JP5022494B2 - アルツハイマー病治療用のα７ニコチン性アセチルコリン受容体リガンドとしてのキヌクリジン−４−イルメチル１Ｈ−インドール−３−カルボキシレート誘導体 - Google Patents

アルツハイマー病治療用のα７ニコチン性アセチルコリン受容体リガンドとしてのキヌクリジン−４−イルメチル１Ｈ−インドール−３−カルボキシレート誘導体 Download PDF

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JP5022494B2
JP5022494B2 JP2010527249A JP2010527249A JP5022494B2 JP 5022494 B2 JP5022494 B2 JP 5022494B2 JP 2010527249 A JP2010527249 A JP 2010527249A JP 2010527249 A JP2010527249 A JP 2010527249A JP 5022494 B2 JP5022494 B2 JP 5022494B2
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indole
ylmethyl
carboxylate
quinuclidin
alkyl
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JP2010540562A (ja
JP2010540562A5 (enExample
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プフィスター，ジュルグ，アール．
ヴェンカトラマン，ミーナクシ，エス．
ザン，ツィアオミン
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コメンティス，インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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JP2010527249A 2007-10-01 2008-09-30 アルツハイマー病治療用のα７ニコチン性アセチルコリン受容体リガンドとしてのキヌクリジン−４−イルメチル１Ｈ−インドール−３−カルボキシレート誘導体 Expired - Fee Related JP5022494B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97672407P 2007-10-01 2007-10-01
US60/976,724 2007-10-01
PCT/US2008/078320 WO2009046025A1 (en) 2007-10-01 2008-09-30 Quinuclidin-4-ylmethyl 1h-indole-3-carboxylate derivatives as alpha 7 nicotinic acetylcholine receptor ligands for the treatment of alzheimer's disease

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JP2010540562A JP2010540562A (ja) 2010-12-24
JP2010540562A5 JP2010540562A5 (enExample) 2011-11-17
JP5022494B2 true JP5022494B2 (ja) 2012-09-12

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US (1) US8114891B2 (enExample)
EP (1) EP2217597B1 (enExample)
JP (1) JP5022494B2 (enExample)
KR (1) KR101565469B1 (enExample)
CN (2) CN101883771A (enExample)
AT (1) ATE503754T1 (enExample)
CA (1) CA2701126A1 (enExample)
DE (1) DE602008005928D1 (enExample)
DK (1) DK2217597T3 (enExample)
ES (1) ES2362326T3 (enExample)
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ES2362326T3 (es) 2011-07-01
CN104193741A (zh) 2014-12-10
US8114891B2 (en) 2012-02-14
CA2701126A1 (en) 2009-04-09
KR20100068290A (ko) 2010-06-22
WO2009046025A1 (en) 2009-04-09
DE602008005928D1 (de) 2011-05-12
HK1204616A1 (en) 2015-11-27
CN101883771A (zh) 2010-11-10
EP2217597B1 (en) 2011-03-30
KR101565469B1 (ko) 2015-11-03
MX2010003375A (es) 2010-05-17
ATE503754T1 (de) 2011-04-15
CN104193741B (zh) 2016-08-24

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