DK2250279T3 - ANTI-IFNAR1 antibodies with reduced Fc ligand affinity- - Google Patents
ANTI-IFNAR1 antibodies with reduced Fc ligand affinity- Download PDFInfo
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- DK2250279T3 DK2250279T3 DK09707396.9T DK09707396T DK2250279T3 DK 2250279 T3 DK2250279 T3 DK 2250279T3 DK 09707396 T DK09707396 T DK 09707396T DK 2250279 T3 DK2250279 T3 DK 2250279T3
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- antibody
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- 239000004246 zinc acetate Substances 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
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- Veterinary Medicine (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Environmental Sciences (AREA)
- Virology (AREA)
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- Physical Education & Sports Medicine (AREA)
- Microbiology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US696208P | 2008-02-08 | 2008-02-08 | |
| US3461808P | 2008-03-07 | 2008-03-07 | |
| US4997008P | 2008-05-02 | 2008-05-02 | |
| PCT/US2009/033358 WO2009100309A2 (en) | 2008-02-08 | 2009-02-06 | Anti-ifnar1 antibodies with reduced fc ligand affinity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2250279T3 true DK2250279T3 (en) | 2016-08-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09707396.9T DK2250279T3 (en) | 2008-02-08 | 2009-02-06 | ANTI-IFNAR1 antibodies with reduced Fc ligand affinity- |
Country Status (25)
| Country | Link |
|---|---|
| US (6) | US20110059078A1 (enExample) |
| EP (1) | EP2250279B1 (enExample) |
| JP (1) | JP5608100B2 (enExample) |
| KR (2) | KR101666229B1 (enExample) |
| CN (1) | CN101952454B (enExample) |
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| CA (1) | CA2713981C (enExample) |
| CY (1) | CY1117827T1 (enExample) |
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| HU (3) | HUE028958T2 (enExample) |
| LT (1) | LTC2250279I2 (enExample) |
| LU (1) | LUC00263I2 (enExample) |
| MX (1) | MX2010008578A (enExample) |
| NL (1) | NL301175I2 (enExample) |
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| PT (1) | PT2250279E (enExample) |
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| SI (1) | SI2250279T1 (enExample) |
| WO (1) | WO2009100309A2 (enExample) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2412202C2 (ru) * | 2004-06-21 | 2011-02-20 | Медарекс, Инк. | Антитела рецептора 1 интерферона альфа и их применение |
| EP3050963B1 (en) | 2005-03-31 | 2019-09-18 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
| IN2014DN10515A (enExample) | 2006-03-31 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | |
| ES2654040T3 (es) | 2006-03-31 | 2018-02-12 | Chugai Seiyaku Kabushiki Kaisha | Método de modificación de anticuerpos para la purificación de anticuerpos biespecíficos |
| ES2687808T3 (es) | 2007-09-26 | 2018-10-29 | Chugai Seiyaku Kabushiki Kaisha | Región constante de anticuerpo modificado |
| MX369784B (es) | 2007-09-26 | 2019-11-21 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
| KR20160074019A (ko) | 2007-12-05 | 2016-06-27 | 추가이 세이야쿠 가부시키가이샤 | 항ｎｒ１０ 항체 및 그의 이용 |
| HRP20160855T1 (hr) * | 2008-02-08 | 2016-09-23 | Medimmune, Llc | Anti-ifnar1 protutijela sa smanjenim afinitetom fc liganda |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| JP5717624B2 (ja) | 2009-03-19 | 2015-05-13 | 中外製薬株式会社 | 抗体定常領域改変体 |
| US20120071634A1 (en) | 2009-03-19 | 2012-03-22 | Chugai Seiyaku Kabushiki Kaisha | Antibody Constant Region Variant |
| PE20120562A1 (es) | 2009-05-15 | 2012-06-06 | Chugai Pharmaceutical Co Ltd | Anticuerpo anti-axl |
| JP5837821B2 (ja) | 2009-09-24 | 2015-12-24 | 中外製薬株式会社 | 抗体定常領域改変体 |
| ES2609043T3 (es) * | 2009-11-30 | 2017-04-18 | Janssen Biotech, Inc. | Anticuerpos mutantes Fc con funciones de efecto abladas |
| US10053513B2 (en) | 2009-11-30 | 2018-08-21 | Janssen Biotech, Inc. | Antibody Fc mutants with ablated effector functions |
| WO2011108714A1 (ja) | 2010-03-04 | 2011-09-09 | 中外製薬株式会社 | 抗体定常領域改変体 |
| ES2720136T3 (es) * | 2010-12-22 | 2019-07-18 | Teva Pharmaceuticals Australia Pty Ltd | Anticuerpo modificado con semivida mejorada |
| WO2012130831A1 (en) | 2011-03-29 | 2012-10-04 | Roche Glycart Ag | Antibody fc variants |
