CN104193741A - 作为α7-烟碱乙酰胆碱受体配体的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物 - Google Patents
作为α7-烟碱乙酰胆碱受体配体的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物 Download PDFInfo
- Publication number
- CN104193741A CN104193741A CN201410331886.8A CN201410331886A CN104193741A CN 104193741 A CN104193741 A CN 104193741A CN 201410331886 A CN201410331886 A CN 201410331886A CN 104193741 A CN104193741 A CN 104193741A
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- Prior art keywords
- compound
- ylmethyl
- indole
- acceptable salt
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC(C)CC1(*)OCCO1 Chemical compound CC(C)CC1(*)OCCO1 0.000 description 2
- OEIJNTVNSOQULQ-UHFFFAOYSA-N CC(C)Oc1ccc2[nH]cc(C(OCC3(CC4)CCN4CC3)=O)c2c1 Chemical compound CC(C)Oc1ccc2[nH]cc(C(OCC3(CC4)CCN4CC3)=O)c2c1 OEIJNTVNSOQULQ-UHFFFAOYSA-N 0.000 description 1
- BYCMSLAAWXLXLI-UHFFFAOYSA-N COc(cc1)cc2c1[nH]cc2C(OCC1(CC2)CN2CC1)=O Chemical compound COc(cc1)cc2c1[nH]cc2C(OCC1(CC2)CN2CC1)=O BYCMSLAAWXLXLI-UHFFFAOYSA-N 0.000 description 1
- FIQMVLVWERPTPV-UHFFFAOYSA-N C[N]1(C)OCCCO1 Chemical compound C[N]1(C)OCCCO1 FIQMVLVWERPTPV-UHFFFAOYSA-N 0.000 description 1
- IAKCKCZHDKSWPT-UHFFFAOYSA-N C[N]1(C)OCCO1 Chemical compound C[N]1(C)OCCO1 IAKCKCZHDKSWPT-UHFFFAOYSA-N 0.000 description 1
- AMLBBMMFMLVCAJ-UHFFFAOYSA-N O=C(c(c1c2)c[nH]c1ccc2OC(F)F)OCC1(CC2)CN2CC1 Chemical compound O=C(c(c1c2)c[nH]c1ccc2OC(F)F)OCC1(CC2)CN2CC1 AMLBBMMFMLVCAJ-UHFFFAOYSA-N 0.000 description 1
- TUCUBBVRRKXMII-UHFFFAOYSA-N O=C(c1c[nH]c2ccc(COC(F)(F)F)cc12)OCC1(CC2)CCN2CC1 Chemical compound O=C(c1c[nH]c2ccc(COC(F)(F)F)cc12)OCC1(CC2)CCN2CC1 TUCUBBVRRKXMII-UHFFFAOYSA-N 0.000 description 1
- GFXKYBZVBAFFEB-UHFFFAOYSA-N O=C(c1n[nH]c2c1cccc2)OCC1(CC2)CCN2CC1 Chemical compound O=C(c1n[nH]c2c1cccc2)OCC1(CC2)CCN2CC1 GFXKYBZVBAFFEB-UHFFFAOYSA-N 0.000 description 1
- PKBVKBLTOFEJGO-UHFFFAOYSA-N O=C(c1n[s]c2ccccc12)NCC1(CC2)CCN2CC1 Chemical compound O=C(c1n[s]c2ccccc12)NCC1(CC2)CCN2CC1 PKBVKBLTOFEJGO-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Abstract
Description
Claims (51)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97672407P | 2007-10-01 | 2007-10-01 | |
US60/976,724 | 2007-10-01 | ||
CN2008801186316A CN101883771A (zh) | 2007-10-01 | 2008-09-30 | 作为α7-烟碱乙酰胆碱受体配体用于治疗阿尔茨海默氏病的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008801186316A Division CN101883771A (zh) | 2007-10-01 | 2008-09-30 | 作为α7-烟碱乙酰胆碱受体配体用于治疗阿尔茨海默氏病的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104193741A true CN104193741A (zh) | 2014-12-10 |
CN104193741B CN104193741B (zh) | 2016-08-24 |
Family
ID=40344599
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008801186316A Pending CN101883771A (zh) | 2007-10-01 | 2008-09-30 | 作为α7-烟碱乙酰胆碱受体配体用于治疗阿尔茨海默氏病的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物 |
CN201410331886.8A Expired - Fee Related CN104193741B (zh) | 2007-10-01 | 2008-09-30 | 作为α7-烟碱乙酰胆碱受体配体的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008801186316A Pending CN101883771A (zh) | 2007-10-01 | 2008-09-30 | 作为α7-烟碱乙酰胆碱受体配体用于治疗阿尔茨海默氏病的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物 |
Country Status (13)
Country | Link |
---|---|
US (1) | US8114891B2 (zh) |
EP (1) | EP2217597B1 (zh) |
JP (1) | JP5022494B2 (zh) |
KR (1) | KR101565469B1 (zh) |
CN (2) | CN101883771A (zh) |
AT (1) | ATE503754T1 (zh) |
CA (1) | CA2701126A1 (zh) |
