DK2696882T3 - Pharmaceutical composition - Google Patents
Pharmaceutical composition Download PDFInfo
- Publication number
- DK2696882T3 DK2696882T3 DK12715932T DK12715932T DK2696882T3 DK 2696882 T3 DK2696882 T3 DK 2696882T3 DK 12715932 T DK12715932 T DK 12715932T DK 12715932 T DK12715932 T DK 12715932T DK 2696882 T3 DK2696882 T3 DK 2696882T3
- Authority
- DK
- Denmark
- Prior art keywords
- pharmaceutical composition
- oxytocin
- seq
- variant
- nothing
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 142
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 claims description 213
- 101800000989 Oxytocin Proteins 0.000 claims description 206
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 claims description 201
- 102400000050 Oxytocin Human genes 0.000 claims description 201
- 229960001723 oxytocin Drugs 0.000 claims description 201
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 68
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
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- Immunology (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| US201161475471P | 2011-04-14 | 2011-04-14 | |
| SE1150324A SE536091C2 (sv) | 2011-04-14 | 2011-04-14 | Farmaceutisk komposition innehållande oxytocin eller fragment eller varianter därav och åtminstone en icke-jonisk cellulosaeter |
| PCT/EP2012/056813 WO2012140216A1 (en) | 2011-04-14 | 2012-04-13 | Pharmaceutical composition |
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|---|---|
| DK2696882T3 true DK2696882T3 (en) | 2015-04-27 |
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|---|---|---|---|
| DK12715932T DK2696882T3 (en) | 2011-04-14 | 2012-04-13 | Pharmaceutical composition |
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| EP (1) | EP2696882B1 (enExample) |
| JP (1) | JP5993442B2 (enExample) |
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| BR (1) | BR112013026153A2 (enExample) |
| CA (1) | CA2832664C (enExample) |
| DK (1) | DK2696882T3 (enExample) |
| ES (1) | ES2535521T3 (enExample) |
| IL (1) | IL228821A (enExample) |
| PL (1) | PL2696882T3 (enExample) |
| RU (1) | RU2605288C2 (enExample) |
| SE (1) | SE536091C2 (enExample) |
| SG (1) | SG194074A1 (enExample) |
| WO (1) | WO2012140216A1 (enExample) |
| ZA (1) | ZA201308157B (enExample) |
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|---|---|---|---|---|
| WO2014057092A1 (en) * | 2012-10-12 | 2014-04-17 | Pep-Tonic Medical Ab | Novel use of a composition comprising oxytocin |
| PL3242676T3 (pl) | 2015-01-07 | 2024-07-15 | Tonix Pharma Limited | Preparaty oksytocyny zawierające magnez i sposoby ich stosowania |
| US9925233B2 (en) | 2015-01-30 | 2018-03-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9937223B2 (en) | 2015-01-30 | 2018-04-10 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| KR20180066071A (ko) * | 2015-10-30 | 2018-06-18 | 데이진 화-마 가부시키가이샤 | 비점막 투여용 의약 조성물 |
| HRP20250215T1 (hr) | 2016-04-12 | 2025-06-20 | Tonix Pharma Limited | Formulacije oksitocina koje sadrže magnezij i postupci upotrebe |
| SE1750680A1 (en) * | 2017-05-30 | 2018-12-01 | Peptonic Medical Ab | Composition for treating or preventing climacteric disorders |
| US20200093884A1 (en) * | 2018-09-20 | 2020-03-26 | Mark C. Manning | Stable intranasal formulations of carbetocin |
| CN110169377B (zh) * | 2019-06-27 | 2021-09-14 | 浙江海洋大学 | 黄姑鱼的人工催产受精方法 |
| SE547797C2 (en) | 2023-09-25 | 2025-11-25 | Letavis Ab | Stimulation of plant germination |
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| US3076797A (en) | 1957-07-22 | 1963-02-05 | Roussel Uclaf | Process of producing oxytocin and intermediates obtained thereby |
| US2938991A (en) | 1957-10-01 | 1960-05-31 | Candace Inc | Electric mattress pad |
| JPS61126014A (ja) * | 1984-11-22 | 1986-06-13 | Teijin Ltd | 経鼻投与用水性液剤 |
| SE9003712L (sv) | 1990-11-22 | 1992-01-07 | Kabi Pharmacia Ab | Gelbildande flytande baerarkomposition samt anvaendning daerav i farmaceutiska kompositioner |
| JP3179538B2 (ja) * | 1990-12-11 | 2001-06-25 | ノバルティス アクチエンゲゼルシャフト | 安定なヒトカルシトニンの水性溶液 |
| GB9326354D0 (en) | 1993-12-23 | 1994-02-23 | British Aerospace | Methods and apparatus for the testing,monitoring and improvement of manufacturing process effectiveness |
| SE9400918L (sv) * | 1994-03-18 | 1995-09-19 | Anne Fjellstad Paulsen | Stabiliserad komposition för oral administrering av peptider |
