ES546654A0 - Metodo de produccion de factor viii:c humano - Google Patents

Metodo de produccion de factor viii:c humano

Info

Publication number
ES546654A0
ES546654A0 ES546654A ES546654A ES546654A0 ES 546654 A0 ES546654 A0 ES 546654A0 ES 546654 A ES546654 A ES 546654A ES 546654 A ES546654 A ES 546654A ES 546654 A0 ES546654 A0 ES 546654A0
Authority
ES
Spain
Prior art keywords
human
production method
factor viii
viii
factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES546654A
Other languages
English (en)
Other versions
ES8800359A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27068312&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES546654(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/546,650 external-priority patent/US4757006A/en
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Publication of ES546654A0 publication Critical patent/ES546654A0/es
Publication of ES8800359A1 publication Critical patent/ES8800359A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
ES546654A 1983-10-28 1985-09-02 Metodo de produccion de factor viii:c humano Expired ES8800359A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/546,650 US4757006A (en) 1983-10-28 1983-10-28 Human factor VIII:C gene and recombinant methods for production
US64403684A 1984-08-24 1984-08-24

Publications (2)

Publication Number Publication Date
ES546654A0 true ES546654A0 (es) 1987-10-16
ES8800359A1 ES8800359A1 (es) 1987-10-16

Family

ID=27068312

Family Applications (4)

Application Number Title Priority Date Filing Date
ES537146A Expired ES8700868A1 (es) 1983-10-28 1984-10-26 Metodo de aislamiento de un fragmento de gen que codifica por lo menos una porcion de una proteina.
ES546654A Expired ES8800359A1 (es) 1983-10-28 1985-09-02 Metodo de produccion de factor viii:c humano
ES546655A Expired ES8704546A1 (es) 1983-10-28 1985-09-02 Metodo de produccion de una proteina con actividad procoagu-lante del tipo de factor viii:c humano
ES546653A Expired ES8800987A1 (es) 1983-10-28 1985-09-02 Metodo de produccion del factor viii:c humano

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES537146A Expired ES8700868A1 (es) 1983-10-28 1984-10-26 Metodo de aislamiento de un fragmento de gen que codifica por lo menos una porcion de una proteina.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES546655A Expired ES8704546A1 (es) 1983-10-28 1985-09-02 Metodo de produccion de una proteina con actividad procoagu-lante del tipo de factor viii:c humano
ES546653A Expired ES8800987A1 (es) 1983-10-28 1985-09-02 Metodo de produccion del factor viii:c humano

Country Status (9)

