DK172748B1 - (1H-azol-1-ylmethyl)substituerede quinolin-, quinazolin- eller quinoxalinderivater, fremgangsmåde til fremstilling deraf og - Google Patents

(1H-azol-1-ylmethyl)substituerede quinolin-, quinazolin- eller quinoxalinderivater, fremgangsmåde til fremstilling deraf og Download PDF

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Publication number
DK172748B1
DK172748B1 DK198905994A DK599489A DK172748B1 DK 172748 B1 DK172748 B1 DK 172748B1 DK 198905994 A DK198905994 A DK 198905994A DK 599489 A DK599489 A DK 599489A DK 172748 B1 DK172748 B1 DK 172748B1
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Prior art keywords
formula
alkyl
hydrogen
parts
phenyl
Prior art date
Application number
DK198905994A
Other languages
Danish (da)
English (en)
Other versions
DK599489A (da
DK599489D0 (da
Inventor
Alfons Herman Marg Raeymaekers
Eddy Jean Edgard Freyne
Marc Gaston Venet
Gerard Charles Sanz
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888827822A external-priority patent/GB8827822D0/en
Priority claimed from GB888827820A external-priority patent/GB8827820D0/en
Priority claimed from GB888827821A external-priority patent/GB8827821D0/en
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of DK599489D0 publication Critical patent/DK599489D0/da
Publication of DK599489A publication Critical patent/DK599489A/da
Application granted granted Critical
Publication of DK172748B1 publication Critical patent/DK172748B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK198905994A 1988-11-29 1989-11-28 (1H-azol-1-ylmethyl)substituerede quinolin-, quinazolin- eller quinoxalinderivater, fremgangsmåde til fremstilling deraf og DK172748B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB8827820 1988-11-29
GB888827822A GB8827822D0 (en) 1988-11-29 1988-11-29 (1h-azol-1-ylmethyl)substituted quinoline derivatives
GB888827820A GB8827820D0 (en) 1988-11-29 1988-11-29 (1h-azol-1-ylmethyl)substituted quinoline derivatives
GB8827821 1988-11-29
GB888827821A GB8827821D0 (en) 1988-11-29 1988-11-29 (1h-azol-1-ylmethyl)substituted quinoline derivatives
GB8827822 1988-11-29

Publications (3)

Publication Number Publication Date
DK599489D0 DK599489D0 (da) 1989-11-28
DK599489A DK599489A (da) 1990-05-30
DK172748B1 true DK172748B1 (da) 1999-06-28

Family

ID=27264207

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198905994A DK172748B1 (da) 1988-11-29 1989-11-28 (1H-azol-1-ylmethyl)substituerede quinolin-, quinazolin- eller quinoxalinderivater, fremgangsmåde til fremstilling deraf og

Country Status (22)

Country Link
EP (1) EP0371564B1 (fr)
JP (1) JP2916181B2 (fr)
CN (3) CN1033752C (fr)
AT (1) ATE124941T1 (fr)
AU (1) AU620946B2 (fr)
CA (1) CA2002864C (fr)
CY (1) CY1920A (fr)
DE (1) DE68923430T2 (fr)
DK (1) DK172748B1 (fr)
ES (1) ES2088889T3 (fr)
FI (1) FI101964B1 (fr)
GR (1) GR3017351T3 (fr)
HK (1) HK118196A (fr)
HU (2) HU205106B (fr)
IE (1) IE67803B1 (fr)
IL (1) IL92486A (fr)
MY (1) MY105871A (fr)
NO (1) NO174509B (fr)
NZ (1) NZ231441A (fr)
PT (1) PT92448B (fr)
RU (1) RU1780536C (fr)
ZW (1) ZW15889A1 (fr)

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ES2260316T3 (es) 2000-12-27 2006-11-01 Janssen Pharmaceutica N.V. Derivados de quinazolina y quinolina 4-sustituidos que inhiben la farnesil transferasa.
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CN1882547B (zh) * 2003-11-20 2011-04-13 詹森药业有限公司 用作聚(adp-核糖)聚合酶抑制剂的6-烯基和6-苯基烷基取代的2-喹啉酮和2-喹喔啉酮
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EA010488B1 (ru) * 2003-12-05 2008-10-30 Янссен Фармацевтика Н.В. 6-замещённые 2-хинолиноны и 2-хиноксалиноны как ингибиторы поли (адф-рибоза) полимеразы
BRPI0417571A (pt) * 2003-12-10 2007-03-20 Janssen Pharmaceutica Nv 2-quinolinonas e 2-quinoxalinonas substituìdas por 6-ciclohexil-alquila substituìda como inibidores da poli(adp-ribose) polimerase
EA012416B1 (ru) 2004-06-30 2009-10-30 Янссен Фармацевтика Н.В. Производные замещенного 2-алкилхиназолинона как ингибиторы parp
JP5100376B2 (ja) 2004-06-30 2012-12-19 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｐａｒｐ阻害剤としてのキナゾリンジオン誘導体
BRPI0512902A (pt) 2004-06-30 2008-04-15 Janssen Pharmaceutica Nv derivados de ftalazina como inibidores de parp
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Also Published As

Publication number Publication date
DE68923430D1 (de) 1995-08-17
NO894734D0 (no) 1989-11-28
CN1042912A (zh) 1990-06-13
EP0371564A3 (fr) 1991-05-29
HU205106B (en) 1992-03-30
MY105871A (en) 1995-02-28
DK599489A (da) 1990-05-30
DK599489D0 (da) 1989-11-28
AU4564689A (en) 1990-06-07
NZ231441A (en) 1991-05-28
HUT52498A (en) 1990-07-28
ZW15889A1 (en) 1991-07-17
JPH02223579A (ja) 1990-09-05
CN1106005A (zh) 1995-08-02
IL92486A (en) 1993-07-08
FI101964B (fi) 1998-09-30
PT92448B (pt) 1995-07-18
CA2002864A1 (fr) 1990-05-29
RU1780536C (ru) 1992-12-07
AU620946B2 (en) 1992-02-27
ES2088889T3 (es) 1996-10-01
DE68923430T2 (de) 1996-02-15
CN1036002C (zh) 1997-10-01
CY1920A (en) 1997-03-07
GR3017351T3 (en) 1995-12-31
CA2002864C (fr) 1999-11-16
IE67803B1 (en) 1996-05-01
ATE124941T1 (de) 1995-07-15
HU896220D0 (en) 1990-02-28
HU211686A9 (en) 1995-12-28
PT92448A (pt) 1990-05-31
JP2916181B2 (ja) 1999-07-05
FI101964B1 (fi) 1998-09-30
IL92486A0 (en) 1990-08-31
EP0371564A2 (fr) 1990-06-06
HK118196A (en) 1996-07-12
NO894734L (no) 1990-05-30
FI895687A0 (fi) 1989-11-28
NO174509C (fr) 1994-05-18
EP0371564B1 (fr) 1995-07-12
NO174509B (no) 1994-02-07
IE893782L (en) 1990-05-29
CN1033752C (zh) 1997-01-08
CN1036003C (zh) 1997-10-01
CN1106004A (zh) 1995-08-02

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