DK174905B1 - DNA-sekvens og fremgangsmåde til den fremstilling, gærhybridvektorer og Saccharomyces cerevisiae indeholdende sekvensen henholdsvis vektoren og fremgangsmåder til deres fremstilling samt deres anvendelse ved fremstilling af polypeptider - Google Patents

DNA-sekvens og fremgangsmåde til den fremstilling, gærhybridvektorer og Saccharomyces cerevisiae indeholdende sekvensen henholdsvis vektoren og fremgangsmåder til deres fremstilling samt deres anvendelse ved fremstilling af polypeptider Download PDF

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Publication number
DK174905B1
DK174905B1 DK198303614A DK361483A DK174905B1 DK 174905 B1 DK174905 B1 DK 174905B1 DK 198303614 A DK198303614 A DK 198303614A DK 361483 A DK361483 A DK 361483A DK 174905 B1 DK174905 B1 DK 174905B1
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Denmark
Prior art keywords
yeast
dna
plasmid
fragment
saccharomyces cerevisiae
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DK198303614A
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Danish (da)
English (en)
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DK361483A (da
DK361483D0 (da
Inventor
Francois Meyer
Albert Hinnen
Bernd Meyhack
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Novartis Ag
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Priority claimed from GB838315145A external-priority patent/GB8315145D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of DK361483D0 publication Critical patent/DK361483D0/da
Publication of DK361483A publication Critical patent/DK361483A/da
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
DK198303614A 1982-08-09 1983-08-08 DNA-sekvens og fremgangsmåde til den fremstilling, gærhybridvektorer og Saccharomyces cerevisiae indeholdende sekvensen henholdsvis vektoren og fremgangsmåder til deres fremstilling samt deres anvendelse ved fremstilling af polypeptider DK174905B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB8222883 1982-08-09
GB8222883 1982-08-09
GB8237026 1982-12-31
GB8237026 1982-12-31
GB8315145 1983-06-02
GB838315145A GB8315145D0 (en) 1982-08-09 1983-06-02 Yeast hybrid vectors

Publications (3)

Publication Number Publication Date
DK361483D0 DK361483D0 (da) 1983-08-08
DK361483A DK361483A (da) 1984-02-10
DK174905B1 true DK174905B1 (da) 2004-02-16

Family

ID=27261693

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198303614A DK174905B1 (da) 1982-08-09 1983-08-08 DNA-sekvens og fremgangsmåde til den fremstilling, gærhybridvektorer og Saccharomyces cerevisiae indeholdende sekvensen henholdsvis vektoren og fremgangsmåder til deres fremstilling samt deres anvendelse ved fremstilling af polypeptider

Country Status (20)

Country Link
EP (1) EP0100561B1 (fi)
JP (2) JPH0653073B2 (fi)
AT (1) ATE43636T1 (fi)
AU (1) AU566348B2 (fi)
CA (1) CA1341381C (fi)
CY (1) CY1451A (fi)
DD (1) DD218118A5 (fi)
DE (1) DE3379960D1 (fi)
DK (1) DK174905B1 (fi)
ES (3) ES8505724A1 (fi)
FI (1) FI80720C (fi)
GB (1) GB2125047B (fi)
GR (1) GR78924B (fi)
HK (1) HK90688A (fi)
HU (1) HU204095B (fi)
IE (1) IE55598B1 (fi)
NO (1) NO172548C (fi)
NZ (1) NZ205178A (fi)
PH (1) PH25617A (fi)
PT (1) PT77167B (fi)

