DK3412290T3 - Androgenreceptormodulator til behandling af prostatacancer og androgenreceptorassocierede sygdomme - Google Patents

Androgenreceptormodulator til behandling af prostatacancer og androgenreceptorassocierede sygdomme Download PDF

Info

Publication number
DK3412290T3
DK3412290T3 DK18181743.8T DK18181743T DK3412290T3 DK 3412290 T3 DK3412290 T3 DK 3412290T3 DK 18181743 T DK18181743 T DK 18181743T DK 3412290 T3 DK3412290 T3 DK 3412290T3
Authority
DK
Denmark
Prior art keywords
androgen receptor
treatment
prostate cancer
associated diseases
receptor modulator
Prior art date
Application number
DK18181743.8T
Other languages
English (en)
Inventor
Michael E Jung
Charles L Sawyers
Samedy Ouk
Chris Tran
John Wongvipat
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38656005&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3412290(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of DK3412290T3 publication Critical patent/DK3412290T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
DK18181743.8T 2006-03-27 2007-03-27 Androgenreceptormodulator til behandling af prostatacancer og androgenreceptorassocierede sygdomme DK3412290T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78597806P 2006-03-27 2006-03-27
US83379006P 2006-07-28 2006-07-28
EP16173574.1A EP3100727B1 (en) 2006-03-27 2007-03-27 Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases

Publications (1)

Publication Number Publication Date
DK3412290T3 true DK3412290T3 (da) 2021-04-19

Family

ID=38656005

Family Applications (6)

Application Number Title Priority Date Filing Date
DK16173574.1T DK3100727T3 (da) 2006-03-27 2007-03-27 Androgenreceptormodulator til behandling af prostatacancer og androgenreceptor-associerede sygdomme
DK18181743.8T DK3412290T3 (da) 2006-03-27 2007-03-27 Androgenreceptormodulator til behandling af prostatacancer og androgenreceptorassocierede sygdomme
DK13178047.0T DK2656841T3 (da) 2006-03-27 2007-03-27 Androgen receptormodulator til behandling af prostatacancer og androgen receptor-associerede sygdomme
DK11163948.0T DK2368550T3 (da) 2006-03-27 2007-03-27 Androgenreceptormodulator til behandlingen af prostatakræft og androgenreceptor-associerede sygdomme
DK07754060.7T DK2004181T6 (da) 2006-03-27 2007-03-27 Androgen receptormodulator til behandling af prostatacancer og androgen receptor-associerede sygdomme
DK13178051.2T DK2656842T3 (da) 2006-03-27 2007-03-27 Androgen receptormodulator til behandling af prostatacancer og androgene receptor-associerede sygdomme

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK16173574.1T DK3100727T3 (da) 2006-03-27 2007-03-27 Androgenreceptormodulator til behandling af prostatacancer og androgenreceptor-associerede sygdomme

Family Applications After (4)

Application Number Title Priority Date Filing Date
DK13178047.0T DK2656841T3 (da) 2006-03-27 2007-03-27 Androgen receptormodulator til behandling af prostatacancer og androgen receptor-associerede sygdomme
DK11163948.0T DK2368550T3 (da) 2006-03-27 2007-03-27 Androgenreceptormodulator til behandlingen af prostatakræft og androgenreceptor-associerede sygdomme
DK07754060.7T DK2004181T6 (da) 2006-03-27 2007-03-27 Androgen receptormodulator til behandling af prostatacancer og androgen receptor-associerede sygdomme
DK13178051.2T DK2656842T3 (da) 2006-03-27 2007-03-27 Androgen receptormodulator til behandling af prostatacancer og androgene receptor-associerede sygdomme

Country Status (20)

