DK173792B1 - Immunoglobulinkonjugater, fremgangsmåde til fremstilling af sådanne og farmaceutiske præparater med indhold deraf - Google Patents

Immunoglobulinkonjugater, fremgangsmåde til fremstilling af sådanne og farmaceutiske præparater med indhold deraf Download PDF

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Publication number
DK173792B1
DK173792B1 DK198801315A DK131588A DK173792B1 DK 173792 B1 DK173792 B1 DK 173792B1 DK 198801315 A DK198801315 A DK 198801315A DK 131588 A DK131588 A DK 131588A DK 173792 B1 DK173792 B1 DK 173792B1
Authority
DK
Denmark
Prior art keywords
ida
antibody
cells
mice
tumor
Prior art date
Application number
DK198801315A
Other languages
Danish (da)
English (en)
Other versions
DK131588A (da
DK131588D0 (da
Inventor
Ian Farquhar Campbell Mckenzie
Geoffrey Allan Pietersz
Mark John Smyth
Original Assignee
Univ Melbourne
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Melbourne, Pharmacia & Upjohn Spa filed Critical Univ Melbourne
Publication of DK131588D0 publication Critical patent/DK131588D0/da
Publication of DK131588A publication Critical patent/DK131588A/da
Application granted granted Critical
Publication of DK173792B1 publication Critical patent/DK173792B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK198801315A 1987-03-11 1988-03-11 Immunoglobulinkonjugater, fremgangsmåde til fremstilling af sådanne og farmaceutiske præparater med indhold deraf DK173792B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AUPI080387 1987-03-11
AUPI080387 1987-03-11
AUPI295587 1987-07-07
AUPI295587 1987-07-07

Publications (3)

Publication Number Publication Date
DK131588D0 DK131588D0 (da) 1988-03-11
DK131588A DK131588A (da) 1988-09-12
DK173792B1 true DK173792B1 (da) 2001-11-05

Family

ID=25643244

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198801315A DK173792B1 (da) 1987-03-11 1988-03-11 Immunoglobulinkonjugater, fremgangsmåde til fremstilling af sådanne og farmaceutiske præparater med indhold deraf

Country Status (29)

Country Link
US (1) US5798097A (xx)
JP (1) JP2736255B2 (xx)
KR (1) KR0130906B1 (xx)
CN (1) CN1045621C (xx)
AT (1) AT395375B (xx)
AU (1) AU622105B2 (xx)
BE (1) BE1001051A4 (xx)
CA (1) CA1329156C (xx)
CH (1) CH678815A5 (xx)
CZ (1) CZ161288A3 (xx)
DE (1) DE3808166C2 (xx)
DK (1) DK173792B1 (xx)
ES (1) ES2006109A6 (xx)
FI (1) FI98706C (xx)
FR (1) FR2612074B1 (xx)
GB (1) GB2203154B (xx)
GR (1) GR1000059B (xx)
HU (1) HU205266B (xx)
IE (1) IE64781B1 (xx)
IL (1) IL85688A0 (xx)
IT (1) IT8819746A0 (xx)
MY (1) MY103231A (xx)
NL (1) NL8800610A (xx)
NO (1) NO178954C (xx)
NZ (1) NZ223834A (xx)
PT (1) PT86960B (xx)
RU (1) RU2106147C1 (xx)
SE (1) SE503402C2 (xx)
YU (1) YU46858B (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6824777B1 (en) * 1992-10-09 2004-11-30 Licentia Ltd. Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
JP4841724B2 (ja) * 1998-10-09 2011-12-21 ベジェニクス ピーティーワイ リミテッド 腫瘍イメージングおよび抗腫瘍治療の標的としてのＦｌｔ４（ＶＥＲＧ−３）
WO2002049672A2 (en) * 2000-12-21 2002-06-27 Mcgill University Conjugates of antibodies and anticancer drugs
ATE359300T1 (de) 2001-01-19 2007-05-15 Ludwig Inst Cancer Res Flt4 (vegfr-3) als ein ziel für krebs darstellung und anti-krebs-behandlung
EP1620564A4 (en) * 2003-04-18 2008-03-12 Cytovia Inc METHOD FOR TREATING DISEASES RESPONSING TO APOPTOSIS INDUCTION AND SCREENING TESTS
GB0511266D0 (en) * 2005-06-02 2005-07-13 Trust Chemical compounds
US20080108138A1 (en) * 2006-06-13 2008-05-08 Vermette Patrick Bioactive compositions and their use in cell patterning
EA034333B1 (ru) 2010-11-30 2020-01-29 Дженентек, Инк. Варианты антитела для переноса соединения через гематоэнцефалический барьер
SI2956476T1 (sl) 2013-02-18 2020-03-31 Vegenics Pty Limited Molekule za vezavo na ligande in uporabe le-teh

