PT3023102T - Inibidores de ibat para o tratamento de doenças hepáticas - Google Patents

Inibidores de ibat para o tratamento de doenças hepáticas

Info

Publication number
PT3023102T
PT3023102T PT15193953T PT15193953T PT3023102T PT 3023102 T PT3023102 T PT 3023102T PT 15193953 T PT15193953 T PT 15193953T PT 15193953 T PT15193953 T PT 15193953T PT 3023102 T PT3023102 T PT 3023102T
Authority
PT
Portugal
Prior art keywords
treatment
liver diseases
ibat inhibitors
ibat
inhibitors
Prior art date
Application number
PT15193953T
Other languages
English (en)
Inventor
Starke Ingemar
Graffner Hans
Per-Göran Gillberg
Original Assignee
Albireo Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albireo Ab filed Critical Albireo Ab
Publication of PT3023102T publication Critical patent/PT3023102T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/36—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
PT15193953T 2010-11-08 2011-11-08 Inibidores de ibat para o tratamento de doenças hepáticas PT3023102T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41095710P 2010-11-08 2010-11-08
SE1051165 2010-11-08

Publications (1)

Publication Number Publication Date
PT3023102T true PT3023102T (pt) 2018-10-18

Family

ID=46051197

Family Applications (3)

Application Number Title Priority Date Filing Date
PT181798844T PT3400944T (pt) 2010-11-08 2011-11-08 Inibidores do ibat para o tratamento de doenças hepáticas
PT15193953T PT3023102T (pt) 2010-11-08 2011-11-08 Inibidores de ibat para o tratamento de doenças hepáticas
PT118403922T PT2637668T (pt) 2010-11-08 2011-11-08 Inibidores de ibat para o tratamento de doenças do fígado

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT181798844T PT3400944T (pt) 2010-11-08 2011-11-08 Inibidores do ibat para o tratamento de doenças hepáticas

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT118403922T PT2637668T (pt) 2010-11-08 2011-11-08 Inibidores de ibat para o tratamento de doenças do fígado

Country Status (32)

Country Link
US (13) US20130225511A1 (pt)
EP (4) EP3777864A1 (pt)
JP (1) JP5889321B2 (pt)
KR (1) KR101890959B1 (pt)
CN (2) CN103260625B (pt)
AU (1) AU2011326871B2 (pt)
BR (1) BR112013010157B1 (pt)
CA (1) CA2815749C (pt)
CY (3) CY1118125T1 (pt)
DK (3) DK3400944T3 (pt)
ES (2) ES2586931T3 (pt)
FR (1) FR22C1002I2 (pt)
HK (2) HK1188730A1 (pt)
HR (2) HRP20160993T1 (pt)
HU (3) HUE030062T2 (pt)
IL (1) IL225601A (pt)
LT (4) LT3400944T (pt)
ME (1) ME02554B (pt)
MX (2) MX338535B (pt)
MY (1) MY163275A (pt)
NL (1) NL301157I2 (pt)
NO (1) NO2021054I1 (pt)
PL (3) PL2637668T3 (pt)
PT (3) PT3400944T (pt)
RS (3) RS57778B1 (pt)
RU (1) RU2591188C2 (pt)
SG (1) SG190029A1 (pt)
SI (3) SI2637668T1 (pt)
SM (1) SMT201600331B (pt)
TR (1) TR201810984T4 (pt)
WO (1) WO2012064266A1 (pt)
ZA (1) ZA201303057B (pt)

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BR112014010223B8 (pt) * 2011-10-28 2021-02-23 Lumena Pharmaceuticals Llc uso de uma composição compreendendo inibidores de reciclagem de ácido de bílis e forma de dosagem pediátrica
JO3301B1 (ar) * 2013-04-26 2018-09-16 Albireo Ab تعديلات بلورية على إيلوبيكسيبات
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KR102296314B1 (ko) * 2014-06-25 2021-09-01 이에이 파마 가부시키가이샤 고형 제제 및 그의 안정화 방법
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KR101844184B1 (ko) * 2017-07-21 2018-04-02 씨제이헬스케어 주식회사 아미노알킬벤조티아제핀 유도체의 용도
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CA3100691A1 (en) * 2018-06-20 2019-12-26 Albireo Ab Crystal modifications of odevixibat
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US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
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WO2022104289A1 (en) * 2020-11-16 2022-05-19 The Regents Of The University Of California Use of pharmaceutical doses of niacin, or an analog thereof, for the regression or reversal of fibrosis and/or liver cirrhosis
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WO2022166680A1 (zh) * 2021-06-25 2022-08-11 苏州科睿思制药有限公司 奥德昔巴特的晶型及其制备方法和用途
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IL225601A (en) 2017-02-28
RS57778B1 (sr) 2018-12-31
SI2637668T1 (sl) 2016-11-30
CY1118125T1 (el) 2017-06-28
FR22C1002I1 (fr) 2022-02-25
EP2637668A1 (en) 2013-09-18
PL3400944T3 (pl) 2020-11-16
US20180362577A1 (en) 2018-12-20
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US20200140484A1 (en) 2020-05-07
RU2591188C2 (ru) 2016-07-10
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US9694018B1 (en) 2017-07-04
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US20180030088A1 (en) 2018-02-01
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CN105288580B (zh) 2019-10-15
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BR112013010157A2 (pt) 2016-09-13
LT3400944T (lt) 2020-09-25
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PT3400944T (pt) 2020-09-30
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US20210340175A1 (en) 2021-11-04
PT2637668T (pt) 2016-08-17
ES2586931T3 (es) 2016-10-19
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TR201810984T4 (tr) 2018-09-21
US20180022776A1 (en) 2018-01-25
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