A EA200500264 A EA 200500264A EA 008666 B1 EA008666 B1 EA 008666B1
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EA
Eurasian Patent Office
Prior art keywords
compound
reaction
diastereomer
cis
tetrahydro
Prior art date
Application number
EA200500264A
Other languages
English (en)
Russian (ru)
Other versions
EA200500264A1 (ru
Inventor
Марк У. Орм
Майкл Джон Мартинелли
Кристофер Уильям Доук
Джозеф Мэттью Полак
Эрик Кристофер Челиус
Original Assignee
ЛИЛЛИ АЙКОС эЛ-эЛ-Си
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31191375&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA008666(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ЛИЛЛИ АЙКОС эЛ-эЛ-Си filed Critical ЛИЛЛИ АЙКОС эЛ-эЛ-Си
Publication of EA200500264A1 publication Critical patent/EA200500264A1/ru
Publication of EA008666B1 publication Critical patent/EA008666B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Indole Compounds (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Confectionery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dental Preparations (AREA)
EA200500264A 2002-07-31 2003-07-14 Модифицированная реакция пикте-шпенглера и полученные с ее использованием продукты EA008666B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40038602P 2002-07-31 2002-07-31
US46016103P 2003-04-03 2003-04-03
PCT/US2003/022039 WO2004011463A1 (en) 2002-07-31 2003-07-14 Modified pictet-spengler reaction and products prepared therefrom

Publications (2)

Publication Number Publication Date
EA200500264A1 EA200500264A1 (ru) 2005-08-25
EA008666B1 true EA008666B1 (ru) 2007-06-29

Family

ID=31191375

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500264A EA008666B1 (ru) 2002-07-31 2003-07-14 Модифицированная реакция пикте-шпенглера и полученные с ее использованием продукты

Country Status (19)

Country Link
US (2) US7550479B2 (https=)
EP (1) EP1546149B1 (https=)
JP (2) JP2005536567A (https=)
KR (1) KR100937915B1 (https=)
CN (1) CN100430395C (https=)
AT (1) ATE415402T1 (https=)
AU (1) AU2003256539B2 (https=)
BR (1) BR0313070B1 (https=)
CA (1) CA2492540C (https=)
DE (1) DE60324949D1 (https=)
EA (1) EA008666B1 (https=)
EG (1) EG23843A (https=)
ES (1) ES2318175T3 (https=)
IL (2) IL166255A (https=)
MX (1) MXPA05001139A (https=)
NO (1) NO331775B1 (https=)
NZ (1) NZ537784A (https=)
PL (1) PL216529B1 (https=)
WO (1) WO2004011463A1 (https=)

Families Citing this family (35)

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WO2005116030A1 (en) * 2004-05-31 2005-12-08 Matrix Laboratories Ltd A process for the preparation of tadalafil
EP2216329A1 (en) * 2004-10-28 2010-08-11 Dr. Reddy's Laboratories Ltd. Processes for the preparation of tadalafi
KR20070072891A (ko) * 2004-11-02 2007-07-06 테바 파마슈티컬 인더스트리즈 리미티드 타달라필 결정형 및 이의 제조 방법
US7417044B2 (en) 2005-02-25 2008-08-26 Teva Pharmaceutical Industries Ltd. Tadalafil having a large particle size and a process for preparation thereof
MX2007010431A (es) * 2005-02-25 2007-10-11 Teva Pharma Proceso para purificar tadalafil.
EP1851222A1 (en) * 2005-02-25 2007-11-07 Teva Pharmaceutical Industries Ltd Process of synthesizing tadalafil
US20060276652A1 (en) * 2005-04-12 2006-12-07 Ben-Zion Dolitzky Preparation of tadalafil intermediates
WO2007052283A1 (en) * 2005-10-31 2007-05-10 Alembic Limited An improved process for preparing tadalafil and its intermediate
EP2004644A1 (en) * 2006-03-24 2008-12-24 Glenmark Pharmaceuticals Limited Process for the preparation of tadalafil
US7527912B2 (en) * 2006-09-28 2009-05-05 Shin-Etsu Chemical Co., Ltd. Photoacid generators, resist compositions, and patterning process
US20080194529A1 (en) * 2007-02-12 2008-08-14 Auspex Pharmaceuticals, Inc. HIGHLY SELECTIVE and LONG-ACTING PDE5 MODULATORS
DK2170880T3 (da) 2007-06-29 2012-09-10 Ranbaxy Lab Ltd Fremgangsmåde til fremstillingen af mellemprodukter af tetracycliske forbindelser
ITMI20080285A1 (it) * 2008-02-22 2009-08-23 Endura Spa Procedimento per la preparazione di esteri di acidi tetraidro-1h-betacarbolin-3-carbossilici
EP2107059A1 (en) 2008-03-31 2009-10-07 LEK Pharmaceuticals D.D. Conversion of tryptophan into ß-carboline derivatives
PL385356A1 (pl) 2008-06-03 2009-12-07 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Sposób wytwarzania tadalafilu
CN101906103A (zh) * 2010-08-08 2010-12-08 浙江华海药业股份有限公司 四氢-β-咔啉化合物合成方法的改进
EP2673275B1 (en) * 2011-02-10 2015-04-08 Interquim, S.A. Process for obtaining compounds derived from tetrahydro-beta-carboline
CN102367253B (zh) * 2011-09-20 2016-04-06 浙江华海药业股份有限公司 一种制备他达拉非晶型a的方法
AR099416A1 (es) 2014-02-28 2016-07-20 Lilly Co Eli Terapia combinada para la hipertensión resistente
CN103980275B (zh) * 2014-05-14 2016-09-28 湖北省医药工业研究院有限公司 磷酸二酯酶5抑制剂他达拉非的制备方法
CN104151313B (zh) * 2014-07-13 2019-04-09 浙江华海药业股份有限公司 一种纯化他达拉非中间体的方法
SI3172207T1 (sl) * 2014-07-23 2019-06-28 Krka D.D., Novo Mesto Proces za pripravo zaviralca CGMP-fosfodiesteraze in oralne farmacevtske formulacije, ki obsega koprecipitate tadalafila
CN105842350B (zh) * 2015-05-14 2018-11-13 湖北生物医药产业技术研究院有限公司 利用高效液相色谱分析他达拉非合成中间体的方法
CN105061428B (zh) * 2015-08-26 2019-12-27 浙江华海药业股份有限公司 一种精制他达拉非的方法
CN106674223A (zh) * 2016-06-29 2017-05-17 浙江华海药业股份有限公司 一种精制他达拉非的方法
CN107663210A (zh) * 2016-07-28 2018-02-06 常州爱诺新睿医药技术有限公司 一种新的制备无水他达拉非晶型i的方法
CN106279155B (zh) * 2016-08-02 2019-03-19 扬子江药业集团四川海蓉药业有限公司 他达拉非的杂质对照品及其制备方法
CN109053724A (zh) * 2018-08-22 2018-12-21 上海青平药业有限公司 一种制备他达拉非过程中的杂质及该杂质的制备方法和他达拉非的纯化方法以及用途
CN110437228B (zh) * 2019-07-22 2022-06-14 山东省药学科学院 一种他达拉非及其中间体的制备方法
US10947253B2 (en) 2019-08-05 2021-03-16 Ankh Life Sciences Limited Fused polycyclic dimers
CN110790764B (zh) * 2019-11-27 2021-04-06 四川省通园制药集团有限公司 一种一锅法制备他达拉非的方法
US12129265B2 (en) 2020-07-21 2024-10-29 Ankh Life Sciences Limited Therapeutic agents and uses thereof
CN114057738A (zh) * 2021-12-14 2022-02-18 京博农化科技有限公司 一种氯吲哚酰肼的合成方法
CN114805345B (zh) * 2022-04-27 2023-11-10 山东省药学科学院 一种他达拉非中间体顺式四氢咔啉盐酸盐的制备方法
CN116715667A (zh) * 2023-06-20 2023-09-08 常州制药厂有限公司 一种他达拉非新晶型b及其制备方法

