DK3134149T3 - Mikrokanyler og fremgangsmåder til fremstilling deraf - Google Patents

Mikrokanyler og fremgangsmåder til fremstilling deraf

Info

Publication number
DK3134149T3
DK3134149T3 DK15783359.1T DK15783359T DK3134149T3 DK 3134149 T3 DK3134149 T3 DK 3134149T3 DK 15783359 T DK15783359 T DK 15783359T DK 3134149 T3 DK3134149 T3 DK 3134149T3
Authority
DK
Denmark
Prior art keywords
microcunnels
manufacturing
methods
Prior art date
Application number
DK15783359.1T
Other languages
Danish (da)
English (en)
Inventor
Devin Mcallister
Mark Prausnitz
Sebastien Henry
Xin Dong Guo
Original Assignee
Georgia Tech Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgia Tech Res Inst filed Critical Georgia Tech Res Inst
Application granted granted Critical
Publication of DK3134149T3 publication Critical patent/DK3134149T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK15783359.1T 2014-04-24 2015-04-24 Mikrokanyler og fremgangsmåder til fremstilling deraf DK3134149T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461983593P 2014-04-24 2014-04-24
PCT/US2015/027672 WO2015164840A1 (en) 2014-04-24 2015-04-24 Microneedles and methods of manufacture thereof

Publications (1)

Publication Number Publication Date
DK3134149T3 true DK3134149T3 (da) 2026-02-02

Family

ID=54333334

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15783359.1T DK3134149T3 (da) 2014-04-24 2015-04-24 Mikrokanyler og fremgangsmåder til fremstilling deraf

Country Status (9)

Country Link
US (4) US10828478B2 (cg-RX-API-DMAC7.html)
EP (2) EP3134149B1 (cg-RX-API-DMAC7.html)
JP (4) JP6934721B2 (cg-RX-API-DMAC7.html)
CN (2) CN106232159B (cg-RX-API-DMAC7.html)
CA (2) CA2981974C (cg-RX-API-DMAC7.html)
DK (1) DK3134149T3 (cg-RX-API-DMAC7.html)
ES (1) ES3059965T3 (cg-RX-API-DMAC7.html)
RU (1) RU2719937C1 (cg-RX-API-DMAC7.html)
WO (1) WO2015164840A1 (cg-RX-API-DMAC7.html)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2817249T3 (es) 2007-04-16 2021-04-06 Corium Inc Matrices de microagujas obtenidas mediante disolución y colada que contienen un principio activo
EP2566501B1 (en) 2010-05-04 2019-03-13 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
EP2934660B1 (en) 2012-12-21 2019-07-17 Corium, Inc. Microarray for delivery of therapeutic agent and method of making same
EP4094799A1 (en) 2013-03-12 2022-11-30 Corium, Inc. Microprojection applicators
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
CA2981974C (en) * 2014-04-24 2023-06-20 Georgia Tech Research Corporation Microneedles and methods of manufacture thereof
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
JP6001043B2 (ja) * 2014-12-15 2016-10-05 日本写真印刷株式会社 マイクロニードルアレイ製造装置及びマイクロニードルアレイの製造方法並びにマイクロニードルアレイを有する製品
ES2945899T3 (es) 2015-04-17 2023-07-10 Georgia Tech Res Inst Dispositivos de administración de fármacos que tienen microagujas separables
US10857093B2 (en) * 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
JP7101121B2 (ja) * 2016-03-01 2022-07-14 ジョージア テック リサーチ コーポレイション マイクロニードル粒子、組成物、治療方法、及び目的の物質の送達方法
CN105797266A (zh) * 2016-03-07 2016-07-27 李媚 一种微结构体及其制备方法
JP2017176652A (ja) 2016-03-31 2017-10-05 花王株式会社 微細中空突起具
JP7034425B2 (ja) * 2016-04-15 2022-03-14 エーディーエムバイオサイエンス インコーポレイテッド 核酸フィルムの製造方法及び核酸フィルムを用いた薬物注入装置
WO2017193066A1 (en) * 2016-05-05 2017-11-09 Liquidia Technologies, Inc. Precision controlled load and release particles for post-operative pain
CN106176573B (zh) * 2016-08-24 2019-06-21 湖北大学 一种可溶性中空微针及其制备方法
US11426571B2 (en) 2016-11-18 2022-08-30 Industry-Academic Cooperation Foundation, Yonsei University Microneedle array with composite formulation, and method for manufacturing same
WO2018116251A1 (en) * 2016-12-21 2018-06-28 Sabic Global Technologies B.V. Method of making microneedles, mold assemblytherefor and microneedles array
CN110582321A (zh) * 2017-03-01 2019-12-17 新加坡国立大学 一种微针装置
US11504512B2 (en) 2017-05-10 2022-11-22 Chee Yen Lim Method of fabricating microneedle patches
US11701506B2 (en) 2017-05-10 2023-07-18 Chee Yen Lim Pyramidal microneedles with enhanced drug loading capacity and method for manufacturing
US20180333899A1 (en) * 2017-05-17 2018-11-22 University Medical Pharmaceuticals Corp. System and method for manufacturing microneedle devices
US11207272B2 (en) 2017-05-17 2021-12-28 Massachusetts Institute Of Technology Tissue anchoring articles
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
DE102017117784A1 (de) * 2017-08-04 2019-02-07 Lts Lohmann Therapie-Systeme Ag Applikatorsystem enthaltend ein Mikronadelarray aufweisend einen Wirkstoff für die Wundheilung
US9968767B1 (en) 2017-10-10 2018-05-15 King Saud University Combination microarray patch for drug delivery and electrochemotherapy device
ES3058677T3 (en) 2017-10-11 2026-03-12 Georgia Tech Res Inst Separable microneedle arrays for sustained release of drug
WO2019094349A1 (en) * 2017-11-07 2019-05-16 NanoCav, LLC Microneedle array device, methods of manufacture and use thereof
KR102184940B1 (ko) * 2017-11-15 2020-12-01 주식회사 엘지생활건강 마이크로니들 연속 제조용 장치 및 공정
KR102139335B1 (ko) * 2017-11-24 2020-07-29 주식회사 엘지생활건강 니들 팁에 코팅부를 보유하는 마이크로니들을 제조하는 방법 및 장치
US11203139B2 (en) * 2017-12-13 2021-12-21 Becton, Dickinson And Company Medical device with overmolded adhesive patch and method for making same
WO2019115670A1 (en) * 2017-12-15 2019-06-20 Koninklijke Philips N.V. Wearable or insertable devices with microneedles that include mechanically-responsive material
US10786203B1 (en) * 2018-01-30 2020-09-29 Daniel M. Besser Medical patch applicator device
CN108578888A (zh) * 2018-02-07 2018-09-28 佛山市顺德区中山大学研究院 一种透皮输送活性益生菌的可溶性微针阵列贴片及其制备方法和应用
WO2019163805A1 (ja) * 2018-02-20 2019-08-29 富士フイルム株式会社 マイクロニードルアレイの製造方法
JP6567716B1 (ja) * 2018-03-19 2019-08-28 ナショナル・タイペイ・ユニバーシティ・オブ・テクノロジーＮａｔｉｏｎａｌ Ｔａｉｐｅｉ Ｕｎｉｖｅｒｓｉｔｙ ｏｆ Ｔｅｃｈｎｏｌｏｇｙ 生分解性マイクロニードルアレイ
CN108379573B (zh) * 2018-03-26 2020-10-16 中国医学科学院生物医学工程研究所 一种百日咳疫苗微针阵列及其制备方法
CN108703942B (zh) * 2018-04-23 2021-04-06 中山大学 载有纳米材料包裹保胎药物的微针给药系统及制备方法
JP6956680B2 (ja) * 2018-05-16 2021-11-02 富士フイルム株式会社 モールドケース及びマイクロニードルアレイの製造方法
AU2019269636A1 (en) 2018-05-17 2020-11-19 Massachusetts Institute Of Technology Systems for electrical stimulation
CN110680908B (zh) * 2018-07-04 2024-02-20 辽宁成大生物股份有限公司 一种速崩型a群c群脑膜炎球菌多糖结合疫苗可溶性微针及其制备方法
JP2020018327A (ja) * 2018-07-17 2020-02-06 ロレアル マイクロニードルシート
DE102018215324A1 (de) * 2018-09-10 2020-03-12 Lts Lohmann Therapie-Systeme Ag Vorrichtung und Verfahren zur Herstellung von Mikrostrukturen
WO2020064083A1 (en) 2018-09-24 2020-04-02 L'oreal Device comprising microneedles for in-situ reaction of a skin
EP3856321A1 (en) * 2018-09-24 2021-08-04 L'oreal Device comprising microneedles for skin-coloring
DE102018009594A1 (de) 2018-12-11 2020-06-18 Lts Lohmann Therapie-Systeme Ag Verfahren und Vorrichtung zur Herstellung von Mikronadeln
DE102019200561A1 (de) * 2019-01-17 2020-07-23 Lts Lohmann Therapie-Systeme Ag Träger
DE102019001251A1 (de) * 2019-02-21 2020-08-27 Lts Lohmann Therapie-Systeme Ag Applikator für Mikronadelpflaster
CA3139308A1 (en) * 2019-05-06 2020-11-12 Atomic Health, Inc. Systems and methods for manufacturing cannabis edibles, and resulting edible products
KR20200144198A (ko) * 2019-06-17 2020-12-29 삼성디스플레이 주식회사 잉크 액적 부피 측정장치와, 그것을 이용한 잉크 액적 부피 측정방법과, 그 잉크 액적 부피 측정장치를 활용하는 박막층 형성장치 및, 상기 박막층 형성장치를 이용한 디스플레이 장치의 제조방법
WO2021016074A1 (en) * 2019-07-22 2021-01-28 The Trustees Of Indiana University Technologies for needles with microchannels
DE102019122648B4 (de) * 2019-08-22 2021-04-29 Lts Lohmann Therapie-Systeme Ag Vorrichtung und Verfahren zur Herstellung von Mikrostrukturen
CN114761054B (zh) * 2019-10-22 2025-07-15 佐治亚科技研究公司 利用浇铸制剂中的组分溶解度的调整来制作微针的方法
CN110625864A (zh) * 2019-10-24 2019-12-31 上海微创生命科技有限公司 微针制备装置及微针制备方法
DE102020104306A1 (de) 2020-02-19 2021-08-19 Lts Lohmann Therapie-Systeme Ag Formelement zur Herstellung von Mikrostrukturen
US11213482B1 (en) 2020-03-05 2022-01-04 University of Pittsburgh—Of the Commonwealth System of Higher Educat SARS-CoV-2 subunit vaccine and microneedle array delivery system
US11745001B2 (en) * 2020-03-10 2023-09-05 University Of Connecticut Therapeutic bandage
DE102020204651A1 (de) * 2020-04-09 2021-10-14 Lts Lohmann Therapie-Systeme Ag Einrichtung zum Herstellen von Mikro-Arrays sowie Verfahren zum Herstellen eines Mikro-Arrays
JP2023523952A (ja) * 2020-04-28 2023-06-08 ティコナ・エルエルシー マイクロニードルアセンブリ
CN115666529B (zh) * 2020-05-29 2025-06-06 佐治亚科技研究公司 用于促进药物的组织递送的装置、系统及方法
JP6846560B2 (ja) * 2020-06-04 2021-03-24 花王株式会社 微細中空突起具
CN115697209A (zh) * 2020-06-11 2023-02-03 新加坡科技研究局 皮肤微生物采样器及相关方法
US11844920B2 (en) 2020-07-23 2023-12-19 Microneedles Inc Microneedle immunotherapeutic multi-component system and a method for vaccination
US11951272B2 (en) * 2020-08-28 2024-04-09 City University Of Hong Kong Cryo formulation-based microneedle device for ocular delivery of bioactive therapeutic agents using a cryo-microneedle patch
US11904126B2 (en) * 2020-08-28 2024-02-20 City University Of Hong Kong Cryo formulation-based microneedle device for transdermal delivery of bioactive therapeutic agents and performing vaccination using a cryo-microneedle patch
US12005221B2 (en) * 2020-08-28 2024-06-11 City University Of Hong Kong Cryo formulation-based microneedle device for transdermal delivery of bioactive therapeutic agents and cancer immunotherapy using a cryo-microneedle patch
US20220096371A1 (en) * 2020-09-28 2022-03-31 University Of Connecticut Biodegradable microneedle system with sustained release
CN114324196B (zh) * 2020-09-29 2024-06-11 华中科技大学 用于增强皮肤光透明性的可溶性聚合物微针的制备及应用
KR102371122B1 (ko) * 2020-10-21 2022-03-08 단국대학교 천안캠퍼스 산학협력단 마이크로 니들을 생산하기 위한 몰드 및 몰드를 이용한 마이크로 니들 생산 방법
CN116782827A (zh) * 2020-11-30 2023-09-19 明德拉公司 微针装置和方法以及皮肤病状测定
CN112811386A (zh) * 2020-12-30 2021-05-18 哈尔滨工业大学（深圳） 3d微电极的制备方法
JP2024501948A (ja) * 2020-12-30 2024-01-17 ジョージア テック リサーチ コーポレイション 医療診断のための汗の誘導のための方法及びデバイス
CN114681354A (zh) * 2020-12-31 2022-07-01 苏州悦肤达医疗科技有限公司 一种微针贴片及其制备方法
KR102491166B1 (ko) * 2021-01-06 2023-01-19 성균관대학교산학협력단 모세관력 및 정전기력을 이용한 미세 패턴의 형성 방법 및 미세 패턴을 포함하는 마이크로 니들
DE102021100396A1 (de) * 2021-01-12 2022-07-14 Lts Lohmann Therapie-Systeme Ag. Verfahren und System zur Herstellung von Mikrostrukturen
US20230415383A1 (en) * 2021-02-11 2023-12-28 The Boeing Company Method and apparatus for fabricating brittle microneedle
KR102297883B1 (ko) * 2021-02-17 2021-09-03 주식회사 지엘캄퍼니 마이크로 니들조립체
CN113144413A (zh) * 2021-04-27 2021-07-23 中国农业大学 一种用于过敏诊断的可溶性复合微针阵列及其制备方法
DE102021112136A1 (de) * 2021-05-10 2022-11-10 Lts Lohmann Therapie-Systeme Ag. Verfahren und Vorrichtung zur Herstellung von Mikronadelelementen, sowie Mikronadelelement
JP2023529034A (ja) * 2021-05-12 2023-07-07 フェロカ インコーポレーテッド マイクロニードルパッチ、マイクロニードルパッチの製造方法及びマイクロニールパッチの製造装置
CN113171930B (zh) * 2021-06-01 2025-07-22 苏州璟丰机电有限公司 微针提拉装置
KR102613830B1 (ko) * 2021-06-17 2023-12-14 주식회사 에스엔비아 마이크로구조체 카트리지 및 마이크로구조체 어플리케이터
GB2607115B (en) * 2021-06-25 2023-10-04 Cipherx Tech Ltd Method of producing a microneedle array
CN113563642B (zh) * 2021-06-28 2022-09-13 深圳职业技术学院 一种生物分析采样用复合微针及其制备方法
US20250082236A1 (en) * 2021-07-19 2025-03-13 Carnegie Mellon University Scalable Manufacturing of Microneedle Arrays Using Automated High-Throughput Manufacturing Systems and High-Capacity Molding
CN113340890A (zh) * 2021-07-22 2021-09-03 山西农业大学 一种微针贴片及其制备方法和应用
EP4402486A4 (en) 2021-09-14 2025-09-10 Transp Authority Inc SYSTEMS AND METHODS FOR PRECISE AND REPEATED DELIVERY OF ACTIVE PHARMACEUTICAL INGREDIENTS
KR102484179B1 (ko) * 2021-11-29 2023-01-04 주식회사 쿼드메디슨 펩타이드 계열 유효 성분을 포함하는 마이크로 니들 및 이를 제조하기 위한 제형 조성물
KR102382088B1 (ko) * 2021-12-14 2022-04-04 주식회사 대웅테라퓨틱스 마이크로니들 제조방법
KR102427901B1 (ko) * 2022-01-28 2022-08-02 주식회사 대웅테라퓨틱스 마이크로니들 제조방법
EP4496619A4 (en) * 2022-03-22 2026-03-18 Georgia Tech Res Inst MICRO-NECK TATTOO PATCHES AND PROCESSES
DE112023002120T5 (de) 2022-04-22 2025-02-20 Rigaku Corporation Halbleiterprüfungsvorrichtung, Halbleiterprüfungssystem und Halbleiterprüfungsverfahren
CN117298434A (zh) * 2022-06-21 2023-12-29 深圳青澜生物技术有限公司 一种微针药膜片的制备方法
CN115089864B (zh) * 2022-07-14 2023-12-29 复旦大学 一种使用冷冻干燥技术制备可溶性微针贴片的方法
FR3137829B1 (fr) * 2022-07-18 2025-03-28 Pkvitality Procédé de fabrication d’un réseau de microaiguilles.
CN115645732B (zh) * 2022-09-07 2025-08-15 河南省洛阳正骨医院（河南省骨科医院） 一种用于治疗风湿疾病的微针贴片及其制备方法
CA3267298A1 (en) 2022-09-13 2024-03-21 Micron Biomedical, Inc. MICRO-NECK STAMP WITH FEEDBACK INDICATOR
CN115342967B (zh) * 2022-09-20 2024-11-26 重庆邮电大学 一种基于多孔链状中空结构明胶的压力电容传感器及其制备方法
CN118370924A (zh) * 2023-01-16 2024-07-23 深圳青澜生物技术有限公司 一种微针阵列及其制备方法
WO2024196881A2 (en) * 2023-03-17 2024-09-26 Corrective Development, Llc Microneedle process
WO2025018937A1 (en) * 2023-07-19 2025-01-23 Chee Yen Lim A mould system for manufacturing dissolvable microneedle patches
WO2025072510A1 (en) 2023-09-26 2025-04-03 Micron Biomedical, Inc. Solid compositions including stabilized lipid nanoparticles and methods of making microneedles comprising same
JP2025112280A (ja) * 2024-01-18 2025-07-31 コスメディ製薬株式会社 マイクロニードルアレイ
US20250325286A1 (en) 2024-04-17 2025-10-23 Micron Biomedical, Inc. Methods and Microneedle Devices for Vaccinations with Enhanced Delivery and Acceptance
WO2026030392A1 (en) 2024-07-29 2026-02-05 Micron Biomedical, Inc. Formulations and methods for a glp-1 agonist microneedle patch
CN120023950B (zh) * 2025-04-22 2025-07-08 苏州大学 一种基于拉伸材料的微纳米喷针制造方法及喷针

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1557460A (en) 1975-12-09 1979-12-12 Johnson & Johnson Absorbent pad
US6007836A (en) 1993-05-28 1999-12-28 Vericade, Inc. Transdermal vasodilator
WO1995001709A1 (en) 1993-07-01 1995-01-12 The University Of Melbourne Cochlear implant devices
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
CA2376128C (en) * 1999-06-04 2009-01-06 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US7141034B2 (en) * 2000-06-08 2006-11-28 Altea Therapeutics Corporation Transdermal drug delivery device, method of making same and method of using same
US6656147B1 (en) 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
EP1345646A2 (en) 2000-12-14 2003-09-24 Georgia Tech Research Corporation Microneedle devices and production thereof
US20020192273A1 (en) 2001-06-15 2002-12-19 Teri Buseman Therapeutic patch useful for the treatment of hemorrhoids
US6881203B2 (en) * 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US7115108B2 (en) * 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US6945952B2 (en) 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
US8062573B2 (en) * 2002-09-16 2011-11-22 Theraject, Inc. Solid micro-perforators and methods of use
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2005094526A2 (en) 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
US7516845B2 (en) 2004-03-31 2009-04-14 Inverness Medical Limited Medical device package with deformable projections
WO2006016364A2 (en) 2004-08-10 2006-02-16 Hellman De Picciotto, Tania Drug delivery devices
US7627938B2 (en) 2004-10-15 2009-12-08 Board Of Regents, The Univeristy Of Texas System Tapered hollow metallic microneedle array assembly and method of making and using the same
CN101060883B (zh) 2004-11-18 2010-06-23 3M创新有限公司 低轮廓微针阵列施放器
DE602005024038D1 (de) 2004-12-10 2010-11-18 3M Innovative Properties Co Medizinische vorrichtung
WO2006138719A2 (en) 2005-06-17 2006-12-28 Georgia Tech Research Corporation Coated microstructures and method of manufacture thereof
JP2008543528A (ja) 2005-06-27 2008-12-04 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルカートリッジアセンブリ及び適用方法
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
EP2258441A3 (en) 2005-09-02 2011-09-21 Intercell USA, Inc. Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs
JP2007089792A (ja) 2005-09-28 2007-04-12 Nano Device & System Research Inc 経皮投与装置
KR100682534B1 (ko) 2005-10-10 2007-02-15 한국과학기술원 미세바늘 어레이 제작방법
WO2007091608A1 (ja) 2006-02-10 2007-08-16 Hisamitsu Pharmaceutical Co., Inc. マイクロニードル付き経皮薬物投与装置
WO2007127976A2 (en) 2006-05-01 2007-11-08 Georgia Tech Research Corporation Particle based molding
US7918814B2 (en) 2006-05-02 2011-04-05 Georgia Tech Research Corporation Method for drug delivery to ocular tissue using microneedle
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
WO2008004597A1 (en) * 2006-07-04 2008-01-10 Toppan Printing Co., Ltd. Method for manufacturing microneedle
KR100793615B1 (ko) * 2006-07-21 2008-01-10 연세대학교 산학협력단 생분해성 솔리드 마이크로니들 및 이의 제조방법
WO2008020632A1 (en) 2006-08-18 2008-02-21 Toppan Printing Co., Ltd. Microneedle and microneedle patch
CN100460028C (zh) * 2006-12-08 2009-02-11 中国科学院上海微系统与信息技术研究所 一种用于药物传输的微针阵列及其制作方法
US8821446B2 (en) 2007-01-22 2014-09-02 Corium International, Inc. Applicators for microneedles
JP2009039171A (ja) 2007-08-06 2009-02-26 Dai Ichi Kasei Kk 微細針形状突起物及びその成形金型及びその製造方法
KR101555391B1 (ko) 2007-11-21 2015-09-23 가부시키가이샤 바이오세렌택 체표 적용 제제 및 체표 적용 제제 보유 시트
CA2745339C (en) 2007-12-24 2016-06-28 The University Of Queensland Coating method
AU2009212106B9 (en) 2008-02-07 2014-05-22 Vaxxas Pty Limited Patch production
JP5285943B2 (ja) * 2008-03-28 2013-09-11 凸版印刷株式会社 針状体アレイおよび針状体アレイ製造方法
KR101028457B1 (ko) 2008-08-07 2011-04-14 (주)마이티시스템 미세바늘 교환형 미세바늘 롤러 및 스탬프
BRPI0916150B1 (pt) * 2008-11-18 2019-09-24 3M Innovative Properties Company Arranjo de microagulhas ocas
WO2010071918A1 (en) * 2008-12-22 2010-07-01 The University Of Queensland Patch production
CN101856538B (zh) * 2009-04-09 2012-06-20 香港理工大学 微针阵列、制造该微针阵列的模铸方法及所使用的模具
US9289925B2 (en) 2009-04-10 2016-03-22 3M Innovative Properties Company Methods of making hollow microneedle arrays and articles and uses therefrom
EP2429627B1 (en) * 2009-04-24 2017-06-14 Corium International, Inc. Methods for manufacturing microprojection arrays
KR101033514B1 (ko) * 2009-06-02 2011-05-09 (주)마이티시스템 유연한 미세바늘 패치 시스템 및 그 제작방법
JP2011012050A (ja) 2009-06-03 2011-01-20 Bioserentack Co Ltd 多孔性基盤を用いたマイクロニードル・アレイとその製造方法
EP2338557A1 (en) * 2009-12-23 2011-06-29 Debiotech S.A. Soluble microneedle
EP2526995A4 (en) 2010-01-22 2013-07-03 Medrx Co Ltd ADHESIVE AID FOR HEALING FOR A MICRO NEEDLE ADHESIVE TRANSDERMAL STAMP
KR101254240B1 (ko) * 2010-12-17 2013-04-12 주식회사 라파스 마이크로구조체 제조방법
RU2570280C2 (ru) * 2010-04-28 2015-12-10 Кимберли-Кларк Ворлдвайд, Инк. Композитная матрица микроигл, содержащая на поверхности наноструктуры
KR101741294B1 (ko) 2010-05-28 2017-05-29 히사미쓰 세이야꾸 가부시키가이샤 미소 돌기가 형성된 어레이를 갖는 디바이스
WO2012006677A1 (en) 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
JP5770055B2 (ja) * 2010-09-29 2015-08-26 富士フイルム株式会社 針状アレイ経皮吸収シートの製造方法
US9017289B2 (en) 2010-11-03 2015-04-28 Covidien Lp Transdermal fluid delivery device
GB201019577D0 (en) * 2010-11-18 2010-12-29 Univ Cork Method
JP5653245B2 (ja) * 2011-02-14 2015-01-14 キヤノン株式会社 インクジェット記録装置及び記録ヘッドの回復方法
US8696637B2 (en) * 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
TWI458504B (zh) * 2011-05-02 2014-11-01 Univ Nat Cheng Kung 經皮藥物釋放貼片及利用近紅外光控制其藥物釋放之方法
JP2012235899A (ja) 2011-05-12 2012-12-06 Bioserentack Co Ltd 大量の目的物質を皮膚内へデリバリーするためのマイクロニードル・アレイ・チップ
US9131900B2 (en) 2011-07-11 2015-09-15 Covidien Lp Force regulating device applicators
JP5897293B2 (ja) 2011-09-29 2016-03-30 東レエンジニアリング株式会社 マイクロニードルシートおよびその製造方法、ならびにマイクロニードルシート用のスタンパ
AU2012323782B2 (en) 2011-10-12 2017-04-06 Vaxxas Pty Limited Delivery device
KR102143482B1 (ko) * 2011-11-30 2020-08-11 쓰리엠 이노베이티브 프로퍼티즈 컴파니 펩티드 치료제 및 아미노산을 포함하는 마이크로니들 장치, 이의 제조 및 사용 방법
US9144671B2 (en) 2011-12-21 2015-09-29 3M Innovative Properties Company Transdermal adhesive patch assembly with removable microneedle array and method of using same
WO2013166162A1 (en) * 2012-05-01 2013-11-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
CN102755691A (zh) * 2012-06-19 2012-10-31 吉林大学 高灵敏医用微针阵列电极
TWI554289B (zh) * 2012-06-29 2016-10-21 國立成功大學 鑲嵌式經皮藥物釋放貼片及其製造方法
WO2014073531A1 (ja) * 2012-11-09 2014-05-15 凸版印刷株式会社 針状構造体及びその製造方法
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
CN103203072B (zh) * 2013-03-25 2015-05-20 清华大学 金属微针阵列柔性贴片、经皮给药器件及经皮给药贴片
CN103263727B (zh) * 2013-05-22 2015-09-30 清华大学 金属微针阵列、经皮给药贴片、微针滚轮及微针电极阵列
CA2925333C (en) 2013-09-30 2021-09-07 Georgia Tech Research Corporation Microneedle patches, systems, and methods
CA2981974C (en) * 2014-04-24 2023-06-20 Georgia Tech Research Corporation Microneedles and methods of manufacture thereof
WO2016123665A1 (en) 2015-02-02 2016-08-11 Vaxxas Pty Limited Microprojection array applicator and method
MA41818A (fr) 2015-03-27 2018-01-30 Leo Pharma As Timbre à micro-aiguilles pour administration d'un principe actif à la peau
JP2017051312A (ja) 2015-09-08 2017-03-16 富士フイルム株式会社 マイクロニードルアレイ
WO2017043627A1 (ja) 2015-09-11 2017-03-16 株式会社バイオセレンタック マイクロニードル製剤
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles

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