DK292385A - Fremstilling af faktor viii og beslaegtede produkter. - Google Patents

Fremstilling af faktor viii og beslaegtede produkter. Download PDF

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Publication number
DK292385A
DK292385A DK292385A DK292385A DK292385A DK 292385 A DK292385 A DK 292385A DK 292385 A DK292385 A DK 292385A DK 292385 A DK292385 A DK 292385A DK 292385 A DK292385 A DK 292385A
Authority
DK
Denmark
Prior art keywords
manufacture
factor viii
related products
products
viii
Prior art date
Application number
DK292385A
Other languages
English (en)
Other versions
DK292385D0 (da
DK174927B1 (da
Inventor
John J Toole Jr
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27068312&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK292385(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/546,650 external-priority patent/US4757006A/en
Application filed by Genetics Inst filed Critical Genetics Inst
Publication of DK292385D0 publication Critical patent/DK292385D0/da
Publication of DK292385A publication Critical patent/DK292385A/da
Application granted granted Critical
Publication of DK174927B1 publication Critical patent/DK174927B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK198502923A 1983-10-28 1985-06-27 DNA, der koder for human faktor VIII:C, vektor omfattende denne DNA, transformeret vært omfattende denne DNA, og fremgangsmåde til fremstilling af human faktor VIII:C DK174927B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US54665083 1983-10-28
US06/546,650 US4757006A (en) 1983-10-28 1983-10-28 Human factor VIII:C gene and recombinant methods for production
US64403684A 1984-08-24 1984-08-24
US64403684 1984-08-24
US8401641 1984-10-12
PCT/US1984/001641 WO1985001961A1 (en) 1983-10-28 1984-10-12 Production of factor viii and related products

Publications (3)

Publication Number Publication Date
DK292385D0 DK292385D0 (da) 1985-06-27
DK292385A true DK292385A (da) 1985-06-27
DK174927B1 DK174927B1 (da) 2004-03-01

Family

ID=27068312

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198502923A DK174927B1 (da) 1983-10-28 1985-06-27 DNA, der koder for human faktor VIII:C, vektor omfattende denne DNA, transformeret vært omfattende denne DNA, og fremgangsmåde til fremstilling af human faktor VIII:C

Country Status (9)

