CN101686680B - 作为p2x7调节剂的双环杂芳基化合物及其用途 - Google Patents

作为p2x7调节剂的双环杂芳基化合物及其用途 Download PDF

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CN101686680B
CN101686680B CN200880014110.6A CN200880014110A CN101686680B CN 101686680 B CN101686680 B CN 101686680B CN 200880014110 A CN200880014110 A CN 200880014110A CN 101686680 B CN101686680 B CN 101686680B
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mol
substituted
methyl
disease
oxo
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CN101686680A (zh
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M·G·凯利
J·金凯德
Y·方
Y·曹
C·卡波
S·高鲁加利
Z·王
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Ivotec America Inc
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Reynolds
Ivotec America Inc
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    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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CN200880014110.6A 2007-03-09 2008-03-07 作为p2x7调节剂的双环杂芳基化合物及其用途 Active CN101686680B (zh)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US90604907P 2007-03-09 2007-03-09
US60/906,049 2007-03-09
US91808607P 2007-03-15 2007-03-15
US91826007P 2007-03-15 2007-03-15
US91812307P 2007-03-15 2007-03-15
US91826107P 2007-03-15 2007-03-15
US60/918,261 2007-03-15
US60/918,086 2007-03-15
US60/918,123 2007-03-15
US60/918,260 2007-03-15
US838607P 2007-12-20 2007-12-20
US837007P 2007-12-20 2007-12-20
US838507P 2007-12-20 2007-12-20
US61/008,386 2007-12-20
US61/008,385 2007-12-20
US61/008,370 2007-12-20
US1067208P 2008-01-10 2008-01-10
US61/010,672 2008-01-10
PCT/US2008/003175 WO2008112205A1 (en) 2007-03-09 2008-03-07 Bicycloheteroaryl compounds as p2x7 modulators and uses thereof

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CN101686680A CN101686680A (zh) 2010-03-31
CN101686680B true CN101686680B (zh) 2015-12-09

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US (1) US8093265B2 (enExample)
EP (1) EP2124562B1 (enExample)
JP (1) JP2010520875A (enExample)
CN (1) CN101686680B (enExample)
CA (1) CA2680275C (enExample)
DK (1) DK2124562T3 (enExample)
ES (1) ES2576643T3 (enExample)
WO (1) WO2008112205A1 (enExample)

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MX2014000894A (es) 2011-07-22 2014-02-27 Actelion Pharmaceuticals Ltd Derivados de amidas heterociclicas como antagonistas de receptores p2x7.
BR112014017735B1 (pt) 2012-01-20 2022-06-28 Idorsia Pharmaceuticals Ltd Compostos derivados de amida heterocíclicos como antagonistas do receptor de p2x7, composição farmacêutica, e, uso de um composto
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CA2891499C (en) 2012-12-18 2021-07-06 Actelion Pharmaceuticals Ltd Indole carboxamide derivatives as p2x7 receptor antagonists
CN104918617B (zh) 2013-01-22 2017-05-10 埃科特莱茵药品有限公司 作为p2x7受体拮抗剂的杂环酰胺衍生物
JP6282017B2 (ja) 2013-01-22 2018-02-21 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｐ２ｘ７受容体アンタゴニストとしての複素環アミド誘導体
US9399623B2 (en) * 2014-06-05 2016-07-26 Merck Patent Gmbh Quinoline derivatives and their use in neurodegenerative diseases
TWI825637B (zh) 2021-03-31 2023-12-11 美商輝瑞股份有限公司 啶－１，６（２ｈ，７ｈ）－二酮
WO2025057074A1 (en) * 2023-09-13 2025-03-20 Suven Life Sciences Limited N-aryl benzamide derivatives as p2x7 receptor antagonists

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