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GB2125047B (en) * 1982-08-09 1986-02-19 Ciba Geigy Ag Yeast hybrid vectors and their use for the production of polypeptides
DE3381566D1 (de) * 1982-08-16 1990-06-21 Agency Science & Tech Hepatitis-b-virus-gen enthaltendes rekombinantes plasmid, mit diesem rekombinanten plasmid transformierte hefe und herstellung von hepatitis-b-virus-oberflaechenantigen.
JPS5936699A (ja) * 1982-08-20 1984-02-28 Chemo Sero Therapeut Res Inst シヤトルベクタ−
JPS5931799A (ja) * 1982-08-16 1984-02-20 Science & Tech Agency Ｂ型肝炎ウイルス遺伝子を組込んだ組換えプラスミド
AU584580B2 (en) * 1982-09-08 1989-06-01 Smith Kline - Rit Hepatitis B virus vaccine
JPS5974988A (ja) * 1982-10-20 1984-04-27 Suntory Ltd 酵母の誘導発現型プラスミドベクタ−およびその利用方法
ZA843275B (en) * 1983-05-05 1984-12-24 Hoffmann La Roche Novel vectors for interferon expression
DD229151A5 (de) * 1983-11-21 1985-10-30 Ciba Geigy Ag Verfahren zur herstellung von gewebeplasminogenaktivatoren
JPS60248181A (ja) * 1984-05-23 1985-12-07 Shiseido Co Ltd 酵母発現ベクタ−
AU600885B2 (en) * 1984-05-25 1990-08-30 Zymogenetics Inc. Stable DNA constructs
US5723292A (en) * 1984-05-25 1998-03-03 Zymogenetics, Inc. Stable DNA constructs
GB8415186D0 (en) * 1984-06-14 1984-07-18 Ciba Geigy Ag Polypeptides
WO1986000638A1 (en) * 1984-07-09 1986-01-30 Lemontt Jeffrey F Yeast cloning vehicle
EP0188555A4 (en) * 1984-07-09 1988-04-18 Integrated Genetics Inc YEAST CLONING VEHICLE.
WO1986000923A1 (en) * 1984-07-31 1986-02-13 Integrated Genetics, Inc. Yeast cloning vehicles
JPS61103895A (ja) * 1984-10-26 1986-05-22 Green Cross Corp:The ＨＢｓＡｇの精製方法
EP0184575B1 (en) * 1984-12-06 1993-04-28 Fina Research S.A. Transformed yeasts producing lysozyme, plasmids used for this transformation, and uses thereof
DE3685044D1 (de) * 1985-02-01 1992-06-04 Ici Plc Analoge interferon-polypeptide, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
GB8521496D0 (en) * 1985-08-29 1985-10-02 Ciba Geigy Ag Repressible yeast promoters
EP0216573B1 (en) * 1985-09-18 1990-11-22 Green Cross Corporation Yeast promoter and method of producing heterologous proteins
JPS62151183A (ja) * 1985-09-18 1987-07-06 Green Cross Corp:The 酵母プロモ−タ−及び異種蛋白質の製造方法
GB8530631D0 (en) 1985-12-12 1986-01-22 Ciba Geigy Ag Thrombin inhibitors
GB2188049B (en) * 1986-03-15 1990-09-05 Ciba Geigy Ag Insecticidal proteinaceous substance
EP0240224A3 (en) * 1986-03-31 1989-02-01 Interferon Sciences, Inc. An alpha interferon analogue
US4857467A (en) * 1986-07-23 1989-08-15 Phillips Petroleum Company Carbon and energy source markers for transformation of strains of the genes Pichia
DE3789413T2 (de) 1986-10-03 1994-07-28 Ciba Geigy Ag Lymphokin-ähnliche Peptide.
US5013652A (en) * 1986-10-14 1991-05-07 Genex Corporation Composite yeast vectors
EP0332576B1 (de) * 1988-03-07 1994-04-06 Ciba-Geigy Ag Modifizierte Proteine
US5180667A (en) * 1988-03-07 1993-01-19 Ciba-Geigy Corporation Genes encoding eglin C mutants
DE68928124T2 (de) 1988-09-02 1997-10-16 Chiron Corp., Emeryville, Calif. Makrophagenabgeleiteter entzündungsmediator(mip-2)
JPH02145193A (ja) * 1988-11-19 1990-06-04 Lotte Confectionery Co Ltd 遺伝子の組換えによる酵母でのヒト・アルファ・インターフェロンの製造方法
AU648214B2 (en) * 1991-12-31 1994-04-14 Lucky Limited Recombinant gene coding for human alpha interferon and expression vector thereof, etc.
DE69434492T2 (de) 1993-03-10 2006-07-13 Smithkline Beecham Corp. Phosphodiesterase des menschlichen gehirns
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
DE60335497D1 (de) 2002-09-13 2011-02-03 Cornell Res Foundation Inc Ergillus-phytasen
DE102005030552B4 (de) * 2005-06-22 2009-05-28 Eucodis Bioscience Selektion von Phosphatase-Aktivität
CN102059495A (zh) * 2010-11-06 2011-05-18 中国长江航运集团宜昌船厂 一种船体框架胎模及加工方法
EP3202897B1 (en) 2010-12-09 2020-04-15 Institut Pasteur Diagnostic use of a fusion polypeptide comprising a viral protein and a mgmt enzyme
US8951752B2 (en) 2011-10-20 2015-02-10 University Of Iowa Research Foundation N-demethyase genes and uses thereof
EP2788478B1 (en) 2011-12-09 2017-08-23 Institut Pasteur Multiplex immuno screening assay
US20150184166A1 (en) 2012-06-15 2015-07-02 Uinversity of Iowa Research Foundation Caffeine responsive promoters and regulatory genes
WO2022049409A1 (en) 2020-09-02 2022-03-10 Sia Terragen Express diagnosticum for sars-cov-2