Country Link
EP (1) EP0162067B1 (da)
JP (4) JPH07106156B2 (da)
DK (1) DK174927B1 (da)
ES (4) ES8700868A1 (da)
FI (1) FI86436C (da)
IE (1) IE57884B1 (da)
IT (1) IT1177066B (da)
MX (1) MX9203437A (da)
WO (1) WO1985001961A1 (da)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703008A (en) * 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
NZ210501A (en) * 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
KR850004274A (ko) * 1983-12-13 1985-07-11 원본미기재 에리트로포이에틴의 제조방법
DE122004000028I1 (de) * 1984-01-12 2004-09-30 Chiron Corp F}r Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen.
US5004804A (en) * 1984-01-12 1991-04-02 Nordisk Gentofte Method and composition for preparation of factor VIIIC
US5045455A (en) * 1984-01-12 1991-09-03 Chiron Corporation Factor VIII:C cDNA cloning and expression
US4716117A (en) * 1984-10-26 1987-12-29 Chiron Corporation Monoclonal antibodies to factor VIIIC
ZA852099B (en) * 1984-03-26 1985-12-24 Meloy Lab Recombinant factor viii-c.
IL74909A (en) * 1984-04-20 1992-01-15 Genentech Inc Preparation of functional human factor viii and dna sequences,expression vectors,transformed microorganisms and cell lines used therein
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
EP0182448A3 (en) * 1984-08-24 1987-10-28 Genetics Institute, Inc. Production of factor viii and related products
US8597910B1 (en) 1985-04-11 2013-12-03 Children's Medical Center Corporation DNA encoding Von Willebrand Factor (VWF) and methods and cells for producing VFW, and VFW produced by the DNA, methods and cells
AU591671B2 (en) * 1985-04-11 1989-12-14 Children's Medical Center Corporation Von willebrand factor
DE3531360A1 (de) * 1985-09-03 1987-05-07 Merck Patent Gmbh Dna-sequenzen, rekombinante dna-molekuele und verfahren zur herstellung des enzyms mutarotase aus acinetobacter calcoaceticus
US5198349A (en) * 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
DE3785102T2 (de) * 1986-01-03 1993-07-22 Genetics Inst Verfahren zur herstellung von faktor-viii:c-typ-proteinen.
US5250421A (en) * 1986-01-03 1993-10-05 Genetics Institute, Inc. Method for producing factor VIII:C-type proteins
US5595886A (en) 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
FR2599754B1 (fr) * 1986-06-06 1989-12-29 Transgene Sa Procede de preparation de facteur viii a partir de cellules de mammiferes
EP0254076B1 (en) 1986-07-11 1991-05-08 Miles Inc. Improved recombinant protein production
AU606925B2 (en) * 1987-01-30 1991-02-21 Biogen, Inc. A method for producing factor viii in high yield
CA1331157C (en) * 1987-04-06 1994-08-02 Randal J. Kaufman Method for producing factor viii:c-type proteins
US6060447A (en) * 1987-05-19 2000-05-09 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
EP0690126B1 (en) 1987-06-12 2001-11-28 Baxter Aktiengesellschaft Novel proteins with factor VIII activitiy: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
EP0670332A3 (en) * 1989-11-17 1995-10-25 Novo Nordisk As Protein complexes with factor VIII: C activity and their production.
US5155218A (en) 1990-05-08 1992-10-13 Neurogenetic Corporation Dna encoding human 5-ht1d receptors
DK53792D0 (da) * 1992-04-24 1992-04-24 Novo Nordisk As Fremgangsmaade til fremstilling af proteiner
US5563045A (en) * 1992-11-13 1996-10-08 Genetics Institute, Inc. Chimeric procoagulant proteins
US5910481A (en) * 1995-11-13 1999-06-08 Immuno Ag Hybrid proteins with modified activity
US6200560B1 (en) 1998-10-20 2001-03-13 Avigen, Inc. Adeno-associated virus vectors for expression of factor VIII by target cells
US6221349B1 (en) 1998-10-20 2001-04-24 Avigen, Inc. Adeno-associated vectors for expression of factor VIII by target cells
CN102199626B (zh) 2003-09-30 2015-06-24 宾夕法尼亚大学托管会 腺伴随病毒(aav)进化支、序列、含有这些序列的载体及它们的应用
WO2005123928A1 (en) * 2004-06-08 2005-12-29 Battelle Memorial Institute Production of human coagulation factor viii from plant cells and whole plants
DK2359867T3 (da) 2005-04-07 2015-01-05 Univ Pennsylvania Fremgangsmåde til forøgelse af en AAV-vektors funktion
KR20130040844A (ko) 2010-03-29 2013-04-24 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 약학적으로 유발된 전이유전자 제거 시스템
US9315825B2 (en) 2010-03-29 2016-04-19 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
MX353930B (es) 2011-02-17 2018-02-02 Univ Pennsylvania Composiciones y metodos para alterar la especificidad tisular y mejorar la transferencia de genes mediada por vector viral adeno-asociado 9.
WO2015012924A2 (en) 2013-04-29 2015-01-29 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof
EP3626274A3 (en) 2015-04-16 2020-06-17 Emory University Recombinant promoters and vectors for protein expression in liver and use thereof
US20240043494A1 (en) 2020-08-07 2024-02-08 Amicus Therapeutics, Inc. Vesicle Targeting Proteins And Uses Of Same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US602312A (en) * 1898-04-12 eades
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4663280A (en) * 1983-05-19 1987-05-05 Public Health Research Institute Of The City Of New York Expression and secretion vectors and method of constructing vectors
IE81141B1 (en) * 1983-06-24 2000-04-05 Genencor Int Procaryotic carbonyl hydrolases
DE122004000028I1 (de) * 1984-01-12 2004-09-30 Chiron Corp F}r Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen.
ZA852099B (en) * 1984-03-26 1985-12-24 Meloy Lab Recombinant factor viii-c.
IL74909A (en) * 1984-04-20 1992-01-15 Genentech Inc Preparation of functional human factor viii and dna sequences,expression vectors,transformed microorganisms and cell lines used therein

Also Published As

Publication number Publication date
EP0162067A4 (en) 1988-03-22
IE57884B1 (en) 1993-05-05
JPH0690763A (ja) 1994-04-05
JPH02182188A (ja) 1990-07-16
EP0162067B1 (en) 1992-07-15
ES8700868A1 (es) 1986-10-16
ES537146A0 (es) 1986-10-16
FI86436C (fi) 1992-08-25
JPH02227078A (ja) 1990-09-10
DK292385D0 (da) 1985-06-27
EP0162067A1 (en) 1985-11-27
ES8800987A1 (es) 1987-12-16
FI852547L (fi) 1985-06-27
ES8704546A1 (es) 1987-04-01
DK174927B1 (da) 2004-03-01
JPH07106156B2 (ja) 1995-11-15
IT1177066B (it) 1987-08-26
WO1985001961A1 (en) 1985-05-09
JP2549049B2 (ja) 1996-10-30
ES546653A0 (es) 1987-12-16
ES8800359A1 (es) 1987-10-16
FI852547A0 (fi) 1985-06-27
FI86436B (fi) 1992-05-15
ES546654A0 (es) 1987-10-16
IT8423351A0 (it) 1984-10-26
ES546655A0 (es) 1987-04-01
MX9203437A (es) 1992-07-01
JPS61500646A (ja) 1986-04-10

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Legal Events

Date Code Title Description
PUP Patent expired
CTFF Application for supplementary protection certificate (spc) filed

Spc suppl protection certif: CA 2004 00019

Filing date: 20040618

Expiry date: 20071204

CTFW Supplementary protection certificate (spc) withdrawn, refused or deemed withdrawn

Free format text: PRODUCT NAME: OCTOCOG ALFA (REKOMBINANT KOAGULATIONSFAKTOR VIII)

Spc suppl protection certif: CA 2004 00019

Filing date: 20040618

CTFW Supplementary protection certificate (spc) withdrawn, refused or deemed withdrawn

Free format text: PRODUCT NAME: OCTOCOG ALFA (REKOMBINANT KOAGULATIONSFAKTOR VIII)

Spc suppl protection certif: CA 2004 00019

Filing date: 20040618