Country Link
US (6) US8445507B2 (da)
EP (7) EP2656841B1 (da)
JP (10) JP5133975B2 (da)
CN (1) CN101454002B (da)
AU (1) AU2007243651C1 (da)
BR (1) BRPI0709771B1 (da)
CY (7) CY1114623T1 (da)
DK (6) DK3100727T3 (da)
ES (6) ES2588606T3 (da)
FI (1) FI2004181T6 (da)
HK (4) HK1126421A1 (da)
HU (6) HUE042037T2 (da)
LT (5) LT2656841T (da)
LU (1) LUC00123I2 (da)
NL (1) NL300993I2 (da)
NZ (1) NZ572335A (da)
PL (6) PL2004181T6 (da)
PT (5) PT3100727T (da)
SI (6) SI2656842T1 (da)
WO (1) WO2007126765A2 (da)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE502298T1 (de) 2003-12-19 2011-04-15 Univ California Verfahren und materialien zur beurteilung von prostatakrebstherapien
NZ550102A (en) 2004-02-24 2010-10-29 Univ California Methods and materials for assessing prostate cancer therapies and compounds (thiohydantoine derivatives)
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
PL2004181T6 (pl) 2006-03-27 2023-09-04 The Regents Of The University Of California Modulator receptorów androgenowych do leczenia raka prostaty i chorób powiązanych z receptorami androgenowymi
CA2648139A1 (en) 2006-03-29 2007-11-08 The Regents Of The University Of California Diaryl thiohydantoin compounds and their use in the treatment of hyperproliferative disorders
WO2008119015A2 (en) * 2007-03-27 2008-10-02 Sloan-Kettering Institute For Cancer Research Synthesis of thiohydantoins
UY31432A1 (es) 2007-10-26 2009-05-29 Compuestos de diarilhidantoina
FR2944524B1 (fr) * 2009-04-17 2012-11-30 Ipsen Pharma Sas Derives d'imidazolidine-2,4-dione et leur utilisation comme medicament
WO2011029392A1 (en) * 2009-09-10 2011-03-17 Youzhi Tong Androgen receptor antagonists and uses thereof
MX2012006615A (es) 2009-12-11 2012-10-05 Autifony Therapeuticts Ltd Derivados de imidazolidinodiona.
JP5702595B2 (ja) * 2009-12-25 2015-04-15 石原産業株式会社 2−クロロ−3−トリフルオロメチルピリジンの製造方法
US9108944B2 (en) 2010-02-16 2015-08-18 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and uses thereof
AU2014271290C1 (en) * 2010-02-16 2016-10-27 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and uses thereof
AU2016208310B2 (en) * 2010-02-16 2017-10-05 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and uses thereof
HUE038637T2 (hu) 2010-02-24 2018-12-28 Medivation Prostate Therapeutics Llc Eljárás a diaril-tiohidantoin és a diaril-hidantoin vegyületek szintetizálására
EP2649066B1 (en) 2010-12-06 2015-10-21 Autifony Therapeutics Limited Hydantoin derivatives useful as kv3 inhibitors
US9193704B2 (en) 2011-06-07 2015-11-24 Autifony Therapeutics Limited Hydantoin derivatives as KV3 inhibitors
BR112014002200A2 (pt) * 2011-07-29 2017-03-07 Medivation Prostate Therapeutics Inc tratamento de câncer de mama
US9708276B2 (en) 2011-10-12 2017-07-18 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer
WO2013056547A1 (zh) * 2011-10-22 2013-04-25 Chen Degui 一组乙内酰脲衍生物的合成及其应用
CN103159680A (zh) * 2011-12-14 2013-06-19 爱美尼迪药物有限公司 咪唑二酮类化合物及其用途
UY34646A (es) 2012-03-02 2013-10-31 Novartis Ag Compuestos de espirohidantoína y su uso como moduladores selectivos del receptor de andrógenos
WO2013152342A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Anti-cancer mtor inhibitor and anti-androgen combination
JP2015517563A (ja) 2012-05-22 2015-06-22 アウトイフオンイ トヘラペウトイクス リミテッド Kv3阻害剤としてのヒダントイン誘導体
WO2013175215A1 (en) 2012-05-22 2013-11-28 Autifony Therapeutics Limited Triazoles as kv3 inhibitors
