DK3472157T3 - Krystallinske faste former af en bet-inhibitor - Google Patents

Krystallinske faste former af en bet-inhibitor Download PDF

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Publication number
DK3472157T3
DK3472157T3 DK17734590.7T DK17734590T DK3472157T3 DK 3472157 T3 DK3472157 T3 DK 3472157T3 DK 17734590 T DK17734590 T DK 17734590T DK 3472157 T3 DK3472157 T3 DK 3472157T3
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Prior art keywords
crystalline solid
solid forms
bet inhibitor
bet
inhibitor
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DK17734590.7T
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Danish (da)
English (en)
Inventor
Shili Chen
Zhongjiang Jia
Pingli Liu
Lei Qiao
Yongzhong Wu
Jiacheng Zhou
Qun Li
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Incyte Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M31/00—Hunting appliances
    • A01M31/06—Decoys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Diabetes (AREA)
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  • Hematology (AREA)
  • Biotechnology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
DK17734590.7T 2016-06-20 2017-06-19 Krystallinske faste former af en bet-inhibitor DK3472157T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662352220P 2016-06-20 2016-06-20
US201662397575P 2016-09-21 2016-09-21
PCT/US2017/038121 WO2017222977A1 (en) 2016-06-20 2017-06-19 Crystalline solid forms of a bet inhibitor

Publications (1)

Publication Number Publication Date
DK3472157T3 true DK3472157T3 (da) 2023-05-01

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DK17734590.7T DK3472157T3 (da) 2016-06-20 2017-06-19 Krystallinske faste former af en bet-inhibitor

Country Status (34)

Country Link
US (6) US10189832B2 (enExample)
EP (2) EP4234554A3 (enExample)
JP (5) JP7096170B2 (enExample)
KR (4) KR102643344B1 (enExample)
CN (3) CN109715625B (enExample)
AU (3) AU2017281286B2 (enExample)
CA (3) CA3220975A1 (enExample)
CL (3) CL2018003702A1 (enExample)
CO (1) CO2018014339A2 (enExample)
CR (2) CR20220651A (enExample)
CY (1) CY1126092T1 (enExample)
DK (1) DK3472157T3 (enExample)
EC (1) ECSP19001982A (enExample)
ES (1) ES2945063T3 (enExample)
FI (1) FI3472157T3 (enExample)
HR (1) HRP20230466T1 (enExample)
HU (1) HUE062234T2 (enExample)
IL (3) IL302528A (enExample)
LT (1) LT3472157T (enExample)
MD (1) MD3472157T2 (enExample)
MX (3) MX389145B (enExample)
MY (2) MY209750A (enExample)
NZ (1) NZ749956A (enExample)
PE (2) PE20240236A1 (enExample)
PH (3) PH12021551886A1 (enExample)
PL (1) PL3472157T3 (enExample)
PT (1) PT3472157T (enExample)
RS (1) RS64274B1 (enExample)
SG (2) SG11201811416VA (enExample)
SI (1) SI3472157T1 (enExample)
SM (1) SMT202300155T1 (enExample)
TW (3) TWI830533B (enExample)
UA (2) UA125476C2 (enExample)
WO (1) WO2017222977A1 (enExample)

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TWI719464B (zh) 2013-03-15 2021-02-21 美商英塞特控股公司 作為bet蛋白抑制劑之三環雜環
US9309246B2 (en) 2013-12-19 2016-04-12 Incyte Corporation Tricyclic heterocycles as BET protein inhibitors
KR20240134245A (ko) 2014-04-23 2024-09-06 인사이트 홀딩스 코포레이션 BET 단백질의 저해제로서의 1H-피롤로[2,3-c]피리딘-7(6H)-온 및 피라졸로[3,4-c]피리딘-7(6H)-온
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US20170121347A1 (en) 2015-10-29 2017-05-04 Incyte Corporation Amorphous solid form of a bet protein inhibitor
EP4234554A3 (en) 2016-06-20 2023-12-27 Incyte Corporation Crystalline solid forms of a bet inhibitor
TWI882964B (zh) * 2018-09-13 2025-05-11 大陸商恒翼生物醫藥（上海）股份有限公司 Bet 溴結構域(bromodomain)抑制劑之固體形式之製備方法
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US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
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TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ｒａｓ相關疾病或病症之組合療法
WO2025034702A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Rmc-6291 for use in the treatment of ras protein-related disease or disorder
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