DK173792B1 - Immunoglobulinkonjugater, fremgangsmåde til fremstilling af sådanne og farmaceutiske præparater med indhold deraf - Google Patents
Immunoglobulinkonjugater, fremgangsmåde til fremstilling af sådanne og farmaceutiske præparater med indhold deraf Download PDFInfo
- Publication number
- DK173792B1 DK173792B1 DK198801315A DK131588A DK173792B1 DK 173792 B1 DK173792 B1 DK 173792B1 DK 198801315 A DK198801315 A DK 198801315A DK 131588 A DK131588 A DK 131588A DK 173792 B1 DK173792 B1 DK 173792B1
- Authority
- DK
- Denmark
- Prior art keywords
- ida
- antibody
- cells
- mice
- tumor
- Prior art date
Links
- 0 *CC(*)C(*)**S[C@](O)OC(N=O)O Chemical compound *CC(*)C(*)**S[C@](O)OC(N=O)O 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/44—Antibodies bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPI080387 | 1987-03-11 | ||
AUPI080387 | 1987-03-11 | ||
AUPI295587 | 1987-07-07 | ||
AUPI295587 | 1987-07-07 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK131588D0 DK131588D0 (da) | 1988-03-11 |
DK131588A DK131588A (da) | 1988-09-12 |
DK173792B1 true DK173792B1 (da) | 2001-11-05 |
Family
ID=25643244
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK198801315A DK173792B1 (da) | 1987-03-11 | 1988-03-11 | Immunoglobulinkonjugater, fremgangsmåde til fremstilling af sådanne og farmaceutiske præparater med indhold deraf |
Country Status (29)
Country | Link |
---|---|
US (1) | US5798097A (de) |
JP (1) | JP2736255B2 (de) |
KR (1) | KR0130906B1 (de) |
CN (1) | CN1045621C (de) |
AT (1) | AT395375B (de) |
AU (1) | AU622105B2 (de) |
BE (1) | BE1001051A4 (de) |
CA (1) | CA1329156C (de) |
CH (1) | CH678815A5 (de) |
CZ (1) | CZ281193B6 (de) |
DE (1) | DE3808166C2 (de) |
DK (1) | DK173792B1 (de) |
ES (1) | ES2006109A6 (de) |
FI (1) | FI98706C (de) |
FR (1) | FR2612074B1 (de) |
GB (1) | GB2203154B (de) |
GR (1) | GR1000059B (de) |
HU (1) | HU205266B (de) |
IE (1) | IE64781B1 (de) |
IL (1) | IL85688A0 (de) |
IT (1) | IT8819746A0 (de) |
MY (1) | MY103231A (de) |
NL (1) | NL8800610A (de) |
NO (1) | NO178954C (de) |
NZ (1) | NZ223834A (de) |
PT (1) | PT86960B (de) |
RU (1) | RU2106147C1 (de) |
SE (1) | SE503402C2 (de) |
YU (1) | YU46858B (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6824777B1 (en) * | 1992-10-09 | 2004-11-30 | Licentia Ltd. | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
CA2345276C (en) * | 1998-10-09 | 2011-03-29 | Ludwig Institute For Cancer Research | Flt4 (vegfr-3) as a target for tumor imaging and anti-tumor therapy |
WO2002049672A2 (en) * | 2000-12-21 | 2002-06-27 | Mcgill University | Conjugates of antibodies and anticancer drugs |
CN1494552A (zh) | 2001-01-19 | 2004-05-05 | ·��ά��֢�о�Ժ | Flt4(VEGFR-3)作为靶用于肿瘤成像和抗肿瘤治疗 |
WO2004094647A2 (en) * | 2003-04-18 | 2004-11-04 | Cytovia, Inc. | Methods of treating diseases responsive to induction of apoptosis and screening assays |
GB0511266D0 (en) * | 2005-06-02 | 2005-07-13 | Trust | Chemical compounds |
US20080108138A1 (en) * | 2006-06-13 | 2008-05-08 | Vermette Patrick | Bioactive compositions and their use in cell patterning |
CA2818173C (en) | 2010-11-30 | 2022-05-03 | Genentech, Inc. | Low affinity blood brain barrier receptor antibodies and uses therefor |
EP2956476B1 (de) | 2013-02-18 | 2019-12-25 | Vegenics Pty Limited | Ligandbindende moleküle und verwendungen davon |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT346838B (de) * | 1975-01-22 | 1978-11-27 | Farmaceutici Italia | Verfahren zur herstellung von neuen optisch aktiven anthracyclinonen |
AT343811B (de) * | 1975-01-22 | 1978-06-26 | Farmaceutici Italia | Verfahren zur herstellung von neuen optisch aktiven anthracyclinonen |
GB1500421A (en) * | 1975-01-22 | 1978-02-08 | Farmaceutici Italia | Optically active anthracyclinones |
AT343812B (de) * | 1975-01-22 | 1978-06-26 | Farmaceutici Italia | Verfahren zur herstellung von neuen optisch aktiven daunosaminylderivaten von anthracyclinonen |
GB1511680A (en) | 1975-11-18 | 1978-05-24 | Farmaceutici Italia | Daunosaminyl anthracyclinones |
GB1541436A (en) * | 1976-02-02 | 1979-02-28 | Searle & Co | Immunological materials |
US4867973A (en) * | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
US5162512A (en) * | 1982-03-09 | 1992-11-10 | Cytogen Corporation | Amine derivatives of anthracycline antibodies |
US4950738A (en) * | 1984-09-13 | 1990-08-21 | Cytogen Corporation | Amine derivatives of anthracycline antibiotics |
JPS59186924A (ja) * | 1983-04-08 | 1984-10-23 | Kureha Chem Ind Co Ltd | ヒト免疫グロブリン結合抗腫瘍剤 |
US4545985A (en) | 1984-01-26 | 1985-10-08 | The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services | Pseudomonas exotoxin conjugate immunotoxins |
