CN104193741B - 作为α7-烟碱乙酰胆碱受体配体的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物 - Google Patents
作为α7-烟碱乙酰胆碱受体配体的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物 Download PDFInfo
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- CN104193741B CN104193741B CN201410331886.8A CN201410331886A CN104193741B CN 104193741 B CN104193741 B CN 104193741B CN 201410331886 A CN201410331886 A CN 201410331886A CN 104193741 B CN104193741 B CN 104193741B
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- compound
- indole
- ylmethyl
- quinuclidine
- carboxylic acid
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97672407P | 2007-10-01 | 2007-10-01 | |
| US60/976,724 | 2007-10-01 | ||
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| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| CN103221411B (zh) | 2010-05-17 | 2016-05-11 | 富瑞姆制药公司 | (R)-7-氯-N-(奎宁环-3-基)苯并[b]噻吩-2-甲酰胺盐酸盐单水合物的晶型 |
| US20130197028A1 (en) * | 2010-06-25 | 2013-08-01 | Oklahoma Medical Research Foundation | nAChRalpha7 Agonists and nAChRalpha7 Antagonists for Treating Ulcerative Colitis (UC) and Crohn's Disease (CD) |
| AU2012279298A1 (en) * | 2011-07-01 | 2014-01-23 | Envivo Pharmaceuticals, Inc. | Methods of treatment of Limited Cognitive Impairment |
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| JP6506248B2 (ja) | 2013-03-14 | 2019-04-24 | ゾーン・ロイヤリティズ・アンド・マイルストーンズ・エルエルシー | 二環式鎮痛化合物 |
| PT3052096T (pt) | 2013-10-03 | 2018-04-04 | Kura Oncology Inc | Inibidores de erk e métodos de utilização |
| KR102380609B1 (ko) | 2013-12-12 | 2022-03-30 | 리커리엄 아이피 홀딩스, 엘엘씨 | 바이사이클릭 알킬 화합물 및 합성 |
| US10654812B2 (en) | 2014-03-07 | 2020-05-19 | Recurium Ip Holdings Llc | Propellane derivates and synthesis |
| EP3166940A4 (en) | 2014-07-11 | 2018-04-25 | Alpharmagen, LLC | Quinuclidine compounds for modulating alpha7 -nicotinic acetylcholine receptor activity |
| KR20170048588A (ko) | 2014-09-17 | 2017-05-08 | 카리라 파마슈티컬스, 아이앤씨. | 바이사이클릭 화합물 |
| WO2017120532A1 (en) * | 2016-01-08 | 2017-07-13 | Alpharmagen, Llc | Polymorphs of a phosphate salt of quinuclidin-4-ylmethyl 4-methyl-1h-indole-3-carboxylate and uses thereof |
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| MX389668B (es) | 2017-05-15 | 2025-03-20 | Recurium Ip Holdings Llc | Compuestos biciclo[1.1.1]pentilo sustituidos y uso de los mismos para el tratamiento del dolor y fiebre. |
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| WO2004029050A1 (en) * | 2002-09-25 | 2004-04-08 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
| WO2006069097A2 (en) * | 2004-12-22 | 2006-06-29 | Memory Pharmaceuticals Corporation | Nicotinic alpha-7 receptor ligands and preparation and uses thereof |
Also Published As
| Publication number | Publication date |
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| HK1204616A1 (en) | 2015-11-27 |
| JP2010540562A (ja) | 2010-12-24 |
| CN101883771A (zh) | 2010-11-10 |
| EP2217597B1 (en) | 2011-03-30 |
| JP5022494B2 (ja) | 2012-09-12 |
| KR101565469B1 (ko) | 2015-11-03 |
| US8114891B2 (en) | 2012-02-14 |
| US20090088418A1 (en) | 2009-04-02 |
| DK2217597T3 (da) | 2011-06-20 |
| CA2701126A1 (en) | 2009-04-09 |
| EP2217597A1 (en) | 2010-08-18 |
| ATE503754T1 (de) | 2011-04-15 |
| WO2009046025A1 (en) | 2009-04-09 |
| MX2010003375A (es) | 2010-05-17 |
| DE602008005928D1 (de) | 2011-05-12 |
| CN104193741A (zh) | 2014-12-10 |
| KR20100068290A (ko) | 2010-06-22 |
| ES2362326T3 (es) | 2011-07-01 |
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