FR2721215B1 - Formulations d'analogues monomères de l'insuline. - Google Patents

Formulations d'analogues monomères de l'insuline.

Info

Publication number
FR2721215B1
FR2721215B1 FR9507095A FR9507095A FR2721215B1 FR 2721215 B1 FR2721215 B1 FR 2721215B1 FR 9507095 A FR9507095 A FR 9507095A FR 9507095 A FR9507095 A FR 9507095A FR 2721215 B1 FR2721215 B1 FR 2721215B1
Authority
FR
France
Prior art keywords
insulin monomer
analog formulations
monomer analog
formulations
insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9507095A
Other languages
English (en)
Other versions
FR2721215A1 (fr
Inventor
Felippis Michael Rosario De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22989963&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2721215(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR2721215A1 publication Critical patent/FR2721215A1/fr
Application granted granted Critical
Publication of FR2721215B1 publication Critical patent/FR2721215B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9507095A 1994-06-16 1995-06-14 Formulations d'analogues monomères de l'insuline. Expired - Lifetime FR2721215B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/260,633 US5461031A (en) 1994-06-16 1994-06-16 Monomeric insulin analog formulations

Publications (2)

Publication Number Publication Date
FR2721215A1 FR2721215A1 (fr) 1995-12-22
FR2721215B1 true FR2721215B1 (fr) 1997-08-14

Family

ID=22989963

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9507095A Expired - Lifetime FR2721215B1 (fr) 1994-06-16 1995-06-14 Formulations d'analogues monomères de l'insuline.

Country Status (37)

