ATE415402T1 - Modifizierte pictet-spengler-reaktion und damit hergestellte verbindungen - Google Patents
Modifizierte pictet-spengler-reaktion und damit hergestellte verbindungenInfo
- Publication number
- ATE415402T1 ATE415402T1 AT03771620T AT03771620T ATE415402T1 AT E415402 T1 ATE415402 T1 AT E415402T1 AT 03771620 T AT03771620 T AT 03771620T AT 03771620 T AT03771620 T AT 03771620T AT E415402 T1 ATE415402 T1 AT E415402T1
- Authority
- AT
- Austria
- Prior art keywords
- made therefrom
- spengler reaction
- compounds made
- modified pictet
- pictet
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40038602P | 2002-07-31 | 2002-07-31 | |
US46016103P | 2003-04-03 | 2003-04-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE415402T1 true ATE415402T1 (de) | 2008-12-15 |
Family
ID=31191375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03771620T ATE415402T1 (de) | 2002-07-31 | 2003-07-14 | Modifizierte pictet-spengler-reaktion und damit hergestellte verbindungen |
Country Status (19)
Country | Link |
---|---|
US (2) | US7550479B2 (de) |
EP (1) | EP1546149B1 (de) |
JP (2) | JP2005536567A (de) |
KR (1) | KR100937915B1 (de) |
CN (1) | CN100430395C (de) |
AT (1) | ATE415402T1 (de) |
AU (1) | AU2003256539B2 (de) |
BR (1) | BR0313070B1 (de) |
CA (1) | CA2492540C (de) |
DE (1) | DE60324949D1 (de) |
EA (1) | EA008666B1 (de) |
EG (1) | EG23843A (de) |
ES (1) | ES2318175T3 (de) |
IL (2) | IL166255A (de) |
MX (1) | MXPA05001139A (de) |
NO (1) | NO331775B1 (de) |
NZ (1) | NZ537784A (de) |
PL (1) | PL216529B1 (de) |
WO (1) | WO2004011463A1 (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005116030A1 (en) * | 2004-05-31 | 2005-12-08 | Matrix Laboratories Ltd | A process for the preparation of tadalafil |
WO2006049986A1 (en) * | 2004-10-28 | 2006-05-11 | Dr. Reddy's Laboratories Ltd. | Polymorphic forms of tadalafil |
KR20070072891A (ko) * | 2004-11-02 | 2007-07-06 | 테바 파마슈티컬 인더스트리즈 리미티드 | 타달라필 결정형 및 이의 제조 방법 |
EP1851222A1 (de) * | 2005-02-25 | 2007-11-07 | Teva Pharmaceutical Industries Ltd | Verfahren zur synthetisierung von tadalafil |
US20070004737A1 (en) * | 2005-02-25 | 2007-01-04 | Inbal Ornan | Process of purifying tadalafil |
KR20070099035A (ko) * | 2005-02-25 | 2007-10-08 | 테바 파마슈티컬 인더스트리즈 리미티드 | 입도가 큰 타달라필 및 이의 제조 방법 |
KR20070110941A (ko) * | 2005-04-12 | 2007-11-20 | 테바 파마슈티컬 인더스트리즈 리미티드 | 타달라필 중간체의 제조 방법 |
WO2007052283A1 (en) * | 2005-10-31 | 2007-05-10 | Alembic Limited | An improved process for preparing tadalafil and its intermediate |
EP2004644A1 (de) * | 2006-03-24 | 2008-12-24 | Glenmark Pharmaceuticals Limited | Verfahren zur herstellung von tadalafil |
KR101035742B1 (ko) * | 2006-09-28 | 2011-05-20 | 신에쓰 가가꾸 고교 가부시끼가이샤 | 신규 광산 발생제 및 이것을 이용한 레지스트 재료 및 패턴형성 방법 |
US20080194529A1 (en) * | 2007-02-12 | 2008-08-14 | Auspex Pharmaceuticals, Inc. | HIGHLY SELECTIVE and LONG-ACTING PDE5 MODULATORS |
US8445698B2 (en) | 2007-06-29 | 2013-05-21 | Ranbaxy Laboratories Limited | Process for the preparation of an intermediate of tadalafil |
ITMI20080285A1 (it) | 2008-02-22 | 2009-08-23 | Endura Spa | Procedimento per la preparazione di esteri di acidi tetraidro-1h-betacarbolin-3-carbossilici |
EP2107059A1 (de) * | 2008-03-31 | 2009-10-07 | LEK Pharmaceuticals D.D. | Umwandlung von Tryptophan in ß-Carbolinderivate |
PL385356A1 (pl) * | 2008-06-03 | 2009-12-07 | Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna | Sposób wytwarzania tadalafilu |
CN101906103A (zh) * | 2010-08-08 | 2010-12-08 | 浙江华海药业股份有限公司 | 四氢-β-咔啉化合物合成方法的改进 |
US8829023B2 (en) | 2011-02-10 | 2014-09-09 | Interquim, S.A. | Process for obtaining compounds derived from tetrahydro-β-carboline |
CN102367253B (zh) * | 2011-09-20 | 2016-04-06 | 浙江华海药业股份有限公司 | 一种制备他达拉非晶型a的方法 |
