BR0313070A - Métodos para preparação de um diastereÈmero desejado de uma tetraidro-beta-carbolina e para preparação de um composto - Google Patents

Métodos para preparação de um diastereÈmero desejado de uma tetraidro-beta-carbolina e para preparação de um composto

Info

Publication number
BR0313070A
BR0313070A BR0313070-3A BR0313070A BR0313070A BR 0313070 A BR0313070 A BR 0313070A BR 0313070 A BR0313070 A BR 0313070A BR 0313070 A BR0313070 A BR 0313070A
Authority
BR
Brazil
Prior art keywords
preparing
carboline
tetrahydro
beta
compound
Prior art date
Application number
BR0313070-3A
Other languages
English (en)
Other versions
BR0313070B1 (pt
Inventor
Mark W Orme
Michael John Martinelli
Christopher William Doecke
Joseph Matthew Pawlak
Erik Christopher Chelius
Original Assignee
Lilly Icos Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31191375&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0313070(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Icos Llc filed Critical Lilly Icos Llc
Publication of BR0313070A publication Critical patent/BR0313070A/pt
Publication of BR0313070B1 publication Critical patent/BR0313070B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Abstract

"MéTODOS PARA PREPARAçãO DE UM DIASTEREÈMERO DESEJADO DE UMA TETRAIDRO-BETA-CARBOLINA E PARA PREPARAçãO DE UM COMPOSTO". Um método para introduzir um segundo centro estereogênico em uma tetraidro-<225>-carbolina tendo dois centros estereogênicos usando uma reação de Pictet-Spengler modificada é descrito. O método fornece um cis- ou trans-isómero desejado em alto rendimento e pureza, e em tempos de processo curtos.
BRPI0313070-3A 2002-07-31 2003-07-14 Métodos para preparação de um diastereômero desejado de uma tetraidro-beta-carbolina e para preparação de um composto BR0313070B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40038602P 2002-07-31 2002-07-31
US60/400,386 2002-07-31
US46016103P 2003-04-03 2003-04-03
US60/460,161 2003-04-03
PCT/US2003/022039 WO2004011463A1 (en) 2002-07-31 2003-07-14 Modified pictet-spengler reaction and products prepared therefrom

Publications (2)

Publication Number Publication Date
BR0313070A true BR0313070A (pt) 2005-06-28
BR0313070B1 BR0313070B1 (pt) 2014-09-09

Family

ID=31191375

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0313070-3A BR0313070B1 (pt) 2002-07-31 2003-07-14 Métodos para preparação de um diastereômero desejado de uma tetraidro-beta-carbolina e para preparação de um composto

Country Status (19)

Country Link
US (2) US7550479B2 (pt)
EP (1) EP1546149B1 (pt)
JP (2) JP2005536567A (pt)
KR (1) KR100937915B1 (pt)
CN (1) CN100430395C (pt)
AT (1) ATE415402T1 (pt)
AU (1) AU2003256539B2 (pt)
BR (1) BR0313070B1 (pt)
CA (1) CA2492540C (pt)
DE (1) DE60324949D1 (pt)
EA (1) EA008666B1 (pt)
EG (1) EG23843A (pt)
ES (1) ES2318175T3 (pt)
IL (2) IL166255A (pt)
MX (1) MXPA05001139A (pt)
NO (1) NO331775B1 (pt)
NZ (1) NZ537784A (pt)
PL (1) PL216529B1 (pt)
WO (1) WO2004011463A1 (pt)