PE20150631A1 (es) 2012-06-07 2015-05-11 Aragon Pharmaceuticals Inc Formas cristalinas de un modulador del receptor androgenico
IN2015DN02875A (da) 2012-09-11 2015-09-11 Medivation Prostate Therapeutics Inc
EA030128B1 (ru) 2012-09-26 2018-06-29 Арагон Фармасьютикалз, Инк. Способ лечения неметастатического кастрационно-резистентного рака простаты
US9175291B2 (en) 2012-10-11 2015-11-03 Isis Pharmaceuticals Inc. Modulation of androgen receptor expression
CA2889756C (en) 2012-10-26 2023-03-14 Memorial Sloan-Kettering Cancer Center Thiohydantoin compounds as androgen receptor modulators
JOP20200097A1 (ar) * 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
CA2908326C (en) * 2013-05-29 2017-09-12 Hinova Pharmaceuticals Inc. Imidazolidinedione compounds and their uses
CN104341396A (zh) * 2013-08-08 2015-02-11 上海医药集团股份有限公司 二芳基乙内酰脲衍生物、其制备方法、药物组合物和应用
WO2015042170A1 (en) 2013-09-17 2015-03-26 Wayne State University Compositions and uses of combinations of dim-related indoles and selected anti-androgen compounds
WO2015042029A1 (en) * 2013-09-19 2015-03-26 Glaxosmithkline Llc Combination drug therapy
JP6564380B2 (ja) * 2013-09-20 2019-08-21 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 前立腺癌を治療するための化合物
US20160257657A1 (en) 2013-09-20 2016-09-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
CN103601671B (zh) * 2013-10-22 2016-08-17 上海泰坦科技股份有限公司 碘代三氟甲基吡啶的制备方法
RU2650678C2 (ru) * 2013-12-31 2018-04-17 Ипсен Фарма С.А.С. Новые производные имидазолидин-2,4-дионов
JP2017505787A (ja) 2014-02-14 2017-02-23 ザ ユニバーシティ オブ ブリティッシュ コロンビア 治療薬としてのヒトアンドロゲン受容体dna結合ドメイン(dbd)化合物およびそれらを使用する方法
CN104003939B (zh) * 2014-06-06 2017-07-07 山东大学 二芳基取代乙内酰硫脲类化合物及其制备方法与应用
WO2015196144A2 (en) 2014-06-20 2015-12-23 England Pamela M Androgen receptor antagonists
HUE051888T2 (hu) * 2014-12-05 2021-03-29 Aragon Pharmaceuticals Inc Rákellenes készítmények
MA41107A (fr) * 2014-12-05 2017-10-10 Aragon Pharmaceuticals Inc Compositions anti-cancéreuses
EP3925598A1 (en) 2014-12-05 2021-12-22 Aragon Pharmaceuticals, Inc. Anticancer compositions
RU2017120330A (ru) 2014-12-12 2019-01-14 Медивэйшн Простейт Терапьютикс, Ллс Способ прогнозирования ответа на терапевтические агенты для лечения рака молочной железы и способ лечения рака молочной железы
MX2017008179A (es) * 2014-12-19 2017-09-18 Aragon Pharmaceuticals Inc Proceso para la preparacion de un compuesto de diariltiohidantoina.
CA2970933C (en) * 2014-12-19 2023-10-10 Aragon Pharmaceuticals, Inc. Processes for the preparation of a diarylthiohydantoin compound
CN105732575A (zh) * 2015-02-06 2016-07-06 苏州晶云药物科技有限公司 一种治疗前列腺癌的新型抗雄激素类药物的新晶型及其制备方法
US10471023B2 (en) 2015-03-12 2019-11-12 British Columbia Cancer Agency Branch Bisphenol ether derivatives and methods for using the same
PT3319959T (pt) 2015-07-06 2021-12-06 Alkermes Inc Inibidores hetero-halo de histona desacetilase
US10421756B2 (en) 2015-07-06 2019-09-24 Rodin Therapeutics, Inc. Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
US10980806B2 (en) 2016-03-24 2021-04-20 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
US20170298033A1 (en) 2016-04-15 2017-10-19 The University Of British Columbia Bisphenol derivatives and their use as androgen receptor activity modulators
US20190209469A1 (en) * 2016-08-20 2019-07-11 Ftf Pharma Private Limited Pharmaceutical composition comprising an androgen receptor inhibitor
CN107954936B (zh) * 2016-10-17 2021-03-19 海创药业股份有限公司 一种制备氘代咪唑二酮类化合物的方法