AR099416A1 (es) | 2014-02-28 | 2016-07-20 | Lilly Co Eli | Terapia combinada para la hipertensión resistente |
CN103980275B (zh) * | 2014-05-14 | 2016-09-28 | 湖北省医药工业研究院有限公司 | 磷酸二酯酶5抑制剂他达拉非的制备方法 |
CN104151313B (zh) * | 2014-07-13 | 2019-04-09 | 浙江华海药业股份有限公司 | 一种纯化他达拉非中间体的方法 |
EP3172207B1 (de) * | 2014-07-23 | 2019-03-06 | KRKA, d.d., Novo mesto | Verfahren zur herstellung des cgmp-phosphodiesterasehemmers und orale pharmazeutische formulierung mit tadalafil-co-präzipitaten |
CN105842350B (zh) * | 2015-05-14 | 2018-11-13 | 湖北生物医药产业技术研究院有限公司 | 利用高效液相色谱分析他达拉非合成中间体的方法 |
CN105061428B (zh) * | 2015-08-26 | 2019-12-27 | 浙江华海药业股份有限公司 | 一种精制他达拉非的方法 |
CN106674223A (zh) * | 2016-06-29 | 2017-05-17 | 浙江华海药业股份有限公司 | 一种精制他达拉非的方法 |
CN107663210A (zh) * | 2016-07-28 | 2018-02-06 | 常州爱诺新睿医药技术有限公司 | 一种新的制备无水他达拉非晶型i的方法 |
CN106279155B (zh) * | 2016-08-02 | 2019-03-19 | 扬子江药业集团四川海蓉药业有限公司 | 他达拉非的杂质对照品及其制备方法 |
CN109053724A (zh) * | 2018-08-22 | 2018-12-21 | 上海青平药业有限公司 | 一种制备他达拉非过程中的杂质及该杂质的制备方法和他达拉非的纯化方法以及用途 |
CN110437228B (zh) * | 2019-07-22 | 2022-06-14 | 山东省药学科学院 | 一种他达拉非及其中间体的制备方法 |
US10947253B2 (en) | 2019-08-05 | 2021-03-16 | Ankh Life Sciences Limited | Fused polycyclic dimers |
CN110790764B (zh) * | 2019-11-27 | 2021-04-06 | 四川省通园制药集团有限公司 | 一种一锅法制备他达拉非的方法 |
CN114057738A (zh) * | 2021-12-14 | 2022-02-18 | 京博农化科技有限公司 | 一种氯吲哚酰肼的合成方法 |
CN114805345B (zh) * | 2022-04-27 | 2023-11-10 | 山东省药学科学院 | 一种他达拉非中间体顺式四氢咔啉盐酸盐的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9401090D0 (en) * | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
GB9514465D0 (en) * | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
GB9514473D0 (en) * | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
MXPA03003971A (es) * | 2000-11-06 | 2004-02-12 | Lilly Icos Llc | Derivados de indol como inhibidores de pde5. |
WO2002098877A1 (en) * | 2001-06-05 | 2002-12-12 | Lilly Icos Llc | Pyrazino 1',2':1,6 pyrido 3,4-b indole1,4-dione derivatives |
-
2003
- 2003-07-14 ES ES03771620T patent/ES2318175T3/es not_active Expired - Lifetime
- 2003-07-14 EP EP03771620A patent/EP1546149B1/de not_active Expired - Lifetime
- 2003-07-14 CN CNB038182386A patent/CN100430395C/zh not_active Expired - Lifetime
- 2003-07-14 MX MXPA05001139A patent/MXPA05001139A/es active IP Right Grant
- 2003-07-14 BR BRPI0313070-3A patent/BR0313070B1/pt not_active IP Right Cessation
- 2003-07-14 NZ NZ537784A patent/NZ537784A/en not_active IP Right Cessation
- 2003-07-14 AU AU2003256539A patent/AU2003256539B2/en not_active Expired
- 2003-07-14 AT AT03771620T patent/ATE415402T1/de not_active IP Right Cessation
- 2003-07-14 JP JP2005505597A patent/JP2005536567A/ja active Pending
- 2003-07-14 EA EA200500264A patent/EA008666B1/ru unknown
- 2003-07-14 US US10/521,393 patent/US7550479B2/en active Active
- 2003-07-14 CA CA2492540A patent/CA2492540C/en not_active Expired - Lifetime
- 2003-07-14 DE DE60324949T patent/DE60324949D1/de not_active Expired - Lifetime
- 2003-07-14 PL PL375092A patent/PL216529B1/pl unknown
- 2003-07-14 WO PCT/US2003/022039 patent/WO2004011463A1/en active Application Filing
- 2003-07-14 KR KR1020057001520A patent/KR100937915B1/ko active IP Right Grant
-
2005
- 2005-01-12 IL IL166255A patent/IL166255A/en active IP Right Grant
- 2005-01-29 EG EGNA2005000016 patent/EG23843A/xx active
- 2005-02-25 NO NO20051022A patent/NO331775B1/no not_active IP Right Cessation
-
2009
- 2009-06-18 US US12/486,817 patent/US20090312548A1/en not_active Abandoned
- 2009-07-15 JP JP2009166570A patent/JP4994427B2/ja not_active Expired - Lifetime
- 2009-09-02 IL IL200692A patent/IL200692A/en active IP Right Grant
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |