DK2762140T3 - Treatment of solid brain tumors with a rapamycin derivative - Google Patents
Treatment of solid brain tumors with a rapamycin derivative Download PDFInfo
- Publication number
- DK2762140T3 DK2762140T3 DK14164565.5T DK14164565T DK2762140T3 DK 2762140 T3 DK2762140 T3 DK 2762140T3 DK 14164565 T DK14164565 T DK 14164565T DK 2762140 T3 DK2762140 T3 DK 2762140T3
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- tumor
- combination
- tumors
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Otolaryngology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pregnancy & Childbirth (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0104072A GB0104072D0 (en) | 2001-02-19 | 2001-02-19 | Organic compounds |
| GB0124957A GB0124957D0 (en) | 2001-10-17 | 2001-10-17 | Organic compounds |
| EP02719864A EP1363627A2 (en) | 2001-02-19 | 2002-02-18 | Treatment of solid tumours with rapamycin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2762140T3 true DK2762140T3 (en) | 2017-07-10 |
Family
ID=26245731
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14164565.5T DK2762140T3 (en) | 2001-02-19 | 2002-02-18 | Treatment of solid brain tumors with a rapamycin derivative |
| DK16186041.6T DK3143995T3 (en) | 2001-02-19 | 2002-02-18 | Rapamycin derivative for the treatment of lung cancer |
| DK10174985.1T DK2269604T3 (en) | 2001-02-19 | 2002-02-18 | Treatment of solid kidney tumors with a rapamycin derivative |
| DK10174983.6T DK2269603T3 (en) | 2001-02-19 | 2002-02-18 | TREATMENT OF BREAST TUMORS WITH A RAPAMYCIN DERIVATIVE IN COMBINATION WITH EXEMESTAN |
| DK18155724.0T DK3342411T3 (da) | 2001-02-19 | 2002-02-18 | Rapamycinderivat til behandling af pancreascancer |
| DK18155644.0T DK3351246T3 (da) | 2001-02-19 | 2002-02-18 | Rapamycinderivat til behandling af en solid tumor, som er associeret med dereguleret angionese |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16186041.6T DK3143995T3 (en) | 2001-02-19 | 2002-02-18 | Rapamycin derivative for the treatment of lung cancer |
| DK10174985.1T DK2269604T3 (en) | 2001-02-19 | 2002-02-18 | Treatment of solid kidney tumors with a rapamycin derivative |
| DK10174983.6T DK2269603T3 (en) | 2001-02-19 | 2002-02-18 | TREATMENT OF BREAST TUMORS WITH A RAPAMYCIN DERIVATIVE IN COMBINATION WITH EXEMESTAN |
| DK18155724.0T DK3342411T3 (da) | 2001-02-19 | 2002-02-18 | Rapamycinderivat til behandling af pancreascancer |
| DK18155644.0T DK3351246T3 (da) | 2001-02-19 | 2002-02-18 | Rapamycinderivat til behandling af en solid tumor, som er associeret med dereguleret angionese |
Country Status (27)
| Country | Link |
|---|---|
| US (10) | US8410131B2 (enExample) |
| EP (11) | EP3345602B1 (enExample) |
| JP (14) | JP2004525899A (enExample) |
| KR (3) | KR100695846B1 (enExample) |
| CN (5) | CN1551767A (enExample) |
| AU (1) | AU2002250968C1 (enExample) |
| BR (1) | BR0207378A (enExample) |
| CA (3) | CA2994779C (enExample) |
| CY (11) | CY1116616T1 (enExample) |
| CZ (5) | CZ309178B6 (enExample) |
| DK (6) | DK2762140T3 (enExample) |
| ES (8) | ES2629317T3 (enExample) |
| HK (2) | HK1250336B (enExample) |
| HU (1) | HUP0303271A3 (enExample) |
| IL (13) | IL157425A0 (enExample) |
| LT (9) | LT2269604T (enExample) |
| LU (3) | LU92880I2 (enExample) |
| MX (3) | MX368013B (enExample) |
| NO (14) | NO333105B1 (enExample) |
| NZ (1) | NZ527692A (enExample) |
| PL (5) | PL231418B1 (enExample) |
| PT (7) | PT2762140T (enExample) |
| RU (8) | RU2322981C2 (enExample) |
| SI (6) | SI3342411T1 (enExample) |
| SK (5) | SK288834B6 (enExample) |
| TW (2) | TW200626151A (enExample) |
| WO (1) | WO2002066019A2 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1158985B1 (en) | 1999-01-13 | 2011-12-28 | Bayer HealthCare LLC | OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| CZ309178B6 (cs) * | 2001-02-19 | 2022-04-20 | Novartis Pharma Ag | 40-O-(2-hydroxyethyl)rapamycin pro použití při léčení |
| PL367267A1 (en) * | 2001-06-01 | 2005-02-21 | Wyeth | Antineoplastic combinations |
| ES2425739T3 (es) | 2002-02-11 | 2013-10-17 | Bayer Healthcare Llc | Sorafenib-tosilato para el tratamiento de enfermedades caracterizadas por angiogénesis anormal |
| PT1545553E (pt) | 2002-07-30 | 2011-09-12 | Aeterna Zentaris Gmbh | Utilização de alquilfosfocolinas em combinação com medicamentos antitumorais |
| US8383605B2 (en) | 2002-07-30 | 2013-02-26 | Aeterna Zentaris Gmbh | Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals |
| US7846141B2 (en) | 2002-09-03 | 2010-12-07 | Bluesky Medical Group Incorporated | Reduced pressure treatment system |
| EP1553939A1 (en) * | 2002-10-11 | 2005-07-20 | Dana-Farber Cancer Institute, Inc. | Epothilone derivatives for the treatment of multiple myeloma |
| US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
| UA83484C2 (uk) * | 2003-03-05 | 2008-07-25 | Уайт | Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція |
| ES2305808T3 (es) | 2003-05-20 | 2008-11-01 | Bayer Healthcare Llc | Diarilureas con actividad inhibidora de quinasas. |
| BRPI0412219B8 (pt) | 2003-07-23 | 2021-07-27 | Bayer Healthcare Llc | compostos ômega-carboxi aril difenil uréia fluoro substituídos e composições farmacêuticas compreendendo os referidos compostos |
| CN102144961A (zh) | 2003-09-18 | 2011-08-10 | 参天制药株式会社 | 经巩膜递送 |
| KR101382077B1 (ko) * | 2004-02-23 | 2014-04-10 | 노파르티스 아게 | Mtor 억제제와 세포독성제의 복합 치료에 대한 바이오마커로서의 p53 야생형 |
| GB0406446D0 (en) * | 2004-03-23 | 2004-04-28 | Astrazeneca Ab | Combination therapy |
| NZ549552A (en) * | 2004-03-23 | 2009-12-24 | Astrazeneca Ab | Combination therapy involving 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline (AZD2171) and a platinum anti-tumour agent |
| CN104147005B (zh) | 2005-02-09 | 2018-07-03 | 参天制药株式会社 | 用于治疗疾病或病症的液体制剂 |
| CN102357104B (zh) * | 2005-03-07 | 2016-01-27 | 罗巴斯研究机构 | 粘液瘤病毒与雷帕霉素的组合在治疗性处理中的应用 |
| GB0504995D0 (en) * | 2005-03-11 | 2005-04-20 | Biotica Tech Ltd | Use of a compound |
| GB0504994D0 (en) * | 2005-03-11 | 2005-04-20 | Biotica Tech Ltd | Novel compounds |
| US20100061994A1 (en) * | 2005-03-11 | 2010-03-11 | Rose Mary Sheridan | Medical uses of 39-desmethoxyrapamycin and analogues thereof |
| GB0507918D0 (en) | 2005-04-19 | 2005-05-25 | Novartis Ag | Organic compounds |
| US20080200486A1 (en) * | 2005-07-20 | 2008-08-21 | Heidi Lane | Combination Of Organic Compounds |
| EP2662082A1 (en) | 2005-11-14 | 2013-11-13 | Ariad Pharmaceuticals, Incorporated | Administration of mTOR inhibitors |
| CA2629245C (en) * | 2005-11-21 | 2016-07-12 | Novartis Ag | Neuroendocrine tumor treatment |
| AU2007211613C1 (en) | 2006-02-02 | 2018-01-04 | Novartis Ag | Tuberous Sclerosis treatment |
| GB0602123D0 (en) * | 2006-02-02 | 2006-03-15 | Novartis Ag | Organic compounds |
| JP5528708B2 (ja) | 2006-02-09 | 2014-06-25 | 参天製薬株式会社 | 安定な製剤ならびにそれらを調製および使用する方法 |
| JP5506378B2 (ja) | 2006-03-23 | 2014-05-28 | 参天製薬株式会社 | 血管透過性に関連する疾患または病気のための製剤および方法 |
| EP2004163B1 (en) * | 2006-04-05 | 2014-09-17 | Novartis Pharma AG | Combination of everolimus and vinorelbine |
| CA2661024A1 (en) * | 2006-08-28 | 2008-03-06 | The Regents Of The University Of California | Small molecule potentiator of hormonal therapy for breast cancer |
| US9820888B2 (en) | 2006-09-26 | 2017-11-21 | Smith & Nephew, Inc. | Wound dressing |
| RU2483714C2 (ru) * | 2007-03-07 | 2013-06-10 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи. | Наночастица, содержащая рапамицин и альбумин, в качестве противоракового агента |
| US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| CN101292980B (zh) * | 2007-04-28 | 2010-11-10 | 上海交通大学医学院附属仁济医院 | 一种含有雷帕霉素的用于治疗大肠癌的药物组合物 |
| ES2706023T3 (es) * | 2007-08-16 | 2019-03-27 | Biocompatibles Uk Ltd | Administración de combinaciones de fármacos |
| US20090149511A1 (en) * | 2007-10-30 | 2009-06-11 | Syndax Pharmaceuticals, Inc. | Administration of an Inhibitor of HDAC and an mTOR Inhibitor |
| US8298200B2 (en) | 2009-06-01 | 2012-10-30 | Tyco Healthcare Group Lp | System for providing continual drainage in negative pressure wound therapy |
| WO2009126965A2 (en) * | 2008-04-11 | 2009-10-15 | The Regents Of The University Of Colorado | Compositions, methods and uses for modulations of brca1 |
| AU2009279806B2 (en) * | 2008-08-04 | 2015-04-30 | Five Prime Therapeutics, Inc. | FGFR extracellular domain acidic region muteins |
| GB0902368D0 (en) | 2009-02-13 | 2009-04-01 | Smith & Nephew | Wound packing |
| GB0922332D0 (en) | 2009-12-22 | 2010-02-03 | Isis Innovation | Method of treatment and screening method |
| US8791315B2 (en) | 2010-02-26 | 2014-07-29 | Smith & Nephew, Inc. | Systems and methods for using negative pressure wound therapy to manage open abdominal wounds |
| CA2794513A1 (en) | 2010-03-31 | 2011-10-06 | Aeterna Zentaris Gmbh | Perifosine and capecitabine as a combined treatment for cancer |
| MY162825A (en) | 2010-08-20 | 2017-07-31 | Novartis Ag | Antibodies for epidermal growth factor receptor 3 (her3) |
| UY34487A (es) * | 2011-12-05 | 2013-07-31 | Novartis Ag | Anticuerpos para receptor de factor de crecimiento epidérmico 3(her3) |
| EP3354293B1 (en) | 2012-05-23 | 2019-12-11 | Smith & Nephew plc | Apparatuses for negative pressure wound therapy |
| EP2879636B1 (en) | 2012-08-01 | 2017-03-22 | Smith & Nephew PLC | Wound dressing |
| CA2880148C (en) | 2012-08-01 | 2021-07-20 | Smith & Nephew Plc | Wound dressing and method of treatment |
| EP2968648B1 (en) | 2013-03-15 | 2020-12-23 | Smith & Nephew plc | Wound dressing and method of treatment |
| US10682415B2 (en) | 2013-07-22 | 2020-06-16 | Wisconsin Alumni Research Foundation | Thermogel formulation for combination drug delivery |
| WO2016066608A1 (en) | 2014-10-28 | 2016-05-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treatment of pulmonary cell senescence and peripheral aging |
| JP6623745B2 (ja) * | 2015-06-29 | 2019-12-25 | 富士通株式会社 | 電子回路及び発振器の制御方法 |
| EP3277842B9 (en) * | 2015-08-17 | 2020-01-15 | Kura Oncology, Inc. | Methods of treating cancer patients with farnesyl transferase inhibitors |
| WO2017160895A1 (en) * | 2016-03-15 | 2017-09-21 | Tyme, Inc. | Pharmaceutical compositions for the treatment of cancer |
| US20200081010A1 (en) | 2016-12-02 | 2020-03-12 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for diagnosing renal cell carcinoma |
| EP4046989A1 (en) | 2017-01-09 | 2022-08-24 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human disease |
| US11584733B2 (en) | 2017-01-09 | 2023-02-21 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human disease |
| WO2019002085A1 (en) | 2017-06-30 | 2019-01-03 | Smith & Nephew Plc | NEGATIVE PRESSURE WOUND TREATMENT APPARATUS |
| AR112834A1 (es) | 2017-09-26 | 2019-12-18 | Novartis Ag | Derivados de rapamicina |
| WO2019089556A1 (en) * | 2017-10-31 | 2019-05-09 | Steve Gorlin | Combinations of chemotherapeutic agents and antimicrobial particles and uses thereof |
| EP3737376B1 (en) | 2018-01-09 | 2024-04-17 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human diseases |
| SG11202010560QA (en) | 2018-05-01 | 2020-11-27 | Revolution Medicines Inc | C26-linked rapamycin analogs as mtor inhibitors |
| FI3788049T3 (fi) | 2018-05-01 | 2023-05-30 | Revolution Medicines Inc | C40-, c28- ja c-32-liittyneitä rapamysiinianalogeja mtor-estäjinä |
| CN108825638A (zh) * | 2018-08-01 | 2018-11-16 | 安徽送变电工程有限公司 | 一种应用于螺纹工件的防盗装置 |
| HRP20250197T1 (hr) | 2018-12-18 | 2025-04-11 | Novartis Ag | Derivati rapamicina |
| GB201905780D0 (en) | 2019-04-25 | 2019-06-05 | La Thangue Nicholas | Cancer therapy |
| CN114173578A (zh) | 2019-05-14 | 2022-03-11 | 迪美公司 | 用于治疗癌症的组合物和方法 |
| US10905698B1 (en) | 2020-05-14 | 2021-02-02 | Tyme, Inc. | Methods of treating SARS-COV-2 infections |
| KR20230053539A (ko) | 2021-10-14 | 2023-04-21 | (주)파로스아이바이오 | 2,3,5-치환된 싸이오펜 화합물을 포함하는 병용 투여용 조성물 |
| AU2023275778A1 (en) | 2022-05-25 | 2024-12-12 | Revolution Medicines, Inc. | Methods of treating cancer with an mtor inhibitor |
Family Cites Families (103)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US876165A (en) | 1904-05-11 | 1908-01-07 | George K Woodworth | Wireless telegraph transmitting system. |
| GB104072A (en) | 1916-04-14 | 1917-02-22 | William Henry Nosworthy | Apparatus for Lighting Fires or Heating or other purposes. |
| GB124957A (en) | 1918-06-04 | 1919-04-10 | Frederick William Miller | Improvement in Glass Moulding. |
| GB1524747A (en) | 1976-05-11 | 1978-09-13 | Ici Ltd | Polypeptide |
| BE877700A (fr) * | 1978-11-03 | 1980-01-14 | Ayerst Mckenna & Harrison | Compositions pharmaceutiques a base de rapamycine pour le traitement de tumeurs carcinogenes |
| US5206018A (en) | 1978-11-03 | 1993-04-27 | Ayerst, Mckenna & Harrison, Inc. | Use of rapamycin in treatment of tumors |
| US5066493A (en) * | 1978-11-03 | 1991-11-19 | American Home Products Corporation | Rapamycin in treatment of tumors |
| US4885171A (en) * | 1978-11-03 | 1989-12-05 | American Home Products Corporation | Use of rapamycin in treatment of certain tumors |
| LU88769I2 (fr) | 1982-07-23 | 1996-11-05 | Zeneca Ltd | Bicalutamide et ses sels et esters pharmaceutiquement acceptables (Casodex (R)) |
| GB8327256D0 (en) | 1983-10-12 | 1983-11-16 | Ici Plc | Steroid derivatives |
| GB8517360D0 (en) | 1985-07-09 | 1985-08-14 | Erba Farmitalia | Substituted androsta-1,4-diene-3,17-diones |
| US5093330A (en) * | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| IL86632A0 (en) | 1987-06-15 | 1988-11-30 | Ciba Geigy Ag | Derivatives substituted at methyl-amino nitrogen |
| US5010099A (en) | 1989-08-11 | 1991-04-23 | Harbor Branch Oceanographic Institution, Inc. | Discodermolide compounds, compositions containing same and method of preparation and use |
| US5194447A (en) * | 1992-02-18 | 1993-03-16 | American Home Products Corporation | Sulfonylcarbamates of rapamycin |
| NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| JP3140228B2 (ja) * | 1992-02-17 | 2001-03-05 | ファイザー製薬株式会社 | 新規な大環状ラクトンおよびその生産菌 |
| US5521184A (en) * | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| TW225528B (enExample) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| US5256790A (en) * | 1992-08-13 | 1993-10-26 | American Home Products Corporation | 27-hydroxyrapamycin and derivatives thereof |
| GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| WO1994009019A1 (en) | 1992-10-14 | 1994-04-28 | Unichema Chemie B.V. | Process for the preparation of alkylglycosides |
| JP3398382B2 (ja) | 1992-10-28 | 2003-04-21 | ジェネンテク,インコーポレイテッド | 血管内皮細胞増殖因子アンタゴニスト |
| US5258389A (en) * | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
| GB2273704B (en) * | 1992-12-16 | 1997-01-22 | Orion Yhtymae Oy | Triazolyl diaryl selective aromatase inhibiting compounds |
| DE4301781C2 (de) | 1993-01-23 | 1995-07-20 | Lohmann Therapie Syst Lts | Nitroglycerinhaltiges Pflaster, Verfahren zu seiner Herstellung und Verwendung |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| US5387680A (en) * | 1993-08-10 | 1995-02-07 | American Home Products Corporation | C-22 ring stabilized rapamycin derivatives |
| EP0729471A1 (en) | 1993-11-19 | 1996-09-04 | Abbott Laboratories | Semisynthetic analogs of rapamycin (macrolides) being immunomodulators |
| GB9325400D0 (en) | 1993-12-11 | 1994-02-16 | Sarll David P G | Temperature recorder |
| CN1046944C (zh) | 1993-12-17 | 1999-12-01 | 山道士有限公司 | 雷怕霉素类衍生物 |
| AU2356195A (en) * | 1994-04-14 | 1995-11-10 | Sepracor, Inc. | Treating estrogen-dependent diseases with (-)-fadrozole |
| US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| GB9417873D0 (en) | 1994-09-06 | 1994-10-26 | Sandoz Ltd | Organic compounds |
| IL129547A (en) | 1994-10-26 | 2001-01-11 | Novartis Ag | Pharmaceutical compositions comprising a macrolide and an acid |
| EP0817775B1 (en) | 1995-03-30 | 2001-09-12 | Pfizer Inc. | Quinazoline derivatives |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| US5843901A (en) | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| US5985890A (en) * | 1995-06-09 | 1999-11-16 | Novartis Ag | Rapamycin derivatives |
| HUP9900330A3 (en) | 1995-07-06 | 2001-08-28 | Novartis Ag | Pyrrolopyrimidines and processes for the preparation thereof |
| US5567831A (en) * | 1995-08-16 | 1996-10-22 | Duguesne University Of The Holy Ghost | Non-steroidal sulfatase inhibitor compounds and their method of use |
| US6245805B1 (en) * | 1995-10-26 | 2001-06-12 | Baker Norton Pharmaceuticals, Inc. | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
| DE19549852B4 (de) * | 1995-11-29 | 2009-06-04 | Novartis Ag | Cyclosporin enthaltende Präparate |
| GB9601120D0 (en) | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
| US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| GB9606452D0 (en) * | 1996-03-27 | 1996-06-05 | Sandoz Ltd | Organic compounds |
| CN1145614C (zh) | 1996-04-12 | 2004-04-14 | 沃尼尔·朗伯公司 | 酪氨酸激酶的不可逆抑制剂,其制药用途及药物组合物 |
| EP0896544B1 (en) * | 1996-06-11 | 2003-02-26 | Novartis AG | Combination of a somatostatin analogue and a rapamycin |
| CA2258548C (en) | 1996-06-24 | 2005-07-26 | Pfizer Inc. | Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases |
| US6492330B1 (en) * | 1996-08-16 | 2002-12-10 | National Institute Of Immunology | Antiangiogenic drugs |
| US5922730A (en) | 1996-09-09 | 1999-07-13 | American Home Products Corporation | Alkylated rapamycin derivatives |
| WO1998009970A2 (en) | 1996-09-09 | 1998-03-12 | American Home Products Corporation | Alkylated rapamycin derivatives |
| DE19638745C2 (de) | 1996-09-11 | 2001-05-10 | Schering Ag | Monoklonale Antikörper gegen die extrazelluläre Domäne des menschlichen VEGF - Rezeptorproteins (KDR) |
| AU4342997A (en) | 1996-09-13 | 1998-04-02 | Sugen, Inc. | Use of quinazoline derivatives for the manufacture of a medicament in the reatment of hyperproliferative skin disorders |
| GB9619631D0 (en) | 1996-09-20 | 1996-11-06 | British Biotech Pharm | Combination therapy |
| EP0837063A1 (en) | 1996-10-17 | 1998-04-22 | Pfizer Inc. | 4-Aminoquinazoline derivatives |
| CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| US5985325A (en) | 1997-06-13 | 1999-11-16 | American Home Products Corporation | Rapamycin formulations for oral administration |
| CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| US6015815A (en) * | 1997-09-26 | 2000-01-18 | Abbott Laboratories | Tetrazole-containing rapamycin analogs with shortened half-lives |
| GB9721069D0 (en) | 1997-10-03 | 1997-12-03 | Pharmacia & Upjohn Spa | Polymeric derivatives of camptothecin |
| US6152347A (en) | 1998-01-30 | 2000-11-28 | Acco Brands, Inc. | Vertical Stapler |
| ID27825A (id) † | 1998-03-26 | 2001-04-26 | Fujisawa Pharmaceutical Co | Sediaan lepas lambat |
| US8029561B1 (en) | 2000-05-12 | 2011-10-04 | Cordis Corporation | Drug combination useful for prevention of restenosis |
| AR018330A1 (es) * | 1998-04-27 | 2001-11-14 | Fujisawa Pharmaceutical Co | Composiciones farmaceuticas que comprenden macrolidos como agentes activos para la terapia y profilaxis de las enfermedades de la piel |
| ES2342240T3 (es) | 1998-08-11 | 2010-07-02 | Novartis Ag | Derivados de isoquinolina con actividad que inhibe la angiogenia. |
| GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
| IL143596A0 (en) | 1998-12-22 | 2002-04-21 | Genentech Inc | Vascular endothelial cell growth factor antagonists and uses thereof |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| AU766081B2 (en) | 1999-03-30 | 2003-10-09 | Novartis Ag | Phthalazine derivatives for treating inflammatory diseases |
| US6333348B1 (en) * | 1999-04-09 | 2001-12-25 | Aventis Pharma S.A. | Use of docetaxel for treating cancers |
| GB9911582D0 (en) | 1999-05-18 | 1999-07-21 | Pharmacia & Upjohn Spa | Combined method of treatment comprising an aromatase inhibitor and a further biologically active compound |
| EP1074265A1 (en) | 1999-08-03 | 2001-02-07 | Erasmus Universiteit Rotterdam | Use of AMH and/or AMH agonists and/or AMH antagonists for long-term control of female fertility |
| ES2222222T3 (es) | 1999-08-18 | 2005-02-01 | Wyeth | Esteres hidrosolubles de sdz-rad. |
| AU2292801A (en) | 1999-12-22 | 2001-07-03 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Compositions and methods for treatment of breast cancer |
| WO2001049338A1 (en) | 1999-12-30 | 2001-07-12 | Li Wei Pin | Controlled delivery of therapeutic agents by insertable medical devices |
| WO2001051049A1 (en) | 2000-01-14 | 2001-07-19 | The Trustees Of The University Of Pennsylvania | O-methylated rapamycin derivatives for alleviation and inhibition of lymphoproliferative disorders |
| US6641811B1 (en) * | 2000-02-10 | 2003-11-04 | Cornell Research Foundation, Inc. | Use of angiotensin II inhibitors to prevent malignancies associated with immunosuppression |
| GB0005257D0 (en) | 2000-03-03 | 2000-04-26 | Pharmacia & Upjohn Spa | Breast cancer hormonal therapy |
| US6761895B2 (en) | 2000-04-17 | 2004-07-13 | Yamanouchi Pharmaceutical Co., Ltd. | Drug delivery system for averting pharmacokinetic drug interaction and method thereof |
| US20020013335A1 (en) | 2000-06-16 | 2002-01-31 | American Home Products Corporation | Method of treating cardiovascular disease |
| GB0017635D0 (en) | 2000-07-18 | 2000-09-06 | Pharmacia & Upjohn Spa | Antitumor combined therapy |
| PT1318837E (pt) * | 2000-08-11 | 2004-12-31 | Wyeth Corp | Metodo de tratamenton de carcinoma positivo a receptor de estrogenio |
| US20050004007A1 (en) * | 2000-09-12 | 2005-01-06 | Steven Grant | Promotion of adoptosis in cancer cells by co-administration of cyclin dependent kinase inhibitiors and cellular differentiation agents |
| US6696483B2 (en) * | 2000-10-03 | 2004-02-24 | Oncopharmaceutical, Inc. | Inhibitors of angiogenesis and tumor growth for local and systemic administration |
| AU2002239436B2 (en) | 2000-10-31 | 2007-04-26 | Cook Medical Technologies Llc | Coated implantable medical device |
| TWI286074B (en) | 2000-11-15 | 2007-09-01 | Wyeth Corp | Pharmaceutical composition containing CCI-779 as an antineoplastic agent |
| AU2002249826A1 (en) * | 2000-12-22 | 2002-07-30 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
| US20020151508A1 (en) * | 2001-02-09 | 2002-10-17 | Schering Corporation | Methods for treating proliferative diseases |
| CZ309178B6 (cs) * | 2001-02-19 | 2022-04-20 | Novartis Pharma Ag | 40-O-(2-hydroxyethyl)rapamycin pro použití při léčení |
| DE60228699D1 (de) | 2001-04-06 | 2008-10-16 | Wyeth Corp | Antineoplastische kombinationspräparate enthaltend cci-779 (rapamycin derivat) zusammen mit gemcitabin oder fluoro-uracil |
| PL367267A1 (en) * | 2001-06-01 | 2005-02-21 | Wyeth | Antineoplastic combinations |
| UA77200C2 (en) | 2001-08-07 | 2006-11-15 | Wyeth Corp | Antineoplastic combination of cci-779 and bkb-569 |
| US7488313B2 (en) | 2001-11-29 | 2009-02-10 | Boston Scientific Scimed, Inc. | Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment |
| JP2003330447A (ja) | 2002-05-15 | 2003-11-19 | Mitsubishi Electric Corp | 画像処理装置 |
| CA2629245C (en) | 2005-11-21 | 2016-07-12 | Novartis Ag | Neuroendocrine tumor treatment |
| BR112013032887B1 (pt) | 2011-07-01 | 2020-10-06 | Coloplast A/S | Cateter retal |
| EP2606816A1 (en) | 2011-12-22 | 2013-06-26 | Koninklijke Philips Electronics N.V. | A method and system for providing an indication as to the amount of milk remaining in a breast during lactation |
-
2002
- 2002-02-18 CZ CZ2018211A patent/CZ309178B6/cs not_active IP Right Cessation
- 2002-02-18 AU AU2002250968A patent/AU2002250968C1/en not_active Expired
- 2002-02-18 SI SI200231097T patent/SI3342411T1/sl unknown
- 2002-02-18 LT LTEP10174985.1T patent/LT2269604T/lt unknown
- 2002-02-18 PT PT141645655T patent/PT2762140T/pt unknown
- 2002-02-18 DK DK14164565.5T patent/DK2762140T3/en active
- 2002-02-18 ES ES14164565.5T patent/ES2629317T3/es not_active Expired - Lifetime
- 2002-02-18 LT LTEP18155644.0T patent/LT3351246T/lt unknown
- 2002-02-18 RU RU2003127391/15A patent/RU2322981C2/ru active
- 2002-02-18 CA CA2994779A patent/CA2994779C/en not_active Expired - Lifetime
- 2002-02-18 EP EP18155722.4A patent/EP3345602B1/en not_active Expired - Lifetime
- 2002-02-18 CZ CZ20032209A patent/CZ303611B6/cs not_active IP Right Cessation
- 2002-02-18 LT LTEP18155724.0T patent/LT3342411T/lt unknown
- 2002-02-18 PL PL414996A patent/PL231418B1/pl unknown
- 2002-02-18 EP EP18181342.9A patent/EP3406249A1/en not_active Withdrawn
- 2002-02-18 IL IL15742502A patent/IL157425A0/xx unknown
- 2002-02-18 SK SK902019A patent/SK288834B6/sk unknown
- 2002-02-18 US US10/468,520 patent/US8410131B2/en not_active Expired - Lifetime
- 2002-02-18 NZ NZ527692A patent/NZ527692A/en not_active IP Right Cessation
- 2002-02-18 KR KR1020037010870A patent/KR100695846B1/ko not_active Expired - Lifetime
- 2002-02-18 PT PT18155644T patent/PT3351246T/pt unknown
- 2002-02-18 PL PL409579A patent/PL409579A1/pl unknown
- 2002-02-18 SI SI200231088A patent/SI2762140T1/sl unknown
- 2002-02-18 SK SK50008-2016A patent/SK288630B6/sk unknown
- 2002-02-18 CN CNA028068440A patent/CN1551767A/zh active Pending
- 2002-02-18 EP EP14164561.4A patent/EP2764865A3/en not_active Withdrawn
- 2002-02-18 MX MX2014014346A patent/MX368013B/es unknown
- 2002-02-18 EP EP16186041.6A patent/EP3143995B2/en not_active Expired - Lifetime
- 2002-02-18 SI SI200231078A patent/SI2269604T1/sl unknown
- 2002-02-18 DK DK16186041.6T patent/DK3143995T3/en active
- 2002-02-18 CN CNB2005100554588A patent/CN1296043C/zh not_active Ceased
- 2002-02-18 PL PL414997A patent/PL414997A1/pl unknown
- 2002-02-18 ES ES18155722T patent/ES2921798T3/es not_active Expired - Lifetime
- 2002-02-18 PT PT101749851T patent/PT2269604T/pt unknown
- 2002-02-18 WO PCT/EP2002/001714 patent/WO2002066019A2/en not_active Ceased
- 2002-02-18 DK DK10174985.1T patent/DK2269604T3/en active
- 2002-02-18 KR KR1020057017585A patent/KR20050095906A/ko not_active Ceased
- 2002-02-18 JP JP2002565579A patent/JP2004525899A/ja active Pending
- 2002-02-18 SI SI200231092T patent/SI3143995T1/sl unknown
- 2002-02-18 EP EP14164565.5A patent/EP2762140B1/en not_active Revoked
- 2002-02-18 DK DK10174983.6T patent/DK2269603T3/en active
- 2002-02-18 EP EP10174985.1A patent/EP2269604B1/en not_active Revoked
- 2002-02-18 PT PT101749836T patent/PT2269603E/pt unknown
- 2002-02-18 CA CA2860306A patent/CA2860306C/en not_active Expired - Lifetime
- 2002-02-18 SI SI200231056T patent/SI2269603T1/sl unknown
- 2002-02-18 SK SK5011-2005A patent/SK288545B6/sk unknown
- 2002-02-18 PT PT18155724T patent/PT3342411T/pt unknown
- 2002-02-18 DK DK18155724.0T patent/DK3342411T3/da active
- 2002-02-18 ES ES14164259.5T patent/ES2640787T3/es not_active Expired - Lifetime
