DE68923430D1 - (1H-Azol-1-ylmethyl)substituierte Quinolin-, Quinazolin- oder Quinoxalin-Derivate. - Google Patents

(1H-Azol-1-ylmethyl)substituierte Quinolin-, Quinazolin- oder Quinoxalin-Derivate.

Info

Publication number
DE68923430D1
DE68923430D1 DE68923430T DE68923430T DE68923430D1 DE 68923430 D1 DE68923430 D1 DE 68923430D1 DE 68923430 T DE68923430 T DE 68923430T DE 68923430 T DE68923430 T DE 68923430T DE 68923430 D1 DE68923430 D1 DE 68923430D1
Authority
DE
Germany
Prior art keywords
azol
ylmethyl
chem
compounds
quinoxaline derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68923430T
Other languages
English (en)
Other versions
DE68923430T2 (de
Inventor
Eddy Jean Edgard Freyne
Marc Gaston Venet
Alfons Herman Marg Raeymaekers
Gerard Charles Sanz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888827821A external-priority patent/GB8827821D0/en
Priority claimed from GB888827822A external-priority patent/GB8827822D0/en
Priority claimed from GB888827820A external-priority patent/GB8827820D0/en
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of DE68923430D1 publication Critical patent/DE68923430D1/de
Publication of DE68923430T2 publication Critical patent/DE68923430T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE68923430T 1988-11-29 1989-11-28 (1H-Azol-1-ylmethyl)substituierte Quinolin-, Quinazolin- oder Quinoxalin-Derivate. Expired - Fee Related DE68923430T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888827821A GB8827821D0 (en) 1988-11-29 1988-11-29 (1h-azol-1-ylmethyl)substituted quinoline derivatives
GB888827822A GB8827822D0 (en) 1988-11-29 1988-11-29 (1h-azol-1-ylmethyl)substituted quinoline derivatives
GB888827820A GB8827820D0 (en) 1988-11-29 1988-11-29 (1h-azol-1-ylmethyl)substituted quinoline derivatives

Publications (2)

Publication Number Publication Date
DE68923430D1 true DE68923430D1 (de) 1995-08-17
DE68923430T2 DE68923430T2 (de) 1996-02-15

Family

ID=27264207

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68923430T Expired - Fee Related DE68923430T2 (de) 1988-11-29 1989-11-28 (1H-Azol-1-ylmethyl)substituierte Quinolin-, Quinazolin- oder Quinoxalin-Derivate.

Country Status (22)

Country Link
EP (1) EP0371564B1 (de)
JP (1) JP2916181B2 (de)
CN (3) CN1033752C (de)
AT (1) ATE124941T1 (de)
AU (1) AU620946B2 (de)
CA (1) CA2002864C (de)
CY (1) CY1920A (de)
DE (1) DE68923430T2 (de)
DK (1) DK172748B1 (de)
ES (1) ES2088889T3 (de)
FI (1) FI101964B1 (de)
GR (1) GR3017351T3 (de)
HK (1) HK118196A (de)
HU (2) HU205106B (de)
IE (1) IE67803B1 (de)
IL (1) IL92486A (de)
MY (1) MY105871A (de)
NO (1) NO174509B (de)
NZ (1) NZ231441A (de)
PT (1) PT92448B (de)
RU (1) RU1780536C (de)
ZW (1) ZW15889A1 (de)

