CN104011065B - 肽纳米粒子及其用途 - Google Patents

肽纳米粒子及其用途 Download PDF

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Publication number
CN104011065B
CN104011065B CN201280052123.9A CN201280052123A CN104011065B CN 104011065 B CN104011065 B CN 104011065B CN 201280052123 A CN201280052123 A CN 201280052123A CN 104011065 B CN104011065 B CN 104011065B
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CN
China
Prior art keywords
peptide
trp
leu
amphiphilic
lys
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Expired - Fee Related
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CN201280052123.9A
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English (en)
Chinese (zh)
Other versions
CN104011065A (zh
Inventor
克里斯蒂安·迪特里希
高登茨·达努斯尔
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Harvard University
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Harvard University
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Publication date
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Publication of CN104011065A publication Critical patent/CN104011065A/zh
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Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280052123.9A 2011-08-23 2012-08-23 肽纳米粒子及其用途 Expired - Fee Related CN104011065B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161526526P 2011-08-23 2011-08-23
US61/526,526 2011-08-23
PCT/US2012/052027 WO2013028843A1 (en) 2011-08-23 2012-08-23 Peptide nanoparticles and uses thereof

Publications (2)

Publication Number Publication Date
CN104011065A CN104011065A (zh) 2014-08-27
CN104011065B true CN104011065B (zh) 2017-06-30

Family

ID=46826904

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280052123.9A Expired - Fee Related CN104011065B (zh) 2011-08-23 2012-08-23 肽纳米粒子及其用途

Country Status (19)

Country Link
US (1) US8828928B2 (cg-RX-API-DMAC7.html)
EP (1) EP2748182B1 (cg-RX-API-DMAC7.html)
JP (1) JP2014524477A (cg-RX-API-DMAC7.html)
KR (1) KR20140068087A (cg-RX-API-DMAC7.html)
CN (1) CN104011065B (cg-RX-API-DMAC7.html)
AU (1) AU2012298824B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014004014A2 (cg-RX-API-DMAC7.html)
CA (1) CA2845886A1 (cg-RX-API-DMAC7.html)
CL (1) CL2014000418A1 (cg-RX-API-DMAC7.html)
DK (1) DK2748182T3 (cg-RX-API-DMAC7.html)
ES (1) ES2610779T3 (cg-RX-API-DMAC7.html)
HU (1) HUE031511T2 (cg-RX-API-DMAC7.html)
IL (1) IL231005A0 (cg-RX-API-DMAC7.html)
MX (1) MX2014002062A (cg-RX-API-DMAC7.html)
PT (1) PT2748182T (cg-RX-API-DMAC7.html)
RU (1) RU2014110901A (cg-RX-API-DMAC7.html)
SG (1) SG11201400073SA (cg-RX-API-DMAC7.html)
WO (1) WO2013028843A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201401210B (cg-RX-API-DMAC7.html)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8153435B1 (en) 2005-03-30 2012-04-10 Tracer Detection Technology Corp. Methods and articles for identifying objects using encapsulated perfluorocarbon tracers
WO2017139746A1 (en) * 2016-02-11 2017-08-17 Mark Daniels Posh inhibitor complex biomolecules and amphiphile micelles
CA3018561A1 (en) 2016-03-21 2017-09-28 Rhode Island Council On Postsecondary Education Ph-sensitive peptides
DE202017007363U1 (de) * 2016-12-16 2021-02-16 The Brigham And Women's Hospital, Inc. Zusammensetzung von Partikeln mit Eisenoxidkernen
CN106832003B (zh) * 2017-02-15 2021-01-05 中国药科大学 一种酸敏性多肽及其应用
EP3773483A4 (en) 2018-04-06 2022-01-26 Amma Therapeutics, Inc. Composition for controlled release of therapeutic agents
US12319711B2 (en) 2019-09-20 2025-06-03 Northwestern University Spherical nucleic acids with tailored and active protein coronae
US12378560B2 (en) 2019-10-29 2025-08-05 Northwestern University Sequence multiplicity within spherical nucleic acids
CN114516819B (zh) * 2022-02-25 2024-02-27 顺毅宜昌化工有限公司 一种n,n’-二乙酰基肼的制备方法
WO2023244536A2 (en) * 2022-06-13 2023-12-21 Neubase Therapeutics, Inc. Oligonucleotide analogue formulations
CN116004221B (zh) * 2022-12-15 2023-12-19 湖南卓润生物科技有限公司 环肽的新应用、吖啶标记复合物与制备方法、检测试剂盒