- 2002-02-18 CZ CZ2010-473A patent/CZ307940B6/cs not_active IP Right Cessation
- 2002-02-18 ES ES10174983.6T patent/ES2543383T3/es not_active Expired - Lifetime
- 2002-02-18 CN CN201410286316.1A patent/CN104116738A/zh active Pending
- 2002-02-18 KR KR1020077022986A patent/KR20070102762A/ko not_active Ceased
- 2002-02-18 CN CN201410469536.8A patent/CN104274442A/zh active Pending
- 2002-02-18 SI SI200231094T patent/SI3351246T1/sl unknown
- 2002-02-18 CN CN201410286300.0A patent/CN104083365A/zh active Pending
- 2002-02-18 PL PL415000A patent/PL415000A1/pl unknown
- 2002-02-18 EP EP18155724.0A patent/EP3342411B1/en not_active Expired - Lifetime
- 2002-02-18 EP EP14164259.5A patent/EP2783686B1/en not_active Revoked
- 2002-02-18 SK SK50003-2016A patent/SK288524B6/sk unknown
- 2002-02-18 EP EP18155644.0A patent/EP3351246B8/en not_active Revoked
- 2002-02-18 EP EP02719864A patent/EP1363627A2/en not_active Withdrawn
- 2002-02-18 ES ES18155724T patent/ES2744377T3/es not_active Expired - Lifetime
- 2002-02-18 EP EP20100174983 patent/EP2269603B1/en not_active Revoked
- 2002-02-18 BR BR0207378-1A patent/BR0207378A/pt not_active Application Discontinuation
- 2002-02-18 PT PT181557224T patent/PT3345602T/pt unknown
- 2002-02-18 ES ES16186041T patent/ES2705016T3/es not_active Expired - Lifetime
- 2002-02-18 ES ES10174985.1T patent/ES2600304T3/es not_active Expired - Lifetime
- 2002-02-18 ES ES18155644T patent/ES2728739T3/es not_active Expired - Lifetime
- 2002-02-18 SK SK1038-2003A patent/SK288546B6/sk unknown
- 2002-02-18 CZ CZ2019-248A patent/CZ309247B6/cs not_active IP Right Cessation
- 2002-02-18 CZ CZ2005-91A patent/CZ307637B6/cs not_active IP Right Cessation
- 2002-02-18 PT PT16186041T patent/PT3143995T/pt unknown
- 2002-02-18 MX MXPA03007418A patent/MXPA03007418A/es active IP Right Grant
- 2002-02-18 LT LTEP16186041.6T patent/LT3143995T/lt unknown
- 2002-02-18 CA CA2438504A patent/CA2438504C/en not_active Expired - Lifetime
- 2002-02-18 DK DK18155644.0T patent/DK3351246T3/da active
- 2002-02-18 HU HU0303271A patent/HUP0303271A3/hu not_active Application Discontinuation
- 2002-02-18 LT LTEP14164565.5T patent/LT2762140T/lt unknown
- 2002-02-18 PL PL02363918A patent/PL363918A1/xx not_active IP Right Cessation
- 2002-02-19 TW TW095103554A patent/TW200626151A/zh unknown
- 2002-02-19 TW TW091102797A patent/TWI334350B/zh not_active IP Right Cessation
-
2003
- 2003-08-14 IL IL157425A patent/IL157425A/en active IP Right Grant
- 2003-08-18 NO NO20033651A patent/NO333105B1/no not_active IP Right Cessation
- 2003-08-19 MX MX2019010879A patent/MX2019010879A/es unknown
-
2004
- 2004-04-15 HK HK18109752.9A patent/HK1250336B/en not_active IP Right Cessation
- 2004-04-15 HK HK18109527.3A patent/HK1250018B/en not_active IP Right Cessation
-
2005
- 2005-03-01 RU RU2005105664/15A patent/RU2325906C2/ru active
-
2006
- 2006-11-16 RU RU2006140514/15A patent/RU2445093C2/ru not_active IP Right Cessation
-
2007
- 2007-08-06 JP JP2007204409A patent/JP2007284454A/ja active Pending
-
2009
- 2009-11-16 IL IL202155A patent/IL202155A/en active IP Right Grant
-
2011
- 2011-09-22 RU RU2011138835/15A patent/RU2483727C1/ru active
-
2012
- 2012-02-23 US US13/403,578 patent/US8436010B2/en not_active Expired - Fee Related
- 2012-02-23 US US13/403,474 patent/US20130059877A1/en not_active Abandoned
- 2012-04-18 NO NO20120451A patent/NO335134B1/no not_active IP Right Cessation
- 2012-04-26 JP JP2012101519A patent/JP5775022B2/ja not_active Expired - Lifetime
- 2012-05-31 IL IL220096A patent/IL220096A/en active IP Right Grant
- 2012-05-31 IL IL220095A patent/IL220095A/en active IP Right Grant
- 2012-07-11 US US13/546,686 patent/US8778962B2/en not_active Expired - Lifetime
-
2013
- 2013-01-09 NO NO20130045A patent/NO334646B1/no not_active IP Right Cessation
- 2013-04-26 RU RU2013119705A patent/RU2665138C2/ru active
- 2013-05-14 US US13/893,537 patent/US20130253000A1/en not_active Abandoned
- 2013-05-14 US US13/893,589 patent/US20130244951A1/en not_active Abandoned
- 2013-06-27 US US13/928,583 patent/US20130296359A1/en not_active Abandoned
- 2013-06-27 US US13/928,891 patent/US8877771B2/en not_active Expired - Fee Related
- 2013-09-24 RU RU2013143306A patent/RU2659725C2/ru active
- 2013-10-30 IL IL229158A patent/IL229158A/en active IP Right Grant
- 2013-10-30 IL IL229156A patent/IL229156A/en active IP Right Grant
- 2013-10-30 IL IL229159A patent/IL229159A0/en unknown
