FR22C1002I1 - Inhibiteurs ibat pour le traitement de maladies du foie - Google Patents

Inhibiteurs ibat pour le traitement de maladies du foie

Info

Publication number
FR22C1002I1
FR22C1002I1 FR22C1002C FR22C1002C FR22C1002I1 FR 22C1002 I1 FR22C1002 I1 FR 22C1002I1 FR 22C1002 C FR22C1002 C FR 22C1002C FR 22C1002 C FR22C1002 C FR 22C1002C FR 22C1002 I1 FR22C1002 I1 FR 22C1002I1
Authority
FR
France
Prior art keywords
treatment
liver diseases
ibat inhibitors
ibat
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR22C1002C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albireo AB
Original Assignee
Albireo AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albireo AB filed Critical Albireo AB
Publication of FR22C1002I1 publication Critical patent/FR22C1002I1/fr
Application granted granted Critical
Publication of FR22C1002I2 publication Critical patent/FR22C1002I2/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/36—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
FR22C1002C 2010-11-08 2022-01-11 Inhibiteurs ibat pour le traitement de maladies du foie Active FR22C1002I2 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41095710P 2010-11-08 2010-11-08
SE1051165 2010-11-08
EP15193953.5A EP3023102B1 (fr) 2010-11-08 2011-11-08 Inhibiteurs ibat pour le traitement de maladies du foie
PCT/SE2011/051335 WO2012064266A1 (fr) 2010-11-08 2011-11-08 Inhibiteurs ibat pour le traitement de maladies du foie
EP11840392.2A EP2637668B1 (fr) 2010-11-08 2011-11-08 Inhibiteurs ibat pour le traitement de maladies du foie

Publications (2)

Publication Number Publication Date
FR22C1002I1 true FR22C1002I1 (fr) 2022-02-25
FR22C1002I2 FR22C1002I2 (fr) 2024-03-08

Family

ID=46051197

Family Applications (1)

Application Number Title Priority Date Filing Date
FR22C1002C Active FR22C1002I2 (fr) 2010-11-08 2022-01-11 Inhibiteurs ibat pour le traitement de maladies du foie

Country Status (32)

Country Link
US (13) US20130225511A1 (fr)
EP (4) EP3023102B1 (fr)
JP (1) JP5889321B2 (fr)
KR (1) KR101890959B1 (fr)
CN (2) CN103260625B (fr)
AU (1) AU2011326871B2 (fr)
BR (1) BR112013010157B1 (fr)
CA (1) CA2815749C (fr)
CY (3) CY1118125T1 (fr)
DK (3) DK2637668T3 (fr)
ES (2) ES2687027T3 (fr)
FR (1) FR22C1002I2 (fr)
HK (2) HK1223566A1 (fr)
HR (2) HRP20160993T1 (fr)
HU (3) HUE039506T2 (fr)
IL (1) IL225601A (fr)
LT (4) LT2637668T (fr)
ME (1) ME02554B (fr)
MX (2) MX338535B (fr)
MY (1) MY163275A (fr)
NL (1) NL301157I2 (fr)
NO (1) NO2021054I1 (fr)
PL (3) PL2637668T3 (fr)
PT (3) PT3023102T (fr)
RS (3) RS55266B1 (fr)
RU (1) RU2591188C2 (fr)
SG (1) SG190029A1 (fr)
SI (3) SI3400944T1 (fr)
SM (1) SMT201600331B (fr)
TR (1) TR201810984T4 (fr)
WO (1) WO2012064266A1 (fr)
ZA (1) ZA201303057B (fr)

