ATE503754T1 - 1h-indol-3-carbonsäure-chinuclidin-4- ylmethylesterderivate als liganden für den nikotinischen alpha-7-acetylcholinrezeptor zur behandlung von alzheimer-krankheit - Google Patents

1h-indol-3-carbonsäure-chinuclidin-4- ylmethylesterderivate als liganden für den nikotinischen alpha-7-acetylcholinrezeptor zur behandlung von alzheimer-krankheit

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Publication number
ATE503754T1
ATE503754T1 AT08835512T AT08835512T ATE503754T1 AT E503754 T1 ATE503754 T1 AT E503754T1 AT 08835512 T AT08835512 T AT 08835512T AT 08835512 T AT08835512 T AT 08835512T AT E503754 T1 ATE503754 T1 AT E503754T1
Authority
AT
Austria
Prior art keywords
quinuclidine
indole
alzheimer
ligands
disease
Prior art date
Application number
AT08835512T
Other languages
German (de)
English (en)
Inventor
Jurg Pfister
Meenakshi Venkatraman
Xiaoming Zhang
Original Assignee
Comentis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Comentis Inc filed Critical Comentis Inc
Application granted granted Critical
Publication of ATE503754T1 publication Critical patent/ATE503754T1/de

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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AT08835512T 2007-10-01 2008-09-30 1h-indol-3-carbonsäure-chinuclidin-4- ylmethylesterderivate als liganden für den nikotinischen alpha-7-acetylcholinrezeptor zur behandlung von alzheimer-krankheit ATE503754T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97672407P 2007-10-01 2007-10-01
PCT/US2008/078320 WO2009046025A1 (en) 2007-10-01 2008-09-30 Quinuclidin-4-ylmethyl 1h-indole-3-carboxylate derivatives as alpha 7 nicotinic acetylcholine receptor ligands for the treatment of alzheimer's disease

Publications (1)

Publication Number Publication Date
ATE503754T1 true ATE503754T1 (de) 2011-04-15

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AT08835512T ATE503754T1 (de) 2007-10-01 2008-09-30 1h-indol-3-carbonsäure-chinuclidin-4- ylmethylesterderivate als liganden für den nikotinischen alpha-7-acetylcholinrezeptor zur behandlung von alzheimer-krankheit

Country Status (12)

Country Link
US (1) US8114891B2 (enExample)
EP (1) EP2217597B1 (enExample)
JP (1) JP5022494B2 (enExample)
KR (1) KR101565469B1 (enExample)
CN (2) CN101883771A (enExample)
AT (1) ATE503754T1 (enExample)
CA (1) CA2701126A1 (enExample)
DE (1) DE602008005928D1 (enExample)
DK (1) DK2217597T3 (enExample)
ES (1) ES2362326T3 (enExample)
MX (1) MX2010003375A (enExample)
WO (1) WO2009046025A1 (enExample)

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JP6506248B2 (ja) 2013-03-14 2019-04-24 ゾーン・ロイヤリティズ・アンド・マイルストーンズ・エルエルシー 二環式鎮痛化合物
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JP6542794B2 (ja) 2013-12-12 2019-07-10 ゼノ ロイアルティー アンド マイルストーンズ リミテッド ライアビリティー カンパニー 二環式アルキル化合物、および合成
KR102401840B1 (ko) 2014-03-07 2022-05-25 리커리엄 아이피 홀딩스, 엘엘씨 프로펠란 유도체 및 합성
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WO2017120532A1 (en) * 2016-01-08 2017-07-13 Alpharmagen, Llc Polymorphs of a phosphate salt of quinuclidin-4-ylmethyl 4-methyl-1h-indole-3-carboxylate and uses thereof
WO2017160925A1 (en) * 2016-03-16 2017-09-21 Kalyra Pharmaceuticals, Inc. Analgesic compounds
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US8114891B2 (en) 2012-02-14
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DK2217597T3 (da) 2011-06-20
JP2010540562A (ja) 2010-12-24
CN104193741A (zh) 2014-12-10
KR101565469B1 (ko) 2015-11-03
JP5022494B2 (ja) 2012-09-12
EP2217597A1 (en) 2010-08-18
CN104193741B (zh) 2016-08-24
HK1204616A1 (en) 2015-11-27
CN101883771A (zh) 2010-11-10
MX2010003375A (es) 2010-05-17
KR20100068290A (ko) 2010-06-22
DE602008005928D1 (de) 2011-05-12
ES2362326T3 (es) 2011-07-01
CA2701126A1 (en) 2009-04-09

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