DK175696B1 - 5'-Indolinyloxazolidin-2-oner med farmaceutisk acceptable salte deraf - Google Patents

5'-Indolinyloxazolidin-2-oner med farmaceutisk acceptable salte deraf Download PDF

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Publication number
DK175696B1
DK175696B1 DK199100455A DK45591A DK175696B1 DK 175696 B1 DK175696 B1 DK 175696B1 DK 199100455 A DK199100455 A DK 199100455A DK 45591 A DK45591 A DK 45591A DK 175696 B1 DK175696 B1 DK 175696B1
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DK
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Prior art keywords
alkyl
acetamidomethyl
oxazolidin
optionally substituted
defined above
Prior art date
Application number
DK199100455A
Other languages
Danish (da)
English (en)
Other versions
DK45591D0 (da
DK45591A (da
Inventor
Steven J Brickner
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DK45591D0 publication Critical patent/DK45591D0/da
Publication of DK45591A publication Critical patent/DK45591A/da
Priority to DK200401246A priority Critical patent/DK175940B1/da
Application granted granted Critical
Publication of DK175696B1 publication Critical patent/DK175696B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK199100455A 1988-09-15 1991-03-13 5'-Indolinyloxazolidin-2-oner med farmaceutisk acceptable salte deraf DK175696B1 (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK200401246A DK175940B1 (da) 1988-09-15 2004-08-18 3-(Nitrogensubstituerede)-phenyl-5beta-aminomethyloxazolidin-2-oner og farmaceutisk acceptable salte deraf samt anvendelse af disse forbindelser til fremstilling af et lægemiddel

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US24498888A 1988-09-15 1988-09-15
US24498888 1988-09-15
US25385088A 1988-10-05 1988-10-05
US25385088 1988-10-05
US32494289A 1989-03-17 1989-03-17
US32494289 1989-03-17
PCT/US1989/003548 WO1990002744A1 (en) 1988-09-15 1989-08-22 In position 3 substituted-5-beta-amidomethyl-oxazolidin-2-ones
US8903548 1989-08-22

Publications (3)

Publication Number Publication Date
DK45591D0 DK45591D0 (da) 1991-03-13
DK45591A DK45591A (da) 1991-03-13
DK175696B1 true DK175696B1 (da) 2005-01-24

Family

ID=27399816

Family Applications (2)

Application Number Title Priority Date Filing Date
DK199100455A DK175696B1 (da) 1988-09-15 1991-03-13 5'-Indolinyloxazolidin-2-oner med farmaceutisk acceptable salte deraf
DK200401246A DK175940B1 (da) 1988-09-15 2004-08-18 3-(Nitrogensubstituerede)-phenyl-5beta-aminomethyloxazolidin-2-oner og farmaceutisk acceptable salte deraf samt anvendelse af disse forbindelser til fremstilling af et lægemiddel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK200401246A DK175940B1 (da) 1988-09-15 2004-08-18 3-(Nitrogensubstituerede)-phenyl-5beta-aminomethyloxazolidin-2-oner og farmaceutisk acceptable salte deraf samt anvendelse af disse forbindelser til fremstilling af et lægemiddel

Country Status (14)

Country Link
EP (3) EP0359418B1 (ja)
JP (2) JP2865211B2 (ja)
KR (1) KR0138262B1 (ja)
AT (2) ATE201870T1 (ja)
AU (1) AU617871B2 (ja)
CA (1) CA1335103C (ja)
DE (2) DE68929303T2 (ja)
DK (2) DK175696B1 (ja)
ES (1) ES2157934T3 (ja)
GR (1) GR3036491T3 (ja)
HK (1) HK1002234A1 (ja)
LV (1) LV12888B (ja)
TW (1) TW219936B (ja)
WO (1) WO1990002744A1 (ja)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
RU2160736C2 (ru) * 1990-06-07 2000-12-20 Зенека Лимитед Производные индола и их физиологически приемлемые соли и сольваты, способы их получения, лекарственное средство для лечения или профилактики клинических состояний, для которых показан прием агониста "5-нт1-подобного" рецептора, и способ его получения
BR9206353A (pt) * 1991-08-14 1995-11-07 Procter & Gamble Pharma Uretanos cíclicos utilizáveis como agentes antiarrítmicos e antifibrilatórios
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
EP0648119A1 (en) * 1992-07-08 1995-04-19 The Upjohn Company 5'-INDOLINYL OXAZOLIDINONES USEFUL AGAINST $i(MYCOBACTERIUM TUBERCULOSIS)
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
DE4425609A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Benzofuranyl- und Benzothienyloxazolidinone
DE4425612A1 (de) * 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
DE4425613A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
DE19514313A1 (de) * 1994-08-03 1996-02-08 Bayer Ag Benzoxazolyl- und Benzothiazolyloxazolidinone
EP0788498B1 (en) * 1994-10-26 2001-08-16 PHARMACIA & UPJOHN COMPANY Phenyloxazolidinone antimicrobials
US5952324A (en) * 1994-11-15 1999-09-14 Pharmacia & Upjohn Company Bicyclic oxazine and thiazine oxazolidinone antibacterials
KR100441334B1 (ko) * 1995-02-03 2004-10-20 파마시아 앤드 업존 캄파니 헤테로-방향족고리치환된페닐옥사졸리딘온항균제
HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
DK0828741T3 (da) * 1995-05-11 2001-11-26 Upjohn Co Spirocykliske og bicykliske diazinyl- og carbazinyloxazolidinoner
MX9703040A (es) * 1995-09-12 1997-07-31 Upjohn Co Antimicrobianos de feniloxazolidinona.
ZA968661B (en) * 1995-11-17 1998-04-14 Upjohn Co Oxazolidinone antibacterial agent with tricyclic substituents.
DE19601265A1 (de) 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
DE19601264A1 (de) * 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
DE19601627A1 (de) 1996-01-18 1997-07-24 Bayer Ag Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
HRP970049A2 (en) 1996-02-06 1998-04-30 Bayer Ag New heteroaryl oxazolidinones
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
US6255304B1 (en) 1997-05-30 2001-07-03 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
US6218413B1 (en) * 1997-05-30 2001-04-17 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
DE19730847A1 (de) * 1997-07-18 1999-01-28 Bayer Ag Tricyclisch substituierte Oxazolidinone
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
CA2303959A1 (en) * 1997-11-12 1999-05-20 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
DE19802239A1 (de) * 1998-01-22 1999-07-29 Bayer Ag Neue mit Bicyclen substituierte Oxazolidinone
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
NZ505902A (en) 1998-01-23 2003-08-29 Upjohn Co Oxazolidinone compounds useful as antimicrobial agents and combinatorial libraries
WO2000073301A1 (en) 1999-05-27 2000-12-07 Pharmacia & Upjohn Company Bicyclic oxazolidinones as antibacterial agent
JP2003513885A (ja) 1999-07-28 2003-04-15 ファルマシア・アンド・アップジョン・カンパニー オキサゾリジノンおよび抗感染薬としてのその使用
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US6734307B2 (en) 2000-07-17 2004-05-11 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
AU9654201A (en) 2000-10-02 2002-04-15 Univ Emory Triptolide analogs for the treatment of autoimmune and inflammatory disorders
PE20020689A1 (es) * 2000-11-17 2002-08-03 Upjohn Co Oxazolidinonas con un heterociclo de 6 o 7 miembros unidos con enlace anular al benceno
US6956040B2 (en) 2001-07-16 2005-10-18 Ranbaxy Laboratories Limited Oxazolidinone piperazinyl derivatives as potential antimicrobials
GB0118407D0 (en) * 2001-07-27 2001-09-19 Cipla Ltd Oxazolidinone derivatives as antibacterial agents
TW200306819A (en) 2002-01-25 2003-12-01 Vertex Pharma Indazole compounds useful as protein kinase inhibitors
US7012088B2 (en) * 2003-02-24 2006-03-14 Pharmacia & Upjohn Company Indolone oxazolidinones and derivatives thereof
AP2007003904A0 (en) * 2004-08-06 2007-02-28 Pharmacia & Upjohn Co Llc Oxazolidinones containing oxindoles as antibacterial agents
SE0402763D0 (sv) * 2004-11-11 2004-11-11 Astrazeneca Ab Nitro indazole derivatives
EA200701895A1 (ru) * 2005-04-06 2008-04-28 ФАРМАЦИЯ ЭНД АПДЖОН КОМПАНИ ЭлЭлСи Оксиндол-оксазолидинон в качестве антибактериального агента
AU2006231919A1 (en) 2005-04-06 2006-10-12 Pharmacia & Upjohn Company Llc 7-fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents
US8461388B2 (en) * 2007-12-24 2013-06-11 Cipla Limited Process for the synthesis of propargylated aminoindan derivatives
CA2794153C (en) 2010-03-25 2018-01-02 Glaxosmithkline Llc Substituted indoline derivatives as perk inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8506659A1 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents

Also Published As

Publication number Publication date
EP0609905A1 (en) 1994-08-10
AU4195789A (en) 1990-04-02
HK1002234A1 (en) 1998-08-07
JPH04500665A (ja) 1992-02-06
ATE112773T1 (de) 1994-10-15
GR3036491T3 (en) 2001-11-30
DE68918792D1 (de) 1994-11-17
LV12888B (en) 2002-12-20
EP0359418B1 (en) 1994-10-12
WO1990002744A1 (en) 1990-03-22
DE68929303D1 (de) 2001-07-12
EP0609905B1 (en) 2001-06-06
DK200401246A (da) 2004-08-18
EP0359418A1 (en) 1990-03-21
KR0138262B1 (ko) 1998-05-15
KR900701780A (ko) 1990-12-04
DE68918792T2 (de) 1995-03-30
AU617871B2 (en) 1991-12-05
DK45591D0 (da) 1991-03-13
JP3188418B2 (ja) 2001-07-16
ES2157934T3 (es) 2001-09-01
JP2865211B2 (ja) 1999-03-08
DK45591A (da) 1991-03-13
ATE201870T1 (de) 2001-06-15
EP0434714A1 (en) 1991-07-03
DE68929303T2 (de) 2002-05-02
JPH1180139A (ja) 1999-03-26
TW219936B (ja) 1994-02-01
CA1335103C (en) 1995-04-04
DK175940B1 (da) 2005-08-01

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