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WO2010062861A2 (fr) 2008-11-26 2010-06-03 Satiogen Pharmaceuticals, Inc. Inhibiteurs de recyclage de l'acide biliaire pour le traitement de l'obésité et du diabète
WO2011150286A2 (fr) 2010-05-26 2011-12-01 Satiogen Pharmaceuticals,Inc. Inhibiteurs et satiogènes de recyclage d'acide biliaire pour traitement du diabète, de l'obésité et d'états inflammatoires gastro-intestinaux
CN103228270B (zh) * 2010-11-08 2016-02-10 阿尔比里奥公司 含ibat抑制剂和胆汁酸结合剂的药物组合
MX338535B (es) * 2010-11-08 2016-04-21 Albireo Ab Inhibidores de ibat para el tratamiento de enfermeades hepaticas.
EP3266457A1 (fr) 2011-10-28 2018-01-10 Lumena Pharmaceuticals LLC Inhibiteurs du recyclage de l'acide biliaire pour le traitement de maladies cholestatiques hépatiques pédiatriques
EP3278796A1 (fr) * 2011-10-28 2018-02-07 Lumena Pharmaceuticals LLC Inhibiteurs du recyclage de l'acide biliaire pour traitement de l'hypercholémie et de la maladie cholestatique hépatique
JO3301B1 (ar) 2013-04-26 2018-09-16 Albireo Ab تعديلات بلورية على إيلوبيكسيبات
JP2017504649A (ja) * 2014-01-31 2017-02-09 ヤンセン ファーマシューティカ エヌ．ベー． 腎障害及び脂肪性肝障害の治療並びに予防のための方法
KR20220082931A (ko) 2014-06-25 2022-06-17 이에이 파마 가부시키가이샤 고형 제제 및 그의 착색 방지 또는 착색 감소 방법
KR102296314B1 (ko) * 2014-06-25 2021-09-01 이에이 파마 가부시키가이샤 고형 제제 및 그의 안정화 방법
EP3012252A1 (fr) 2014-10-24 2016-04-27 Ferring BV Formes crystallines d'Elobixibat
CN105395532B (zh) * 2015-11-25 2017-11-14 中国医学科学院医药生物技术研究所 2‑苯磺酰胺基苯甲酰胺类化合物在肝损伤保护和肝纤维化防治中的应用
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US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
KR101844184B1 (ko) * 2017-07-21 2018-04-02 씨제이헬스케어 주식회사 아미노알킬벤조티아제핀 유도체의 용도
CA3071285A1 (fr) 2017-08-09 2019-02-14 Albireo Ab Granules de cholestyramine, formulations orales de cholestyramine et leur utilisation
TWI823573B (zh) 2018-03-09 2023-11-21 瑞典商依洛比克斯公司 用於製備1,5-苯并噻氮呯化合物之方法
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US10793534B2 (en) 2018-06-05 2020-10-06 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
WO2019234077A1 (fr) 2018-06-05 2019-12-12 Albireo Ab Composés de benzothia(di)azépine et leur utilisation en tant que modulateurs de l'acide biliaire
US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
AU2019290337B2 (en) * 2018-06-20 2023-01-12 Albireo Ab Crystal modifications of odevixibat
US11549878B2 (en) 2018-08-09 2023-01-10 Albireo Ab In vitro method for determining the adsorbing capacity of an insoluble adsorbant
US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
US10941127B2 (en) 2019-02-06 2021-03-09 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
CN114072153A (zh) 2019-02-12 2022-02-18 米鲁姆制药公司 用于治疗胆汁淤积的方法
CR20220315A (es) 2019-12-04 2022-10-26 Albireo Ab Compuestos de benzoti(di)azepina y su uso como moduladores del ácido biliar
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
EP4069361B1 (fr) 2019-12-04 2024-01-03 Albireo AB Composés de benzothia(di)azépine et leur utilisation en tant que modulateurs de l'acide biliaire
CN114761018A (zh) 2019-12-04 2022-07-15 阿尔比里奥公司 苯并硫杂二氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
CA3158276A1 (fr) 2019-12-04 2021-06-10 Per-Goran Gillberg Composes de benzothia(di)azepine et leur utilisation en tant que modulateurs d'acide biliaire
EP4188541A1 (fr) 2020-08-03 2023-06-07 Albireo AB Composés de benzothia(di)azepine et leur utilisation en tant que modulateurs de l'acide biliaire