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT346838B (de) * 1975-01-22 1978-11-27 Farmaceutici Italia Verfahren zur herstellung von neuen optisch aktiven anthracyclinonen
AT343812B (de) * 1975-01-22 1978-06-26 Farmaceutici Italia Verfahren zur herstellung von neuen optisch aktiven daunosaminylderivaten von anthracyclinonen
GB1500421A (en) * 1975-01-22 1978-02-08 Farmaceutici Italia Optically active anthracyclinones
AT343811B (de) * 1975-01-22 1978-06-26 Farmaceutici Italia Verfahren zur herstellung von neuen optisch aktiven anthracyclinonen
GB1511680A (en) 1975-11-18 1978-05-24 Farmaceutici Italia Daunosaminyl anthracyclinones
GB1541436A (en) * 1976-02-02 1979-02-28 Searle & Co Immunological materials
US5162512A (en) * 1982-03-09 1992-11-10 Cytogen Corporation Amine derivatives of anthracycline antibodies
US4867973A (en) * 1984-08-31 1989-09-19 Cytogen Corporation Antibody-therapeutic agent conjugates
US4950738A (en) * 1984-09-13 1990-08-21 Cytogen Corporation Amine derivatives of anthracycline antibiotics
JPS59186924A (ja) * 1983-04-08 1984-10-23 Kureha Chem Ind Co Ltd ヒト免疫グロブリン結合抗腫瘍剤
US4545985A (en) 1984-01-26 1985-10-08 The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services Pseudomonas exotoxin conjugate immunotoxins
GB8413464D0 (en) * 1984-05-25 1984-07-04 Erba Farmitalia Anthracycline-anionic polymer conjugates
JPS61155334A (ja) * 1984-12-28 1986-07-15 Teijin Ltd 殺細胞性修飾免疫グロブリン及びその製造方法
FR2584293B1 (fr) * 1985-07-04 1989-03-17 Ire Celltarg Sa Anticorps utiles comme agents de pilotage et conjugues les incorporant

Also Published As

Publication number Publication date
KR880010775A (ko) 1988-10-24
FI881158A (fi) 1988-09-12
GR880100148A (en) 1989-01-31
DK131588A (da) 1988-09-12
YU46858B (sh) 1994-06-24
GB8805865D0 (en) 1988-04-13
NO178954B (no) 1996-04-01
MY103231A (en) 1993-05-29
FI98706B (fi) 1997-04-30
AU622105B2 (en) 1992-04-02
NO881105D0 (no) 1988-03-11
CN88101810A (zh) 1988-11-09
AU1288188A (en) 1988-09-15
GR1000059B (el) 1990-06-27
CZ281193B6 (cs) 1996-07-17
IL85688A0 (en) 1988-08-31
JP2736255B2 (ja) 1998-04-02
FI98706C (fi) 1997-08-11
CN1045621C (zh) 1999-10-13
FR2612074B1 (fr) 1991-06-21
FR2612074A1 (fr) 1988-09-16
NZ223834A (en) 1990-05-28
BE1001051A4 (fr) 1989-06-20
NO881105L (no) 1988-09-12
PT86960A (pt) 1988-04-01
DK131588D0 (da) 1988-03-11
NL8800610A (nl) 1988-10-03
HU205266B (en) 1992-04-28
CA1329156C (en) 1994-05-03
PT86960B (pt) 1992-06-30
IE64781B1 (en) 1995-09-06
ES2006109A6 (es) 1989-04-01
YU48288A (en) 1989-08-31
DE3808166A1 (de) 1988-09-22
SE8800886L (sv) 1989-09-12
KR0130906B1 (ko) 1998-04-23
CZ161288A3 (en) 1996-07-17
GB2203154B (en) 1991-06-26
ATA67488A (de) 1992-05-15
NO178954C (no) 1996-07-10
US5798097A (en) 1998-08-25
JPS63301832A (ja) 1988-12-08
FI881158A0 (fi) 1988-03-11
HUT46547A (en) 1988-11-28
IT8819746A0 (it) 1988-03-11
AT395375B (de) 1992-12-10
NL195078C (xx) 2003-07-30
GB2203154A (en) 1988-10-12
CH678815A5 (xx) 1991-11-15
SE503402C2 (sv) 1996-06-10
RU2106147C1 (ru) 1998-03-10
SE8800886D0 (sv) 1988-03-11
DE3808166C2 (de) 1997-08-28
IE880701L (en) 1988-09-11

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment
B1 Patent granted (law 1993)
PUP Patent expired