DK3100727T3 - Androgenreceptormodulator til behandling af prostatacancer og androgenreceptor-associerede sygdomme - Google Patents
Androgenreceptormodulator til behandling af prostatacancer og androgenreceptor-associerede sygdomme Download PDFInfo
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- DK3100727T3 DK3100727T3 DK16173574.1T DK16173574T DK3100727T3 DK 3100727 T3 DK3100727 T3 DK 3100727T3 DK 16173574 T DK16173574 T DK 16173574T DK 3100727 T3 DK3100727 T3 DK 3100727T3
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- compounds
- prostate cancer
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (15)
1. Farmaceutisk sammensætning, der omfatter en farmaceutisk acceptabel bærer, fortynder eller adjuvans og en forbindelse med formlen: F O NC^-N g CH3 ncy% t Z/n'chj XX λ XT X—ArTf eller ° 9 eller et farmaceutisk acceptabelt salt deraf, hvilken sammensætning er formuleret i en delt doseringsform, hvor administration af to eller flere delte doseringsformer over tidsrummet af én dag tilvejebringer en terapeutisk virksom mængde af forbindelsen til et individ med behov derfor.
2. Farmaceutisk sammensætning ifølge krav 1, hvor forbindelsen har formlen: F O Ύϊ å F CXA N N -XX
3. Farmaceutisk sammensætning ifølge krav 1, hvor forbindelsen har formlen: X /_
4. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 1 til 3, hvor den delte doseringsform er formuleret i en delt oral doseringsform.
5. Farmaceutisk sammensætning ifølge krav 4, hvor forbindelsen eller det farmaceutisk acceptable salt deraf er til stede i den delte orale doseringsform i en mængde på fra 0,0005 til 500 mg.
6. Farmaceutisk sammensætning ifølge krav 5, hvor forbindelsen eller det farmaceutisk acceptable salt deraf er til stede i den delte orale doseringsform i en mængde på fra 0,01 til 50 mg.
7. Farmaceutisk sammensætning ifølge krav 6, hvor forbindelsen eller det farmaceutisk acceptable salt deraf er til stede i den delte orale doseringsform i en mængde på fra 0,05 til 10 mg.
8. Farmaceutisk sammensætning ifølge krav 4, hvor den delte orale doseringsform er et pulver, en kapsel, tablet, pille, depotkapsel, depottablet eller depotpille.
9. Farmaceutisk sammensætning ifølge krav 1, hvor administration af den delte doseringsform to, tre eller fire gange over tidsrummet af én dag tilvejebringer en terapeutisk effektiv mængde af forbindelsen.
10. Farmaceutisk sammensætning ifølge krav 1, hvor administration af den delte doseringsform mere end fire gange over tidsrummet af én dag tilvejebringer en terapeutisk effektiv mængde af forbindelsen.
11. Farmaceutisk sammensætning som defineret i et hvilket som helst af kravene 1 til 10 til anvendelse i behandlingen afen hyperproliferativ forstyrrelse.
12. Farmaceutisk sammensætning til anvendelse ifølge krav 11, hvor den hyperproliferative forstyrrelse er prostatacancer.
13. Farmaceutisk sammensætning til anvendelse ifølge krav 12, hvor prostatacanceren er en hormonsensitiv prostatacancer eller hormonrefraktær prostatacancer.
14. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af kravene 11 til 13, hvor den terapeutisk virksomme mængde af forbindelsen eller det farmaceutisk acceptable salt deraf ligger i intervallet på fra 0,1 mg pr. kg kropsvægt pr. dag til 200 mg pr. kg kropsvægt pr. dag.
15. Farmaceutisk sammensætning til anvendelse ifølge krav 14, hvor den terapeutisk virksomme mængde af forbindelsen eller det farmaceutisk acceptable salt deraf ligger i intervallet på fra 1 mg pr. kg kropsvægt pr. dag til 50 mg pr. kg kropsvægt pr. dag.
