DK2124562T3 - BICYCLOHETEROARYLFORBINDELSER AS P2X7 modulators and uses thereof - Google Patents

Info

Publication number

DK2124562T3

DK2124562T3 DK08726672.2T DK08726672T DK2124562T3 DK 2124562 T3 DK2124562 T3 DK 2124562T3 DK 08726672 T DK08726672 T DK 08726672T DK 2124562 T3 DK2124562 T3 DK 2124562T3

Authority

DK

Denmark

Prior art keywords

substituted

methyl

mol

unsubstituted

oxo

Prior art date

2007-03-09

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• 102100037602 P2X purinoceptor 7 Human genes 0.000 title description 34
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• 238000000034 method Methods 0.000 claims description 78
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• 125000001072 heteroaryl group Chemical group 0.000 claims description 44
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• 229910052739 hydrogen Inorganic materials 0.000 claims description 41
• 239000001257 hydrogen Substances 0.000 claims description 41
• 125000003545 alkoxy group Chemical group 0.000 claims description 35
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• 229910052736 halogen Inorganic materials 0.000 claims description 19
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• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 14
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• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 12
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• JECILOFRRYCNDH-ZDUSSCGKSA-N 2-[3-fluoro-4-(trifluoromethyl)phenyl]-n-[2-[(2s)-1-hydroxypropan-2-yl]-6-methyl-1-oxoisoquinolin-5-yl]acetamide Chemical compound CC1=CC=C2C(=O)N([C@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C(F)=C1 JECILOFRRYCNDH-ZDUSSCGKSA-N 0.000 claims description 4
• CSYHHBNQBKHTNI-UHFFFAOYSA-N 2-[3-fluoro-4-(trifluoromethyl)phenyl]-n-[6-methyl-2-[2-(methylamino)ethyl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound CC1=CC=C2C(=O)N(CCNC)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C(F)=C1 CSYHHBNQBKHTNI-UHFFFAOYSA-N 0.000 claims description 4
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• 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 4
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• 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims description 4
• PSTNSIKFKNCGHB-CQSZACIVSA-N 2-[3-fluoro-4-(trifluoromethyl)phenyl]-n-[6-methyl-2-[(2r)-1-(methylamino)propan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound CC1=CC=C2C(=O)N([C@H](C)CNC)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C(F)=C1 PSTNSIKFKNCGHB-CQSZACIVSA-N 0.000 claims description 3
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