- 2013-10-30 IL IL229160A patent/IL229160B/en active IP Right Grant
- 2013-10-30 IL IL229157A patent/IL229157A0/en unknown
- 2013-11-19 NO NO20131544A patent/NO336208B1/no not_active IP Right Cessation
- 2013-11-19 NO NO20131547A patent/NO336581B1/no not_active IP Right Cessation
- 2013-11-19 NO NO20131545A patent/NO336428B1/no not_active Application Discontinuation
- 2013-11-19 NO NO20131546A patent/NO336110B1/no not_active IP Right Cessation
- 2013-12-19 US US14/134,419 patent/US20140105895A1/en not_active Abandoned
-
2014
- 2014-05-02 JP JP2014095034A patent/JP5873128B2/ja not_active Expired - Lifetime
- 2014-06-02 JP JP2014114297A patent/JP5879391B2/ja not_active Expired - Lifetime
- 2014-06-02 JP JP2014114296A patent/JP2014208657A/ja not_active Withdrawn
-
2015
- 2015-03-18 NO NO2015010C patent/NO2015010I1/no unknown
- 2015-04-08 JP JP2015079430A patent/JP6333766B2/ja not_active Expired - Lifetime
- 2015-04-09 NO NO20150413A patent/NO20150413L/no not_active Application Discontinuation
- 2015-06-24 NO NO20150831A patent/NO340553B1/no not_active IP Right Cessation
- 2015-07-08 NO NO20150895A patent/NO339240B1/no not_active IP Right Cessation
- 2015-08-13 CY CY20151100711T patent/CY1116616T1/el unknown
- 2015-11-17 LU LU92880C patent/LU92880I2/xx unknown
- 2015-11-19 CY CY2015044C patent/CY2015044I1/el unknown
-
2016
- 2016-06-28 US US15/195,018 patent/US20160303092A1/en not_active Abandoned
- 2016-07-29 JP JP2016149701A patent/JP6310970B2/ja not_active Expired - Lifetime
- 2016-08-24 NO NO20161348A patent/NO340924B1/no not_active IP Right Cessation
- 2016-10-21 CY CY20161101060T patent/CY1118316T1/el unknown
- 2016-11-23 LU LU93320C patent/LU93320I2/fr unknown
- 2016-11-28 LT LTPA2016035C patent/LTC2269604I2/lt unknown
- 2016-12-20 CY CY2016047C patent/CY2016047I1/el unknown
-
2017
- 2017-01-06 JP JP2017001065A patent/JP6383814B2/ja not_active Expired - Lifetime
- 2017-02-20 IL IL250676A patent/IL250676B/en active IP Right Grant
- 2017-03-19 IL IL251270A patent/IL251270B/en active IP Right Grant
- 2017-05-16 NO NO20170803A patent/NO343599B1/no not_active IP Right Cessation
- 2017-06-22 CY CY20171100668T patent/CY1119029T1/el unknown
-
2018
- 2018-02-08 JP JP2018021352A patent/JP6349474B2/ja not_active Expired - Lifetime
- 2018-02-08 JP JP2018021354A patent/JP6349476B2/ja not_active Expired - Lifetime
- 2018-02-08 JP JP2018021353A patent/JP6349475B2/ja not_active Expired - Lifetime
- 2018-05-31 IL IL259724A patent/IL259724B/en unknown
- 2018-06-08 RU RU2018121314A patent/RU2018121314A/ru not_active Application Discontinuation
- 2018-07-06 JP JP2018129096A patent/JP2018168188A/ja not_active Withdrawn
- 2018-07-30 RU RU2018127821A patent/RU2018127821A/ru not_active Application Discontinuation
-
2019
- 2019-01-10 CY CY20191100021T patent/CY1121314T1/el unknown
- 2019-03-04 NO NO20190290A patent/NO20190290A1/no not_active Application Discontinuation
- 2019-06-04 CY CY2019030C patent/CY2019030I1/el unknown
- 2019-06-04 LT LTPA2019511C patent/LTPA2019511I1/lt unknown
- 2019-06-04 LU LU00122C patent/LUC00122I2/fr unknown
- 2019-06-14 CY CY20191100619T patent/CY1121715T1/el unknown
- 2019-09-03 CY CY20191100925T patent/CY1121983T1/el unknown
- 2019-11-21 CY CY2019043C patent/CY2019043I1/el unknown
- 2019-11-21 LT LTPA2019521 patent/LTPA2019521I1/lt unknown
-
2020
- 2020-02-20 LT LTPA2020503C patent/LTPA2020503I1/lt unknown
- 2020-02-20 CY CY2020005C patent/CY2020005I1/el unknown
- 2020-05-26 JP JP2020091227A patent/JP6904640B2/ja not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2762140T3 (en) | Treatment of solid brain tumors with a rapamycin derivative | |
| HK1197723B (en) | Treatment of solid brain tumours with a rapamycin derivative | |
| HK1146245B (en) | Treatment of solid kidney tumours with a rapamycin derivative | |
| HK1232469B (en) | Rapamycin derivative for the treatment of lung cancer | |
| AU2019222912B2 (en) | Cancer treatment | |
| AU2014202334B2 (en) | Cancer treatment | |
| HK1198946B (en) | Combination of a rapamycin derivative and letrozole for treating breast cancer | |
| AU2011226835B2 (en) | Cancer treatment | |
| HK1146247B (en) | Treatment of breast tumors with a rapamycin derivative in combination with exemestane | |
| AU2007201060B2 (en) | Cancer treatment | |
| SK288719B6 (sk) | 40-O-(2-hydroxyetyl)-rapamycín na použitie ako jediná účinná zložka pri liečení pevného nádoru | |
| AU2005247029A1 (en) | Cancer treatment |