DK2212691T3 - Mikrochip - Google Patents
Mikrochip Download PDFInfo
- Publication number
- DK2212691T3 DK2212691T3 DK08838206.4T DK08838206T DK2212691T3 DK 2212691 T3 DK2212691 T3 DK 2212691T3 DK 08838206 T DK08838206 T DK 08838206T DK 2212691 T3 DK2212691 T3 DK 2212691T3
- Authority
- DK
- Denmark
- Prior art keywords
- microchip
- micro
- chip
- heater
- pcr
- Prior art date
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
- B01L2300/0851—Bottom walls
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analyzing Materials Using Thermal Means (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Optical Measuring Cells (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (14)
1. Mikrochip (10) fremstillet af samtidigt brændte lavtemperaturkeramiklag, der omfatter et reaktionskammer (11), der er dannet i en flerhed af lag til påfyldning af en prøve, kendetegnet ved, at en flerhed af ledende ringe (52) omgiver reaktionskammeret (11), hvor hver af flerheden af ledende ringe (52) er forbundet med hinanden via en flerhed af stifter (51); en leder er indlejret i et ledende lag (33), der placeret under reaktionskammeret (11), hvor det ledende lag (33) er forbundet med de ledende ringe (52) via stifterne (51), og en opvarmer (12) er indlejret i et opvarmerlag (32) placerer under det ledende lag (33), hvor reaktionskammeret (11) opvarmes af opvarmeren (12) via det ledende lag (33) forbundet med de ledende ringe (52).
2. Mikrochip (10) ifølge krav 1, hvor chippen (10) omfatter en temperatursensor (13), der er placeret uden for chippen (10) eller indlejret i mindst ét sensorlag af chippen (10).
3. Mikrochip (10) ifølge krav 1, hvor chippen (10) omfatter kontaktpuder (16a og 16b) til at forbinde en ekstern styrekreds med temperatursensoren (13) og opvarmeren (12).
4. Mikrochip (10) ifølge krav 1, hvor der er en åbning mellem reaktionskammerets (11) bund og opvarmeren (12), og åbningen er i intervallet fra ca. 0,2 mm til ca. 0,7 mm.
5. Mikrochip (10) ifølge krav 1, hvor reaktionskammeret (11) har et volumen i intervallet fra ca. 1 pi til ca. 25 μΙ.
6. Fremgangsmåde til fremstilling afen mikrochip (10), hvilken fremgangsmåde omfatter trinnene med anbringelse af en flerhed af lag fremstillet af samtidigt brændt lavtemperaturkeramik og med en brønd til at danne et reaktionskammer (11), kendetegnet ved, at reaktionskammeret (11) er omgivet af flerheden af ledende ringe (52) og mikrochippen (10) er mikrochippen (10) ifølge krav 1, hvor fremgangsmåden omfatter følgende yderligere trin: forbindelse af hver af flerheden af ledende ringe (52) via flerheden af stifter (51); placering af mindst ét lag af samtidigt brændt lavtemperaturkeramik, der omfatter opvarmeren (12), under kammeret (11); placering af ét eller flere ledende lag (33) mellem opvarmeren (12) og reaktionskammeret (11) og forbindelse af lagene med hinanden for at danne mikrochippen (10).
7. Mikro-PCR-enhed, der omfatter en mikrochip (10), en temperatursensor (13), der er indlejret i mikrochippen (10) eller placeret uden for chippen (10), til måling af chippens temperatur, en styrekreds (43) til at styre opvarmeren (12) baseret på temperatursensorens indlæsning, og et optisk system til at detektere fluorescenssignal fra prøven, kendetegnet ved, at mikrochippen (10) er mikrochippen (10) ifølge krav 1.
8. Mikro-PCR-enhed ifølge krav 7, hvor enheden er en håndholdt enhed.
9. Mikro-PCR-enhed ifølge krav 7, hvor enheden styres med en bærbar beregningsplatform.
10. Mikro-PCR-enhed ifølge krav 7, hvor mikrochippen (10) er anbragt i et netværk til udførelse af talrige PCR’er.
11. Mikro-PCR-enhed ifølge krav 7, hvor mikrochippen (10) kan frigøres fra enheden.
12. Fremgangsmåde til detektering afen analysand i en prøve eller diagnosticering afen sygdomstilstand ved anvendelse afen mikro-PCR-enhed, hvilken fremgangsmåde omfatter følgende trin: påfyldning af en prøve, der omfatter nukleinsyre, på en mikrochip (10), der omfatter en flerhed af LTCC-lag, hvilken mikrochip (10) har et reaktionskammer (11), amplificering af nukleinsyren ved kørsel af mikro-PCR-enheden; og bestemmelse af tilstedeværelsen eller fraværet af analysanden baseret på en fluorescensaflæsning af den amplificerede nukleinsyre, eller bestemmelse af tilstedeværelsen eller fraværet af et patogen baseret på en fluorescensaflæsning af den amplificerede nukleinsyre med henblik på diagnosticering af sygdomstilstanden, kendetegnet ved, at reaktionskammeret (11) er omgivet af ledende ringe (52) og mikro-PCR-enheden er en mikro-PCR-enhed ifølge krav 7.
13. Fremgangsmåde ifølge krav 12, hvor nukleinsyren enten er DNA eller RNA.
14. Fremgangsmåde ifølge krav 12, hvor fremgangsmåden tilvejebringer både kvalitativ og kvantitativ analyse af de amplificerede produkter.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2312CH2007 | 2007-10-12 | ||
IN2311CH2007 | 2007-10-12 | ||
IN2313CH2007 | 2007-10-12 | ||
IN2314CH2007 | 2007-10-12 | ||
IN2328CH2007 | 2007-10-15 | ||
PCT/IN2008/000666 WO2009047805A2 (en) | 2007-10-12 | 2008-10-13 | Micro chip |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2212691T3 true DK2212691T3 (da) | 2019-04-01 |
Family
ID=40549716
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08838206.4T DK2212691T3 (da) | 2007-10-12 | 2008-10-13 | Mikrochip |
DK08838330.2T DK2212692T3 (da) | 2007-10-12 | 2008-10-13 | Håndholdt mikro-PCR-apparat |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08838330.2T DK2212692T3 (da) | 2007-10-12 | 2008-10-13 | Håndholdt mikro-PCR-apparat |
Country Status (34)
Country | Link |
---|---|
US (2) | US9044754B2 (da) |
EP (2) | EP2212692B1 (da) |
JP (2) | JP5226075B2 (da) |
KR (2) | KR101571038B1 (da) |
CN (2) | CN101868722B (da) |
AP (2) | AP2930A (da) |
AR (2) | AR071730A1 (da) |
AU (2) | AU2008310525B2 (da) |
BR (2) | BRPI0816357B1 (da) |
CA (2) | CA2702418C (da) |
CL (2) | CL2008003007A1 (da) |
CO (2) | CO6270380A2 (da) |
CY (2) | CY1121430T1 (da) |
DK (2) | DK2212691T3 (da) |
EA (2) | EA027913B1 (da) |
ES (2) | ES2714559T3 (da) |
HK (2) | HK1149080A1 (da) |
HR (2) | HRP20190418T1 (da) |
HU (2) | HUE043078T2 (da) |
IL (2) | IL204997A (da) |
LT (2) | LT2212691T (da) |
MA (2) | MA31804B1 (da) |
MX (2) | MX2010003976A (da) |
MY (2) | MY166387A (da) |
NZ (2) | NZ584592A (da) |
PE (2) | PE20090965A1 (da) |
PL (2) | PL2212692T3 (da) |
PT (2) | PT2212691T (da) |
SI (2) | SI2212692T1 (da) |
TN (2) | TN2010000156A1 (da) |
TR (1) | TR201903278T4 (da) |
TW (2) | TWI523949B (da) |
WO (2) | WO2009047805A2 (da) |
ZA (1) | ZA201002536B (da) |
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