Citations (1)

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US5859006A (en) * 1994-01-21 1999-01-12 Icos Corporation Tetracyclic derivatives; process of preparation and use

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ATE337320T1 (de) * 2000-11-06 2006-09-15 Lilly Icos Llc Indolderivate als pde5-inhibitoren
ES2307758T3 (es) * 2001-06-05 2008-12-01 Lilly Icos Llc Derivados de pirazino (1',2':1,6)pirido(3,4-b)indol 1,4-diona.

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
US5859006A (en) * 1994-01-21 1999-01-12 Icos Corporation Tetracyclic derivatives; process of preparation and use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BAILEY, P.D. ET AL.: "Dlastereo- and enantioselectivity in the Pictet-Spengler reaction", J. CHEM. SOC. PERKIN TRANS. 1, 1993, pages 431-439, XP009018958, page 432, table 1; page 436. *
MADRIGAL, A. ET AL.: "The fate of the tryptophan stereocenter ...", TETRAHEDRON ASYMMETRY, vol. 11, 2000, pages 3516-3526, XP002259164, pages 3520-3521, paragraph 3.1; and page 3517, 2nd paragraph. *

Also Published As

Publication number Publication date
NO331775B1 (no) 2012-03-26
EA200500264A1 (ru) 2005-08-25
ES2318175T3 (es) 2009-05-01
IL200692A (en) 2011-11-30
CA2492540A1 (en) 2004-02-05
US20060004203A1 (en) 2006-01-05
KR100937915B1 (ko) 2010-01-21
JP2009235096A (ja) 2009-10-15
AU2003256539A1 (en) 2004-02-16
CN1671706A (zh) 2005-09-21
EG23843A (en) 2007-10-17
US20090312548A1 (en) 2009-12-17
BR0313070B1 (pt) 2014-09-09
IL166255A0 (en) 2006-01-15
CA2492540C (en) 2010-05-04
DE60324949D1 (de) 2009-01-08
AU2003256539B2 (en) 2010-03-04
BR0313070A (pt) 2005-06-28
NZ537784A (en) 2008-01-31
US7550479B2 (en) 2009-06-23
MXPA05001139A (es) 2005-05-16
EP1546149A1 (en) 2005-06-29
IL166255A (en) 2010-04-29
JP4994427B2 (ja) 2012-08-08
JP2005536567A (ja) 2005-12-02
KR20050030961A (ko) 2005-03-31
PL375092A1 (en) 2005-11-14
IL200692A0 (en) 2010-05-17
EP1546149B1 (en) 2008-11-26
PL216529B1 (pl) 2014-04-30
CN100430395C (zh) 2008-11-05
NO20051022L (no) 2005-04-22
WO2004011463A1 (en) 2004-02-05
ATE415402T1 (de) 2008-12-15

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PC4A Registration of transfer of a eurasian patent by assignment