DE (1) | DE602008005928D1 (zh) |
DK (1) | DK2217597T3 (zh) |
ES (1) | ES2362326T3 (zh) |
HK (1) | HK1204616A1 (zh) |
MX (1) | MX2010003375A (zh) |
WO (1) | WO2009046025A1 (zh) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
TR201807944T4 (tr) | 2008-11-19 | 2018-06-21 | Forum Pharmaceuticals Inc | (R)-7-kloro-N-(kinüklidin-3-il)benzo[b]tiyofen-2-karboksamit ve bunun farmasötik olarak kabul edilebilir tuzları ile şizofreninin negatif belirtilerinin tedavisi. |
JP5808319B2 (ja) * | 2009-05-11 | 2015-11-10 | フォルム ファーマシューティカルズ、インコーポレイテッド | アセチルコリンエステラーゼ阻害剤と組み合わせた特定のα7ニコチン酸受容体を用いた認知障害の治療 |
JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
ES2746850T3 (es) | 2010-05-17 | 2020-03-09 | Forum Pharmaceuticals Inc | Formulaciones farmacéuticas que comprenden formas cristalinas de clorhidrato de (R)-7-cloro-N-(quinuclidin-3-il)benzo(b)tiofeno-2-carboxamida monohidratado |
WO2011163539A2 (en) * | 2010-06-25 | 2011-12-29 | The Johns Hopkins University | nAChRα7 AGONISTS AND nAChRα7 ANTAGONISTS FOR TREATING ULCERATIVE COLITIS (UC) AND CROHN'S DISEASE (CD) |
MX2014000146A (es) * | 2011-07-01 | 2014-02-19 | Envivo Pharmaceuticals Inc | Metodos de tratamiento del deterioro cognitivo limitado. |
KR20150000900A (ko) | 2012-04-10 | 2015-01-05 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 신규한 1-치환된 인다졸 유도체 |
MX358512B (es) | 2012-05-08 | 2018-08-24 | Forum Pharmaceuticals Inc | Uso de (r)-7cloro-n-(quinuclidin-3-il) benzo[b] tiofeno-2-carboxamida o una sal farmacéuticamente aceptable de la misma para preparar una composición farmacéutica en el tratamiento de una disfunción cognitiva. |
WO2014087904A1 (ja) * | 2012-12-05 | 2014-06-12 | 国立大学法人大阪大学 | 破骨細胞が関与する疾患の予防又は治療剤 |
US9447026B2 (en) | 2013-03-14 | 2016-09-20 | Kalyra Pharmaceuticals, Inc. | Bicyclic analgesic compounds |
EP3052096B8 (en) | 2013-10-03 | 2018-03-07 | Kura Oncology, Inc. | Inhibitors of erk and methods of use |
US10189780B2 (en) | 2013-12-12 | 2019-01-29 | Zeno Royalties & Milestones, LLC | Bicyclic alkyl compounds and synthesis |
CN106232567B (zh) | 2014-03-07 | 2021-11-02 | 里科瑞尔姆Ip控股有限责任公司 | 螺桨烷衍生物及合成 |
WO2016007630A1 (en) * | 2014-07-11 | 2016-01-14 | Alpharmagen, Llc | Quinuclidine compounds for modulating alpha7 -nicotinic acetylcholine receptor activity |
EP3193855B1 (en) | 2014-09-17 | 2021-05-19 | Recurium IP Holdings, LLC | Bicyclic compounds |
WO2017120532A1 (en) * | 2016-01-08 | 2017-07-13 | Alpharmagen, Llc | Polymorphs of a phosphate salt of quinuclidin-4-ylmethyl 4-methyl-1h-indole-3-carboxylate and uses thereof |
WO2017160925A1 (en) * | 2016-03-16 | 2017-09-21 | Kalyra Pharmaceuticals, Inc. | Analgesic compounds |
CA3063729A1 (en) | 2017-05-15 | 2018-11-22 | Recurium Ip Holdings, Llc | Analgesic compounds |
EP3520803A1 (en) * | 2018-01-31 | 2019-08-07 | Zarodex Therapeutics Limited | Novel uses |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004029050A1 (en) * | 2002-09-25 | 2004-04-08 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
WO2006069097A2 (en) * | 2004-12-22 | 2006-06-29 | Memory Pharmaceuticals Corporation | Nicotinic alpha-7 receptor ligands and preparation and uses thereof |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ203861A (en) | 1982-04-14 | 1986-07-11 | Beecham Group Plc | Bicyclic heterocyclic compounds and pharmaceutical compositions containing such |