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| EP13178051.2A EP2656842B1 (en) | 2006-03-27 | 2007-03-27 | Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases |
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| DK11163948.0T DK2368550T3 (da) | 2006-03-27 | 2007-03-27 | Androgenreceptormodulator til behandlingen af prostatakræft og androgenreceptor-associerede sygdomme |
| DK13178051.2T DK2656842T3 (da) | 2006-03-27 | 2007-03-27 | Androgen receptormodulator til behandling af prostatacancer og androgene receptor-associerede sygdomme |
| DK07754060.7T DK2004181T6 (da) | 2006-03-27 | 2007-03-27 | Androgen receptormodulator til behandling af prostatacancer og androgen receptor-associerede sygdomme |
| DK16173574.1T DK3100727T3 (da) | 2006-03-27 | 2007-03-27 | Androgenreceptormodulator til behandling af prostatacancer og androgenreceptor-associerede sygdomme |
| DK13178047.0T DK2656841T3 (da) | 2006-03-27 | 2007-03-27 | Androgen receptormodulator til behandling af prostatacancer og androgen receptor-associerede sygdomme |
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| DK18181743.8T DK3412290T3 (da) | 2006-03-27 | 2007-03-27 | Androgenreceptormodulator til behandling af prostatacancer og androgenreceptorassocierede sygdomme |
| DK11163948.0T DK2368550T3 (da) | 2006-03-27 | 2007-03-27 | Androgenreceptormodulator til behandlingen af prostatakræft og androgenreceptor-associerede sygdomme |
| DK13178051.2T DK2656842T3 (da) | 2006-03-27 | 2007-03-27 | Androgen receptormodulator til behandling af prostatacancer og androgene receptor-associerede sygdomme |
| DK07754060.7T DK2004181T6 (da) | 2006-03-27 | 2007-03-27 | Androgen receptormodulator til behandling af prostatacancer og androgen receptor-associerede sygdomme |
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| DK13178047.0T DK2656841T3 (da) | 2006-03-27 | 2007-03-27 | Androgen receptormodulator til behandling af prostatacancer og androgen receptor-associerede sygdomme |
Country Status (20)
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| US (7) | US8445507B2 (da) |
| EP (8) | EP2656842B1 (da) |
| JP (10) | JP5133975B2 (da) |
| CN (1) | CN101454002B (da) |
| AU (1) | AU2007243651C1 (da) |
| BR (1) | BRPI0709771B1 (da) |
| CY (7) | CY1114623T1 (da) |
| DK (6) | DK3412290T3 (da) |
| ES (6) | ES2564388T7 (da) |
| FI (1) | FI2004181T6 (da) |
| HK (4) | HK1126421A1 (da) |
| HU (6) | HUE042037T2 (da) |
| LT (5) | LT2656842T (da) |
| LU (1) | LUC00123I2 (da) |
| NL (1) | NL300993I2 (da) |
| NZ (1) | NZ572335A (da) |
| PL (6) | PL2368550T3 (da) |
| PT (5) | PT3412290T (da) |
| SI (6) | SI2004181T1 (da) |
| WO (1) | WO2007126765A2 (da) |
Families Citing this family (99)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2005060661A2 (en) | 2003-12-19 | 2005-07-07 | The Regents Of The University Of California | Methods and materials for assessing prostate cancer therapies |
| US7718684B2 (en) | 2004-02-24 | 2010-05-18 | The Regents Of The University Of California | Methods and materials for assessing prostate cancer therapies and compounds |
| US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
| PT3412290T (pt) | 2006-03-27 | 2021-04-19 | Univ California | Modulador do recetor de androgénios para o tratamento de cancro da próstata e doenças associadas ao recetor de androgénios |