Country Link
EP (1) EP0162067B1 (es)
JP (4) JPH07106156B2 (es)
DK (1) DK174927B1 (es)
ES (4) ES8700868A1 (es)
FI (1) FI86436C (es)
IE (1) IE57884B1 (es)
IT (1) IT1177066B (es)
MX (1) MX9203437A (es)
WO (1) WO1985001961A1 (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ210501A (en) * 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
US4703008A (en) * 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
KR850004274A (ko) * 1983-12-13 1985-07-11 원본미기재 에리트로포이에틴의 제조방법
US5004804A (en) * 1984-01-12 1991-04-02 Nordisk Gentofte Method and composition for preparation of factor VIIIC
JPH0826078B2 (ja) * 1984-01-12 1996-03-13 カイロン コーポレイション フアクタ−ｖ▲ｉｉｉ▼ｃ組成物
US4716117A (en) * 1984-10-26 1987-12-29 Chiron Corporation Monoclonal antibodies to factor VIIIC
US5045455A (en) * 1984-01-12 1991-09-03 Chiron Corporation Factor VIII:C cDNA cloning and expression
ZA852099B (en) * 1984-03-26 1985-12-24 Meloy Lab Recombinant factor viii-c.
FI86885C (fi) * 1984-04-20 1992-10-26 Genentech Inc Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
EP0182448A3 (en) * 1984-08-24 1987-10-28 Genetics Institute, Inc. Production of factor viii and related products
WO1986006096A1 (en) * 1985-04-11 1986-10-23 The Children's Medical Center Corporation Von willebrand factor
US8597910B1 (en) 1985-04-11 2013-12-03 Children's Medical Center Corporation DNA encoding Von Willebrand Factor (VWF) and methods and cells for producing VFW, and VFW produced by the DNA, methods and cells
DE3531360A1 (de) * 1985-09-03 1987-05-07 Merck Patent Gmbh Dna-sequenzen, rekombinante dna-molekuele und verfahren zur herstellung des enzyms mutarotase aus acinetobacter calcoaceticus
US5198349A (en) * 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
US5250421A (en) * 1986-01-03 1993-10-05 Genetics Institute, Inc. Method for producing factor VIII:C-type proteins
ATE87663T1 (de) * 1986-01-03 1993-04-15 Genetics Inst Verfahren zur herstellung von faktor-viii:c-typ- proteinen.
US5595886A (en) 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
FR2599754B1 (fr) * 1986-06-06 1989-12-29 Transgene Sa Procede de preparation de facteur viii a partir de cellules de mammiferes
EP0254076B1 (en) 1986-07-11 1991-05-08 Miles Inc. Improved recombinant protein production
EP0302925A4 (en) * 1987-01-30 1989-04-24 Biogen Nv METHOD FOR PRODUCING FACTOR VIII IN LARGE QUANTITIES.
CA1331157C (en) * 1987-04-06 1994-08-02 Randal J. Kaufman Method for producing factor viii:c-type proteins
US6060447A (en) * 1987-05-19 2000-05-09 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
EP0294910B1 (en) 1987-06-12 1996-09-11 Immuno Ag Novel proteins with factor VIII activity, process for their preparation using genetically engineered cells and pharmaceutical compositions containing them
JP2865861B2 (ja) * 1989-11-17 1999-03-08 ノボ ノルディスク アクティーゼルスカブ 第▲ｖｉｉｉ▼：ｃ因子活性を有するタンパク質複合体およびその製法
US5155218A (en) 1990-05-08 1992-10-13 Neurogenetic Corporation Dna encoding human 5-ht1d receptors
DK53792D0 (da) * 1992-04-24 1992-04-24 Novo Nordisk As Fremgangsmaade til fremstilling af proteiner
US5563045A (en) * 1992-11-13 1996-10-08 Genetics Institute, Inc. Chimeric procoagulant proteins
US5910481A (en) * 1995-11-13 1999-06-08 Immuno Ag Hybrid proteins with modified activity
US6221349B1 (en) 1998-10-20 2001-04-24 Avigen, Inc. Adeno-associated vectors for expression of factor VIII by target cells
US6200560B1 (en) 1998-10-20 2001-03-13 Avigen, Inc. Adeno-associated virus vectors for expression of factor VIII by target cells
ES2648241T3 (es) 2003-09-30 2017-12-29 The Trustees Of The University Of Pennsylvania Clados de virus adenoasociados (AAV), secuencias, vectores que contienen el mismo, y usos de los mismos
WO2005123928A1 (en) * 2004-06-08 2005-12-29 Battelle Memorial Institute Production of human coagulation factor viii from plant cells and whole plants
ES2525067T3 (es) 2005-04-07 2014-12-17 The Trustees Of The University Of Pennsylvania Método de incremento de la función de un vector de AAV
US9315825B2 (en) 2010-03-29 2016-04-19 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
CA2793633A1 (en) 2010-03-29 2011-10-13 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
BR112013020734A2 (pt) 2011-02-17 2017-06-13 Univ Pennsylvania composições e métodos para alterar a especificidade do tecido e aprimorar a transferência gênica mediada por aav9
WO2015012924A2 (en) 2013-04-29 2015-01-29 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof
CN115074366A (zh) 2015-04-16 2022-09-20 埃默里大学 用于肝脏中蛋白质表达的重组启动子和载体及其用途
US20240043494A1 (en) 2020-08-07 2024-02-08 Amicus Therapeutics, Inc. Vesicle Targeting Proteins And Uses Of Same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US602312A (en) * 1898-04-12 eades
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4663280A (en) * 1983-05-19 1987-05-05 Public Health Research Institute Of The City Of New York Expression and secretion vectors and method of constructing vectors
IE81141B1 (en) * 1983-06-24 2000-04-05 Genencor Int Procaryotic carbonyl hydrolases
JPH0826078B2 (ja) * 1984-01-12 1996-03-13 カイロン コーポレイション フアクタ−ｖ▲ｉｉｉ▼ｃ組成物
ZA852099B (en) * 1984-03-26 1985-12-24 Meloy Lab Recombinant factor viii-c.
FI86885C (fi) * 1984-04-20 1992-10-26 Genentech Inc Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill

Also Published As

Publication number Publication date
DK174927B1 (da) 2004-03-01
EP0162067A1 (en) 1985-11-27
ES537146A0 (es) 1986-10-16
JPS61500646A (ja) 1986-04-10
ES8800987A1 (es) 1987-12-16
EP0162067B1 (en) 1992-07-15
JPH02182188A (ja) 1990-07-16
FI852547A0 (fi) 1985-06-27
ES8800359A1 (es) 1987-10-16
DK292385A (da) 1985-06-27
FI852547L (fi) 1985-06-27
FI86436B (fi) 1992-05-15
JPH02227078A (ja) 1990-09-10
WO1985001961A1 (en) 1985-05-09
EP0162067A4 (en) 1988-03-22
IT1177066B (it) 1987-08-26
MX9203437A (es) 1992-07-01
JPH0690763A (ja) 1994-04-05
ES546653A0 (es) 1987-12-16
FI86436C (fi) 1992-08-25
JPH07106156B2 (ja) 1995-11-15
IE57884B1 (en) 1993-05-05
ES8704546A1 (es) 1987-04-01
JP2549049B2 (ja) 1996-10-30
ES546655A0 (es) 1987-04-01
DK292385D0 (da) 1985-06-27
IT8423351A0 (it) 1984-10-26
ES8700868A1 (es) 1986-10-16

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