| US9428560B2 (en) * | 2011-06-21 | 2016-08-30 | Kyowa Hakko Kirin Co., Ltd | Protein comprising truncated form of extracellular region protein of Frizzled 2, and pharmaceutical composition for treating bone diseases which comprises said protein |
| RU2014120375A (ru) * | 2011-11-01 | 2015-12-10 | Рош Гликарт Аг | Модель антителозависимой клеточной цитотоксичности в живом организме |
| KR102320059B1 (ko) * | 2012-06-13 | 2021-11-01 | 아스트라제네카 아베 | 항-i형 인터페론 수용체(ifnar) 항체에 대한 고정 투여 계획 |
| TW201402611A (zh) | 2012-06-21 | 2014-01-16 | Univ Indiana Res & Tech Corp | 具有改變之ｆｃ效應子功能之腸促胰島素受體配體多肽ｆｃ區融合多肽及結合物 |
| US11180572B2 (en) | 2012-07-06 | 2021-11-23 | Genmab B.V. | Dimeric protein with triple mutations |
| HRP20181595T1 (hr) | 2012-07-13 | 2018-12-14 | Roche Glycart Ag | Bispecifična anti-vegf/anti-ang-2 protutijela i njihova upotreba u liječenju očnih krvožilnih bolesti |
| US9657105B2 (en) | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
| HRP20221262T1 (hr) * | 2013-09-13 | 2022-12-09 | Beigene Switzerland Gmbh | Protutijela anti-pd1 i njihova uporaba kao terapeutskih i dijagnostičkih sredstava |
| KR102441231B1 (ko) | 2013-09-27 | 2022-09-06 | 추가이 세이야쿠 가부시키가이샤 | 폴리펩티드 이종 다량체의 제조방법 |
| CN113307880B (zh) * | 2014-01-13 | 2025-07-04 | 希望之城公司 | 在Fc间隔物区中具有突变的嵌合抗原受体(CAR)及其使用方法 |
| WO2015132365A1 (en) * | 2014-03-05 | 2015-09-11 | Ucb Biopharma Sprl | Multimeric fc proteins |
| ES2901705T3 (es) | 2014-06-06 | 2022-03-23 | Bristol Myers Squibb Co | Anticuerpos contra el receptor del factor de necrosis tumoral inducido por glucocorticoides (GITR) y usos de los mismos |
| CN110156892B (zh) | 2014-07-03 | 2023-05-16 | 百济神州有限公司 | 抗pd-l1抗体及其作为治疗剂及诊断剂的用途 |
| TW201619200A (zh) | 2014-10-10 | 2016-06-01 | 麥迪紐有限責任公司 | 人類化抗－ｏｘ４０抗體及其用途 |
| RS60998B1 (sr) | 2014-11-21 | 2020-11-30 | Bristol Myers Squibb Co | Antitela koja sadrže modifikovane regione teškog lanca |
| SI3221363T1 (sl) | 2014-11-21 | 2020-09-30 | Bristol-Myers Squibb Company | Protitelesa proti CD73 in njihova uporaba |
| WO2016131893A1 (en) | 2015-02-18 | 2016-08-25 | Medimmune Limited | Incretin fusion polypeptides |
| CA2972393A1 (en) | 2015-02-27 | 2016-09-01 | Chugai Seiyaku Kabushiki Kaisha | Composition for treating il-6-related diseases |
| US11142587B2 (en) | 2015-04-01 | 2021-10-12 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide hetero-oligomer |
| US10690674B2 (en) | 2015-06-03 | 2020-06-23 | Bristol-Myers Squibb Company | Anti-GITR antibodies for cancer diagnostics |
| PL3769781T3 (pl) * | 2015-08-19 | 2023-07-17 | Astrazeneca Ab | Stabilna formulacja anty-ifnar1 |
| JP6936221B2 (ja) * | 2015-11-02 | 2021-09-15 | ファイブ プライム セラピューティクス， インコーポレイテッド | Ｃｄ８０細胞外ドメインポリペプチドと、がん治療でのそれらの使用 |
| BR112018010172A2 (pt) | 2015-11-19 | 2018-11-21 | Bristol Myers Squibb Co | anticorpos contra receptor de fator de necrose de tumor induzido por glicocorticoide (gitr) e usos dos mesmos |
| SG11201803989WA (en) | 2015-12-28 | 2018-06-28 | Chugai Pharmaceutical Co Ltd | Method for promoting efficiency of purification of fc region-containing polypeptide |
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- 2009-02-06 MX MX2010008578A patent/MX2010008578A/es active IP Right Grant
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- 2009-02-06 KR KR1020167014946A patent/KR20160070165A/ko not_active Ceased
- 2009-02-06 PL PL09707396.9T patent/PL2250279T3/pl unknown
- 2009-02-06 CA CA2713981A patent/CA2713981C/en active Active
- 2009-02-06 BR BRPI0907735-9A patent/BRPI0907735B1/pt active IP Right Grant
- 2009-02-06 ES ES09707396.9T patent/ES2581917T3/es active Active
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2016
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2017
- 2017-09-21 US US15/711,197 patent/US9988459B2/en active Active
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2018
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2019
- 2019-04-08 US US16/377,769 patent/US20200172625A1/en not_active Abandoned
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2022
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- 2022-05-18 LU LU00263C patent/LUC00263I2/en unknown
- 2022-05-18 FR FR22C1019C patent/FR22C1019I2/fr active Active
- 2022-05-25 NO NO2022016C patent/NO2022016I1/no unknown
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2023
- 2023-02-27 US US18/174,940 patent/US20250101116A1/en active Pending
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