| US5833647A (en) * | 1995-10-10 | 1998-11-10 | The Penn State Research Foundation | Hydrogels or lipogels with enhanced mass transfer for transdermal drug delivery |
| CN1155368C (zh) | 1996-02-27 | 2004-06-30 | 帝人株式会社 | 鼻腔给药的粉剂组合物 |
| SE9701161D0 (sv) | 1997-03-27 | 1997-03-27 | Karolinska Innovations Ab | New use I |
| SE9701162D0 (sv) | 1997-03-27 | 1997-03-27 | Karolinska Innovations Ab | New use II |
| SE9701184D0 (sv) | 1997-04-01 | 1997-04-01 | Karolinska Innovations Ab | Substanser för att åstadkomma preferens och skapa acceptans |
| SE9803272D0 (sv) | 1998-09-25 | 1998-09-25 | Kerstin Uvnaes Moberg | A drug for cell regeneration |
| US20070032410A1 (en) | 2000-01-11 | 2007-02-08 | Atossa Healthcare, Inc. | Compositions and methods for the treatment of psychiatric disorders |
| SE0001440D0 (sv) * | 2000-04-18 | 2000-04-18 | Entretech Medical Ab | A drug against climacteric disorders |
| SE0100684D0 (sv) | 2001-02-28 | 2001-02-28 | Kerstin Uvnaes Moberg | New subject-matter |
| SE0102184D0 (sv) | 2001-06-19 | 2001-06-19 | Uvnaes Moberg Kerstin | New subject-matter |
| SE0102910D0 (sv) * | 2001-08-31 | 2001-08-31 | Moberg Kerstin Uvnaes | New use |
| JO2492B1 (en) * | 2003-04-28 | 2009-10-05 | شيرينج ايه جي | A pharmaceutical formula in the form of aqueous gel for the skin use of its active ingredients |
| US7884076B2 (en) * | 2003-11-06 | 2011-02-08 | The Trustees Of Columbia University In The City Of New York | Multipeptide regimen for the treatment of autistic spectrum, behavioral, emotional and visceral inflammation/autoimmune disorders |
| CA2570599C (en) * | 2004-06-24 | 2012-03-27 | Idexx Laboratories, Inc. | Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same |
| EP2248518B1 (en) | 2009-04-17 | 2013-01-16 | Merz Pharma GmbH & Co. KGaA | Formulation for stabilizing proteins, peptides or mixtures thereof. |
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2011
- 2011-04-14 SE SE1150324A patent/SE536091C2/sv not_active IP Right Cessation
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2012
- 2012-04-13 SG SG2013074133A patent/SG194074A1/en unknown
- 2012-04-13 AU AU2012241805A patent/AU2012241805B2/en not_active Ceased
- 2012-04-13 DK DK12715932T patent/DK2696882T3/en active
- 2012-04-13 RU RU2013147739/15A patent/RU2605288C2/ru active
- 2012-04-13 KR KR1020137029608A patent/KR101940341B1/ko not_active Expired - Fee Related
- 2012-04-13 PL PL12715932T patent/PL2696882T3/pl unknown
- 2012-04-13 CN CN201280027310.1A patent/CN103596582B/zh not_active Expired - Fee Related
- 2012-04-13 WO PCT/EP2012/056813 patent/WO2012140216A1/en not_active Ceased
- 2012-04-13 ES ES12715932.5T patent/ES2535521T3/es active Active
- 2012-04-13 US US14/111,072 patent/US9034821B2/en active Active
- 2012-04-13 BR BR112013026153A patent/BR112013026153A2/pt not_active Application Discontinuation
- 2012-04-13 CA CA2832664A patent/CA2832664C/en active Active
- 2012-04-13 EP EP12715932.5A patent/EP2696882B1/en active Active
- 2012-04-13 JP JP2014504346A patent/JP5993442B2/ja not_active Expired - Fee Related
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2013
- 2013-10-10 IL IL228821A patent/IL228821A/en active IP Right Grant
- 2013-10-31 ZA ZA2013/08157A patent/ZA201308157B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE1150324A1 (sv) | 2012-10-15 |
| SG194074A1 (en) | 2013-11-29 |
| EP2696882A1 (en) | 2014-02-19 |
| IL228821A (en) | 2016-08-31 |
| CN103596582A (zh) | 2014-02-19 |
| SE536091E5 (enExample) | 2015-04-21 |
| US9034821B2 (en) | 2015-05-19 |
| ES2535521T3 (es) | 2015-05-12 |
| HK1189158A1 (en) | 2014-05-30 |
| IL228821A0 (en) | 2013-12-31 |
| WO2012140216A1 (en) | 2012-10-18 |
| RU2605288C2 (ru) | 2016-12-20 |
| AU2012241805B2 (en) | 2016-08-11 |
| CA2832664C (en) | 2020-03-24 |
| US20140171369A1 (en) | 2014-06-19 |
| PL2696882T3 (pl) | 2015-08-31 |
| KR101940341B1 (ko) | 2019-01-18 |
| AU2012241805A1 (en) | 2013-10-24 |
| SE536091C2 (sv) | 2013-04-30 |
| CN103596582B (zh) | 2016-03-16 |
| JP5993442B2 (ja) | 2016-09-14 |
| ZA201308157B (en) | 2015-01-28 |
| BR112013026153A2 (pt) | 2019-09-17 |
| RU2013147739A (ru) | 2015-05-20 |
| EP2696882B1 (en) | 2015-03-04 |
| CA2832664A1 (en) | 2012-10-18 |
| KR20140019830A (ko) | 2014-02-17 |
| JP2014515747A (ja) | 2014-07-03 |
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