GB8413464D0 (en) * | 1984-05-25 | 1984-07-04 | Erba Farmitalia | Anthracycline-anionic polymer conjugates |
JPS61155334A (ja) * | 1984-12-28 | 1986-07-15 | Teijin Ltd | 殺細胞性修飾免疫グロブリン及びその製造方法 |
FR2584293B1 (fr) * | 1985-07-04 | 1989-03-17 | Ire Celltarg Sa | Anticorps utiles comme agents de pilotage et conjugues les incorporant |
-
1988
- 1988-03-10 BE BE8800268A patent/BE1001051A4/fr not_active IP Right Cessation
- 1988-03-10 KR KR1019880002464A patent/KR0130906B1/ko not_active IP Right Cessation
- 1988-03-10 MY MYPI88000250A patent/MY103231A/en unknown
- 1988-03-10 NZ NZ223834A patent/NZ223834A/xx unknown
- 1988-03-10 JP JP63055074A patent/JP2736255B2/ja not_active Expired - Lifetime
- 1988-03-10 CA CA000561042A patent/CA1329156C/en not_active Expired - Lifetime
- 1988-03-10 AU AU12881/88A patent/AU622105B2/en not_active Expired
- 1988-03-10 IE IE70188A patent/IE64781B1/xx not_active IP Right Cessation
- 1988-03-10 YU YU48288A patent/YU46858B/sh unknown
- 1988-03-10 IL IL85688A patent/IL85688A0/xx not_active IP Right Cessation
- 1988-03-10 ES ES8800719A patent/ES2006109A6/es not_active Expired
- 1988-03-10 HU HU881160A patent/HU205266B/hu unknown
- 1988-03-11 IT IT8819746A patent/IT8819746A0/it unknown
- 1988-03-11 CH CH936/88A patent/CH678815A5/de not_active IP Right Cessation
- 1988-03-11 GR GR880100148A patent/GR1000059B/el not_active IP Right Cessation
- 1988-03-11 FI FI881158A patent/FI98706C/fi not_active IP Right Cessation
- 1988-03-11 DK DK198801315A patent/DK173792B1/da not_active IP Right Cessation
- 1988-03-11 DE DE3808166A patent/DE3808166C2/de not_active Expired - Lifetime
- 1988-03-11 AT AT0067488A patent/AT395375B/de not_active IP Right Cessation
- 1988-03-11 NO NO881105A patent/NO178954C/no not_active IP Right Cessation
- 1988-03-11 GB GB8805865A patent/GB2203154B/en not_active Expired - Lifetime
- 1988-03-11 CN CN88101810A patent/CN1045621C/zh not_active Expired - Lifetime
- 1988-03-11 CZ CS881612A patent/CZ281193B6/cs not_active IP Right Cessation
- 1988-03-11 FR FR888803233A patent/FR2612074B1/fr not_active Expired - Lifetime
- 1988-03-11 SE SE8800886A patent/SE503402C2/sv not_active IP Right Cessation
- 1988-03-11 NL NL8800610A patent/NL8800610A/nl not_active IP Right Cessation
- 1988-03-11 PT PT86960A patent/PT86960B/pt not_active IP Right Cessation
-
1992
- 1992-06-15 RU SU5052164A patent/RU2106147C1/ru active
-
1995
- 1995-04-11 US US08/420,712 patent/US5798097A/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA1222694A (en) | Immunochemotherapy for malignant tumors, particularly pancreatic cancer | |
US4880935A (en) | Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates | |
Smyth et al. | Specific targeting of chlorambucil to tumors with the use of monoclonal antibodies | |
Pietersz et al. | Immunochemotherapy of a murine thymoma with the use of idarubicin monoclonal antibody conjugates | |
DK173792B1 (da) | Immunoglobulinkonjugater, fremgangsmåde til fremstilling af sådanne og farmaceutiske præparater med indhold deraf | |
Smyth et al. | Selective enhancement of antitumor activity of N-acetyl melphalan upon conjugation to monoclonal antibodies | |
US5075108A (en) | Melphalan derivatives | |
EP0248040B1 (de) | Ricin-antikörper-konjugate | |
EP0485749A2 (de) | Chemische Modifizierung von Antikörpern zur Erzeugung von Immunokonjugaten | |
RU2009500C1 (ru) | Способ получения цитотоксического коньюгата | |
Arnon | Antibodies and dextran as anti-tumour drug carriers | |
US20080095802A1 (en) | Targeted delivery of cytotoxic drugs A) to activated lymphocytes in patients iwth transplanted organs, B) as radiosensitizers to cancer cells in paients undergoing radiation therapy, and C) in vitaminpbinding proteins as drug carriers in the diagnosis and treatment of cancer | |
CA2414401A1 (en) | Targeted delivery of cytotoxic drugs a) to activated lymphocytes in patients with transplanted organs, b) as radiosensitizers to cancer cells in patients undergoing radiation therapy, and c) in vitamin-binding proteins as drug carriers in the diagnosis and treatment of cancer | |
Arnon | Novel Application for Antibodies | |
AU2007201744A1 (en) | Targeted delivery of cytotoxic drugs A) to activated lymphocytes in patients with transplanted organs, B) as radiosensitizers to cancer cells in patients undergoing radiation therapy, and C) in vitamin binding proteins as drug carriers in the diagnosis and treatment of cancer | |
WO1998056823A1 (en) | Induction of immune tolerance by immunotoxin | |
WO1992014758A1 (en) | Conjugate molecules |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment | ||
B1 | Patent granted (law 1993) | ||
PUP | Patent expired |