DK3400944T3 - Ibat-inhibitorer til behandling af leversygdomme - Google Patents

Ibat-inhibitorer til behandling af leversygdomme Download PDF

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Publication number
DK3400944T3
DK3400944T3 DK18179884.4T DK18179884T DK3400944T3 DK 3400944 T3 DK3400944 T3 DK 3400944T3 DK 18179884 T DK18179884 T DK 18179884T DK 3400944 T3 DK3400944 T3 DK 3400944T3
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DK
Denmark
Prior art keywords
treatment
liver diseases
ibat inhibitors
ibat
inhibitors
Prior art date
Application number
DK18179884.4T
Other languages
English (en)
Inventor
Per-Göran Gillberg
Hans Graffner
Ingemar Starke
Original Assignee
Albireo Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albireo Ab filed Critical Albireo Ab
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Publication of DK3400944T3 publication Critical patent/DK3400944T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/36—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DK18179884.4T 2010-11-08 2011-11-08 Ibat-inhibitorer til behandling af leversygdomme DK3400944T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41095710P 2010-11-08 2010-11-08
SE1051165 2010-11-08
EP15193953.5A EP3023102B1 (en) 2010-11-08 2011-11-08 Ibat inhibitors for the treatment of liver diseases

Publications (1)

Publication Number Publication Date
DK3400944T3 true DK3400944T3 (da) 2020-10-12

Family

ID=46051197

Family Applications (3)

Application Number Title Priority Date Filing Date
DK11840392.2T DK2637668T3 (da) 2010-11-08 2011-11-08 Ibat-inhibitorer til behandling af leversygdomme
DK18179884.4T DK3400944T3 (da) 2010-11-08 2011-11-08 Ibat-inhibitorer til behandling af leversygdomme
DK15193953.5T DK3023102T3 (da) 2010-11-08 2011-11-08 Ibat-inhibitorer til behandlingen af leversygdomme

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK11840392.2T DK2637668T3 (da) 2010-11-08 2011-11-08 Ibat-inhibitorer til behandling af leversygdomme

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK15193953.5T DK3023102T3 (da) 2010-11-08 2011-11-08 Ibat-inhibitorer til behandlingen af leversygdomme

Country Status (32)

Country Link
US (13) US20130225511A1 (da)
EP (4) EP2637668B1 (da)
JP (1) JP5889321B2 (da)
KR (1) KR101890959B1 (da)
CN (2) CN105288580B (da)
AU (1) AU2011326871B2 (da)
BR (1) BR112013010157B1 (da)
CA (1) CA2815749C (da)
CY (3) CY1118125T1 (da)
DK (3) DK2637668T3 (da)
ES (2) ES2586931T3 (da)
FR (1) FR22C1002I2 (da)
HK (2) HK1188730A1 (da)
HR (2) HRP20160993T1 (da)
HU (3) HUE039506T2 (da)
IL (1) IL225601A (da)
LT (4) LT3023102T (da)
ME (1) ME02554B (da)
MX (2) MX338535B (da)
MY (1) MY163275A (da)
NL (1) NL301157I2 (da)
NO (1) NO2021054I1 (da)
PL (3) PL3400944T3 (da)
PT (3) PT3400944T (da)
RS (3) RS60901B1 (da)
RU (1) RU2591188C2 (da)
SG (1) SG190029A1 (da)
SI (3) SI3400944T1 (da)
SM (1) SMT201600331B (da)
TR (1) TR201810984T4 (da)
WO (1) WO2012064266A1 (da)
ZA (1) ZA201303057B (da)

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EA201691555A1 (ru) * 2014-01-31 2017-01-30 Янссен Фармацевтика Нв Способы лечения и предотвращения заболеваний почек и жировых дистрофий печени
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CN103260625A (zh) 2013-08-21
RS60901B1 (sr) 2020-11-30
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US11261212B2 (en) 2022-03-01
IL225601A0 (en) 2013-06-27
PT3023102T (pt) 2018-10-18
WO2012064266A1 (en) 2012-05-18
NO2021054I1 (no) 2021-12-22
RS57778B1 (sr) 2018-12-31
ES2586931T3 (es) 2016-10-19
ES2687027T3 (es) 2018-10-23
ME02554B (me) 2017-02-20
US20230109432A1 (en) 2023-04-06
EP3400944B1 (en) 2020-07-15
RU2591188C2 (ru) 2016-07-10
US20130225511A1 (en) 2013-08-29
FR22C1002I2 (fr) 2024-03-08
EP3400944A1 (en) 2018-11-14
HUS2100055I1 (hu) 2022-01-28
KR101890959B1 (ko) 2018-08-22
AU2011326871A1 (en) 2013-04-11
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US10981952B2 (en) 2021-04-20
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US10487111B2 (en) 2019-11-26
SMT201600331B (it) 2016-11-10
HUE030062T2 (en) 2017-04-28
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US20150031636A1 (en) 2015-01-29
CN105288580B (zh) 2019-10-15
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US20180162904A1 (en) 2018-06-14
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HRP20160993T1 (hr) 2016-12-30
US10093697B2 (en) 2018-10-09
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US20160193277A1 (en) 2016-07-07
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MX366925B (es) 2019-07-31
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PL3023102T3 (pl) 2018-11-30
US20170182059A1 (en) 2017-06-29
US11732006B2 (en) 2023-08-22
LT2637668T (lt) 2016-09-12
US20180030089A1 (en) 2018-02-01
PT2637668T (pt) 2016-08-17
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US20210340175A1 (en) 2021-11-04
US10000528B2 (en) 2018-06-19

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