CN108069869B (zh) * 2016-11-09 2022-03-01 上海医药工业研究院 一种Apalutamide的制备方法及其中间体
ES2952770T3 (es) 2016-12-13 2023-11-06 Watson Lab Inc Formas de estado sólido de apalutamida
US9951069B1 (en) 2017-01-11 2018-04-24 Rodin Therapeutics, Inc. Bicyclic inhibitors of histone deacetylase
TW201831461A (zh) * 2017-01-18 2018-09-01 台灣神隆股份有限公司 製備阿帕魯醯胺的方法
CA3071861A1 (en) 2017-08-07 2019-02-14 Rodin Therapeutics, Inc. Bicyclic inhibitors of histone deacetylase
CN113563311A (zh) 2017-08-07 2021-10-29 正大天晴药业集团股份有限公司 用作雄激素受体拮抗剂的二芳基硫代乙内酰脲化合物
CN111094255B (zh) 2017-09-14 2023-10-03 第一三共株式会社 具有环状结构的化合物
AU2018351714A1 (en) 2017-10-16 2020-04-30 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer
CN108047200A (zh) * 2017-12-05 2018-05-18 上海丰瑞医药科技有限公司 一种二芳基乙内酰硫脲类化合物的制备方法及其中间体
CN108003093A (zh) * 2017-12-07 2018-05-08 山东汇盟生物科技有限公司 2-羟基-3-三氟甲基吡啶的制备方法
CN107987055A (zh) * 2017-12-19 2018-05-04 刘秀云 硫代咪唑二酮类雄激素受体拮抗剂及其用途
CN109988077A (zh) * 2017-12-29 2019-07-09 上海法默生物科技有限公司 一种阿帕鲁胺的合成方法及中间体
WO2019135254A1 (en) 2018-01-02 2019-07-11 Mylan Laboratories Limited Apalutamide polymorphs and their preparation thereof
US10513504B2 (en) 2018-03-08 2019-12-24 Apotex Inc. Processes for the preparation of apalutamide and intermediates thereof
US10807965B2 (en) * 2018-03-28 2020-10-20 Cadila Healthcare Limited Process for preparation of apalutamide
US10934269B2 (en) * 2018-03-28 2021-03-02 Cadila Healthcare Limited Process for preparation of apalutamide
CN108314646B (zh) * 2018-04-11 2021-03-19 武汉慧敏科技中心 一种高分散双金属纳米材料制备泌尿生殖系统用药物中间体的方法
CN108311155B (zh) * 2018-05-14 2020-11-06 上海奥萝拉医药科技有限公司 一种催化制备治疗前列腺癌症药物阿帕鲁胺中间体的方法
WO2019226991A1 (en) 2018-05-25 2019-11-28 Essa Pharma, Inc. Androgen receptor modulators and methods for their use
WO2019242439A1 (zh) 2018-06-20 2019-12-26 苏州科睿思制药有限公司 Arn-509的晶型及其制备方法和用途
CN108976171B (zh) * 2018-08-27 2020-06-16 长沙泽达医药科技有限公司 化合物、组合物及其在药物制备中的用途
WO2020049598A2 (en) 2018-09-08 2020-03-12 Cipla Limited Apalutamide polymorphs
JP2022509917A (ja) 2018-11-05 2022-01-25 ファイザー・インク がんを処置するための組合せ
US11292782B2 (en) 2018-11-30 2022-04-05 Nuvation Bio Inc. Diarylhydantoin compounds and methods of use thereof
IT201900003839A1 (it) 2019-03-15 2020-09-15 Olon Spa Sintesi di apalutamide amorfa stabile
WO2020198710A1 (en) * 2019-03-28 2020-10-01 Essa Pharma, Inc. Pharmaceutical compositions and combinations comprising inhibitors of the androgen receptor and uses thereof
IT201900010593A1 (it) 2019-07-01 2021-01-01 Dipharma Francis Srl Forma cristallina di un inibitore di recettori degli androgeni
CA3148115A1 (en) 2019-08-08 2021-02-11 Laekna Limited Method of treating cancer
US20220281836A1 (en) * 2019-08-22 2022-09-08 Dr. Reddy's Laboratories Limited Process for the preparation of apalutamide
IT201900015974A1 (it) 2019-09-10 2021-03-10 Olon Spa Apalutamide cristallina stabile in forma pura e processo per la sua preparazione
EP4135675A4 (en) 2020-04-17 2024-04-10 Essa Pharma Inc SOLID FORMS OF AN N-TERMINAL DOMAIN ANDROGEN RECEPTOR INHIBITOR AND USES THEREOF
MX2023001823A (es) 2020-08-13 2023-03-13 Pfizer Terapia de combinacion.
WO2022049265A1 (en) 2020-09-04 2022-03-10 Synthon B.V. Improved process for preparation of apalutamide
CN114621184A (zh) * 2020-12-10 2022-06-14 奥锐特药业股份有限公司 一种阿帕他胺的制备方法
CA3214316A1 (en) 2021-03-24 2022-09-29 Pfizer Inc. Combination of talazoparib and an anti-androgen for the treatment of ddr gene mutated metastatic castration-sensitive prostate cancer

