DK2217597T3 - Quinuclidin-4-ylmethyl-1h-indol-3-carboxylatderivater som alpha-7-nicotin-acetylcholin-receptor-ligander til behandling af Alzheimers sygdom - Google Patents

Quinuclidin-4-ylmethyl-1h-indol-3-carboxylatderivater som alpha-7-nicotin-acetylcholin-receptor-ligander til behandling af Alzheimers sygdom

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Publication number
DK2217597T3
DK2217597T3 DK08835512.8T DK08835512T DK2217597T3 DK 2217597 T3 DK2217597 T3 DK 2217597T3 DK 08835512 T DK08835512 T DK 08835512T DK 2217597 T3 DK2217597 T3 DK 2217597T3
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Prior art keywords
quinuclidin
nicotine
ylmethyl
indole
alzheimer
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Application number
DK08835512.8T
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Danish (da)
English (en)
Inventor
Jurg R Pfister
Meenakshi S Venkatraman
Xiaoming Zhang
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Comentis Inc
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Publication date
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Publication of DK2217597T3 publication Critical patent/DK2217597T3/da

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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DK08835512.8T 2007-10-01 2008-09-30 Quinuclidin-4-ylmethyl-1h-indol-3-carboxylatderivater som alpha-7-nicotin-acetylcholin-receptor-ligander til behandling af Alzheimers sygdom DK2217597T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97672407P 2007-10-01 2007-10-01
PCT/US2008/078320 WO2009046025A1 (en) 2007-10-01 2008-09-30 Quinuclidin-4-ylmethyl 1h-indole-3-carboxylate derivatives as alpha 7 nicotinic acetylcholine receptor ligands for the treatment of alzheimer's disease

Publications (1)

Publication Number Publication Date
DK2217597T3 true DK2217597T3 (da) 2011-06-20

Family

ID=40344599

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08835512.8T DK2217597T3 (da) 2007-10-01 2008-09-30 Quinuclidin-4-ylmethyl-1h-indol-3-carboxylatderivater som alpha-7-nicotin-acetylcholin-receptor-ligander til behandling af Alzheimers sygdom

Country Status (12)

Country Link
US (1) US8114891B2 (enExample)
EP (1) EP2217597B1 (enExample)
JP (1) JP5022494B2 (enExample)
KR (1) KR101565469B1 (enExample)
CN (2) CN101883771A (enExample)
AT (1) ATE503754T1 (enExample)
CA (1) CA2701126A1 (enExample)
DE (1) DE602008005928D1 (enExample)
DK (1) DK2217597T3 (enExample)
ES (1) ES2362326T3 (enExample)
MX (1) MX2010003375A (enExample)
WO (1) WO2009046025A1 (enExample)

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WO2015134710A1 (en) 2014-03-07 2015-09-11 Kalyra Pharmaceuticals, Inc. Propellane derivates and synthesis
EP3166940A4 (en) 2014-07-11 2018-04-25 Alpharmagen, LLC Quinuclidine compounds for modulating alpha7 -nicotinic acetylcholine receptor activity
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WO2017120532A1 (en) * 2016-01-08 2017-07-13 Alpharmagen, Llc Polymorphs of a phosphate salt of quinuclidin-4-ylmethyl 4-methyl-1h-indole-3-carboxylate and uses thereof
US20190083460A1 (en) * 2016-03-16 2019-03-21 Zeno Royalties & Milestones, LLC Analgesic compounds
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US20090088418A1 (en) 2009-04-02
WO2009046025A1 (en) 2009-04-09
JP2010540562A (ja) 2010-12-24
MX2010003375A (es) 2010-05-17
ATE503754T1 (de) 2011-04-15
DE602008005928D1 (de) 2011-05-12
CN104193741B (zh) 2016-08-24
CN104193741A (zh) 2014-12-10
KR20100068290A (ko) 2010-06-22
JP5022494B2 (ja) 2012-09-12
HK1204616A1 (en) 2015-11-27
US8114891B2 (en) 2012-02-14
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CA2701126A1 (en) 2009-04-09

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