JP2023549226A (ja) 2020-11-12 2023-11-22 アルビレオ エービー 進行性家族性肝内胆汁うっ滞症（ｐｆｉｃ）を処置するためのオデビキシバット
US20220152012A1 (en) * 2020-11-16 2022-05-19 The Regents Of The University Of California Methods for regressing or reversing fibrosis and/or liver cirrhosis in a subject in need thereof using high-dose niacin, or a niacin analog thereof
BR112023010799A2 (pt) 2020-12-04 2023-10-03 Albireo Ab Compostos de benzotia(di)azepina e seus usos como moduladores de ácidos biliares
WO2022166680A1 (fr) * 2021-06-25 2022-08-11 苏州科睿思制药有限公司 Forme cristalline d'odévixibat, procédé de préparation et utilisation associés
TW202333724A (zh) * 2021-11-05 2023-09-01 美商米魯姆製藥公司 以迴腸膽酸轉運蛋白(ibat)抑制劑治療以增加無事件存活期(efs)
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US20150031636A1 (en) 2015-01-29
US20210340175A1 (en) 2021-11-04
EP3400944A1 (fr) 2018-11-14
LT2637668T (lt) 2016-09-12
IL225601A (en) 2017-02-28
ZA201303057B (en) 2015-11-25
MX2013005093A (es) 2013-10-17
CN105288580B (zh) 2019-10-15
WO2012064266A1 (fr) 2012-05-18
MX366925B (es) 2019-07-31
HUE039506T2 (hu) 2019-01-28
MY163275A (en) 2017-08-30
LTPA2021012I1 (fr) 2021-11-25
JP2013541584A (ja) 2013-11-14
FR22C1002I2 (fr) 2024-03-08
SI3400944T1 (sl) 2020-11-30
EP3777864A1 (fr) 2021-02-17
NO2021054I1 (no) 2021-12-22
ES2586931T3 (es) 2016-10-19
US20180362577A1 (en) 2018-12-20
US20160193277A1 (en) 2016-07-07
EP3023102B1 (fr) 2018-06-27
PT3400944T (pt) 2020-09-30
DK3023102T3 (en) 2018-09-24
HUE030062T2 (en) 2017-04-28
RU2013126116A (ru) 2014-12-20
BR112013010157A2 (pt) 2016-09-13
KR20140032952A (ko) 2014-03-17
CA2815749C (fr) 2019-12-03
LT3023102T (lt) 2018-09-25
US20230109432A1 (en) 2023-04-06
EP3023102A1 (fr) 2016-05-25
HRP20181185T1 (hr) 2018-10-19
US20160194353A1 (en) 2016-07-07
PT2637668T (pt) 2016-08-17
JP5889321B2 (ja) 2016-03-22
CN103260625B (zh) 2016-01-06
EP2637668A1 (fr) 2013-09-18
SI3023102T1 (sl) 2018-11-30
US10487111B2 (en) 2019-11-26
LT3400944T (lt) 2020-09-25
AU2011326871B2 (en) 2015-02-12
DK3400944T3 (da) 2020-10-12
NL301157I2 (nl) 2023-11-09
ES2687027T3 (es) 2018-10-23
US20180162904A1 (en) 2018-06-14
US10221212B2 (en) 2019-03-05
HK1188730A1 (zh) 2014-05-16
MX338535B (es) 2016-04-21
KR101890959B1 (ko) 2018-08-22
RS60901B1 (sr) 2020-11-30
RS57778B1 (sr) 2018-12-31
PT3023102T (pt) 2018-10-18
HRP20160993T1 (hr) 2016-12-30
US9694018B1 (en) 2017-07-04
CA2815749A1 (fr) 2012-05-18
HUS2100055I1 (hu) 2022-01-28
PL3400944T3 (pl) 2020-11-16
US10011633B2 (en) 2018-07-03
SI2637668T1 (sl) 2016-11-30
AU2011326871A1 (en) 2013-04-11
RS55266B1 (sr) 2017-02-28
PL3023102T3 (pl) 2018-11-30
US9688720B2 (en) 2017-06-27
EP2637668A4 (fr) 2014-03-26
CN105288580A (zh) 2016-02-03
DK2637668T3 (en) 2016-08-29
US20170182059A1 (en) 2017-06-29
US20180030089A1 (en) 2018-02-01
EP3400944B1 (fr) 2020-07-15
US10093697B2 (en) 2018-10-09
US10000528B2 (en) 2018-06-19
US20180022776A1 (en) 2018-01-25
US20180030088A1 (en) 2018-02-01
ME02554B (fr) 2017-02-20
CY1121065T1 (el) 2020-05-29
PL2637668T3 (pl) 2017-01-31
US11732006B2 (en) 2023-08-22
EP2637668B1 (fr) 2016-05-11
US20130225511A1 (en) 2013-08-29
US11261212B2 (en) 2022-03-01
US20200140484A1 (en) 2020-05-07
CY1118125T1 (el) 2017-06-28
TR201810984T4 (tr) 2018-09-21
SMT201600331B (it) 2016-11-10
IL225601A0 (en) 2013-06-27
CY1123470T1 (el) 2022-03-24
CN103260625A (zh) 2013-08-21
RU2591188C2 (ru) 2016-07-10

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