MX2018016281A - Formas solidas cristalinas de inhibidor de bromodominio y extra-terminal (bet). - Google Patents

Formas solidas cristalinas de inhibidor de bromodominio y extra-terminal (bet).

Info

Publication number
MX2018016281A
MX2018016281A MX2018016281A MX2018016281A MX2018016281A MX 2018016281 A MX2018016281 A MX 2018016281A MX 2018016281 A MX2018016281 A MX 2018016281A MX 2018016281 A MX2018016281 A MX 2018016281A MX 2018016281 A MX2018016281 A MX 2018016281A
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MX
Mexico
Prior art keywords
crystalline solid
solid forms
bet inhibitor
preparation
inhibitor
Prior art date
Application number
MX2018016281A
Other languages
English (en)
Inventor
Qiao Lei
Zhou Jiacheng
Chen Shili
Liu Pingli
Wu Yongzhong
Li Qun
Jia Zhongjiang
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of MX2018016281A publication Critical patent/MX2018016281A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
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    • C07F5/025—Boronic and borinic acid compounds
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    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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Abstract

La presente solicitud hace referencia a formas sólidas cristalinas de un inhibidor de proteínas BET, tales como BRD2, BRD3, BRD4 y BRD-t, lo que incluye métodos para su preparación e intermedios en su preparación, en los que el compuesto es útil para el tratamiento de enfermedades tales como cáncer. 1. Una forma sólida de un compuesto de fórmula: (ver Fórmula) Compuesto 1 en el que la forma sólida es cristalina.
MX2018016281A 2016-06-20 2017-06-19 Formas solidas cristalinas de inhibidor de bromodominio y extra-terminal (bet). MX2018016281A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662352220P 2016-06-20 2016-06-20
US201662397575P 2016-09-21 2016-09-21
PCT/US2017/038121 WO2017222977A1 (en) 2016-06-20 2017-06-19 Crystalline solid forms of a bet inhibitor

Publications (1)

Publication Number Publication Date
MX2018016281A true MX2018016281A (es) 2019-08-22

Family

ID=59258384

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2018016281A MX2018016281A (es) 2016-06-20 2017-06-19 Formas solidas cristalinas de inhibidor de bromodominio y extra-terminal (bet).
MX2023009524A MX2023009524A (es) 2016-06-20 2018-12-19 Formas solidas cristalinas de inhibidor de bromodominio y extra-terminal (bet).
MX2021009776A MX2021009776A (es) 2016-06-20 2018-12-19 Formas solidas cristalinas de inhibidor de bromodominio y extra-terminal (bet).

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2023009524A MX2023009524A (es) 2016-06-20 2018-12-19 Formas solidas cristalinas de inhibidor de bromodominio y extra-terminal (bet).
MX2021009776A MX2021009776A (es) 2016-06-20 2018-12-19 Formas solidas cristalinas de inhibidor de bromodominio y extra-terminal (bet).

Country Status (32)

Country Link
US (5) US10189832B2 (es)
EP (2) EP4234554A3 (es)
JP (4) JP7096170B2 (es)
KR (3) KR102643344B1 (es)
CN (3) CN114366748A (es)
AU (3) AU2017281286B2 (es)
BR (1) BR112018076486A2 (es)
CA (3) CA3220957A1 (es)
CL (3) CL2018003702A1 (es)
CO (1) CO2018014339A2 (es)
CR (2) CR20190027A (es)
CY (1) CY1126092T1 (es)
DK (1) DK3472157T3 (es)
EC (1) ECSP19001982A (es)
ES (1) ES2945063T3 (es)
FI (1) FI3472157T3 (es)
HR (1) HRP20230466T1 (es)
HU (1) HUE062234T2 (es)
IL (3) IL302528A (es)
LT (1) LT3472157T (es)
MD (1) MD3472157T2 (es)
MX (3) MX2018016281A (es)
PE (2) PE20240236A1 (es)
PH (1) PH12018502709A1 (es)
PL (1) PL3472157T3 (es)
PT (1) PT3472157T (es)
RS (1) RS64274B1 (es)
SG (2) SG10201912398PA (es)
SI (1) SI3472157T1 (es)
TW (2) TWI830533B (es)
UA (2) UA125476C2 (es)
WO (1) WO2017222977A1 (es)

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EP3581576B1 (en) 2013-03-15 2022-01-26 Incyte Holdings Corporation Tricyclic heterocycles as bet protein inhibitors for use in the treatment of a proliferative disease in combination with a janus kinase inhibitor
US9309246B2 (en) 2013-12-19 2016-04-12 Incyte Corporation Tricyclic heterocycles as BET protein inhibitors
AR100160A1 (es) 2014-04-23 2016-09-14 Incyte Corp 1H-PIRROLO[2,3-c]PIRIDIN-7(6H)-ONAS Y PIRAZOLO[3,4-c]PIRIDIN-7(6H)-ONAS COMO INHIBIDORES DE PROTEÍNAS BET
EP3194406B8 (en) 2014-09-15 2021-03-31 Incyte Corporation Tricyclic heterocycles for use as bet protein inhibitors
TW201722966A (zh) 2015-10-29 2017-07-01 英塞特公司 Bet蛋白質抑制劑之非晶固體形式
PT3472157T (pt) 2016-06-20 2023-05-30 Incyte Corp Formas sólidas cristalinas de um inibidor bet
TW202024078A (zh) * 2018-09-13 2020-07-01 加拿大商增你智表觀遺傳學公司 Bet溴結構域(bromodomain)抑制劑之固體形式之製備方法
WO2021217117A1 (en) * 2020-04-24 2021-10-28 Memorial Sloan Kettering Cancer Center Targeted therapy for the treatment & prevention of life-threatening complications of infection
JP2023529365A (ja) 2020-06-03 2023-07-10 インサイト・コーポレイション 骨髄増殖性腫瘍の治療のための、ルキソリチニブとｉｎｃｂ０５７６４３との組合わせ
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