Family Cites Families (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE550650A (da) 1955-08-30
US3823240A (en) 1970-10-06 1974-07-09 Rhone Poulenc Sa Fungicidal hydantoin derivatives
GB1472467A (en) 1974-04-19 1977-05-04 Wyeth John & Brother Ltd Thiohydantoins
FR2329276A1 (fr) 1975-10-29 1977-05-27 Roussel Uclaf Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
DE2614831A1 (de) 1976-04-06 1977-10-20 Bayer Ag 1,3,4-thiadiazolylderivate, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide
IL55774A (en) 1977-10-28 1982-04-30 Sparamedica Ag Pharmaceutical compositions containing urea derivatives,certain such novel derivatives and their manufacture
MC1220A1 (fr) 1977-10-28 1979-07-20 Hoffmann La Roche Nouveaux derives d'imidazolidine
ZA786739B (en) 1977-12-01 1980-07-30 Wellcome Found Hydantoin derivatives and salts thereof,their syntheses,and intermediates,and pharmaceutical formulations
EP0004723A1 (en) 1978-03-30 1979-10-17 Beecham Group Plc Deoxyhydantoins, processes for their preparation and pharmaceutical compositions containing them
FR2449448B1 (fr) 1979-02-20 1983-05-27 Inst Nat Radio Elements Composition pharmaceutique comprenant un derive de phenylhydantoine, derives mis en oeuvre et leur preparation
FI801184A (fi) 1979-04-24 1980-10-25 Hoffmann La Roche Foerfarande foer framstaellning av imidazolidinderivat
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
EP0065404A3 (en) * 1981-05-08 1984-06-06 Ace Coin Equipment Limited Video gaming or amusement machine
JPS57197268A (en) 1981-05-29 1982-12-03 Sumitomo Chem Co Ltd Substituted phenylhydantoin derivative, its preparation, and herbicide containing the same as active ingredient
EP0091596B1 (de) 1982-04-08 1991-09-11 Shell Internationale Researchmaatschappij B.V. Neue Hydantoine, ihre Herstellung und Verwendung
US4473393A (en) 1982-08-06 1984-09-25 Buffalo Color Corporation Pesticidal thiohydantoin compositions
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
JPS59210083A (ja) * 1983-05-13 1984-11-28 Otsuka Chem Co Ltd 1,3,4−チアジアゾ−ル−5−オン誘導体、その製造法及び該誘導体を有効成分とする除草剤
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
JPS6092285A (ja) 1983-10-26 1985-05-23 Shionogi & Co Ltd イソオキサゾ−ル系環状尿素類
JPS60239737A (ja) * 1984-05-14 1985-11-28 Konishiroku Photo Ind Co Ltd ハロゲン化銀写真感光材料
DE3604042A1 (de) 1986-02-08 1987-08-13 Hoechst Ag Imidazolidin(thi)on-derivate, verfahren zu ihrer herstellung sowie ihre verwendung im pflanzenschutz
US5071773A (en) 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
JPS649978A (en) * 1987-07-02 1989-01-13 Shionogi & Co Perfluoroalkylisoxazole derivative
US4859228A (en) 1987-07-16 1989-08-22 Ici Americas Inc Novel 5-aminomethylene-2,4-imidazolidinediones and 5-aminomethylene-2-thionoimidazolidine-4-ones
US5010182A (en) 1987-07-28 1991-04-23 Chiron Corporation DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides
FR2619381B1 (fr) 1987-08-13 1989-12-08 Roussel Uclaf Nouvelles imidazolidines substituees par un radical hydroxymethyle et un radical phenyl substitue, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant et un intermediaire pour leur preparation
CA1331757C (en) 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
US5614620A (en) 1988-03-30 1997-03-25 Arch Development Corporation DNA binding proteins including androgen receptor
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US6307030B1 (en) 1988-04-15 2001-10-23 The University Of North Carolina At Chapel Hill Androgen receptor proteins, recombinant DNA molecules coding for such, and use of such compositions
JPH0219363A (ja) 1988-07-06 1990-01-23 Fujisawa Pharmaceut Co Ltd イミダゾリジン誘導体
AU4005289A (en) 1988-08-25 1990-03-01 Smithkline Beecham Corporation Recombinant saccharomyces
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
DE3835168A1 (de) 1988-10-15 1990-04-19 Bayer Ag N-aryl-stickstoffheterocyclen, mehrere verfahren zu ihrer herstellung und ihre verwendung als herbizide
FR2646437B1 (fr) 1989-04-28 1991-08-30 Transgene Sa Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
FR2656302B1 (fr) 1989-12-22 1992-05-07 Roussel Uclaf Nouveau procede de preparation de l'anandron et derives de l'anandron.
FR2693461B1 (fr) 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2671348B1 (fr) 1991-01-09 1993-03-26 Roussel Uclaf Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