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WO2005116030A1 (en) * 2004-05-31 2005-12-08 Matrix Laboratories Ltd A process for the preparation of tadalafil
WO2006049986A1 (en) * 2004-10-28 2006-05-11 Dr. Reddy's Laboratories Ltd. Polymorphic forms of tadalafil
WO2006050458A2 (en) * 2004-11-02 2006-05-11 Teva Pharmaceutical Industries, Ltd. Tadalafil crystal forms and processes for preparing them
CA2596667A1 (en) * 2005-02-25 2006-08-31 Teva Pharmaceutical Industries Ltd. Process of synthesizing tadalafil
US7417044B2 (en) 2005-02-25 2008-08-26 Teva Pharmaceutical Industries Ltd. Tadalafil having a large particle size and a process for preparation thereof
MX2007010431A (es) * 2005-02-25 2007-10-11 Teva Pharma Proceso para purificar tadalafil.
MX2007012607A (es) * 2005-04-12 2008-01-11 Teva Pharma Preparacion de intermedios de tadalafil.
WO2007052283A1 (en) * 2005-10-31 2007-05-10 Alembic Limited An improved process for preparing tadalafil and its intermediate
WO2007110734A1 (en) * 2006-03-24 2007-10-04 Glenmark Pharmaceuticals Limited Process for the preparation of tadalafil
US7527912B2 (en) * 2006-09-28 2009-05-05 Shin-Etsu Chemical Co., Ltd. Photoacid generators, resist compositions, and patterning process
US20080194529A1 (en) * 2007-02-12 2008-08-14 Auspex Pharmaceuticals, Inc. HIGHLY SELECTIVE and LONG-ACTING PDE5 MODULATORS
PT2170880E (pt) 2007-06-29 2012-10-29 Ranbaxy Lab Ltd Processo para a preparação de intermediários de compostos tetracíclicos
ITMI20080285A1 (it) 2008-02-22 2009-08-23 Endura Spa Procedimento per la preparazione di esteri di acidi tetraidro-1h-betacarbolin-3-carbossilici
EP2107059A1 (en) 2008-03-31 2009-10-07 LEK Pharmaceuticals D.D. Conversion of tryptophan into ß-carboline derivatives
PL385356A1 (pl) 2008-06-03 2009-12-07 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Sposób wytwarzania tadalafilu
CN101906103A (zh) * 2010-08-08 2010-12-08 浙江华海药业股份有限公司 四氢-β-咔啉化合物合成方法的改进
ES2541421T3 (es) 2011-02-10 2015-07-20 Interquim, S.A. Procedimiento de obtención de compuestos derivados de tetrahidro-ß-carbolina
CN102367253B (zh) * 2011-09-20 2016-04-06 浙江华海药业股份有限公司 一种制备他达拉非晶型a的方法
AR099416A1 (es) 2014-02-28 2016-07-20 Lilly Co Eli Terapia combinada para la hipertensión resistente
CN103980275B (zh) * 2014-05-14 2016-09-28 湖北省医药工业研究院有限公司 磷酸二酯酶5抑制剂他达拉非的制备方法
CN104151313B (zh) * 2014-07-13 2019-04-09 浙江华海药业股份有限公司 一种纯化他达拉非中间体的方法
WO2016012539A1 (en) * 2014-07-23 2016-01-28 Krka, D.D., Novo Mesto A process for the preparation of cgmp-phosphodiesterase inhibitor and oral pharmaceutical formulation comprising tadalafil co-precipitates
CN105842350B (zh) * 2015-05-14 2018-11-13 湖北生物医药产业技术研究院有限公司 利用高效液相色谱分析他达拉非合成中间体的方法
CN105061428B (zh) * 2015-08-26 2019-12-27 浙江华海药业股份有限公司 一种精制他达拉非的方法
CN106674223A (zh) * 2016-06-29 2017-05-17 浙江华海药业股份有限公司 一种精制他达拉非的方法
CN107663210A (zh) * 2016-07-28 2018-02-06 常州爱诺新睿医药技术有限公司 一种新的制备无水他达拉非晶型i的方法
CN106279155B (zh) * 2016-08-02 2019-03-19 扬子江药业集团四川海蓉药业有限公司 他达拉非的杂质对照品及其制备方法
CN109053724A (zh) * 2018-08-22 2018-12-21 上海青平药业有限公司 一种制备他达拉非过程中的杂质及该杂质的制备方法和他达拉非的纯化方法以及用途
CN110437228B (zh) * 2019-07-22 2022-06-14 山东省药学科学院 一种他达拉非及其中间体的制备方法
US10947253B2 (en) 2019-08-05 2021-03-16 Ankh Life Sciences Limited Fused polycyclic dimers
CN110790764B (zh) * 2019-11-27 2021-04-06 四川省通园制药集团有限公司 一种一锅法制备他达拉非的方法
CN114057738A (zh) * 2021-12-14 2022-02-18 京博农化科技有限公司 一种氯吲哚酰肼的合成方法
CN114805345B (zh) * 2022-04-27 2023-11-10 山东省药学科学院 一种他达拉非中间体顺式四氢咔啉盐酸盐的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9514465D0 (en) * 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
GB9401090D0 (en) * 1994-01-21 1994-03-16 Glaxo Lab Sa Chemical compounds
GB9514473D0 (en) * 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
DE60122559T2 (de) * 2000-11-06 2006-12-07 Lilly Icos Llc, Wilmington Indolderivate als pde5-inhibitoren
WO2002098877A1 (en) * 2001-06-05 2002-12-12 Lilly Icos Llc Pyrazino 1',2':1,6 pyrido 3,4-b indole1,4-dione derivatives

Also Published As

Publication number Publication date
AU2003256539A1 (en) 2004-02-16
CN1671706A (zh) 2005-09-21
US20060004203A1 (en) 2006-01-05
JP2009235096A (ja) 2009-10-15
EA008666B1 (ru) 2007-06-29
EA200500264A1 (ru) 2005-08-25
JP4994427B2 (ja) 2012-08-08
NO331775B1 (no) 2012-03-26
KR20050030961A (ko) 2005-03-31
PL375092A1 (en) 2005-11-14
IL200692A0 (en) 2010-05-17
ATE415402T1 (de) 2008-12-15
CN100430395C (zh) 2008-11-05
EP1546149B1 (en) 2008-11-26
CA2492540C (en) 2010-05-04
IL200692A (en) 2011-11-30
EP1546149A1 (en) 2005-06-29
NZ537784A (en) 2008-01-31
US7550479B2 (en) 2009-06-23
JP2005536567A (ja) 2005-12-02
PL216529B1 (pl) 2014-04-30
NO20051022L (no) 2005-04-22
IL166255A (en) 2010-04-29
US20090312548A1 (en) 2009-12-17
MXPA05001139A (es) 2005-05-16
BR0313070B1 (pt) 2014-09-09
AU2003256539B2 (en) 2010-03-04
WO2004011463A1 (en) 2004-02-05
IL166255A0 (en) 2006-01-15
CA2492540A1 (en) 2004-02-05
EG23843A (en) 2007-10-17
KR100937915B1 (ko) 2010-01-21
ES2318175T3 (es) 2009-05-01
DE60324949D1 (de) 2009-01-08

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: ICOS CORPORATION (US)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/09/2014, OBSERVADAS AS CONDICOES LEGAIS.

B17A Notification of administrative nullity (patentee has 60 days time to reply to this notification)

Free format text: REQUERENTE DA NULIDADE: EMS S.A. - PETICAO NO020150003973 DE 23/02/2015.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time
B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)