AU2009212273B2 - Anti-IFNAR1 antibodies with reduced Fc ligand affinity - Google Patents

Anti-IFNAR1 antibodies with reduced Fc ligand affinity Download PDF

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Publication number
AU2009212273B2
AU2009212273B2 AU2009212273A AU2009212273A AU2009212273B2 AU 2009212273 B2 AU2009212273 B2 AU 2009212273B2 AU 2009212273 A AU2009212273 A AU 2009212273A AU 2009212273 A AU2009212273 A AU 2009212273A AU 2009212273 B2 AU2009212273 B2 AU 2009212273B2
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antibody
antibodies
seq
disease
chain variable
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AU2009212273A1 (en
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Ricardo Cibotti
Anthony Coyle
Peter Kiener
Herren Wu
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AstraZeneca AB
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AstraZeneca AB
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
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    • A61P13/00Drugs for disorders of the urinary system
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/01Animal expressing industrially exogenous proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2299/00Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71Decreased effector function due to an Fc-modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734Complement-dependent cytotoxicity [CDC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
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AU2009212273A 2008-02-08 2009-02-06 Anti-IFNAR1 antibodies with reduced Fc ligand affinity Active 2034-02-06 AU2009212273B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2014256356A AU2014256356A1 (en) 2008-02-08 2014-10-29 Anti-ifnar1 antibodies with reduced fc ligand affinity

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US696208P 2008-02-08 2008-02-08
US61/006,962 2008-02-08
US3461808P 2008-03-07 2008-03-07
US61/034,618 2008-03-07
US4997008P 2008-05-02 2008-05-02
US61/049,970 2008-05-02
PCT/US2009/033358 WO2009100309A2 (en) 2008-02-08 2009-02-06 Anti-ifnar1 antibodies with reduced fc ligand affinity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2014256356A Division AU2014256356A1 (en) 2008-02-08 2014-10-29 Anti-ifnar1 antibodies with reduced fc ligand affinity

Publications (2)

Publication Number Publication Date
AU2009212273A1 AU2009212273A1 (en) 2009-08-13
AU2009212273B2 true AU2009212273B2 (en) 2014-07-31

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AU2009212273A Active 2034-02-06 AU2009212273B2 (en) 2008-02-08 2009-02-06 Anti-IFNAR1 antibodies with reduced Fc ligand affinity

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US (6) US20110059078A1 (enExample)
EP (1) EP2250279B1 (enExample)
JP (1) JP5608100B2 (enExample)
KR (2) KR101666229B1 (enExample)
CN (1) CN101952454B (enExample)
AU (1) AU2009212273B2 (enExample)
BR (2) BR122020023189B1 (enExample)
CA (1) CA2713981C (enExample)
CY (1) CY1117827T1 (enExample)
DK (1) DK2250279T3 (enExample)
ES (1) ES2581917T3 (enExample)
FI (1) FIC20220024I1 (enExample)
FR (1) FR22C1019I2 (enExample)
HR (1) HRP20160855T1 (enExample)
HU (3) HUE028958T2 (enExample)
LT (1) LTC2250279I2 (enExample)
LU (1) LUC00263I2 (enExample)
MX (1) MX2010008578A (enExample)
NL (1) NL301175I2 (enExample)
NO (1) NO2022016I1 (enExample)
PL (1) PL2250279T3 (enExample)
PT (1) PT2250279E (enExample)
SG (1) SG188129A1 (enExample)
SI (1) SI2250279T1 (enExample)
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