DK3880670T3 - Forbedret syntese af nøglemellemprodukt af kras-g12c-hæmmerforbindelse - Google Patents

Forbedret syntese af nøglemellemprodukt af kras-g12c-hæmmerforbindelse Download PDF

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Publication number
DK3880670T3
DK3880670T3 DK19820938.9T DK19820938T DK3880670T3 DK 3880670 T3 DK3880670 T3 DK 3880670T3 DK 19820938 T DK19820938 T DK 19820938T DK 3880670 T3 DK3880670 T3 DK 3880670T3
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Prior art keywords
kras
inhibitor compound
key intermediate
improved synthesis
synthesis
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Application number
DK19820938.9T
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Danish (da)
English (en)
Inventor
Andrew Thomas Parsons
Brian Mcneil Cochran
Iv William Powazinik
Marc Anthony Caporini
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Amgen Inc
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Publication of DK3880670T3 publication Critical patent/DK3880670T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/06—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK19820938.9T 2018-11-16 2019-11-15 Forbedret syntese af nøglemellemprodukt af kras-g12c-hæmmerforbindelse DK3880670T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862768802P 2018-11-16 2018-11-16
PCT/US2019/061815 WO2020102730A1 (en) 2018-11-16 2019-11-15 Improved synthesis of key intermediate of kras g12c inhibitor compound

Publications (1)

Publication Number Publication Date
DK3880670T3 true DK3880670T3 (da) 2023-08-21

Family

ID=68887130

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19820938.9T DK3880670T3 (da) 2018-11-16 2019-11-15 Forbedret syntese af nøglemellemprodukt af kras-g12c-hæmmerforbindelse

Country Status (25)

Country Link
US (2) US11299491B2 (lt)
EP (2) EP3880670B1 (lt)
JP (2) JP7516029B2 (lt)
KR (1) KR20210093276A (lt)
CN (1) CN113015724A (lt)
AR (1) AR117101A1 (lt)
AU (1) AU2019381817A1 (lt)
BR (1) BR112021009384A2 (lt)
CA (1) CA3117221A1 (lt)
CL (1) CL2021001266A1 (lt)
DK (1) DK3880670T3 (lt)
EA (1) EA202191381A1 (lt)
ES (1) ES2953752T3 (lt)
FI (1) FI3880670T3 (lt)
HU (1) HUE062656T2 (lt)
IL (1) IL282682A (lt)
LT (1) LT3880670T (lt)
MA (1) MA54233A (lt)
MX (2) MX2021005598A (lt)
PL (1) PL3880670T3 (lt)
PT (1) PT3880670T (lt)
SG (1) SG11202104927QA (lt)
SI (1) SI3880670T1 (lt)
TW (1) TW202035354A (lt)
WO (1) WO2020102730A1 (lt)

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WO2022028346A1 (zh) 2020-08-02 2022-02-10 上海喆邺生物科技有限公司 一种芳香类化合物及其在抗肿瘤药物中的应用
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JP2023550386A (ja) 2020-11-20 2023-12-01 アムジエン・インコーポレーテツド ７－クロロ－６－フルオロ－１－（２－イソプロピル－４－メチルピリジン－３－イル）ピリド［２，３－ｄ］ピリミジン－２，４（１Ｈ，３Ｈ）－ジオンを調製するためのプロセス
WO2022214594A1 (en) 2021-04-09 2022-10-13 Boehringer Ingelheim International Gmbh Anticancer therapy
US20240254122A1 (en) 2021-05-19 2024-08-01 Teva Pharmaceuticals International Gmbh Process for preparation of sotorasib and solid state form thereof
CN114605406B (zh) * 2021-09-18 2023-05-26 都创(上海)医药开发有限公司 Amg510化合物的晶型及其制备方法和用途
KR20240128852A (ko) 2021-12-01 2024-08-27 베링거 인겔하임 인터내셔날 게엠베하 암 치료를 위한 고리형 2-아미노-3-시아노 티오펜 및 유도체
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CN115466259B (zh) * 2022-08-16 2023-12-05 山东大学 一种kras g12c抑制剂索托拉西布的制备方法
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US20200216446A1 (en) 2020-07-09
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