DK2277874T3 - Aktivator til peroxisom-proliferator-aktiveret receptor - Google Patents

Aktivator til peroxisom-proliferator-aktiveret receptor Download PDF

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Publication number
DK2277874T3
DK2277874T3 DK09731677.2T DK09731677T DK2277874T3 DK 2277874 T3 DK2277874 T3 DK 2277874T3 DK 09731677 T DK09731677 T DK 09731677T DK 2277874 T3 DK2277874 T3 DK 2277874T3
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DK
Denmark
Prior art keywords
methyl
benzothiophen
trifluoromethyl
propionyl
ethyl
Prior art date
Application number
DK09731677.2T
Other languages
English (en)
Inventor
Shogo Sakuma
Rie Takahashi
Hideki Nakamura
Original Assignee
Nippon Chemiphar Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co filed Critical Nippon Chemiphar Co
Application granted granted Critical
Publication of DK2277874T3 publication Critical patent/DK2277874T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK09731677.2T 2008-04-15 2009-04-15 Aktivator til peroxisom-proliferator-aktiveret receptor DK2277874T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008105899 2008-04-15
PCT/JP2009/057946 WO2009128558A1 (ja) 2008-04-15 2009-04-15 ペルオキシソーム増殖剤活性化受容体の活性化剤

Publications (1)

Publication Number Publication Date
DK2277874T3 true DK2277874T3 (da) 2018-08-06

Family

ID=41199240

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09731677.2T DK2277874T3 (da) 2008-04-15 2009-04-15 Aktivator til peroxisom-proliferator-aktiveret receptor

Country Status (24)

Country Link
US (1) US8648208B2 (da)
EP (2) EP2277874B1 (da)
JP (1) JP5474769B2 (da)
KR (2) KR101871665B1 (da)
CN (2) CN102083810B (da)
AU (1) AU2009236877B2 (da)
BR (1) BRPI0911197A2 (da)
CA (1) CA2721339C (da)
CY (1) CY1120477T1 (da)
DK (1) DK2277874T3 (da)
ES (1) ES2683012T3 (da)
HR (1) HRP20181168T1 (da)
HU (1) HUE039145T2 (da)
IL (1) IL208754A (da)
LT (1) LT2277874T (da)
MX (1) MX2010011252A (da)
NZ (1) NZ588612A (da)
PL (1) PL2277874T3 (da)
PT (1) PT2277874T (da)
RU (1) RU2501794C2 (da)
SI (1) SI2277874T1 (da)
TW (1) TWI440633B (da)
WO (1) WO2009128558A1 (da)
ZA (1) ZA201007392B (da)

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WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013068486A1 (en) 2011-11-08 2013-05-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of male infertility
US20170101209A1 (en) * 2015-10-08 2017-04-13 Cash J Viedt Growler
CN111148742B (zh) * 2017-11-30 2021-11-16 四川科伦博泰生物医药股份有限公司 芳香族化合物及其药物组合物和用途
CN111393405B (zh) * 2019-01-02 2022-11-25 中国科学院上海药物研究所 一类含氟取代的苯并噻吩类化合物及其药物组合物及应用
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Also Published As

Publication number Publication date
AU2009236877A1 (en) 2009-10-22
EP2277874A4 (en) 2011-10-12
CY1120477T1 (el) 2019-07-10
HUE039145T2 (hu) 2018-12-28
IL208754A (en) 2016-04-21
JPWO2009128558A1 (ja) 2011-08-04
PL2277874T3 (pl) 2018-11-30
EP2277874A1 (en) 2011-01-26
RU2501794C2 (ru) 2013-12-20
CN102083810B (zh) 2014-10-29
SI2277874T1 (sl) 2019-01-31
CN104672220A (zh) 2015-06-03
KR20100132070A (ko) 2010-12-16
US8648208B2 (en) 2014-02-11
EP2277874B1 (en) 2018-06-27
HRP20181168T1 (hr) 2018-11-02
ZA201007392B (en) 2012-01-25
US20110098480A1 (en) 2011-04-28
TW200946514A (en) 2009-11-16
TWI440633B (zh) 2014-06-11
JP5474769B2 (ja) 2014-04-16
KR101871665B1 (ko) 2018-06-27
CA2721339C (en) 2017-01-24
EP3424917A1 (en) 2019-01-09
BRPI0911197A2 (pt) 2015-10-13
LT2277874T (lt) 2018-10-10
NZ588612A (en) 2012-08-31
CN102083810A (zh) 2011-06-01
IL208754A0 (en) 2010-12-30
RU2010146166A (ru) 2012-05-20
PT2277874T (pt) 2018-08-10
MX2010011252A (es) 2010-11-30
CN104672220B (zh) 2017-09-22
WO2009128558A1 (ja) 2009-10-22
KR20170021918A (ko) 2017-02-28
ES2683012T3 (es) 2018-09-24
KR101710340B1 (ko) 2017-02-27
CA2721339A1 (en) 2009-10-22
AU2009236877B2 (en) 2014-01-23

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