FI952932A - Monomeeriset insuliinianalogivalmisteet - Google Patents
Monomeeriset insuliinianalogivalmisteet Download PDFInfo
- Publication number
- FI952932A FI952932A FI952932A FI952932A FI952932A FI 952932 A FI952932 A FI 952932A FI 952932 A FI952932 A FI 952932A FI 952932 A FI952932 A FI 952932A FI 952932 A FI952932 A FI 952932A
- Authority
- FI
- Finland
- Prior art keywords
- monomera
- insulin analogue
- analogue preparation
- preparation
- insulin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26063394 | 1994-06-16 | ||
US08/260,633 US5461031A (en) | 1994-06-16 | 1994-06-16 | Monomeric insulin analog formulations |
Publications (3)
Publication Number | Publication Date |
---|---|
FI952932A0 FI952932A0 (fi) | 1995-06-14 |
FI952932A true FI952932A (fi) | 1995-12-17 |
FI118208B FI118208B (fi) | 2007-08-31 |
Family
ID=22989963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI952932A FI118208B (fi) | 1994-06-16 | 1995-06-14 | Monomeeriset insuliinianalogivalmisteet |
Country Status (37)
Country | Link |
---|---|
US (3) | US5461031A (fi) |
JP (1) | JP3812962B2 (fi) |
KR (1) | KR100386038B1 (fi) |
CN (1) | CN1145641C (fi) |
AT (1) | AT408611B (fi) |
BE (1) | BE1009409A5 (fi) |
BR (1) | BR9502797A (fi) |
CA (1) | CA2151564C (fi) |
CH (2) | CH693019A5 (fi) |
CO (1) | CO4410204A1 (fi) |
CZ (1) | CZ294556B6 (fi) |
DE (1) | DE19521753B4 (fi) |
DK (1) | DK176213B1 (fi) |
ES (1) | ES2091728B1 (fi) |
FI (1) | FI118208B (fi) |
FR (1) | FR2721215B1 (fi) |
GB (1) | GB2290294B (fi) |
GR (1) | GR1002494B (fi) |
HU (1) | HU218943B (fi) |
IE (1) | IE68852B1 (fi) |
IL (1) | IL114153A (fi) |
IT (1) | IT1276722B1 (fi) |
LU (1) | LU88627A1 (fi) |
MY (1) | MY116831A (fi) |
NL (2) | NL1000565C2 (fi) |
NO (1) | NO320808B1 (fi) |
NZ (1) | NZ272360A (fi) |
PE (1) | PE34496A1 (fi) |
PL (1) | PL183284B1 (fi) |
PT (1) | PT101723B (fi) |
RO (1) | RO115124B1 (fi) |
SE (1) | SE509295C2 (fi) |
SI (1) | SI9500199A (fi) |
TW (1) | TW347334B (fi) |
UA (1) | UA34468C2 (fi) |
YU (1) | YU39795A (fi) |
ZA (1) | ZA954941B (fi) |
Families Citing this family (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6024090A (en) * | 1993-01-29 | 2000-02-15 | Aradigm Corporation | Method of treating a diabetic patient by aerosolized administration of insulin lispro |
US6131567A (en) * | 1993-01-29 | 2000-10-17 | Aradigm Corporation | Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin |
EP1607086A1 (en) * | 1993-01-29 | 2005-12-21 | Aradigm Corporation | Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin |
US5888477A (en) * | 1993-01-29 | 1999-03-30 | Aradigm Corporation | Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin |
DK72793D0 (da) * | 1993-06-21 | 1993-06-21 | Novo Nordisk As | Nyt produkt |
US5461031A (en) * | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
US5547929A (en) * | 1994-09-12 | 1996-08-20 | Eli Lilly And Company | Insulin analog formulations |
YU18596A (sh) * | 1995-03-31 | 1998-07-10 | Eli Lilly And Company | Analogne formulacije monomernog insulina |
DE69630527T2 (de) * | 1995-06-30 | 2004-08-05 | Novo Nordisk A/S | Vorbeugung einer krankheit mit diabetes charakter |
AU720484B2 (en) * | 1996-06-20 | 2000-06-01 | Novo Nordisk A/S | Insulin preparations containing NaCl |
JP3343129B2 (ja) * | 1997-02-07 | 2002-11-11 | ノボ ノルディスク アクティーゼルスカブ | タンパク質の結晶化 |
US5898067A (en) * | 1997-02-07 | 1999-04-27 | Novo Nordisk A/S | Crystallization of proteins |
PE79099A1 (es) * | 1997-06-13 | 1999-08-24 | Lilly Co Eli | Formulaciones de insulina estables |
DK1283051T3 (da) * | 1997-06-13 | 2006-10-16 | Lilly Co Eli | Stabile insulinformuleringer |
PE123799A1 (es) * | 1997-10-24 | 1999-12-13 | Lilly Co Eli | Composiciones insolubles de insulina |
