HRP20190871T1 - Ručni mikro pcr uređaj - Google Patents
Ručni mikro pcr uređaj Download PDFInfo
- Publication number
- HRP20190871T1 HRP20190871T1 HRP20190871TT HRP20190871T HRP20190871T1 HR P20190871 T1 HRP20190871 T1 HR P20190871T1 HR P20190871T T HRP20190871T T HR P20190871TT HR P20190871 T HRP20190871 T HR P20190871T HR P20190871 T1 HRP20190871 T1 HR P20190871T1
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- Croatia
- Prior art keywords
- devices
- temperature
- chip
- heater
- thermal
- Prior art date
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- 230000003287 optical effect Effects 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 238000004891 communication Methods 0.000 claims 7
- 238000001514 detection method Methods 0.000 claims 7
- 238000003752 polymerase chain reaction Methods 0.000 claims 7
- 239000000919 ceramic Substances 0.000 claims 2
- 239000004020 conductor Substances 0.000 claims 2
- 230000001960 triggered effect Effects 0.000 claims 2
- 230000000977 initiatory effect Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 238000007789 sealing Methods 0.000 claims 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
- B01L2300/0851—Bottom walls
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analyzing Materials Using Thermal Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Optical Measuring Cells (AREA)
Claims (16)
1. Ručni mikro uređaj za lančanu reakciju polimeraze (109), koji sadrži:
nisko temperaturni zajednički okidani keramički mikro čip lančane reakcije polimeraze (103) koji sadrži grijač (202), reakcijsku komoru (201) za punjenje uzorka,
kontrolu grijača (102) radi regulacije grijača (202) na temelju ulaza dobivenog od temperaturnog senzora (203),
optički sustav detekcije (105) za otkrivanje signala fluorescencije iz uzorka, te
najmanje jedno komunikacijsko sučelje (107) za interakciju s jednim ili više drugih uređaja (101) odabranih iz skupine koja sadrži pametni telefon, PDA i programabilni uređaj;
naznačen time što
je mikrokontroler (106) povezan s najmanje jednim komunikacijskim sučeljem (107), mikrokontroler (106) sadrži analogno-digitalni i digitalno-analogni pretvarač, te je mikrokontroler konfiguriran:
za prikupljanje toplinskih profila uključujući temperaturu i vrijeme kao postavljene zadane vrijednosti i broj ciklusa od jednog ili više drugih uređaja (101) kroz komunikacijsko sučelje (107),
za osiguravanje toplinskih profila za upravljački krug (102) koji ima kontrolu grijača i pogonski krug, koji upravlja grijačem, te
za osiguravanje temperature koju detektira krug osjetnika temperature (107) i signala detektiranog optičkim sustavom detekcije (105) jednog ili više drugih uređaja (101) putem komunikacijskog sučelja (107).
2. Uređaj prema patentnom zahtjevu 1, naznačen time što je između grijača (202) i reakcijske komore (201) predviđen najmanje jedan sloj vodiča (403).
3. Uređaj prema patentnom zahtjevu 1, naznačen time što je reakcijska komora (201) okružena vodljivim prstenovima (502).
4. Uređaj prema patentnom zahtjevu 3, naznačen time što su vodljivi prstenovi (502) spojeni na sloj vodiča preko vodova (501).
5. Uređaj prema patentnom zahtjevu 1, naznačen time što je temperaturni senzor (203) postavljen izvan čipa (103) ili ugrađen u najmanje jednom sloju čipa (103) radi mjerenja temperature čipa (103).
6. Uređaj prema patentnom zahtjevu 1, naznačen time što je temperaturni senzor (203) spojen kao jedan krak mostnog kruga (706), a izlaz navedenog mostnog kruga (706) se pojačava prije njegovog dovođenja na kontrolu grijača (102) radi regulacije grijača (202).
7. Uređaj prema patentnom zahtjevu 1, naznačen time što čip (103) sadrži prozirni poklopac za brtvljenje koji prekriva reakcijsku komoru (201).
8. Uređaj prema patentnom zahtjevu 1, naznačen time što optički sustav (105) sadrži izvor svjetlosti (193) i foto-detektor, pri čemu je navedeni optički sustav za detekciju odabran iz skupine koja sadrži sustav za optičku detekciju s razdvajanjem snopa, hibridni sustav za optičku detekciju i bifurkacijski sustav za optičku detekciju.
9. Uređaj prema patentnom zahtjevu 1, naznačen time što je najmanje jedno komunikacijsko sučelje (107) odabrano iz skupine koja sadrži serijsko sučelje, USB sučelje, Bluetooth ili njihove kombinacije.
10. Uređaj prema patentnom zahtjevu 1, naznačen time što je jedan ili više drugih uređaja (101) odabrano iz skupine koja sadrži pametni telefon, PDA i programabilni uređaj koji prikuplja temperaturu čipa (103) i pojačani signal iz ručnog uređaja (109).
11. Postupak za nadgledanje i upravljanje ručnim mikro uređajem za lančanu reakciju polimeraze (109), naznačen time što je uređaj za lančanu reakciju polimeraze (109) uređaj za lančanu reakciju polimeraze (109) kako je zatraženo u patentnom zahtjevu 1, te navedeni postupak obuhvaća slijedeće korake:
uspostavljanje komunikacije između ručnog mikro uređaja za lančanu reakciju polimeraze (109) i jednog ili više drugih uređaja preko komunikacijskog sučelja (107),
iniciranje toplinskog kružnog procesa na temelju vrijednosti toplinskog profila dobivenih od jednog ili više drugih uređaja za kontrolu nisko temperaturnog zajednički okidanog keramičkog mikro čipa lančane reakcije polimeraze (103), i
slanje optičkog signala koji detektira sustav optičke detekcije (105) i podataka temperaturnog senzora (203) na jedan ili više drugih uređaja (101).
12. Postupak prema patentnom zahtjevu 11, naznačen time što se dovođenje vrijednosti toplinskog profila u jedan ili više drugih uređaja (101), kreiranje, modificiranje ili brisanje toplinskih profila odvija preko korisničkog sučelja.
13. Postupak prema patentnom zahtjevu 11, naznačen time što jedan ili više drugih uređaja (101) osiguravaju provjeru autentičnosti korisnika, te navedeni jedan ili više drugih uređaja (101) pohranjuju mnoštvo toplinskih profila.
14. Postupak prema patentnom zahtjevu 11, naznačen time što toplinski profil osigurava postavljanje zadane vrijednosti i broja ciklusa, pri čemu se čip (103) održava na temperaturi i tijekom vremena određenog postavljenom zadanom vrijednošću.
15. Postupak prema patentnom zahtjevu 11, naznačen time što temperatura mikro PCR čipa (103) dovodi do sobne temperature pauziranjem toplinskog kružnog procesa i održavanjem konstantne temperature mikro PCR čipa kada je toplinski ciklus pauziran.
16. Postupak prema patentnom zahtjevu 11, naznačen time što obuhvaća prikazivanje toplinskih i optičkih podataka na jedinici za prikaz jednog ili više drugih uređaja (101).
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2314CH2007 | 2007-10-12 | ||
| IN2313CH2007 | 2007-10-12 | ||
| IN2312CH2007 | 2007-10-12 | ||
| IN2311CH2007 | 2007-10-12 | ||
| IN2328CH2007 | 2007-10-15 | ||
| EP08838330.2A EP2212692B1 (en) | 2007-10-12 | 2008-10-13 | Hand held micro pcr device |
| PCT/IN2008/000665 WO2009047804A2 (en) | 2007-10-12 | 2008-10-13 | Hand held micro pcr device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20190871T1 true HRP20190871T1 (hr) | 2019-08-23 |
Family
ID=40549716
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20190418TT HRP20190418T1 (hr) | 2007-10-12 | 2019-03-04 | Mikročip |
| HRP20190871TT HRP20190871T1 (hr) | 2007-10-12 | 2019-05-13 | Ručni mikro pcr uređaj |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20190418TT HRP20190418T1 (hr) | 2007-10-12 | 2019-03-04 | Mikročip |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US9044754B2 (hr) |
| EP (2) | EP2212692B1 (hr) |
| JP (2) | JP5167362B2 (hr) |
| KR (2) | KR101571038B1 (hr) |
| CN (2) | CN101868721B (hr) |
| AP (2) | AP2930A (hr) |
| AR (2) | AR070659A1 (hr) |
| AU (2) | AU2008310525B2 (hr) |
| BR (2) | BRPI0817985B1 (hr) |
| CA (2) | CA2702549C (hr) |
| CL (2) | CL2008003008A1 (hr) |
| CO (2) | CO6270381A2 (hr) |
| CY (2) | CY1121430T1 (hr) |
| DK (2) | DK2212691T3 (hr) |
| EA (2) | EA015713B1 (hr) |
| ES (2) | ES2714559T3 (hr) |
| HK (2) | HK1149080A1 (hr) |
| HR (2) | HRP20190418T1 (hr) |
| HU (2) | HUE045587T2 (hr) |
| IL (2) | IL204996A (hr) |
| LT (2) | LT2212692T (hr) |
| MA (2) | MA31803B1 (hr) |
| MX (2) | MX2010003976A (hr) |
| MY (2) | MY166386A (hr) |
| NZ (2) | NZ584594A (hr) |
| PE (2) | PE20090965A1 (hr) |
| PL (2) | PL2212691T3 (hr) |
| PT (2) | PT2212692T (hr) |
| SI (2) | SI2212692T1 (hr) |
| TN (2) | TN2010000157A1 (hr) |
| TR (1) | TR201903278T4 (hr) |
| TW (2) | TWI448686B (hr) |
| WO (2) | WO2009047804A2 (hr) |
| ZA (1) | ZA201002536B (hr) |
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