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FR2458585A1 (fr) * 1979-06-07 1981-01-02 Pasteur Institut Procede de production de proteines par expression des genes correspondants dans des micro-organismes et vecteurs susceptibles d'etre mis en oeuvre dans de tels procedes
WO1981002425A1 (en) * 1980-02-25 1981-09-03 R Axel The use of eucaryotic promoter sequences in the production of proteinaceous materials
IL63270A0 (en) * 1980-08-05 1981-10-30 Univ Leland Stanford Junior Eukaryotic autonomously replicating segment
IL63035A (en) * 1980-09-09 1985-05-31 Univ California Dnas capable of replication and stable mitotic maintenance in a host eukaryote,their preparation and eukaryotic cells comprising them
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
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GB2125047B (en) * 1982-08-09 1986-02-19 Ciba Geigy Ag Yeast hybrid vectors and their use for the production of polypeptides
JPS5931799A (ja) * 1982-08-16 1984-02-20 Science & Tech Agency Ｂ型肝炎ウイルス遺伝子を組込んだ組換えプラスミド

Also Published As

Publication number Publication date
EP0100561B1 (en) 1989-05-31
DK361483A (da) 1984-02-10
HU204095B (en) 1991-11-28
ES8607026A1 (es) 1986-05-16
HK90688A (en) 1988-11-18
CY1451A (en) 1989-03-10
GB8319099D0 (en) 1983-08-17
ES524816A0 (es) 1985-06-01
NZ205178A (en) 1986-09-10
ES8607391A1 (es) 1986-05-16
ES8505724A1 (es) 1985-06-01
PT77167A (en) 1983-09-01
PT77167B (en) 1986-03-20
ES540881A0 (es) 1986-05-16
AU566348B2 (en) 1987-10-15
EP0100561A1 (en) 1984-02-15
DK361483D0 (da) 1983-08-08
NO172548C (no) 1993-08-04
JPH0813277B2 (ja) 1996-02-14
ATE43636T1 (de) 1989-06-15
FI832825A (fi) 1984-02-10
IE831860L (en) 1984-02-09
JPH0653073B2 (ja) 1994-07-20
DE3379960D1 (en) 1989-07-06
ES540880A0 (es) 1986-05-16
CA1341381C (en) 2002-08-06
PH25617A (en) 1991-08-08
FI80720C (fi) 1990-07-10
NO832848L (no) 1984-02-10
AU1768283A (en) 1984-02-16
GB2125047B (en) 1986-02-19
GR78924B (fi) 1984-10-02
JPS5948082A (ja) 1984-03-19
JPH0515379A (ja) 1993-01-26
IE55598B1 (en) 1990-11-21
FI832825A0 (fi) 1983-08-05
FI80720B (fi) 1990-03-30
NO172548B (no) 1993-04-26
GB2125047A (en) 1984-02-29
DD218118A5 (de) 1985-01-30

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