DK2360176T3 - Hybrid- og tandem-ekspression af neisserialt afledte proteiner - Google Patents
Hybrid- og tandem-ekspression af neisserialt afledte proteiner Download PDFInfo
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- DK2360176T3 DK2360176T3 DK10179788.4T DK10179788T DK2360176T3 DK 2360176 T3 DK2360176 T3 DK 2360176T3 DK 10179788 T DK10179788 T DK 10179788T DK 2360176 T3 DK2360176 T3 DK 2360176T3
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- Prior art keywords
- ala
- gly
- antigen
- lys
- thr
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Claims (9)
1. Sammensætning omfattende de følgende proteiner: (1) NH2-A-[-X-L-]n-B-COOH, hvorn=2, Χχ=287, X2=953 (2) 961 (3) NH2-A-[-X-L-]n-B-COOH, hvor n=2, Χχ=936, X2=741, hvor 287 er SEQ ID NO: 3104 fra WO99/57280 eller et protein, der har 80% eller mere sekvensidentitet dertil, 953 er SEQ ID NO: 2918 fra WO99/57280 eller et protein, der har 80% eller mere sekvensidentitet dertil, 961 er SEQ ID NO: 940 fra WO99/57280 eller et protein, der har 80% eller mere sekvensidentitet dertil, 936 er SEQ ID NO: 2884 fra WO99/57280 eller et protein, der har 80% eller mere sekvensidentitet dertil, 741 er SEQ ID NO: 2536 fra WO99/57280 eller et protein, der har 80% eller mere sekvensidentitet dertil, og hvor hver L er en eventuel linker-aminosyresekvens, A er en eventuel N-terminal-aminosyresekvens og B er en eventuel C-terminal-aminosyresekvens.
2. Sammensætning ifølge krav 1, hvor protein (2) omfatter SEQ ID 4, protein (1) omfatter SEQ ID 1 eller SEQ ID 2 og protein (3) omfatter SEQ ID 3.
3. Sammensætning ifølge et hvilket som helst af krav 1 til 2, yderligere omfattende: - et protein-antigen fra N.meningitidis; - en ydre-membran-vesikel (OMV)-sammensætning fra N.meningitidis; - et saccharid-antigen fra N.meningitidis; - et saccharid-antigen fra Streptococcus pneumoniae; - et antigen fra hepatitis A, B eller C virus; - et antigen fra Bordetella pertussis; - et difteri-antigen; - et tetanus-antigen; - et protein-antigen fra Helicobacter pylori; - et saccharid-antigen fra Haemophilus influenzae; - et antigen fra N.gonorrhoeae; - et antigen fra Chlamydia pneumoniae; - et antigen fra Chlamydia trachomatis; - et antigen fra Porphyromonas gingivalis; - polio-antigen(er); - rabies-antigen(er); - mæslinge-, fåresyge- og/eller rubella-antigener; - influenza-antigen(er); - et antigen fra Moraxella catarrhalis; - et antigen fra Streptococcus agalactiae; - et antigen fra Streptococcus pyogenes; og/eller - et antigen fra Staphylococcus aureus.
4. Sammensætning ifølge et hvilket som helst af krav 1 til 3, yderligere omfattende et farmaceutisk acceptabelt bærestof.
5. Sammensætning ifølge krav 4 til anvendelse som et lægemiddel.
6. Sammensætning ifølge et hvilket som helst af de foregående krav, hvor sammensætningen er en vaccine.
7. Sammensætning ifølge et hvilket som helst af de foregående krav til anvendelse i en fremgangsmåde til at forebygge og/eller at behandle en sygdom forårsaget af en Neisseria.
8. Anvendelse af en sammensætning ifølge et hvilket som helst af krav 1 til 6 til fremstilling af et lægemiddel til forebyggelse og/eller behandling af en sygdom forårsaget af en Neisseria.
9. Sammensætning ifølge krav 7 eller anvendelse ifølge krav 8, hvor sygdommen er bakteriel meningitis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0121591.2A GB0121591D0 (en) | 2001-09-06 | 2001-09-06 | Hybrid and tandem expression of neisserial proteins |
| EP02777592A EP1423419B1 (en) | 2001-09-06 | 2002-09-06 | Hybrid and tandem expression of neisserial proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2360176T3 true DK2360176T3 (da) | 2015-12-14 |
Family
ID=9921633
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10179788.4T DK2360176T3 (da) | 2001-09-06 | 2002-09-06 | Hybrid- og tandem-ekspression af neisserialt afledte proteiner |
| DK10179755.3T DK2327719T3 (da) | 2001-09-06 | 2002-09-06 | Hybrid- og tandemekspression af neisseria-proteiner |
| DK02777592.3T DK1423419T3 (da) | 2001-09-06 | 2002-09-06 | Hybrid- og tandemekspression af Neisseria-proteiner |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10179755.3T DK2327719T3 (da) | 2001-09-06 | 2002-09-06 | Hybrid- og tandemekspression af neisseria-proteiner |
| DK02777592.3T DK1423419T3 (da) | 2001-09-06 | 2002-09-06 | Hybrid- og tandemekspression af Neisseria-proteiner |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US8980277B2 (da) |
| EP (4) | EP2327719B1 (da) |
| JP (4) | JP4511832B2 (da) |
| CN (2) | CN100390196C (da) |
| AT (1) | ATE496063T1 (da) |
| AU (2) | AU2002339217B2 (da) |
| BR (1) | BR0212363A (da) |
| CA (1) | CA2459816C (da) |
| CY (2) | CY1113218T1 (da) |
| DE (1) | DE60238993D1 (da) |
| DK (3) | DK2360176T3 (da) |
| ES (3) | ES2357503T3 (da) |
| GB (1) | GB0121591D0 (da) |
| MX (2) | MXPA04002216A (da) |
| NZ (3) | NZ537976A (da) |
| PT (3) | PT1423419E (da) |
| RU (2) | RU2339646C2 (da) |
| WO (1) | WO2003020756A2 (da) |
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