DE3429830A1 (de) * | 1983-08-26 | 1985-03-07 | Sandoz-Patent-GmbH, 7850 Lörrach | Automatische carbonsaeure- und sulfonsaeureester oder -amide |
US4910193A (en) * | 1985-12-16 | 1990-03-20 | Sandoz Ltd. | Treatment of gastrointestinal disorders |
HU202108B (en) * | 1986-07-30 | 1991-02-28 | Sandoz Ag | Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol |
WO1989000158A1 (en) | 1987-07-02 | 1989-01-12 | Pfizer Inc. | Bridged-diazabicycloalkyl quinolone carboxylic acids and esters |
US4950759A (en) * | 1988-07-07 | 1990-08-21 | Duphar International Research B.V. | Substituted 1,7-annelated 1H-indazoles |
IT1228293B (it) * | 1989-02-06 | 1991-06-07 | Angeli Inst Spa | Benzoderivati di composti eterociclici contenenti azoto. |
US5187166A (en) * | 1990-07-31 | 1993-02-16 | Nisshin Flour Milling Co., Ltd. | Azabicyclo derivatives and their use as antiemetics |
HU211081B (en) * | 1990-12-18 | 1995-10-30 | Sandoz Ag | Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same |
JPH04308950A (ja) | 1991-04-05 | 1992-10-30 | Nec Software Ltd | 通信メモリ管理装置 |
GB9201751D0 (en) | 1992-01-28 | 1992-03-11 | Smithkline Beecham Plc | Compounds |
US5190953A (en) * | 1992-03-26 | 1993-03-02 | A. H. Robins Company, Incorporated | Heterocyclic carboxylic acid amides and esters of azabicyclic compounds as gastric prokinetic, antiemetic, anxiolytic and antiarrhythmic agents |
US5300512A (en) * | 1992-06-24 | 1994-04-05 | G. D. Searle & Co. | Benzimidazole compounds |
IL107184A (en) | 1992-10-09 | 1997-08-14 | Abbott Lab | Heterocyclic ether compounds that enhance cognitive function |
US5852041A (en) * | 1993-04-07 | 1998-12-22 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acethylcholine receptors |
JP3235913B2 (ja) * | 1993-07-30 | 2001-12-04 | エーザイ株式会社 | アミノ安息香酸誘導体 |
US5399562A (en) * | 1994-02-04 | 1995-03-21 | G. D. Searle & Co. | Indolones useful as serotonergic agents |
IT1274018B (it) * | 1994-02-23 | 1997-07-14 | Riace Ets | Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica |
GB2295387A (en) | 1994-11-23 | 1996-05-29 | Glaxo Inc | Quinazoline antagonists of alpha 1c adrenergic receptors |
US5604231A (en) * | 1995-01-06 | 1997-02-18 | Smith; Carr J. | Pharmaceutical compositions for prevention and treatment of ulcerative colitis |
US5597919A (en) * | 1995-01-06 | 1997-01-28 | Dull; Gary M. | Pyrimidinyl or Pyridinyl alkenyl amine compounds |
US5585388A (en) | 1995-04-07 | 1996-12-17 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acetylcholine receptors |
US5583140A (en) | 1995-05-17 | 1996-12-10 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of central nervous system disorders |
IL118279A (en) | 1995-06-07 | 2006-10-05 | Abbott Lab | Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission |
US5712270A (en) * | 1995-11-06 | 1998-01-27 | American Home Products Corporation | 2-arylamidothiazole derivatives with CNS activity |
SE9600683D0 (sv) | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
AUPN862996A0 (en) | 1996-03-13 | 1996-04-04 | Fujisawa Pharmaceutical Co., Ltd. | A novel substituted-acetamide compound |
AT403803B (de) * | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
AR013184A1 (es) | 1997-07-18 | 2000-12-13 | Astrazeneca Ab | Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis |
HU226859B1 (en) | 1997-10-27 | 2009-12-28 | Neurosearch As | Phenyl- or heteroaryl-homopiperazines, their use and medicaments containing them |