US5411981A (en) 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
USRE35956E (en) 1991-01-09 1998-11-10 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
JP2845384B2 (ja) 1991-11-14 1999-01-13 キヤノン株式会社 画像処理装置
US5346913A (en) 1992-05-26 1994-09-13 Rohm And Haas Company N-iodopropargyl hydantoin compounds, compositions, preparation, and use as antimicrobial agents
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2715402B1 (fr) 1994-01-05 1996-10-04 Roussel Uclaf Nouvelles phénylimidazolines éventuellement substituées, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
TW521073B (en) 1994-01-05 2003-02-21 Hoechst Marion Roussel Inc New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
WO1995019770A1 (en) 1994-01-21 1995-07-27 Sepracor, Inc. Methods and compositions for treating androgen-dependent diseases using optically pure r-(-)-casodex
JPH089997A (ja) 1994-06-28 1996-01-16 Shimadzu Corp 核酸合成法およびそれに用いる試薬キット
EP0721944B1 (en) 1994-07-29 2001-01-17 Suntory Limited Imidazolidine derivative and use thereof
FR2725206B1 (fr) * 1994-09-29 1996-12-06 Roussel Uclaf Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
US5656651A (en) 1995-06-16 1997-08-12 Biophysica Inc. Androgenic directed compositions
DE19540027A1 (de) * 1995-10-27 1997-04-30 Gruenenthal Gmbh Substituierte Imidazolidin-2,4-dion-Verbindungen als pharmazeutische Wirkstoffe
FR2741346B1 (fr) 1995-11-16 1997-12-19 Roussel Uclaf Nouveau procede de preparation de derives phenylimidazolidine
FR2741342B1 (fr) 1995-11-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques
US5554607A (en) * 1995-11-28 1996-09-10 American Home Products Corporation Use of 2-thioxo-imidazolin-4-one derivatives in the treatment of atherosclerosis
TW418195B (en) 1995-11-28 2001-01-11 American Home Prod 2-thioxo-imidazolidin-4-one derivatives
WO1997019931A1 (en) 1995-11-28 1997-06-05 American Home Products Corporation 2-(substituted sulfanyl)-3,5-dihydro-imidazol-4-one derivatives
FR2742749B1 (fr) 1995-12-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines comportant notamment un radical nitrooxy ou carbonyloxy, procede et intermediaires de preparation, application comme medicaments, nouvelles utilisations et compositions pharmaceutiques
US6489163B1 (en) 1996-05-08 2002-12-03 Board Of Regents, The University Of Texas System Ribozyme mediated inactivation of the androgen receptor
JP3697320B2 (ja) 1996-06-20 2005-09-21 株式会社日立製作所 光ファイバセンサ
US5726061A (en) 1996-10-08 1998-03-10 Smithkline Beechum Corporation Method of diagnosing and monitoring colorectal cancer
US7053263B2 (en) 1996-10-15 2006-05-30 The Regents Of The University Of California Mouse models of human prostate cancer progression
US6506607B1 (en) 1997-12-24 2003-01-14 Millennium Pharmaceuticals, Inc. Methods and compositions for the identification and assessment of prostate cancer therapies and the diagnosis of prostate cancer
WO1999065494A1 (en) 1998-06-15 1999-12-23 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
BR9914018A (pt) 1998-09-22 2001-07-03 Yamanouchi Pharmaceuticals Co Derivado de cianofenila
ATE240944T1 (de) 1998-09-22 2003-06-15 Degussa Verfahren zur herstellung von imidazolidin-2,4- dionen
WO2000026195A1 (en) * 1998-10-30 2000-05-11 G.D. Searle & Co. Novel amino acid heterocyclic amide derivatives useful as nitric oxide synthase inhibitors
US6472415B1 (en) 1998-12-18 2002-10-29 Biophysica, Inc. Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes
AU2847200A (en) 1999-01-27 2000-08-18 G.D. Searle & Co. Novel hydroxyamidino carboxylate derivatives useful as nitric oxide synthase inhibitors
US6350763B1 (en) 1999-07-21 2002-02-26 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful in the treatment of inflammation disease
US6479063B2 (en) 1999-12-27 2002-11-12 Kenneth Weisman Therapeutic uses of hormonal manipulation using combinations of various agents to treat atherosclerosis
US6699888B2 (en) * 2000-05-31 2004-03-02 Tanabe Seiyaku Co., Ltd. Inhibitors of αLβ2 mediated cell adhesion
US6482829B2 (en) * 2000-06-08 2002-11-19 Hoffmann-La Roche Inc. Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor
WO2002053155A1 (en) 2000-12-30 2002-07-11 Geron Corporation Telomerase inhibitor