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ATE143013T1 (de) * 1992-10-27 1996-10-15 Janssen Pharmaceutica Nv 4-chinolinyl derivate mit anti-helicobacter wirkung
KR100224135B1 (ko) * 1993-01-28 1999-10-15 다께다 구니오 퀴놀린 또는 퀴나졸린 유도체, 그 제조 및 용도
AU664337B2 (en) * 1993-06-17 1995-11-09 Otsuka Pharmaceutical Factory, Inc. Phosphonic diester derivative
TW316902B (de) * 1994-12-28 1997-10-01 Janssen Pharmaceutica Nv
US6110911A (en) * 1995-06-07 2000-08-29 Warner-Lambert Company Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
MY132385A (en) * 1995-08-31 2007-10-31 Novartis Ag 2,3-dioxo-1,2,3,4-tetrahydro-quinoxalinyl derivatives
TW349948B (en) * 1995-10-31 1999-01-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 2-quinolone derivatives
DE69620445T2 (de) * 1995-12-08 2002-12-12 Janssen Pharmaceutica N.V., Beerse (imidazol-5-yl)methyl-2-chinolinoderivate als farnesyl protein transferase inhibitoren
US5739338A (en) * 1996-11-05 1998-04-14 Allergan N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity
TW591030B (en) * 1997-03-10 2004-06-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
CA2288140C (en) * 1997-04-25 2007-04-03 Janssen Pharmaceutica N.V. Farnesyltransferase inhibiting quinazolinones
TW403740B (en) 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
CA2312720A1 (en) 1997-12-11 1999-06-17 Janssen-Cilag S.A. Retinoic acid mimetic anilides
EP1107962B1 (de) * 1998-08-27 2005-02-23 Pfizer Products Inc. Quinolin-2-on-derivate verwendbar als antikrebsmittel
UA71592C2 (uk) 1998-12-23 2004-12-15 Янссен Фармацевтика Н.В. Похідні 1,2-анельованого хіноліну, спосіб їх одержання (варіанти), фармацевтична композиція, що їх містить, проміжна сполука та спосіб її одержання
AU2001267852B2 (en) * 2000-06-30 2006-01-19 Msd K.K. Novel pyrazinone derivatives
AU2001293826A1 (en) 2000-09-25 2002-04-02 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting quinoline and quinazoline derivatives as farnesyl transferase inhibitors
EP1322650B1 (de) 2000-09-25 2008-09-24 Janssen Pharmaceutica N.V. Farnesyl transferase-hemmende 6-heterocyclylmethyl-chinolin und chinazol-derivate
US7067531B2 (en) 2000-09-25 2006-06-27 Angibaud Patrick Rene Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives
US7173040B2 (en) 2000-09-25 2007-02-06 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 6-[(substituted phenyl)methyl]-quinoline and quinazoline derinazoline derivatives
AU2002214056A1 (en) * 2000-11-21 2002-06-03 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting benzoheterocyclic derivatives
ATE319704T1 (de) 2000-12-27 2006-03-15 Janssen Pharmaceutica Nv Farnesyltransferase hemmende, in der 4-stellung substituierte chinolin- und chinazolinderivate
KR100417705B1 (ko) * 2001-07-24 2004-02-11 한국화학연구원 4-아졸일-2-퀴놀리논 유도체 및 이를 포함하는 살균제조성물
ATE336496T1 (de) 2002-04-15 2006-09-15 Janssen Pharmaceutica Nv Farnesyl transferase hemmende tricyclische quinazolinederivate substitutiert mit kohlenstoff-gebundenen imidazolen oder triazolen
FR2860235A1 (fr) * 2003-09-29 2005-04-01 Yang Ji Chemical Company Ltd Utilisation d'un compose de formule (i) inhibiteur de l'aromatase a des fins therapeutiques et composes de formule (i) en tant que tels
EP1687277B1 (de) * 2003-11-20 2018-04-04 Janssen Pharmaceutica NV 6-alkenyl- und 6-phenylalkylsubstituierte 2-chinolinone und 2-chinoxalinone als poly(adp-ribose)-polymerase-inhibitoren
ES2670349T3 (es) * 2003-11-20 2018-05-30 Janssen Pharmaceutica Nv 2-Quinolinonas y 2-quinoxalinonas sustituidas con 6-alquenilo y 6-fenilalquilo como inhibidores de poli(ADP-ribosa) polimerasa
UA86777C2 (en) * 2003-11-20 2009-05-25 Янссен Фармацевтика Н.В. 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
MXPA06005686A (es) 2003-11-20 2006-08-17 Janssen Pharmaceutica Nv 2-quinolinonas y 2-quinoxalinonas 7-fenilaquilo sustituidas como inhibidores de la poli(adp-ribosa)polimerasa.
NZ547193A (en) * 2003-12-05 2010-03-26 Janssen Pharmaceutica Nv 6-Substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
UA91007C2 (ru) * 2003-12-10 2010-06-25 Янссен Фармацевтика Н.В. Замещенные 6-циклогексилалкилом замещенные 2-хинолиноны и 2-хиноксалиноны как ингибиторы поли-(адф-рибоза)полимеразы
UA86237C2 (uk) 2004-06-30 2009-04-10 Янссен Фармацевтика Н.В. Похідні заміщеного 2-алкілхіназолінону як інгібітори parp
CN1980913B (zh) 2004-06-30 2011-12-14 詹森药业有限公司 作为parp抑制剂的喹唑啉二酮衍生物
US7803795B2 (en) 2004-06-30 2010-09-28 Janssen Pharmaceutica N.V. Phthalazine derivatives as parp inhibitors
US8426429B2 (en) 2004-08-06 2013-04-23 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8436006B2 (en) 2004-08-06 2013-05-07 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8383637B2 (en) 2004-08-06 2013-02-26 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
JP4643948B2 (ja) * 2004-08-23 2011-03-02 大日本住友製薬株式会社 キナゾリノン化合物の安定化方法
WO2007092839A2 (en) 2006-02-06 2007-08-16 Janssen Pharmaceutica N.V. Macrocycle derivatives useful as inhibitors of beta-secretase (bace)
US7868022B2 (en) 2006-02-06 2011-01-11 Janssen Pharmaceutica Nv 2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE)
KR101307497B1 (ko) * 2006-04-19 2013-09-11 주식회사 동진쎄미켐 디이미다졸계 화합물 및 이를 이용한 유기발광소자
US7429589B2 (en) * 2006-04-27 2008-09-30 Hoffmann-La Roche Inc. Mono-nitration of aromatic compounds via nitrate salts
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EP2134691B1 (de) 2007-03-08 2012-01-25 Janssen Pharmaceutica, N.V. Chinolinonderivate als parp und tank-inhibitoren
US8404713B2 (en) 2007-10-26 2013-03-26 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP inhibitors
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KR20150070348A (ko) 2012-10-16 2015-06-24 얀센 파마슈티카 엔.브이. RoRγt의 헤테로아릴 결합 퀴놀리닐 조절제
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US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
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JP6423423B2 (ja) 2013-10-15 2018-11-14 ヤンセン ファーマシューティカ エヌ．ベー． Ｒｏｒγｔのアルキル結合キノリニルモジュレーター
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt

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US4792561A (en) * 1986-05-29 1988-12-20 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors
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Also Published As

Publication number Publication date
HK118196A (en) 1996-07-12
NZ231441A (en) 1991-05-28
CN1036002C (zh) 1997-10-01
NO174509C (de) 1994-05-18
RU1780536C (ru) 1992-12-07
GR3017351T3 (en) 1995-12-31
IL92486A0 (en) 1990-08-31
MY105871A (en) 1995-02-28
CA2002864A1 (en) 1990-05-29
CN1033752C (zh) 1997-01-08
CN1106004A (zh) 1995-08-02
HU211686A9 (en) 1995-12-28
CN1042912A (zh) 1990-06-13
NO894734D0 (no) 1989-11-28
DE68923430T2 (de) 1996-02-15
ATE124941T1 (de) 1995-07-15
ES2088889T3 (es) 1996-10-01
HU896220D0 (en) 1990-02-28
FI101964B (fi) 1998-09-30
JPH02223579A (ja) 1990-09-05
AU620946B2 (en) 1992-02-27
CY1920A (en) 1997-03-07
HUT52498A (en) 1990-07-28
IL92486A (en) 1993-07-08
IE893782L (en) 1990-05-29
CN1106005A (zh) 1995-08-02
AU4564689A (en) 1990-06-07
PT92448A (pt) 1990-05-31
ZW15889A1 (en) 1991-07-17
FI101964B1 (fi) 1998-09-30
EP0371564A3 (de) 1991-05-29
DK599489D0 (da) 1989-11-28
HU205106B (en) 1992-03-30
PT92448B (pt) 1995-07-18
EP0371564B1 (de) 1995-07-12
EP0371564A2 (de) 1990-06-06
NO894734L (no) 1990-05-30
NO174509B (no) 1994-02-07
FI895687A0 (fi) 1989-11-28
IE67803B1 (en) 1996-05-01
DK172748B1 (da) 1999-06-28
DK599489A (da) 1990-05-30
CA2002864C (en) 1999-11-16
JP2916181B2 (ja) 1999-07-05
CN1036003C (zh) 1997-10-01

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