ATE255888T1 (de) | 1998-06-01 | 2003-12-15 | Ortho Mcneil Pharm Inc | Tetrahydronaphtalene verbindungen und deren verwendung zur behandlung von neurodegenerativen krankheiten |
SE9904176D0 (sv) | 1999-11-18 | 1999-11-18 | Astra Ab | New use |
KR100751981B1 (ko) * | 2000-06-27 | 2007-08-28 | 라보라토리오스 살바트, 에스.에이. | 아릴알킬아민으로부터 유도된 카바메이트 |
US6492386B2 (en) | 2000-08-18 | 2002-12-10 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl compounds for treatment of disease |
AU2001282874A1 (en) | 2000-08-18 | 2002-03-04 | Pharmacia And Upjohn Company | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) |
US6486172B2 (en) | 2000-08-18 | 2002-11-26 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl compounds for treatment of disease |
AU2001282875A1 (en) | 2000-08-21 | 2002-03-04 | Pharmacia And Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
WO2002015662A2 (en) | 2000-08-21 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists |
JP2004506734A (ja) | 2000-08-21 | 2004-03-04 | ファルマシア・アンド・アップジョン・カンパニー | 疾患治療用のキヌクリド置換ヘテロアリール部分 |
CA2441896A1 (en) | 2000-12-22 | 2002-07-04 | Almirall Prodesfarma Ag | Quinuclidine carbamate derivatives and their use as m3 antagonists |
CA2567977A1 (en) * | 2004-04-22 | 2006-01-05 | Memory Pharmaceutical Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof |
-
2008
- 2008-09-30 WO PCT/US2008/078320 patent/WO2009046025A1/en active Application Filing
- 2008-09-30 CA CA2701126A patent/CA2701126A1/en not_active Abandoned
- 2008-09-30 ES ES08835512T patent/ES2362326T3/es active Active
- 2008-09-30 KR KR1020107008479A patent/KR101565469B1/ko not_active IP Right Cessation
- 2008-09-30 DK DK08835512.8T patent/DK2217597T3/da active
- 2008-09-30 CN CN2008801186316A patent/CN101883771A/zh active Pending
- 2008-09-30 CN CN201410331886.8A patent/CN104193741B/zh not_active Expired - Fee Related
- 2008-09-30 JP JP2010527249A patent/JP5022494B2/ja not_active Expired - Fee Related
- 2008-09-30 DE DE602008005928T patent/DE602008005928D1/de active Active
- 2008-09-30 EP EP08835512A patent/EP2217597B1/en not_active Not-in-force
- 2008-09-30 US US12/242,389 patent/US8114891B2/en not_active Expired - Fee Related
- 2008-09-30 AT AT08835512T patent/ATE503754T1/de active
- 2008-09-30 MX MX2010003375A patent/MX2010003375A/es active IP Right Grant
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004029050A1 (en) * | 2002-09-25 | 2004-04-08 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
WO2006069097A2 (en) * | 2004-12-22 | 2006-06-29 | Memory Pharmaceuticals Corporation | Nicotinic alpha-7 receptor ligands and preparation and uses thereof |
Also Published As
Publication number | Publication date |
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MX2010003375A (es) | 2010-05-17 |
EP2217597B1 (en) | 2011-03-30 |
US8114891B2 (en) | 2012-02-14 |
ES2362326T3 (es) | 2011-07-01 |
DK2217597T3 (da) | 2011-06-20 |
CN101883771A (zh) | 2010-11-10 |
US20090088418A1 (en) | 2009-04-02 |
CN104193741B (zh) | 2016-08-24 |
KR101565469B1 (ko) | 2015-11-03 |
DE602008005928D1 (de) | 2011-05-12 |
ATE503754T1 (de) | 2011-04-15 |
JP2010540562A (ja) | 2010-12-24 |
HK1204616A1 (zh) | 2015-11-27 |
KR20100068290A (ko) | 2010-06-22 |
WO2009046025A1 (en) | 2009-04-09 |
EP2217597A1 (en) | 2010-08-18 |
JP5022494B2 (ja) | 2012-09-12 |
CA2701126A1 (en) | 2009-04-09 |
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