FR2823209B1 (fr) * 2001-04-04 2003-12-12 Fournier Lab Sa Nouvelles thiohydantoines et leur utilisation en therapeutique
HUP0402338A3 (en) 2001-10-01 2008-10-28 Bristol Myers Squibb Co Spiro-hydantoin compounds, their use as anti-inflammatory agents, pharmaceutical compositions containing them and intermediates for preparing them
WO2003032994A2 (de) * 2001-10-17 2003-04-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg 5-substituierte 4-amino-2-phenylamino-pyrimidinderivate und ihre verwendung als beta-amyloid modulatoren
US6861432B2 (en) 2001-11-23 2005-03-01 Schering Aktiengesellschaft Piperazine derivatives that destabilize androgen receptors
GB0200283D0 (en) 2002-01-08 2002-02-20 Smithkline Beecham Plc Compounds
DE10218963A1 (de) 2002-04-27 2003-11-20 Aventis Pharma Gmbh Zubereitungen zur topischen Applikation von antiandrogen wirksamen Substanzen
TW200407324A (en) * 2002-05-17 2004-05-16 Bristol Myers Squibb Co Bicyclic modulators of androgen receptor function
AU2003262717A1 (en) 2002-08-15 2004-03-03 Genzyme Corporation Brain endothelial cell expression patterns
AU2002951247A0 (en) * 2002-09-06 2002-09-19 Alchemia Limited Compounds that interact with kinases
FR2845384B1 (fr) 2002-10-04 2004-12-31 Fournier Lab Sa Composes derives de la 2-thiohydantoine et leur utilisation en therapeutique
FR2845385B1 (fr) 2002-10-04 2004-12-31 Fournier Lab Sa Composes derives de la 2-thiohydantoine et leur utilisation en therapeutique
WO2004030633A2 (en) * 2002-10-03 2004-04-15 Cypress Bioscience, Inc. Dosage escalation and divided daily dose of anti-depressants to treat neurological disorders
JP2006510600A (ja) 2002-10-04 2006-03-30 ラボラトワール フルニエ エス・アー 2−チオヒダントインに由来する化合物及び治療におけるその使用
UA79504C2 (en) 2002-11-07 2007-06-25 Organon Nv Indols for treating diseases associated with androgen receptors
FR2850652B1 (fr) 2003-01-31 2008-05-30 Aventis Pharma Sa Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
WO2004111031A1 (en) * 2003-06-12 2004-12-23 Novo Nordisk A/S Pyridinyl carbamates as hormone-sensitive lipase inhibitors
EP1634874A4 (en) 2003-06-12 2008-04-02 Chugai Pharmaceutical Co Ltd imidazolidine
TW200523252A (en) * 2003-10-31 2005-07-16 Takeda Pharmaceutical Pyridine compounds
US7256208B2 (en) 2003-11-13 2007-08-14 Bristol-Myers Squibb Company Monocyclic N-Aryl hydantoin modulators of androgen receptor function
EP1709152A4 (en) 2003-12-15 2007-11-07 Univ California MOLECULAR SIGNATURE OF PTEN TUMOR SUPPRESSOR
ATE502298T1 (de) 2003-12-19 2011-04-15 Univ California Verfahren und materialien zur beurteilung von prostatakrebstherapien
NZ550102A (en) 2004-02-24 2010-10-29 Univ California Methods and materials for assessing prostate cancer therapies and compounds (thiohydantoine derivatives)
CN1960725A (zh) * 2004-03-15 2007-05-09 Ptc医疗公司 用于抑制血管发生的四环咔啉衍生物
EP1576967B1 (en) * 2004-03-18 2007-09-12 Institut Pasteur Recombinant protein, carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof, therapeutic uses thereof
EP1621536A1 (en) 2004-07-27 2006-02-01 Aventis Pharma S.A. Amino cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621539A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Heterocycle -substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
JP4912148B2 (ja) 2004-08-03 2012-04-11 中外製薬株式会社 新規イミダゾリジン誘導体
AU2005280908A1 (en) * 2004-09-09 2006-03-16 Chugai Seiyaku Kabushiki Kaisha Novel imidazolidine derivative and use thereof
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
NZ591119A (en) * 2005-05-13 2012-08-31 Univ California Use of diarylhydantoin compounds for treating specific cancers
GB0521373D0 (en) 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
CN101032483B (zh) * 2006-03-09 2011-05-04 陈德桂 调节雄激素受体活性的乙内酰脲衍生物及其应用
PL2004181T6 (pl) 2006-03-27 2023-09-04 The Regents Of The University Of California Modulator receptorów androgenowych do leczenia raka prostaty i chorób powiązanych z receptorami androgenowymi
CA2648139A1 (en) 2006-03-29 2007-11-08 The Regents Of The University Of California Diaryl thiohydantoin compounds and their use in the treatment of hyperproliferative disorders
WO2008119015A2 (en) 2007-03-27 2008-10-02 Sloan-Kettering Institute For Cancer Research Synthesis of thiohydantoins

