DK2748182T3 - Peptide nanoparticles and their applications - Google Patents

Peptide nanoparticles and their applications Download PDF

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Publication number
DK2748182T3
DK2748182T3 DK12756593.5T DK12756593T DK2748182T3 DK 2748182 T3 DK2748182 T3 DK 2748182T3 DK 12756593 T DK12756593 T DK 12756593T DK 2748182 T3 DK2748182 T3 DK 2748182T3
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DK
Denmark
Prior art keywords
peptide
trp
leu
amphiphilic
lys
Prior art date
Application number
DK12756593.5T
Other languages
Danish (da)
English (en)
Inventor
Christian Dittrich
Gaudenz Danuser
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of DK2748182T3 publication Critical patent/DK2748182T3/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/711Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816Wall or shell material
    • A61K9/4825Proteins, e.g. gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5169Proteins, e.g. albumin, gelatin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK12756593.5T 2011-08-23 2012-08-23 Peptide nanoparticles and their applications DK2748182T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161526526P 2011-08-23 2011-08-23
PCT/US2012/052027 WO2013028843A1 (en) 2011-08-23 2012-08-23 Peptide nanoparticles and uses thereof

Publications (1)

Publication Number Publication Date
DK2748182T3 true DK2748182T3 (en) 2017-02-06

Family

ID=46826904

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12756593.5T DK2748182T3 (en) 2011-08-23 2012-08-23 Peptide nanoparticles and their applications

Country Status (19)

Country Link
US (1) US8828928B2 (cg-RX-API-DMAC7.html)
EP (1) EP2748182B1 (cg-RX-API-DMAC7.html)
JP (1) JP2014524477A (cg-RX-API-DMAC7.html)
KR (1) KR20140068087A (cg-RX-API-DMAC7.html)
CN (1) CN104011065B (cg-RX-API-DMAC7.html)
AU (1) AU2012298824B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014004014A2 (cg-RX-API-DMAC7.html)
CA (1) CA2845886A1 (cg-RX-API-DMAC7.html)
CL (1) CL2014000418A1 (cg-RX-API-DMAC7.html)
DK (1) DK2748182T3 (cg-RX-API-DMAC7.html)
ES (1) ES2610779T3 (cg-RX-API-DMAC7.html)
HU (1) HUE031511T2 (cg-RX-API-DMAC7.html)
IL (1) IL231005A0 (cg-RX-API-DMAC7.html)
MX (1) MX2014002062A (cg-RX-API-DMAC7.html)
PT (1) PT2748182T (cg-RX-API-DMAC7.html)
RU (1) RU2014110901A (cg-RX-API-DMAC7.html)
SG (1) SG11201400073SA (cg-RX-API-DMAC7.html)
WO (1) WO2013028843A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201401210B (cg-RX-API-DMAC7.html)

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US8153435B1 (en) 2005-03-30 2012-04-10 Tracer Detection Technology Corp. Methods and articles for identifying objects using encapsulated perfluorocarbon tracers
WO2017139746A1 (en) * 2016-02-11 2017-08-17 Mark Daniels Posh inhibitor complex biomolecules and amphiphile micelles
CA3018561A1 (en) 2016-03-21 2017-09-28 Rhode Island Council On Postsecondary Education Ph-sensitive peptides
DE202017007363U1 (de) * 2016-12-16 2021-02-16 The Brigham And Women's Hospital, Inc. Zusammensetzung von Partikeln mit Eisenoxidkernen
CN106832003B (zh) * 2017-02-15 2021-01-05 中国药科大学 一种酸敏性多肽及其应用
EP3773483A4 (en) 2018-04-06 2022-01-26 Amma Therapeutics, Inc. Composition for controlled release of therapeutic agents
US12319711B2 (en) 2019-09-20 2025-06-03 Northwestern University Spherical nucleic acids with tailored and active protein coronae
US12378560B2 (en) 2019-10-29 2025-08-05 Northwestern University Sequence multiplicity within spherical nucleic acids
CN114516819B (zh) * 2022-02-25 2024-02-27 顺毅宜昌化工有限公司 一种n,n’-二乙酰基肼的制备方法
WO2023244536A2 (en) * 2022-06-13 2023-12-21 Neubase Therapeutics, Inc. Oligonucleotide analogue formulations
CN116004221B (zh) * 2022-12-15 2023-12-19 湖南卓润生物科技有限公司 环肽的新应用、吖啶标记复合物与制备方法、检测试剂盒

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US3270960A (en) 1964-09-11 1966-09-06 Sperry Rand Corp Fluid sensor
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3872925A (en) 1973-04-24 1975-03-25 Gearhart Owen Industries Through-tubing bridge plug
US3842067A (en) 1973-07-27 1974-10-15 American Home Prod Synthesis of(des-asn5)-srif and intermediates
JPS5726506B2 (cg-RX-API-DMAC7.html) 1974-03-08 1982-06-04
US4105603A (en) 1977-03-28 1978-08-08 The Salk Institute For Biological Studies Peptides which effect release of hormones
US4511390A (en) 1983-06-10 1985-04-16 E. I. Du Pont De Nemours And Company Aralkylcarbamoyl peptide alcohols
US5643873A (en) 1992-05-06 1997-07-01 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
US5654276A (en) 1995-06-07 1997-08-05 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
FR2736642B1 (fr) 1995-07-10 1997-09-12 Pasteur Institut Immunovecteurs, notamment anticorps et fragments d'anticorps utilisables pour le transport intracellulaire et intranucleaire de principes biologiquement actifs notamment d'haptenes, de proteines et d'acides nucleiques
US6124128A (en) 1996-08-16 2000-09-26 The Regents Of The University Of California Long wavelength engineered fluorescent proteins
WO2001009191A1 (en) 1999-08-02 2001-02-08 Synt:Em S.A. Computational design methods for making molecular mimetics
CA2439400A1 (en) 2001-02-26 2002-09-06 The Regents Of The University Of California Non-oligomerizing tandem fluorescent proteins
CA2572964C (en) 2004-07-06 2018-03-06 3D Matrix, Inc. Purified amphiphilic peptide compositions and uses thereof
JP6088123B2 (ja) * 2008-02-01 2017-03-01 アルファ−オー・ペプチドズ・アーゲーAlpha−O Peptides Ag ワクチンとして有用な自己会合ペプチドナノ粒子
US20110112040A1 (en) * 2008-04-28 2011-05-12 President And Fellows Of Harvard College Supercharged proteins for cell penetration

Also Published As

Publication number Publication date
MX2014002062A (es) 2014-05-28
CN104011065B (zh) 2017-06-30
KR20140068087A (ko) 2014-06-05
US20130064895A1 (en) 2013-03-14
IL231005A0 (en) 2014-03-31
SG11201400073SA (en) 2014-03-28
CA2845886A1 (en) 2013-02-28
AU2012298824A1 (en) 2014-03-20
EP2748182A1 (en) 2014-07-02
RU2014110901A (ru) 2015-09-27
CL2014000418A1 (es) 2014-07-25
US8828928B2 (en) 2014-09-09
ES2610779T3 (es) 2017-05-03
NZ622045A (en) 2016-02-26
ZA201401210B (en) 2015-12-23
WO2013028843A1 (en) 2013-02-28
AU2012298824B2 (en) 2017-06-01
PT2748182T (pt) 2017-01-20
JP2014524477A (ja) 2014-09-22
CN104011065A (zh) 2014-08-27
EP2748182B1 (en) 2016-10-19
BR112014004014A2 (pt) 2020-10-27
HUE031511T2 (en) 2017-07-28

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