ES2362326T3 - Derivados de 1h-indol-3-carboxilato de quinuclidin-4-ilmetilo como ligandos del receptor nicotínico alfa 7 de la acetilcolina para el tratamiento de enfermedad de alzheimer. - Google Patents

Derivados de 1h-indol-3-carboxilato de quinuclidin-4-ilmetilo como ligandos del receptor nicotínico alfa 7 de la acetilcolina para el tratamiento de enfermedad de alzheimer. Download PDF

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Publication number
ES2362326T3
ES2362326T3 ES08835512T ES08835512T ES2362326T3 ES 2362326 T3 ES2362326 T3 ES 2362326T3 ES 08835512 T ES08835512 T ES 08835512T ES 08835512 T ES08835512 T ES 08835512T ES 2362326 T3 ES2362326 T3 ES 2362326T3
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Prior art keywords
ylmethyl
indole
carboxylate
quinuclidin
heptan
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ES08835512T
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English (en)
Spanish (es)
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Jurg R. Pfister
Meenakshi S. Venkatraman
Xiaoming Zhang
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CoMentis Inc
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CoMentis Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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ES08835512T 2007-10-01 2008-09-30 Derivados de 1h-indol-3-carboxilato de quinuclidin-4-ilmetilo como ligandos del receptor nicotínico alfa 7 de la acetilcolina para el tratamiento de enfermedad de alzheimer. Active ES2362326T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97672407P 2007-10-01 2007-10-01
US976724P 2007-10-01

Publications (1)

Publication Number Publication Date
ES2362326T3 true ES2362326T3 (es) 2011-07-01

Family

ID=40344599

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ES08835512T Active ES2362326T3 (es) 2007-10-01 2008-09-30 Derivados de 1h-indol-3-carboxilato de quinuclidin-4-ilmetilo como ligandos del receptor nicotínico alfa 7 de la acetilcolina para el tratamiento de enfermedad de alzheimer.

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Country Link
US (1) US8114891B2 (enExample)
EP (1) EP2217597B1 (enExample)
JP (1) JP5022494B2 (enExample)
KR (1) KR101565469B1 (enExample)
CN (2) CN101883771A (enExample)
AT (1) ATE503754T1 (enExample)
CA (1) CA2701126A1 (enExample)
DE (1) DE602008005928D1 (enExample)
DK (1) DK2217597T3 (enExample)
ES (1) ES2362326T3 (enExample)
MX (1) MX2010003375A (enExample)
WO (1) WO2009046025A1 (enExample)

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JP6261048B2 (ja) * 2012-12-05 2018-01-17 国立大学法人 新潟大学 破骨細胞が関与する疾患の予防又は治療剤
KR102243637B1 (ko) 2013-03-14 2021-04-26 리커리엄 아이피 홀딩스, 엘엘씨 바이사이클릭 진통 화합물
JP6427197B2 (ja) 2013-10-03 2018-11-21 クラ オンコロジー， インコーポレイテッド Ｅｒｋの阻害剤および使用方法
EP3080072A4 (en) 2013-12-12 2017-07-19 Kalyra Pharmaceuticals, inc. Bicyclic alkyl compounds and synthesis
WO2015134710A1 (en) 2014-03-07 2015-09-11 Kalyra Pharmaceuticals, Inc. Propellane derivates and synthesis
EP3166940A4 (en) 2014-07-11 2018-04-25 Alpharmagen, LLC Quinuclidine compounds for modulating alpha7 -nicotinic acetylcholine receptor activity
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WO2017120532A1 (en) * 2016-01-08 2017-07-13 Alpharmagen, Llc Polymorphs of a phosphate salt of quinuclidin-4-ylmethyl 4-methyl-1h-indole-3-carboxylate and uses thereof
US20190083460A1 (en) * 2016-03-16 2019-03-21 Zeno Royalties & Milestones, LLC Analgesic compounds
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ATE503754T1 (de) 2011-04-15
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CN104193741A (zh) 2014-12-10
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JP5022494B2 (ja) 2012-09-12
HK1204616A1 (en) 2015-11-27
US8114891B2 (en) 2012-02-14
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