Country Link
US (3) US5461031A (fr)
JP (1) JP3812962B2 (fr)
KR (1) KR100386038B1 (fr)
CN (1) CN1145641C (fr)
AT (1) AT408611B (fr)
BE (1) BE1009409A5 (fr)
BR (1) BR9502797A (fr)
CA (1) CA2151564C (fr)
CH (2) CH693019A5 (fr)
CO (1) CO4410204A1 (fr)
CZ (1) CZ294556B6 (fr)
DE (1) DE19521753B4 (fr)
DK (1) DK176213B1 (fr)
ES (1) ES2091728B1 (fr)
FI (1) FI118208B (fr)
FR (1) FR2721215B1 (fr)
GB (1) GB2290294B (fr)
GR (1) GR1002494B (fr)
HU (1) HU218943B (fr)
IE (1) IE68852B1 (fr)
IL (1) IL114153A (fr)
IT (1) IT1276722B1 (fr)
LU (1) LU88627A1 (fr)
MY (1) MY116831A (fr)
NL (2) NL1000565C2 (fr)
NO (1) NO320808B1 (fr)
NZ (1) NZ272360A (fr)
PE (1) PE34496A1 (fr)
PL (1) PL183284B1 (fr)
PT (1) PT101723B (fr)
RO (1) RO115124B1 (fr)
SE (1) SE509295C2 (fr)
SI (1) SI9500199A (fr)
TW (1) TW347334B (fr)
UA (1) UA34468C2 (fr)
YU (1) YU39795A (fr)
ZA (1) ZA954941B (fr)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6024090A (en) * 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US6131567A (en) * 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
EP1607086A1 (fr) * 1993-01-29 2005-12-21 Aradigm Corporation Procédé d'utilisation d'insuline monomère en tant que moyen servant à améliorer la réproductibilité de l'insuline inhalée
US5888477A (en) * 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
DK72793D0 (da) * 1993-06-21 1993-06-21 Novo Nordisk As Nyt produkt
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5547929A (en) * 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
YU18596A (sh) * 1995-03-31 1998-07-10 Eli Lilly And Company Analogne formulacije monomernog insulina
DE69630527T2 (de) * 1995-06-30 2004-08-05 Novo Nordisk A/S Vorbeugung einer krankheit mit diabetes charakter
AU720484B2 (en) * 1996-06-20 2000-06-01 Novo Nordisk A/S Insulin preparations containing NaCl
JP3343129B2 (ja) * 1997-02-07 2002-11-11 ノボ ノルディスク アクティーゼルスカブ タンパク質の結晶化
US5898067A (en) * 1997-02-07 1999-04-27 Novo Nordisk A/S Crystallization of proteins
PE79099A1 (es) * 1997-06-13 1999-08-24 Lilly Co Eli Formulaciones de insulina estables
DK1283051T3 (da) * 1997-06-13 2006-10-16 Lilly Co Eli Stabile insulinformuleringer
PE123799A1 (es) * 1997-10-24 1999-12-13 Lilly Co Eli Composiciones insolubles de insulina
US6531448B1 (en) 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
US20010053761A1 (en) * 1998-01-08 2001-12-20 Dimarchi Richard Dennis Method for administering aspb28-human insulin
US20040214747A1 (en) * 1999-01-06 2004-10-28 Dimarchi Richard Dennis Method for administering monomeric insulin
US6624141B1 (en) * 1999-03-17 2003-09-23 The Regents Of The University Of Michigan Protamine fragment compositions and methods of use
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
CN1406131A (zh) * 2000-12-25 2003-03-26 株式会社资生堂 活化交感神经的香料组合物
JP4489352B2 (ja) * 2001-02-09 2010-06-23 ジェネンテック， インコーポレイテッド Ｉｇｆ−１の結晶化
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
MXPA04001560A (es) * 2001-08-28 2004-05-17 Lilly Co Eli Premezclas de glp-1 e insulina basal.
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US7166571B2 (en) 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US20030068361A1 (en) * 2001-10-09 2003-04-10 Rimona Margalit Liposome-encapsulated insulin formulations
CA2463803A1 (fr) * 2001-10-19 2003-05-01 Eli Lilly And Company Melanges biphasiques de glp-1 et d'insuline
AU2002346491A1 (en) * 2001-12-19 2003-07-09 Eli Lilly And Company Crystalline compositions for controlling blood glucose
US7601688B2 (en) * 2002-06-13 2009-10-13 Biocon Limited Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
US20060258561A1 (en) * 2003-03-13 2006-11-16 Novo Nordisk A/S Novel NPH insulin preparations
BRPI0411479A (pt) 2003-06-17 2006-07-25 Sembiosys Genetics Inc métodos para a produção de insulina em plantas
US20050054818A1 (en) * 2003-07-02 2005-03-10 Brader Mark Laurence Crystalline compositions for controlling blood glucose
WO2005012346A1 (fr) * 2003-07-25 2005-02-10 Conjuchem, Inc. Derives de l'insuline longue duree et procedes associes
US7658721B2 (en) * 2004-01-16 2010-02-09 Biodel Inc. Sublingual drug delivery device
US20080096800A1 (en) * 2004-03-12 2008-04-24 Biodel, Inc. Rapid mucosal gel or film insulin compositions
AU2005222613B2 (en) * 2004-03-12 2009-12-17 Biodel, Inc. Rapid acting drug delivery compositions
US20080085298A1 (en) * 2004-03-12 2008-04-10 Biodel, Inc. Rapid Mucosal Gel or Film Insulin Compositions
US20080090753A1 (en) * 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
UA103758C2 (ru) 2004-07-19 2013-11-25 Биокон Лимитед Конъюгаты олигомеров инсулина, их композиции и применение
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
JP2008513356A (ja) * 2004-08-09 2008-05-01 アリオス バイオファーマ インク． 合成高度糖鎖付加プロテアーゼ耐性ポリペプチド変異体、それを使用する経口製剤および方法
SI2918286T1 (sl) * 2004-10-05 2020-06-30 Novo Nordisk A/S Farmacevtski pripravek, ki vsebuje inzulin v kristalni obliki in tudi v obliki raztopine
CN101060856B (zh) 2004-11-22 2011-01-19 诺和诺德公司 可溶、稳定的含胰岛素制剂
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
US7713929B2 (en) * 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
US8084420B2 (en) * 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
CN100371346C (zh) * 2005-12-14 2008-02-27 浙江大学 人工合成胰岛素模拟肽及其应用
ATE557037T1 (de) * 2006-02-27 2012-05-15 Novo Nordisk As Insulin derivate
CA2649109A1 (fr) * 2006-04-12 2007-10-25 Biodel, Inc. Formulations de combinaison d'insuline a action prolongee et a action rapide
US8927015B2 (en) 2006-04-12 2015-01-06 Emisphere Technologies, Inc. Formulations for delivering insulin
CN101062948B (zh) * 2006-04-29 2010-05-12 上海生物泰生命科学研究有限公司 单体速效胰岛素及其制法和用途
WO2008124522A2 (fr) * 2007-04-04 2008-10-16 Biodel, Inc. Formulations contenant de l'amyline
US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
BRPI0818004B8 (pt) 2007-10-16 2021-05-25 Biocon Ltd composição farmacêutica sólida administrável por via oral e o processo da mesma.
AU2009204309B2 (en) * 2008-01-04 2012-11-22 Biodel, Inc. Insulin formulations for insulin release as a function of tissue glucose levels
WO2010028175A1 (fr) 2008-09-08 2010-03-11 The Board Of Trustees Of The Leland Stanford Junior University Modulateurs de l'activité de l'aldéhyde déshydrogénase et leurs procédés d'utilisation
EP2349279A4 (fr) 2008-10-28 2013-12-25 Univ Leland Stanford Junior Modulateurs d'aldéhyde déshydrogénase et procédés d'utilisation de ceux-ci
MA33064B1 (fr) * 2009-01-28 2012-02-01 Smartcells Inc Systemes à base de conjugués pour administration contrôlée de médicaments
WO2010088286A1 (fr) 2009-01-28 2010-08-05 Smartcells, Inc. Conjugués synthétiques et leurs utilisations
CN102316892B (zh) 2009-02-12 2014-06-04 西马生物医学计划公司 心肌营养素-1用于治疗代谢病的用途
US9060927B2 (en) * 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
WO2010107519A1 (fr) 2009-03-20 2010-09-23 Smartcells, Inc. Conjugués fonctionnalisés aux extrémités et leurs utilisations
HUP0900482A2 (en) * 2009-08-03 2011-03-28 Cera Med Kft Pharmaceutical formulation for oral administration
WO2012015692A2 (fr) 2010-07-28 2012-02-02 Smartcells, Inc. Polypeptides d'insuline exprimés de façon recombinante et utilisations de ceux-ci
MX347014B (es) * 2010-11-24 2017-04-07 Durect Corp Composición para administración de fármaco biodegradable.
AU2012208349A1 (en) 2011-01-20 2013-07-18 Zealand Pharma A/S Combination of acylated glucagon analogues with insulin analogues
WO2012149106A1 (fr) 2011-04-29 2012-11-01 The Board Of Trustees Of The Leland Stanford Junior University Compositions et procédés d'augmentation de la prolifération de cellules souches salivaires adultes
EP2925345B1 (fr) 2012-12-03 2018-09-05 Merck Sharp & Dohme Corp. Méthode de préparation d'insuline et d'analogues d'insuline à base du peptide de la partie terminale carboxy (ctp) o-glycosylé
EP2970124B1 (fr) 2013-03-14 2019-05-22 The Board of Trustees of the Leland Stanford Junior University Modulateurs de l'aldéhyde déshydrogénase-2 mitochondriale et leurs procédés d'utilisation
MX366852B (es) 2013-10-04 2019-07-25 Merck Sharp & Dohme Conjugados de insulina sensibles a glucosa.
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
CN105899191B (zh) * 2014-01-09 2020-06-16 赛诺菲 胰岛素类似物和/或胰岛素衍生物的稳定化不含甘油的药物制剂
WO2015106269A2 (fr) * 2014-01-13 2015-07-16 Thermalin Diabetes, Llc Formulations d'insuline à action rapide et systèmes d'administration pharmaceutique
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
DK3006045T3 (en) 2014-10-07 2017-07-17 Cyprumed Gmbh Pharmaceutical formulations for oral administration of peptide or protein drugs
WO2017163159A1 (fr) 2016-03-21 2017-09-28 Wockhardt Limited Composition pharmaceutique biphasique d'insuline humaine
KR102665710B1 (ko) 2017-08-24 2024-05-14 노보 노르디스크 에이/에스 Glp-1 조성물 및 그 용도
US11110063B2 (en) 2017-08-25 2021-09-07 MAIA Pharmaceuticals, Inc. Storage stable sincalide formulations
EP3727424A4 (fr) 2017-12-18 2021-10-27 Merck Sharp & Dohme Corp. Systèmes à base de conjugués pour l'administration contrôlée d'insuline
WO2019125879A2 (fr) 2017-12-18 2019-06-27 Merck Sharp & Dohme Corp. Systèmes à base de conjugués pour l'administration contrôlée d'insuline
CN110063932A (zh) * 2019-04-12 2019-07-30 浙江大学 一种多肽蛋白类药物的缓释组合物制剂及其制备方法
US20230082544A1 (en) 2020-02-18 2023-03-16 Novo Nordisk A/S Pharmaceutical formulations
AU2021247169A1 (en) 2020-03-31 2022-10-20 Protomer Technologies Inc. Conjugates for selective responsiveness to vicinal diols
CA3198757A1 (fr) 2020-11-19 2022-05-27 Protomer Technologies Inc. Composes aromatiques contenant du bore et analogues d'insuline
TW202409070A (zh) 2022-05-18 2024-03-01 美商普羅托莫科技公司 芳族含硼化合物及相關胰島素類似物

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2538018A (en) * 1944-04-04 1951-01-16 Nordisk Insulinlab Crystalline product of insulin and alkaline protein and process of making it
US2801953A (en) * 1952-02-28 1957-08-06 Hoechst Ag Process of preparing crystallized insulin preparations
US2849370A (en) * 1953-06-04 1958-08-26 Novo Terapeutisk Labortorium A Injectable insulin preparations with protracted effect and process of producing same
US3060093A (en) * 1957-07-18 1962-10-23 Nordisk Insulinlab Slowly acting insulin preparation in crystalline form and method of preparation
US3868358A (en) * 1971-04-30 1975-02-25 Lilly Co Eli Protamine-insulin product
DE3326473A1 (de) * 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
EP0280534B1 (fr) * 1987-02-25 1993-04-21 Novo Nordisk A/S Nouveaux dérivés de l'insuline
DE3717370A1 (de) * 1987-05-22 1988-12-01 Hoechst Ag Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus
EP0425482B1 (fr) * 1988-07-20 1993-08-18 Novo Nordisk A/S Analogues d'insuline humaine et preparations les contenant
WO1990007522A1 (fr) * 1988-12-23 1990-07-12 Novo Nordisk A/S Analogues d'insuline humaine
US5514646A (en) * 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
NZ232375A (en) * 1989-02-09 1992-04-28 Lilly Co Eli Insulin analogues modified at b29
DE122006000015I1 (de) * 1993-06-21 2006-06-29 Novo Nordisk As Asp-B28-Insulinkristalle
DK72793D0 (da) * 1993-06-21 1993-06-21 Novo Nordisk As Nyt produkt
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations

Also Published As

Publication number Publication date
HU9501717D0 (en) 1995-08-28
NO320808B1 (no) 2006-01-30
DK67695A (da) 1995-12-17
JPH083064A (ja) 1996-01-09
SE9502168L (sv) 1995-12-17
IL114153A (en) 2000-09-28
ES2091728A1 (es) 1996-11-01
UA34468C2 (uk) 2001-03-15
HUT71908A (en) 1996-02-28
CH693019A5 (de) 2003-01-31
NL1004643C2 (nl) 1997-02-12
NO952356L (no) 1995-12-18
HU218943B (hu) 2001-01-29
GR1002494B (el) 1996-12-12
ATA101795A (de) 2001-06-15
FI952932A0 (fi) 1995-06-14
CN1145641C (zh) 2004-04-14
AT408611B (de) 2002-01-25
DE19521753A1 (de) 1995-12-21
IT1276722B1 (it) 1997-11-03
IE950435A1 (en) 1995-12-27
MY116831A (en) 2004-04-30
ES2091728B1 (es) 1998-02-01
ITMI951277A0 (it) 1995-06-14
GB9512105D0 (en) 1995-08-09
SE9502168D0 (sv) 1995-06-14
DK176213B1 (da) 2007-02-12
SE509295C2 (sv) 1999-01-11
SI9500199A (en) 1996-02-29
CZ154395A3 (en) 1996-02-14
FI118208B (fi) 2007-08-31
FI952932A (fi) 1995-12-17
GB2290294B (en) 1999-03-17
PL309100A1 (en) 1995-12-27
IE68852B1 (en) 1996-07-24
RO115124B1 (ro) 1999-11-30
NO952356D0 (no) 1995-06-14
CZ294556B6 (cs) 2005-02-16
PE34496A1 (es) 1996-10-01
KR960000923A (ko) 1996-01-25
FR2721215A1 (fr) 1995-12-22
BR9502797A (pt) 1996-03-12
TW347334B (en) 1998-12-11
NZ272360A (en) 1997-02-24
US5747642A (en) 1998-05-05
DE19521753B4 (de) 2009-07-23
PT101723A (pt) 1995-12-29
CA2151564C (fr) 2003-02-11
JP3812962B2 (ja) 2006-08-23
US5650486A (en) 1997-07-22
CH689934A5 (de) 2000-02-15
ITMI951277A1 (it) 1996-12-14
ZA954941B (en) 1996-12-17
NL1000565C2 (nl) 1996-12-03
LU88627A1 (fr) 1996-02-01
YU39795A (sh) 1998-05-15
NL1000565A1 (nl) 1995-12-18
IL114153A0 (en) 1995-10-31
US5461031A (en) 1995-10-24
CA2151564A1 (fr) 1995-12-17
BE1009409A5 (fr) 1997-03-04
PL183284B1 (pl) 2002-06-28
PT101723B (pt) 1997-02-28
GB2290294A (en) 1995-12-20
CO4410204A1 (es) 1997-01-09
KR100386038B1 (ko) 2003-08-27
NL1004643A1 (nl) 1996-12-17
CN1116629A (zh) 1996-02-14

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