| JP5350217B2 (ja) | 2006-03-29 | 2013-11-27 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ジアリールチオヒダントイン化合物 |
| WO2008119015A2 (en) | 2007-03-27 | 2008-10-02 | Sloan-Kettering Institute For Cancer Research | Synthesis of thiohydantoins |
| CA2966280A1 (en) | 2007-10-26 | 2009-04-30 | The Regents Of The University Of California | Diarylhydantoin compounds |
| FR2944524B1 (fr) * | 2009-04-17 | 2012-11-30 | Ipsen Pharma Sas | Derives d'imidazolidine-2,4-dione et leur utilisation comme medicament |
| EP2475647B1 (en) * | 2009-09-10 | 2015-11-04 | Suzhou Kintor Pharmaceuticals, Inc. | Androgen receptor antagonists and uses thereof |
| ES2575215T3 (es) | 2009-12-11 | 2016-06-27 | Autifony Therapeutics Limited | Derivados de imidazolidindiona |
| JP5702595B2 (ja) * | 2009-12-25 | 2015-04-15 | 石原産業株式会社 | ２−クロロ−３−トリフルオロメチルピリジンの製造方法 |
| AU2014271290C1 (en) * | 2010-02-16 | 2016-10-27 | Aragon Pharmaceuticals, Inc. | Androgen receptor modulators and uses thereof |
| EA028869B1 (ru) * | 2010-02-16 | 2018-01-31 | Арагон Фармасьютикалс, Инк. | Модуляторы рецептора андрогенов и их применение |
| AU2016208310B2 (en) * | 2010-02-16 | 2017-10-05 | Aragon Pharmaceuticals, Inc. | Androgen receptor modulators and uses thereof |
| DK2538785T3 (da) | 2010-02-24 | 2018-05-22 | Medivation Prostate Therapeutics Llc | Fremgangsmåder til syntese af diarylthiohydantoin- og diarylhydantoinforbindelser |
| BR112013013914B1 (pt) | 2010-12-06 | 2021-10-26 | Autifony Therapeutics Limited | Compostos derivados de hidantoína úteis como inibidores de kv3, usos dos referidos compostos e composição farmacêutica compreendendo os mesmos |
| WO2012168710A1 (en) | 2011-06-07 | 2012-12-13 | Autifony Therapeutics Limited | Hydantoin derivates as kv3 inhibitors |
| EA028452B1 (ru) | 2011-07-29 | 2017-11-30 | Медивейшн Простейт Терапьютикс, Инк. | Лечение рака молочной железы |
| US9708276B2 (en) | 2011-10-12 | 2017-07-18 | University of Pittsburgh—of the Commonwealth System of Higher Education | Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer |
| WO2013056547A1 (zh) * | 2011-10-22 | 2013-04-25 | Chen Degui | 一组乙内酰脲衍生物的合成及其应用 |
| CN103159680A (zh) | 2011-12-14 | 2013-06-19 | 爱美尼迪药物有限公司 | 咪唑二酮类化合物及其用途 |
| UY34646A (es) | 2012-03-02 | 2013-10-31 | Novartis Ag | Compuestos de espirohidantoína y su uso como moduladores selectivos del receptor de andrógenos |
| WO2013152342A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Anti-cancer mtor inhibitor and anti-androgen combination |
| BR112014028991A2 (pt) | 2012-05-22 | 2017-06-27 | Autifony Therapeutics Ltd | triazóis como inibidores de kv3 |
| US9669030B2 (en) | 2012-05-22 | 2017-06-06 | Autifony Therapeutics Limited | Hydantoin derivatives as Kv3 inhibitors |
| PE20150631A1 (es) * | 2012-06-07 | 2015-05-11 | Aragon Pharmaceuticals Inc | Formas cristalinas de un modulador del receptor androgenico |
| DK3725778T3 (da) | 2012-09-11 | 2021-09-20 | Medivation Prostate Therapeutics Llc | Formuleringer af enzalutamid |
| NZ745682A (en) | 2012-09-26 | 2019-09-27 | Aragon Pharmaceuticals Inc | Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer |
| US9175291B2 (en) | 2012-10-11 | 2015-11-03 | Isis Pharmaceuticals Inc. | Modulation of androgen receptor expression |
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