Also Published As

Publication number Publication date
US20210121450A1 (en) 2021-04-29
JP2023001259A (ja) 2023-01-04
NL300993I2 (nl) 2019-07-11
JP2012092149A (ja) 2012-05-17
ES2428291T3 (es) 2013-11-06
EP2004181B3 (en) 2023-05-24
PT3100727T (pt) 2018-11-09
CY1117540T1 (el) 2017-04-26
EP2656842A3 (en) 2014-04-02
US9987261B2 (en) 2018-06-05
HK1163495A1 (en) 2012-09-14
PL2656842T3 (pl) 2017-01-31
HUS1900030I1 (hu) 2020-04-28
SI3412290T1 (sl) 2021-09-30
PL2004181T6 (pl) 2023-09-04
EP2656841A1 (en) 2013-10-30
ES2564388T3 (es) 2016-03-22
EP2004181B1 (en) 2016-02-24
JP5133975B2 (ja) 2013-01-30
BRPI0709771A2 (pt) 2011-07-26
EP2368550B1 (en) 2013-09-04
US11771687B2 (en) 2023-10-03
LT3100727T (lt) 2018-12-10
PL3412290T3 (pl) 2021-09-06
SI2656842T1 (sl) 2016-10-28
CN101454002A (zh) 2009-06-10
JP2020193234A (ja) 2020-12-03
JP6027662B2 (ja) 2016-11-16
JP6422519B2 (ja) 2018-11-14
CY1118026T1 (el) 2017-05-17
EP2656842A2 (en) 2013-10-30
US20130072511A1 (en) 2013-03-21
JP2009531439A (ja) 2009-09-03
DK2656841T3 (da) 2016-12-05
EP2004181A4 (en) 2010-11-10
NZ572335A (en) 2011-09-30
US20140309262A1 (en) 2014-10-16
EP3835294A1 (en) 2021-06-16
BRPI0709771B1 (pt) 2022-01-25
LT2656841T (lt) 2016-09-26
US8445507B2 (en) 2013-05-21
PT3412290T (pt) 2021-04-19
DK2368550T3 (da) 2013-09-30
CN101454002B (zh) 2011-06-08
EP3412290A1 (en) 2018-12-12
LT2656842T (lt) 2016-09-26
US8802689B2 (en) 2014-08-12
US20180318276A1 (en) 2018-11-08
CY2019028I2 (el) 2019-11-27
US9388159B2 (en) 2016-07-12
PL2004181T3 (pl) 2016-06-30
EP3100727A1 (en) 2016-12-07
EP2656842B1 (en) 2016-08-10
LT3412290T (lt) 2021-04-26
LTPA2019512I1 (lt) 2019-07-25
HK1190928A1 (zh) 2014-07-18
JP2018065879A (ja) 2018-04-26
JP6057518B2 (ja) 2017-01-11
FI2004181T6 (fi) 2023-09-01
DK3100727T3 (da) 2018-11-12
SI3100727T1 (sl) 2018-11-30
EP3100727B1 (en) 2018-08-22
EP3412290B1 (en) 2021-03-03
HUE031079T2 (en) 2017-06-28
HK1231375A1 (zh) 2017-12-22
HUE053877T2 (hu) 2021-07-28
HUE042037T2 (hu) 2019-06-28
AU2007243651C1 (en) 2013-03-14
JP2017105845A (ja) 2017-06-15
PT2656841T (pt) 2016-09-28
AU2007243651A1 (en) 2007-11-08
CY2019028I1 (el) 2019-11-27
JP2014133755A (ja) 2014-07-24
CY1114623T1 (el) 2016-10-05
ES2588606T3 (es) 2016-11-03
DK2656842T3 (da) 2016-11-07
JP2016011315A (ja) 2016-01-21
ES2863798T3 (es) 2021-10-11
JP2019081815A (ja) 2019-05-30
LUC00123I1 (da) 2019-06-06
CY1124147T1 (el) 2022-05-27
WO2007126765A3 (en) 2008-11-06
US20110003839A1 (en) 2011-01-06
PL3100727T3 (pl) 2019-01-31
US10857139B2 (en) 2020-12-08
JP7257692B2 (ja) 2023-04-14
ES2564388T7 (es) 2023-12-21
JP2016014069A (ja) 2016-01-28
LUC00123I2 (da) 2019-12-27
US20170014399A1 (en) 2017-01-19
WO2007126765A2 (en) 2007-11-08
EP2004181A2 (en) 2008-12-24
DK2004181T3 (da) 2016-04-25
PL2368550T3 (pl) 2014-01-31
HUE032085T2 (en) 2017-09-28
PL2656841T3 (pl) 2017-01-31
HUE027894T2 (en) 2016-11-28
ES2593379T3 (es) 2016-12-09
JP6701237B2 (ja) 2020-05-27
DK2004181T6 (da) 2023-08-21
SI2004181T1 (sl) 2016-07-29
ES2689292T3 (es) 2018-11-13
SI2368550T1 (sl) 2013-11-29
SI2656841T1 (sl) 2016-11-30
CY1120828T1 (el) 2019-12-11
LTC2368550I2 (lt) 2020-01-10
PT2656842T (pt) 2016-10-04
PT2368550E (pt) 2013-12-03
AU2007243651B2 (en) 2012-08-30
HK1126421A1 (zh) 2009-09-04
EP2368550A1 (en) 2011-09-28
CY1117958T1 (el) 2017-05-17
EP2656841B1 (en) 2016-08-10

Similar Documents

Publication Publication Date Title
DK2368550T3 (da) Androgenreceptormodulator til behandlingen af prostatakræft og androgenreceptor-associerede sygdomme
DK2195015T3 (da) Sammensætning til behandling af prostatacancer
DK2340042T3 (da) Fremgangsmåder og præparater til behandling af cancer
DK2155188T3 (da) Fremgangsmåder og sammensætninger til behandling af tilbagevendende kræft
DK2478907T3 (da) Sammensætninger til behandling af kræft
DK2322221T3 (da) Farmaceutisk sammensætning til behandling og forebyggelse af cancer
DK2601962T3 (da) Lag-3-doseringsskema til anvendelse i behandling af cancer
DK2056842T3 (da) Modificeret galactosylceramid til behandling af cancerøse sygdomme
DK2356093T3 (da) Carbazolforbindelser og terapeutiske anvendelser af forbindelserne
DK2154971T3 (da) Synergistisk farmaceutisk kombination til behandling af cancer
DK2063881T3 (da) Sammensætning og fremgangsmåde til virksom og sikker administration af halopyruvat til behandlingen af cancer
DK2109432T3 (da) Behandlingssystem til repositionering af patient og legemsdel
DK2235002T3 (da) 4-pyridinonforbindelser og anvendelse heraf til behandling af cancer
DK2117565T3 (da) Anvendelse af chitosaner til behandlingen af negleinflammatoriske sygdomme
DK2331092T3 (da) Fremgangsmåder og sammensætninger til indgivelse af 3-halopyruvat og associerede forbindelser til behandling af cancer
DK3388111T3 (da) Organoarsenforbindelse til behandlingen af kræft
GB0700281D0 (en) Methods and Means for the Treatment of Cancer