ES2362326T3 - Derivados de 1h-indol-3-carboxilato de quinuclidin-4-ilmetilo como ligandos del receptor nicotínico alfa 7 de la acetilcolina para el tratamiento de enfermedad de alzheimer. - Google Patents

Derivados de 1h-indol-3-carboxilato de quinuclidin-4-ilmetilo como ligandos del receptor nicotínico alfa 7 de la acetilcolina para el tratamiento de enfermedad de alzheimer. Download PDF

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Publication number
ES2362326T3
ES2362326T3 ES08835512T ES08835512T ES2362326T3 ES 2362326 T3 ES2362326 T3 ES 2362326T3 ES 08835512 T ES08835512 T ES 08835512T ES 08835512 T ES08835512 T ES 08835512T ES 2362326 T3 ES2362326 T3 ES 2362326T3
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Prior art keywords
ylmethyl
indole
carboxylate
quinuclidin
heptan
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ES08835512T
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English (en)
Spanish (es)
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Jurg R. Pfister
Meenakshi S. Venkatraman
Xiaoming Zhang
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CoMentis Inc
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CoMentis Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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ES08835512T 2007-10-01 2008-09-30 Derivados de 1h-indol-3-carboxilato de quinuclidin-4-ilmetilo como ligandos del receptor nicotínico alfa 7 de la acetilcolina para el tratamiento de enfermedad de alzheimer. Active ES2362326T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97672407P 2007-10-01 2007-10-01
US976724P 2007-10-01

Publications (1)

Publication Number Publication Date
ES2362326T3 true ES2362326T3 (es) 2011-07-01

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ID=40344599

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ES08835512T Active ES2362326T3 (es) 2007-10-01 2008-09-30 Derivados de 1h-indol-3-carboxilato de quinuclidin-4-ilmetilo como ligandos del receptor nicotínico alfa 7 de la acetilcolina para el tratamiento de enfermedad de alzheimer.

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Country Link
US (1) US8114891B2 (enExample)
EP (1) EP2217597B1 (enExample)
JP (1) JP5022494B2 (enExample)
KR (1) KR101565469B1 (enExample)
CN (2) CN101883771A (enExample)
AT (1) ATE503754T1 (enExample)
CA (1) CA2701126A1 (enExample)
DE (1) DE602008005928D1 (enExample)
DK (1) DK2217597T3 (enExample)
ES (1) ES2362326T3 (enExample)
MX (1) MX2010003375A (enExample)
WO (1) WO2009046025A1 (enExample)

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WO2014087904A1 (ja) * 2012-12-05 2014-06-12 国立大学法人大阪大学 破骨細胞が関与する疾患の予防又は治療剤
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CN113336653A (zh) 2014-03-07 2021-09-03 里科瑞尔姆Ip控股有限责任公司 螺桨烷衍生物及合成
US20170166561A1 (en) * 2014-07-11 2017-06-15 Alpharmagen, Llc Quinuclidine compounds for modulating alpha7-nicotinic acetylcholine receptor activity
CN106999451B (zh) 2014-09-17 2021-04-02 里科瑞尔姆Ip控股有限责任公司 双环化合物
WO2017120532A1 (en) * 2016-01-08 2017-07-13 Alpharmagen, Llc Polymorphs of a phosphate salt of quinuclidin-4-ylmethyl 4-methyl-1h-indole-3-carboxylate and uses thereof
WO2017160925A1 (en) * 2016-03-16 2017-09-21 Kalyra Pharmaceuticals, Inc. Analgesic compounds
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US8114891B2 (en) 2012-02-14
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US20090088418A1 (en) 2009-04-02
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JP5022494B2 (ja) 2012-09-12
EP2217597A1 (en) 2010-08-18
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