DK176213B1 - Insulinanalog-protamin-komplekser, parenterale formuleringer indeholdende disse samt fremgangsmåde til fremstilling af LysB28ProB29-human insulin-protaminkrystaller og fremgangsmåde til fremstilling af insulin-protamin-komplekser og -krystaller - Google Patents

Insulinanalog-protamin-komplekser, parenterale formuleringer indeholdende disse samt fremgangsmåde til fremstilling af LysB28ProB29-human insulin-protaminkrystaller og fremgangsmåde til fremstilling af insulin-protamin-komplekser og -krystaller Download PDF

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Publication number
DK176213B1
DK176213B1 DK199500676A DK67695A DK176213B1 DK 176213 B1 DK176213 B1 DK 176213B1 DK 199500676 A DK199500676 A DK 199500676A DK 67695 A DK67695 A DK 67695A DK 176213 B1 DK176213 B1 DK 176213B1
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Denmark
Prior art keywords
protamine
insulin
approx
human insulin
zinc
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DK199500676A
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Danish (da)
English (en)
Other versions
DK67695A (da
Inventor
Michael Rosario De Felippis
Original Assignee
Lilly Co Eli
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Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK67695A publication Critical patent/DK67695A/da
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK199500676A 1994-06-16 1995-06-14 Insulinanalog-protamin-komplekser, parenterale formuleringer indeholdende disse samt fremgangsmåde til fremstilling af LysB28ProB29-human insulin-protaminkrystaller og fremgangsmåde til fremstilling af insulin-protamin-komplekser og -krystaller DK176213B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26063394 1994-06-16
US08/260,633 US5461031A (en) 1994-06-16 1994-06-16 Monomeric insulin analog formulations

Publications (2)

Publication Number Publication Date
DK67695A DK67695A (da) 1995-12-17
DK176213B1 true DK176213B1 (da) 2007-02-12

Family

ID=22989963

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199500676A DK176213B1 (da) 1994-06-16 1995-06-14 Insulinanalog-protamin-komplekser, parenterale formuleringer indeholdende disse samt fremgangsmåde til fremstilling af LysB28ProB29-human insulin-protaminkrystaller og fremgangsmåde til fremstilling af insulin-protamin-komplekser og -krystaller

Country Status (37)

Country Link
US (3) US5461031A (fr)
JP (1) JP3812962B2 (fr)
KR (1) KR100386038B1 (fr)
CN (1) CN1145641C (fr)
AT (1) AT408611B (fr)
BE (1) BE1009409A5 (fr)
BR (1) BR9502797A (fr)
CA (1) CA2151564C (fr)
CH (2) CH689934A5 (fr)
CO (1) CO4410204A1 (fr)
CZ (1) CZ294556B6 (fr)
DE (1) DE19521753B4 (fr)
DK (1) DK176213B1 (fr)
ES (1) ES2091728B1 (fr)
FI (1) FI118208B (fr)
FR (1) FR2721215B1 (fr)
GB (1) GB2290294B (fr)
GR (1) GR1002494B (fr)
HU (1) HU218943B (fr)
IE (1) IE68852B1 (fr)
IL (1) IL114153A (fr)
IT (1) IT1276722B1 (fr)
LU (1) LU88627A1 (fr)
MY (1) MY116831A (fr)
NL (2) NL1000565C2 (fr)
NO (1) NO320808B1 (fr)
NZ (1) NZ272360A (fr)
PE (1) PE34496A1 (fr)
PL (1) PL183284B1 (fr)
PT (1) PT101723B (fr)
RO (1) RO115124B1 (fr)
SE (1) SE509295C2 (fr)
SI (1) SI9500199A (fr)
TW (1) TW347334B (fr)
UA (1) UA34468C2 (fr)
YU (1) YU39795A (fr)
ZA (1) ZA954941B (fr)

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Also Published As

Publication number Publication date
FR2721215B1 (fr) 1997-08-14
TW347334B (en) 1998-12-11
ES2091728B1 (es) 1998-02-01
SE509295C2 (sv) 1999-01-11
ES2091728A1 (es) 1996-11-01
US5650486A (en) 1997-07-22
CN1145641C (zh) 2004-04-14
LU88627A1 (fr) 1996-02-01
SE9502168L (sv) 1995-12-17
FI118208B (fi) 2007-08-31
NO952356L (no) 1995-12-18
CO4410204A1 (es) 1997-01-09
CH689934A5 (de) 2000-02-15
GR1002494B (el) 1996-12-12
YU39795A (sh) 1998-05-15
CA2151564C (fr) 2003-02-11
CN1116629A (zh) 1996-02-14
NO952356D0 (no) 1995-06-14
NO320808B1 (no) 2006-01-30
PL309100A1 (en) 1995-12-27
NZ272360A (en) 1997-02-24
GB2290294A (en) 1995-12-20
PT101723A (pt) 1995-12-29
PE34496A1 (es) 1996-10-01
IE950435A1 (en) 1995-12-27
DK67695A (da) 1995-12-17
SE9502168D0 (sv) 1995-06-14
US5461031A (en) 1995-10-24
KR100386038B1 (ko) 2003-08-27
BR9502797A (pt) 1996-03-12
IL114153A0 (en) 1995-10-31
PT101723B (pt) 1997-02-28
CZ154395A3 (en) 1996-02-14
SI9500199A (en) 1996-02-29
AT408611B (de) 2002-01-25
NL1004643A1 (nl) 1996-12-17
HU218943B (hu) 2001-01-29
MY116831A (en) 2004-04-30
CA2151564A1 (fr) 1995-12-17
RO115124B1 (ro) 1999-11-30
HUT71908A (en) 1996-02-28
NL1000565C2 (nl) 1996-12-03
IL114153A (en) 2000-09-28
NL1004643C2 (nl) 1997-02-12
PL183284B1 (pl) 2002-06-28
GB9512105D0 (en) 1995-08-09
ZA954941B (en) 1996-12-17
JP3812962B2 (ja) 2006-08-23
IT1276722B1 (it) 1997-11-03
ITMI951277A1 (it) 1996-12-14
DE19521753A1 (de) 1995-12-21
KR960000923A (ko) 1996-01-25
DE19521753B4 (de) 2009-07-23
CH693019A5 (de) 2003-01-31
CZ294556B6 (cs) 2005-02-16
NL1000565A1 (nl) 1995-12-18
ATA101795A (de) 2001-06-15
FR2721215A1 (fr) 1995-12-22
HU9501717D0 (en) 1995-08-28
FI952932A0 (fi) 1995-06-14
BE1009409A5 (fr) 1997-03-04
IE68852B1 (en) 1996-07-24
UA34468C2 (uk) 2001-03-15
FI952932A (fi) 1995-12-17
GB2290294B (en) 1999-03-17
US5747642A (en) 1998-05-05
ITMI951277A0 (it) 1995-06-14
JPH083064A (ja) 1996-01-09

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