EA005674B1 - Способ получения циталопрама - Google Patents

Способ получения циталопрама Download PDF

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Publication number
EA005674B1
EA005674B1 EA200201211A EA200201211A EA005674B1 EA 005674 B1 EA005674 B1 EA 005674B1 EA 200201211 A EA200201211 A EA 200201211A EA 200201211 A EA200201211 A EA 200201211A EA 005674 B1 EA005674 B1 EA 005674B1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
compound
intermediate compound
alkylation
compounds
Prior art date
Application number
EA200201211A
Other languages
English (en)
Russian (ru)
Other versions
EA200201211A1 (ru
Inventor
Ханс Петерсен
Роберт Дансер
Original Assignee
Х.Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х.Лундбекк А/С filed Critical Х.Лундбекк А/С
Publication of EA200201211A1 publication Critical patent/EA200201211A1/ru
Publication of EA005674B1 publication Critical patent/EA005674B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Furan Compounds (AREA)
EA200201211A 2000-05-12 2001-05-10 Способ получения циталопрама EA005674B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200000783 2000-05-12
PCT/DK2001/000333 WO2001085712A1 (en) 2000-05-12 2001-05-10 Method for the preparation of citalopram

Publications (2)

Publication Number Publication Date
EA200201211A1 EA200201211A1 (ru) 2003-04-24
EA005674B1 true EA005674B1 (ru) 2005-04-28

Family

ID=8159493

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200201211A EA005674B1 (ru) 2000-05-12 2001-05-10 Способ получения циталопрама

Country Status (30)

Country Link
US (1) US6660873B2 (de)
EP (1) EP1296970B1 (de)
JP (1) JP2003532721A (de)
CN (1) CN100422166C (de)
AR (1) AR032455A1 (de)
AT (1) ATE389645T1 (de)
AU (2) AU2001258239B2 (de)
BG (1) BG65820B1 (de)
BR (1) BR0110996A (de)
CA (1) CA2408292C (de)
CZ (1) CZ20024065A3 (de)
DE (1) DE60133280T2 (de)
DK (1) DK1296970T3 (de)
EA (1) EA005674B1 (de)
ES (1) ES2301541T3 (de)
HK (1) HK1056171A1 (de)
HR (1) HRP20020881A2 (de)
HU (1) HUP0301942A2 (de)
IL (2) IL152645A0 (de)
IS (1) IS2586B (de)
MX (1) MXPA02011125A (de)
NO (1) NO327963B1 (de)
NZ (1) NZ522475A (de)
PL (1) PL358144A1 (de)
PT (1) PT1296970E (de)
SI (1) SI1296970T1 (de)
SK (1) SK287035B6 (de)
UA (1) UA72039C2 (de)
WO (1) WO2001085712A1 (de)
ZA (1) ZA200208973B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1173431T2 (sl) 1999-04-14 2009-12-31 Lundbeck & Co As H Postopek za pripravo citaloprama
US6310222B1 (en) * 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
US6433196B1 (en) * 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
IL151566A0 (en) 2000-03-13 2003-04-10 Lundbeck & Co As H Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IN192057B (de) * 2001-07-19 2004-02-14 Ranbaxy Lab Ltd
WO2004085416A1 (en) * 2003-03-24 2004-10-07 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
WO2005042473A1 (en) * 2003-10-28 2005-05-12 Wockhardt Limited Improved process for the manufacture of citalopram hydrobromide
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
ES2285972T1 (es) 2004-08-23 2007-12-01 Sun Pharmaceutical Industries Limited Procedimiento de fabricacion de citalopram y enantiomeros.

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (de) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
AU737610B2 (en) 1997-07-08 2001-08-23 H. Lundbeck A/S Method for the preparation of citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
CZ292911B6 (cs) 1997-11-11 2004-01-14 H. Lundbeck A/S Způsob výroby citalopramu
EP1123284B1 (de) 1998-10-20 2003-01-08 H. Lundbeck A/S Verfahren zur herstellung von citalopram
BR9916955A (pt) 1998-12-23 2001-09-11 Lundbeck & Co As H Método para preparação de 5-cianoftalida
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
SI1173431T2 (sl) 1999-04-14 2009-12-31 Lundbeck & Co As H Postopek za pripravo citaloprama
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
EP1228056B1 (de) 1999-10-25 2004-09-22 H. Lundbeck A/S Verfahren zur herstellung von citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
DK1246812T3 (da) 1999-12-28 2004-07-05 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
WO2001049672A1 (en) 1999-12-30 2001-07-12 H. Lundbeck A/S Method for the preparation of citalopram
CA2397270C (en) 2000-01-14 2007-08-21 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
IT1317729B1 (it) 2000-01-18 2003-07-15 Norpharma S P A Procedimento per la preparazione della 5-carbossiftalide.
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
GB2357762B (en) 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
IL151566A0 (en) 2000-03-13 2003-04-10 Lundbeck & Co As H Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
WO2001068631A1 (en) 2000-03-13 2001-09-20 H. Lundbeck A/S Method for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
EA005094B1 (ru) 2000-03-14 2004-10-28 Х.Лундбекк А/С Способ получения циталопрама
PL360115A1 (en) 2000-03-16 2004-09-06 H.Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
EA200200332A1 (ru) 2000-07-06 2002-06-27 Х.Лундбекк А/С Способ получения циталопрама
FI20011621A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
AU3920101A (en) 2000-12-22 2001-07-03 H. Lundbeck A/S Method for the preparation of pure citalopram
MXPA01013336A (es) 2000-12-28 2002-07-09 Lundbeck & Co As H Proceso para la preparacion de citalopram puro.

Also Published As

Publication number Publication date
NO327963B1 (no) 2009-10-26
MXPA02011125A (es) 2003-03-10
US20030134895A1 (en) 2003-07-17
CA2408292A1 (en) 2001-11-15
PT1296970E (pt) 2008-06-11
IL152645A (en) 2009-12-24
HK1056171A1 (en) 2004-02-06
AR032455A1 (es) 2003-11-12
WO2001085712A1 (en) 2001-11-15
CN100422166C (zh) 2008-10-01
IS6605A (is) 2002-10-31
DE60133280T2 (de) 2009-04-16
CA2408292C (en) 2009-11-10
UA72039C2 (en) 2005-01-17
EP1296970A1 (de) 2003-04-02
DE60133280D1 (de) 2008-04-30
US6660873B2 (en) 2003-12-09
ATE389645T1 (de) 2008-04-15
BG65820B1 (bg) 2010-01-29
DK1296970T3 (da) 2008-07-14
NZ522475A (en) 2004-09-24
ES2301541T3 (es) 2008-07-01
IS2586B (is) 2010-02-15
EA200201211A1 (ru) 2003-04-24
SI1296970T1 (sl) 2008-08-31
ZA200208973B (en) 2003-11-05
BG107349A (bg) 2003-09-30
NO20025423D0 (no) 2002-11-12
PL358144A1 (en) 2004-08-09
CZ20024065A3 (cs) 2003-03-12
JP2003532721A (ja) 2003-11-05
AU5823901A (en) 2001-11-20
BR0110996A (pt) 2003-03-18
SK17542002A3 (sk) 2003-04-01
CN1441795A (zh) 2003-09-10
EP1296970B1 (de) 2008-03-19
IL152645A0 (en) 2003-06-24
SK287035B6 (sk) 2009-10-07
HRP20020881A2 (en) 2004-12-31
HUP0301942A2 (hu) 2003-09-29
AU2001258239B2 (en) 2005-12-08
NO20025423L (no) 2002-11-12

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU