DK174927B1 - DNA, der koder for human faktor VIII:C, vektor omfattende denne DNA, transformeret vært omfattende denne DNA, og fremgangsmåde til fremstilling af human faktor VIII:C - Google Patents
DNA, der koder for human faktor VIII:C, vektor omfattende denne DNA, transformeret vært omfattende denne DNA, og fremgangsmåde til fremstilling af human faktor VIII:C Download PDFInfo
- Publication number
- DK174927B1 DK174927B1 DK198502923A DK292385A DK174927B1 DK 174927 B1 DK174927 B1 DK 174927B1 DK 198502923 A DK198502923 A DK 198502923A DK 292385 A DK292385 A DK 292385A DK 174927 B1 DK174927 B1 DK 174927B1
- Authority
- DK
- Denmark
- Prior art keywords
- ser
- cac
- leu
- cca
- clu
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54665083 | 1983-10-28 | ||
US06/546,650 US4757006A (en) | 1983-10-28 | 1983-10-28 | Human factor VIII:C gene and recombinant methods for production |
US64403684A | 1984-08-24 | 1984-08-24 | |
US64403684 | 1984-08-24 | ||
US8401641 | 1984-10-12 | ||
PCT/US1984/001641 WO1985001961A1 (fr) | 1983-10-28 | 1984-10-12 | Production du facteur viii et des produits relatifs |
Publications (3)
Publication Number | Publication Date |
---|---|
DK292385A DK292385A (da) | 1985-06-27 |
DK292385D0 DK292385D0 (da) | 1985-06-27 |
DK174927B1 true DK174927B1 (da) | 2004-03-01 |
Family
ID=27068312
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK198502923A DK174927B1 (da) | 1983-10-28 | 1985-06-27 | DNA, der koder for human faktor VIII:C, vektor omfattende denne DNA, transformeret vært omfattende denne DNA, og fremgangsmåde til fremstilling af human faktor VIII:C |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0162067B1 (fr) |
JP (4) | JPH07106156B2 (fr) |
DK (1) | DK174927B1 (fr) |
ES (4) | ES8700868A1 (fr) |
FI (1) | FI86436C (fr) |
IE (1) | IE57884B1 (fr) |
IT (1) | IT1177066B (fr) |
MX (1) | MX9203437A (fr) |
WO (1) | WO1985001961A1 (fr) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ210501A (en) * | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
US4703008A (en) * | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
KR850004274A (ko) * | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
US4716117A (en) * | 1984-10-26 | 1987-12-29 | Chiron Corporation | Monoclonal antibodies to factor VIIIC |
US5004804A (en) * | 1984-01-12 | 1991-04-02 | Nordisk Gentofte | Method and composition for preparation of factor VIIIC |
DE10399011I1 (de) * | 1984-01-12 | 2003-10-23 | Chiron Corp | F}r Fakton-VIIIc kodierende DNA-Sequenzen und ver wandte DNA-Konstruktionen |
US5045455A (en) * | 1984-01-12 | 1991-09-03 | Chiron Corporation | Factor VIII:C cDNA cloning and expression |
ZA852099B (en) * | 1984-03-26 | 1985-12-24 | Meloy Lab | Recombinant factor viii-c. |
IL74909A (en) * | 1984-04-20 | 1992-01-15 | Genentech Inc | Preparation of functional human factor viii and dna sequences,expression vectors,transformed microorganisms and cell lines used therein |
US4965199A (en) * | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
EP0182448A3 (fr) * | 1984-08-24 | 1987-10-28 | Genetics Institute, Inc. | Production de facteur VIII et produits apparentés |
JPS62502589A (ja) * | 1985-04-11 | 1987-10-08 | ザ・チヤイルドレンズ・メデイカル・センタ−・コ−ポレ−シヨン | フオン・ビルブラント因子 |
US8597910B1 (en) | 1985-04-11 | 2013-12-03 | Children's Medical Center Corporation | DNA encoding Von Willebrand Factor (VWF) and methods and cells for producing VFW, and VFW produced by the DNA, methods and cells |
DE3531360A1 (de) * | 1985-09-03 | 1987-05-07 | Merck Patent Gmbh | Dna-sequenzen, rekombinante dna-molekuele und verfahren zur herstellung des enzyms mutarotase aus acinetobacter calcoaceticus |
US5250421A (en) * | 1986-01-03 | 1993-10-05 | Genetics Institute, Inc. | Method for producing factor VIII:C-type proteins |
DE3785102T2 (de) * | 1986-01-03 | 1993-07-22 | Genetics Inst | Verfahren zur herstellung von faktor-viii:c-typ-proteinen. |
US5198349A (en) * | 1986-01-03 | 1993-03-30 | Genetics Institute, Inc. | Method for producing factor VIII:C and analogs |
US5595886A (en) * | 1986-01-27 | 1997-01-21 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
FR2599754B1 (fr) * | 1986-06-06 | 1989-12-29 | Transgene Sa | Procede de preparation de facteur viii a partir de cellules de mammiferes |
EP0254076B1 (fr) | 1986-07-11 | 1991-05-08 | Miles Inc. | Protéine recombinante |
JP2872255B2 (ja) * | 1987-01-30 | 1999-03-17 | バイオジエン,インコーポレイティド | ファクター▲viii▼の高収量生産法 |
CA1331157C (fr) * | 1987-04-06 | 1994-08-02 | Randal J. Kaufman | Methode de production du facteur viii : proteines de type c |
US6060447A (en) * | 1987-05-19 | 2000-05-09 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
EP0294910B1 (fr) | 1987-06-12 | 1996-09-11 | Immuno Ag | Protéines à activité de facteur VIII, procédé pour leur production utilisant des cellules modifiées par génie génétique et compositions pharmaceutiques les contenant |
EP0500734B1 (fr) * | 1989-11-17 | 1998-02-11 | Novo Nordisk A/S | Complexes de proteines presentant l'activite du facteur viii:c, et leur production |
US5155218A (en) | 1990-05-08 | 1992-10-13 | Neurogenetic Corporation | Dna encoding human 5-ht1d receptors |
DK53792D0 (da) * | 1992-04-24 | 1992-04-24 | Novo Nordisk As | Fremgangsmaade til fremstilling af proteiner |
US5563045A (en) * | 1992-11-13 | 1996-10-08 | Genetics Institute, Inc. | Chimeric procoagulant proteins |
US5910481A (en) * | 1995-11-13 | 1999-06-08 | Immuno Ag | Hybrid proteins with modified activity |
US6221349B1 (en) | 1998-10-20 | 2001-04-24 | Avigen, Inc. | Adeno-associated vectors for expression of factor VIII by target cells |
US6200560B1 (en) | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
JP5054975B2 (ja) | 2003-09-30 | 2012-10-24 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | アデノ随伴ウイルス(aav)の同源系統群、配列、それらを含有するベクターおよびそれらの用途 |
WO2005123928A1 (fr) * | 2004-06-08 | 2005-12-29 | Battelle Memorial Institute | Production du facteur viii de coagulation humain à partir de cellules végétales et de plantes entières |
JP5702519B2 (ja) | 2005-04-07 | 2015-04-15 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | Aavベクターの機能を上げる方法 |
US20130023033A1 (en) | 2010-03-29 | 2013-01-24 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
US9315825B2 (en) | 2010-03-29 | 2016-04-19 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
ES2724800T3 (es) | 2011-02-17 | 2019-09-16 | Univ Pennsylvania | Composiciones y métodos para alterar la especificidad de tejido y mejorar la transferencia génica mediada por AAV9 |
US9719106B2 (en) | 2013-04-29 | 2017-08-01 | The Trustees Of The University Of Pennsylvania | Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof |
ES2763551T3 (es) | 2015-04-16 | 2020-05-29 | Univ Emory | Promotores y vectores recombinantes para la expresión de proteínas en el hígado y uso de los mismos |
US20240043494A1 (en) | 2020-08-07 | 2024-02-08 | Amicus Therapeutics, Inc. | Vesicle Targeting Proteins And Uses Of Same |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US602312A (en) * | 1898-04-12 | eades | ||
US4361509A (en) * | 1981-12-14 | 1982-11-30 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
US4663280A (en) * | 1983-05-19 | 1987-05-05 | Public Health Research Institute Of The City Of New York | Expression and secretion vectors and method of constructing vectors |
IE81141B1 (en) * | 1983-06-24 | 2000-04-05 | Genencor Int | Procaryotic carbonyl hydrolases |
DE10399011I1 (de) * | 1984-01-12 | 2003-10-23 | Chiron Corp | F}r Fakton-VIIIc kodierende DNA-Sequenzen und ver wandte DNA-Konstruktionen |
ZA852099B (en) * | 1984-03-26 | 1985-12-24 | Meloy Lab | Recombinant factor viii-c. |
IL74909A (en) * | 1984-04-20 | 1992-01-15 | Genentech Inc | Preparation of functional human factor viii and dna sequences,expression vectors,transformed microorganisms and cell lines used therein |
-
1984
- 1984-10-12 WO PCT/US1984/001641 patent/WO1985001961A1/fr active IP Right Grant
- 1984-10-12 JP JP59504050A patent/JPH07106156B2/ja not_active Expired - Lifetime
- 1984-10-12 EP EP84904025A patent/EP0162067B1/fr not_active Expired - Lifetime
- 1984-10-23 IE IE2734/84A patent/IE57884B1/en not_active IP Right Cessation
- 1984-10-26 ES ES537146A patent/ES8700868A1/es not_active Expired
- 1984-10-26 IT IT23351/84A patent/IT1177066B/it active
-
1985
- 1985-06-27 FI FI852547A patent/FI86436C/fi not_active IP Right Cessation
- 1985-06-27 DK DK198502923A patent/DK174927B1/da active Protection Beyond IP Right Term
- 1985-09-02 ES ES546653A patent/ES8800987A1/es not_active Expired
- 1985-09-02 ES ES546654A patent/ES8800359A1/es not_active Expired
- 1985-09-02 ES ES546655A patent/ES8704546A1/es not_active Expired
-
1989
- 1989-08-21 JP JP1215851A patent/JPH02227078A/ja active Pending
- 1989-08-21 JP JP1215850A patent/JPH02182188A/ja active Pending
-
1992
- 1992-06-26 MX MX9203437A patent/MX9203437A/es unknown
-
1993
- 1993-01-20 JP JP5024748A patent/JP2549049B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES8704546A1 (es) | 1987-04-01 |
MX9203437A (es) | 1992-07-01 |
ES537146A0 (es) | 1986-10-16 |
IE57884B1 (en) | 1993-05-05 |
FI86436C (fi) | 1992-08-25 |
JPS61500646A (ja) | 1986-04-10 |
ES8800359A1 (es) | 1987-10-16 |
ES546654A0 (es) | 1987-10-16 |
JP2549049B2 (ja) | 1996-10-30 |
EP0162067A1 (fr) | 1985-11-27 |
EP0162067B1 (fr) | 1992-07-15 |
EP0162067A4 (fr) | 1988-03-22 |
IT8423351A0 (it) | 1984-10-26 |
DK292385A (da) | 1985-06-27 |
IT1177066B (it) | 1987-08-26 |
JPH0690763A (ja) | 1994-04-05 |
JPH07106156B2 (ja) | 1995-11-15 |
ES546655A0 (es) | 1987-04-01 |
DK292385D0 (da) | 1985-06-27 |
JPH02182188A (ja) | 1990-07-16 |
WO1985001961A1 (fr) | 1985-05-09 |
FI86436B (fi) | 1992-05-15 |
FI852547L (fi) | 1985-06-27 |
ES546653A0 (es) | 1987-12-16 |
JPH02227078A (ja) | 1990-09-10 |
ES8800987A1 (es) | 1987-12-16 |
ES8700868A1 (es) | 1986-10-16 |
FI852547A0 (fi) | 1985-06-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUP | Patent expired | ||
CTFF | Application for supplementary protection certificate (spc) filed |
Spc suppl protection certif: CA 2004 00019 Filing date: 20040618 Expiry date: 20071204 |
|
CTFW | Supplementary protection certificate (spc) withdrawn, refused or deemed withdrawn |
Free format text: PRODUCT NAME: OCTOCOG ALFA (REKOMBINANT KOAGULATIONSFAKTOR VIII) Spc suppl protection certif: CA 2004 00019 Filing date: 20040618 |
|
CTFW | Supplementary protection certificate (spc) withdrawn, refused or deemed withdrawn |
Free format text: PRODUCT NAME: OCTOCOG ALFA (REKOMBINANT KOAGULATIONSFAKTOR VIII) Spc suppl protection certif: CA 2004 00019 Filing date: 20040618 |