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101932594A (zh) * 2008-02-01 2010-12-29 阿尔法-O肽股份公司 可用作疫苗的自装配肽纳米颗粒
CN102066405A (zh) * 2008-04-28 2011-05-18 哈佛大学校长及研究员协会 用于细胞穿透的超荷电蛋白

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US3270960A (en) 1964-09-11 1966-09-06 Sperry Rand Corp Fluid sensor
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3872925A (en) 1973-04-24 1975-03-25 Gearhart Owen Industries Through-tubing bridge plug
US3842067A (en) 1973-07-27 1974-10-15 American Home Prod Synthesis of(des-asn5)-srif and intermediates
JPS5726506B2 (cg-RX-API-DMAC7.html) 1974-03-08 1982-06-04
US4105603A (en) 1977-03-28 1978-08-08 The Salk Institute For Biological Studies Peptides which effect release of hormones
US4511390A (en) 1983-06-10 1985-04-16 E. I. Du Pont De Nemours And Company Aralkylcarbamoyl peptide alcohols
US5643873A (en) 1992-05-06 1997-07-01 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
US5654276A (en) 1995-06-07 1997-08-05 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
FR2736642B1 (fr) 1995-07-10 1997-09-12 Pasteur Institut Immunovecteurs, notamment anticorps et fragments d'anticorps utilisables pour le transport intracellulaire et intranucleaire de principes biologiquement actifs notamment d'haptenes, de proteines et d'acides nucleiques
US6124128A (en) 1996-08-16 2000-09-26 The Regents Of The University Of California Long wavelength engineered fluorescent proteins
WO2001009191A1 (en) 1999-08-02 2001-02-08 Synt:Em S.A. Computational design methods for making molecular mimetics
CA2439400A1 (en) 2001-02-26 2002-09-06 The Regents Of The University Of California Non-oligomerizing tandem fluorescent proteins
CA2572964C (en) 2004-07-06 2018-03-06 3D Matrix, Inc. Purified amphiphilic peptide compositions and uses thereof

Patent Citations (2)

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CN101932594A (zh) * 2008-02-01 2010-12-29 阿尔法-O肽股份公司 可用作疫苗的自装配肽纳米颗粒
CN102066405A (zh) * 2008-04-28 2011-05-18 哈佛大学校长及研究员协会 用于细胞穿透的超荷电蛋白

Non-Patent Citations (2)

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Peptide and protein drug delivery to and into tumors: challenges and solutions;Vladimir P. Torchilin等;《Drug Discovery Today》;20030331;第8卷(第6期);第262页、摘要 *
Solid Peptide Nanoparticles – Structural Characterization and Quantification of Cargo Encapsulation;Christian Dittrich等;《Macromolecular Bioscience》;20101231;第10卷(第12期);摘要，第1407页左栏最后一段至右栏第二段、第1411页左栏第2段、表3 *

Also Published As

Publication number Publication date
MX2014002062A (es) 2014-05-28
KR20140068087A (ko) 2014-06-05
US20130064895A1 (en) 2013-03-14
IL231005A0 (en) 2014-03-31
SG11201400073SA (en) 2014-03-28
CA2845886A1 (en) 2013-02-28
AU2012298824A1 (en) 2014-03-20
EP2748182A1 (en) 2014-07-02
RU2014110901A (ru) 2015-09-27
CL2014000418A1 (es) 2014-07-25
US8828928B2 (en) 2014-09-09
ES2610779T3 (es) 2017-05-03
NZ622045A (en) 2016-02-26
ZA201401210B (en) 2015-12-23
WO2013028843A1 (en) 2013-02-28
AU2012298824B2 (en) 2017-06-01
PT2748182T (pt) 2017-01-20
DK2748182T3 (en) 2017-02-06
JP2014524477A (ja) 2014-09-22
CN104011065A (zh) 2014-08-27
EP2748182B1 (en) 2016-10-19
BR112014004014A2 (pt) 2020-10-27
HUE031511T2 (en) 2017-07-28

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Granted publication date: 20170630

Termination date: 20190823