US6531448B1 (en) | 1997-12-23 | 2003-03-11 | Eli Lilly And Company | Insoluble compositions for controlling blood glucose |
US20010053761A1 (en) * | 1998-01-08 | 2001-12-20 | Dimarchi Richard Dennis | Method for administering aspb28-human insulin |
US20040214747A1 (en) * | 1999-01-06 | 2004-10-28 | Dimarchi Richard Dennis | Method for administering monomeric insulin |
US6624141B1 (en) * | 1999-03-17 | 2003-09-23 | The Regents Of The University Of Michigan | Protamine fragment compositions and methods of use |
US7169889B1 (en) | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
CN1406131A (zh) * | 2000-12-25 | 2003-03-26 | 株式会社资生堂 | 活化交感神经的香料组合物 |
JP4489352B2 (ja) * | 2001-02-09 | 2010-06-23 | ジェネンテック, インコーポレイテッド | Igf−1の結晶化 |
US7060675B2 (en) | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
US6867183B2 (en) | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US6828305B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6713452B2 (en) * | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6835802B2 (en) * | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
US6858580B2 (en) * | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6828297B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US7713932B2 (en) | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
MXPA04001560A (es) * | 2001-08-28 | 2004-05-17 | Lilly Co Eli | Premezclas de glp-1 e insulina basal. |
US6770625B2 (en) | 2001-09-07 | 2004-08-03 | Nobex Corporation | Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith |
US7030082B2 (en) * | 2001-09-07 | 2006-04-18 | Nobex Corporation | Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith |
US7166571B2 (en) | 2001-09-07 | 2007-01-23 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US6913903B2 (en) | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US7196059B2 (en) | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US7312192B2 (en) | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US20030068361A1 (en) * | 2001-10-09 | 2003-04-10 | Rimona Margalit | Liposome-encapsulated insulin formulations |
CA2463803A1 (en) * | 2001-10-19 | 2003-05-01 | Eli Lilly And Company | Biphasic mixtures of glp-1 and insulin |
AU2002346491A1 (en) * | 2001-12-19 | 2003-07-09 | Eli Lilly And Company | Crystalline compositions for controlling blood glucose |
US7601688B2 (en) * | 2002-06-13 | 2009-10-13 | Biocon Limited | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
US20060258561A1 (en) * | 2003-03-13 | 2006-11-16 | Novo Nordisk A/S | Novel NPH insulin preparations |
BRPI0411479A (pt) | 2003-06-17 | 2006-07-25 | Sembiosys Genetics Inc | métodos para a produção de insulina em plantas |
US20050054818A1 (en) * | 2003-07-02 | 2005-03-10 | Brader Mark Laurence | Crystalline compositions for controlling blood glucose |
WO2005012346A1 (en) * | 2003-07-25 | 2005-02-10 | Conjuchem, Inc. | Long lasting insulin derivatives and methods thereof |
US7658721B2 (en) * | 2004-01-16 | 2010-02-09 | Biodel Inc. | Sublingual drug delivery device |
US20080096800A1 (en) * | 2004-03-12 | 2008-04-24 | Biodel, Inc. | Rapid mucosal gel or film insulin compositions |
AU2005222613B2 (en) * | 2004-03-12 | 2009-12-17 | Biodel, Inc. | Rapid acting drug delivery compositions |
US20080085298A1 (en) * | 2004-03-12 | 2008-04-10 | Biodel, Inc. | Rapid Mucosal Gel or Film Insulin Compositions |
US20080090753A1 (en) * | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
UA103758C2 (ru) | 2004-07-19 | 2013-11-25 | Биокон Лимитед | Конъюгаты олигомеров инсулина, их композиции и применение |
US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
JP2008513356A (ja) * | 2004-08-09 | 2008-05-01 | アリオス バイオファーマ インク. | 合成高度糖鎖付加プロテアーゼ耐性ポリペプチド変異体、それを使用する経口製剤および方法 |
SI2918286T1 (sl) * | 2004-10-05 | 2020-06-30 | Novo Nordisk A/S | Farmacevtski pripravek, ki vsebuje inzulin v kristalni obliki in tudi v obliki raztopine |
CN101060856B (zh) | 2004-11-22 | 2011-01-19 | 诺和诺德公司 | 可溶、稳定的含胰岛素制剂 |
US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
US7713929B2 (en) * | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
US8084420B2 (en) * | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
CN100371346C (zh) * | 2005-12-14 | 2008-02-27 | 浙江大学 | 人工合成胰岛素模拟肽及其应用 |
ATE557037T1 (de) * | 2006-02-27 | 2012-05-15 | Novo Nordisk As | Insulin derivate |
CA2649109A1 (en) * | 2006-04-12 | 2007-10-25 | Biodel, Inc. | Rapid acting and long acting insulin combination formulations |
US8927015B2 (en) | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
CN101062948B (zh) * | 2006-04-29 | 2010-05-12 | 上海生物泰生命科学研究有限公司 | 单体速效胰岛素及其制法和用途 |
WO2008124522A2 (en) * | 2007-04-04 | 2008-10-16 | Biodel, Inc. | Amylin formulations |
US20080260820A1 (en) * | 2007-04-19 | 2008-10-23 | Gilles Borrelly | Oral dosage formulations of protease-resistant polypeptides |
BRPI0818004B8 (pt) | 2007-10-16 | 2021-05-25 | Biocon Ltd | composição farmacêutica sólida administrável por via oral e o processo da mesma. |
AU2009204309B2 (en) * | 2008-01-04 | 2012-11-22 | Biodel, Inc. | Insulin formulations for insulin release as a function of tissue glucose levels |
WO2010028175A1 (en) | 2008-09-08 | 2010-03-11 | The Board Of Trustees Of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase activity and methods of use thereof |
EP2349279A4 (en) | 2008-10-28 | 2013-12-25 | Univ Leland Stanford Junior | ALDEHYDE DEHYDROGENASE MODULATORS AND METHOD OF USE THEREOF |
MA33064B1 (fr) * | 2009-01-28 | 2012-02-01 | Smartcells Inc | Systemes à base de conjugués pour administration contrôlée de médicaments |
WO2010088286A1 (en) | 2009-01-28 | 2010-08-05 | Smartcells, Inc. | Synthetic conjugates and uses thereof |
CN102316892B (zh) | 2009-02-12 | 2014-06-04 | 西马生物医学计划公司 | 心肌营养素-1用于治疗代谢病的用途 |
US9060927B2 (en) * | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
WO2010107519A1 (en) | 2009-03-20 | 2010-09-23 | Smartcells, Inc. | Terminally-functionalized conjugates and uses thereof |
HUP0900482A2 (en) * | 2009-08-03 | 2011-03-28 | Cera Med Kft | Pharmaceutical formulation for oral administration |
WO2012015692A2 (en) | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Recombinantly expressed insulin polypeptides and uses thereof |
MX347014B (es) * | 2010-11-24 | 2017-04-07 | Durect Corp | Composición para administración de fármaco biodegradable. |
AU2012208349A1 (en) | 2011-01-20 | 2013-07-18 | Zealand Pharma A/S | Combination of acylated glucagon analogues with insulin analogues |
WO2012149106A1 (en) | 2011-04-29 | 2012-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
EP2925345B1 (en) | 2012-12-03 | 2018-09-05 | Merck Sharp & Dohme Corp. | Method for making o-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues |
EP2970124B1 (en) | 2013-03-14 | 2019-05-22 | The Board of Trustees of the Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
MX366852B (es) | 2013-10-04 | 2019-07-25 | Merck Sharp & Dohme | Conjugados de insulina sensibles a glucosa. |
US20160303242A1 (en) | 2013-12-09 | 2016-10-20 | Durect Corporation | Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same |
CN105899191B (zh) * | 2014-01-09 | 2020-06-16 | 赛诺菲 | 胰岛素类似物和/或胰岛素衍生物的稳定化不含甘油的药物制剂 |
WO2015106269A2 (en) * | 2014-01-13 | 2015-07-16 | Thermalin Diabetes, Llc | Rapid action insulin formulations and pharmaceutical delivery systems |
AR099569A1 (es) | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
DK3006045T3 (en) | 2014-10-07 | 2017-07-17 | Cyprumed Gmbh | Pharmaceutical formulations for oral administration of peptide or protein drugs |
WO2017163159A1 (en) | 2016-03-21 | 2017-09-28 | Wockhardt Limited | Biphasic pharmaceutical composition of insulin human |
KR102665710B1 (ko) | 2017-08-24 | 2024-05-14 | 노보 노르디스크 에이/에스 | Glp-1 조성물 및 그 용도 |
US11110063B2 (en) | 2017-08-25 | 2021-09-07 | MAIA Pharmaceuticals, Inc. | Storage stable sincalide formulations |
EP3727424A4 (en) | 2017-12-18 | 2021-10-27 | Merck Sharp & Dohme Corp. | CONJUGATE-BASED SYSTEMS FOR CONTROLLED INSULIN RELEASE |
WO2019125879A2 (en) | 2017-12-18 | 2019-06-27 | Merck Sharp & Dohme Corp. | Conjugate based systems for controlled insulin delivery |
CN110063932A (zh) * | 2019-04-12 | 2019-07-30 | 浙江大学 | 一种多肽蛋白类药物的缓释组合物制剂及其制备方法 |
US20230082544A1 (en) | 2020-02-18 | 2023-03-16 | Novo Nordisk A/S | Pharmaceutical formulations |
AU2021247169A1 (en) | 2020-03-31 | 2022-10-20 | Protomer Technologies Inc. | Conjugates for selective responsiveness to vicinal diols |
CA3198757A1 (en) | 2020-11-19 | 2022-05-27 | Protomer Technologies Inc. | Aromatic boron-containing compounds and insulin analogs |
TW202409070A (zh) | 2022-05-18 | 2024-03-01 | 美商普羅托莫科技公司 | 芳族含硼化合物及相關胰島素類似物 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2538018A (en) * | 1944-04-04 | 1951-01-16 | Nordisk Insulinlab | Crystalline product of insulin and alkaline protein and process of making it |
US2801953A (en) * | 1952-02-28 | 1957-08-06 | Hoechst Ag | Process of preparing crystallized insulin preparations |
US2849370A (en) * | 1953-06-04 | 1958-08-26 | Novo Terapeutisk Labortorium A | Injectable insulin preparations with protracted effect and process of producing same |
US3060093A (en) * | 1957-07-18 | 1962-10-23 | Nordisk Insulinlab | Slowly acting insulin preparation in crystalline form and method of preparation |
US3868358A (en) * | 1971-04-30 | 1975-02-25 | Lilly Co Eli | Protamine-insulin product |
DE3326473A1 (de) * | 1983-07-22 | 1985-01-31 | Hoechst Ag, 6230 Frankfurt | Pharmazeutisches mittel zur behandlung des diabetes mellitus |
DE3327709A1 (de) * | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
DK119785D0 (da) * | 1985-03-15 | 1985-03-15 | Nordisk Gentofte | Insulinpraeparat |
PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
EP0280534B1 (en) * | 1987-02-25 | 1993-04-21 | Novo Nordisk A/S | Novel insulin derivatives |
DE3717370A1 (de) * | 1987-05-22 | 1988-12-01 | Hoechst Ag | Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus |
EP0425482B1 (en) * | 1988-07-20 | 1993-08-18 | Novo Nordisk A/S | Human insulin analogs and preparations containing them |
WO1990007522A1 (en) * | 1988-12-23 | 1990-07-12 | Novo Nordisk A/S | Human insulin analogues |
US5514646A (en) * | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
NZ232375A (en) * | 1989-02-09 | 1992-04-28 | Lilly Co Eli | Insulin analogues modified at b29 |
DE122006000015I1 (de) * | 1993-06-21 | 2006-06-29 | Novo Nordisk As | Asp-B28-Insulinkristalle |
DK72793D0 (da) * | 1993-06-21 | 1993-06-21 | Novo Nordisk As | Nyt produkt |
US5474978A (en) * | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
US5461031A (en) * | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
-
1994
- 1994-06-16 US US08/260,633 patent/US5461031A/en not_active Expired - Lifetime
- 1994-06-24 TW TW083105766A patent/TW347334B/zh not_active IP Right Cessation
-
1995
- 1995-06-01 US US08/458,151 patent/US5747642A/en not_active Expired - Lifetime
- 1995-06-01 US US08/458,150 patent/US5650486A/en not_active Expired - Lifetime
- 1995-06-12 CA CA002151564A patent/CA2151564C/en not_active Expired - Lifetime
- 1995-06-13 HU HU9501717A patent/HU218943B/hu unknown
- 1995-06-13 YU YU39795A patent/YU39795A/sh unknown
- 1995-06-14 MY MYPI95001592A patent/MY116831A/en unknown
- 1995-06-14 FR FR9507095A patent/FR2721215B1/fr not_active Expired - Lifetime
- 1995-06-14 PT PT101723A patent/PT101723B/pt not_active IP Right Cessation
- 1995-06-14 CO CO95026236A patent/CO4410204A1/es unknown
- 1995-06-14 IT IT95MI001277A patent/IT1276722B1/it active IP Right Grant
- 1995-06-14 ZA ZA954941A patent/ZA954941B/xx unknown
- 1995-06-14 NO NO19952356A patent/NO320808B1/no not_active IP Right Cessation
- 1995-06-14 LU LU88627A patent/LU88627A1/fr unknown
- 1995-06-14 PL PL95309100A patent/PL183284B1/pl unknown
- 1995-06-14 JP JP14729695A patent/JP3812962B2/ja not_active Expired - Lifetime
- 1995-06-14 BE BE9500527A patent/BE1009409A5/fr active
- 1995-06-14 NZ NZ272360A patent/NZ272360A/en not_active IP Right Cessation
- 1995-06-14 FI FI952932A patent/FI118208B/fi not_active IP Right Cessation
- 1995-06-14 CN CNB95106567XA patent/CN1145641C/zh not_active Ceased
- 1995-06-14 GB GB9512105A patent/GB2290294B/en not_active Expired - Lifetime
- 1995-06-14 RO RO95-01141A patent/RO115124B1/ro unknown
- 1995-06-14 SE SE9502168A patent/SE509295C2/sv not_active IP Right Cessation
- 1995-06-14 IL IL11415395A patent/IL114153A/xx not_active IP Right Cessation
- 1995-06-14 GR GR950100228A patent/GR1002494B/el not_active IP Right Cessation
- 1995-06-14 DE DE19521753A patent/DE19521753B4/de not_active Expired - Lifetime
- 1995-06-14 CH CH02083/99A patent/CH693019A5/de not_active IP Right Cessation
- 1995-06-14 CH CH01764/95A patent/CH689934A5/de not_active IP Right Cessation
- 1995-06-14 BR BR9502797A patent/BR9502797A/pt not_active IP Right Cessation
- 1995-06-14 SI SI9500199A patent/SI9500199A/sl not_active IP Right Cessation
- 1995-06-14 AT AT0101795A patent/AT408611B/de not_active IP Right Cessation
- 1995-06-14 PE PE1995271265A patent/PE34496A1/es not_active IP Right Cessation
- 1995-06-14 KR KR1019950015781A patent/KR100386038B1/ko active IP Right Grant
- 1995-06-14 ES ES09501196A patent/ES2091728B1/es not_active Expired - Fee Related
- 1995-06-14 UA UA95062796A patent/UA34468C2/uk unknown
- 1995-06-14 NL NL1000565A patent/NL1000565C2/xx not_active IP Right Cessation
- 1995-06-14 CZ CZ19951543A patent/CZ294556B6/cs not_active IP Right Cessation
- 1995-06-14 IE IE950435A patent/IE68852B1/en not_active IP Right Cessation
- 1995-06-14 DK DK199500676A patent/DK176213B1/da not_active IP Right Cessation
-
1996
- 1996-11-29 NL NL1004643A patent/NL1004643C2/nl not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI952932A (fi) | Monomeeriset insuliinianalogivalmisteet | |
FI952931A0 (fi) | Insuliinianalogiformulaatioita | |
NO964106D0 (no) | Spröyte | |
FI971279A (fi) | Lääkkeitä | |
DE69510024D1 (de) | Spritze | |
EE9600122A (et) | Infuuser | |
DE69527782D1 (de) | Reibungsfreie spritze | |
KR920017793U (ko) | 드로우어웨이 팁 | |
BR9508339A (pt) | Medicamento | |
DE69521906D1 (de) | Zahnhygiene - präparate | |
BR9503004A (pt) | Conjunto de seringa | |
DE69522857D1 (de) | Insulinstandardlösung | |
FI951155A0 (fi) | Farmaseuttinen valmiste | |
DK137191A (da) | Insulinpraeparat | |
ATA194094A (de) | Artikulator | |
DE69521768D1 (de) | Zahnärztliche Spritze | |
DK88093D0 (da) | Stabilt praeparat | |
KR950022733U (ko) | 세척기 | |
DK103393D0 (da) | Praeparat | |
KR960016384U (ko) | 주사기 | |
KR950026744U (ko) | 주사기 | |
SE9403012D0 (sv) | Preparation | |
NO942021D0 (no) | Tannstikker | |
SE9302099L (sv) | Kanylprotes | |
FI1750U1 (fi) | Stol |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Patent granted |
Ref document number: 118208 Country of ref document: FI |
|
MA | Patent expired |