DK172152B1 - Quinolon- og naphthyridinderivater - Google Patents

Quinolon- og naphthyridinderivater Download PDF

Info

Publication number
DK172152B1
DK172152B1 DK467388A DK467388A DK172152B1 DK 172152 B1 DK172152 B1 DK 172152B1 DK 467388 A DK467388 A DK 467388A DK 467388 A DK467388 A DK 467388A DK 172152 B1 DK172152 B1 DK 172152B1
Authority
DK
Denmark
Prior art keywords
amino
oxo
pyrrolidinyl
dihydro
cyclopropyl
Prior art date
Application number
DK467388A
Other languages
Danish (da)
English (en)
Other versions
DK467388A (da
DK467388D0 (da
Inventor
Joseph Peter Sanchez
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of DK467388D0 publication Critical patent/DK467388D0/da
Publication of DK467388A publication Critical patent/DK467388A/da
Application granted granted Critical
Publication of DK172152B1 publication Critical patent/DK172152B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK467388A 1987-08-21 1988-08-19 Quinolon- og naphthyridinderivater DK172152B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8795087A 1987-08-21 1987-08-21
US8795087 1987-08-21
US22017788 1988-07-20
US07/220,177 US4851418A (en) 1987-08-21 1988-07-20 Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent

Publications (3)

Publication Number Publication Date
DK467388D0 DK467388D0 (da) 1988-08-19
DK467388A DK467388A (da) 1989-02-22
DK172152B1 true DK172152B1 (da) 1997-12-01

Family

ID=26777552

Family Applications (1)

Application Number Title Priority Date Filing Date
DK467388A DK172152B1 (da) 1987-08-21 1988-08-19 Quinolon- og naphthyridinderivater

Country Status (16)

Country Link
US (1) US4851418A (xx)
EP (1) EP0304087B1 (xx)
JP (1) JP2679818B2 (xx)
KR (1) KR0120389B1 (xx)
AU (1) AU608881B2 (xx)
CA (1) CA1339216C (xx)
DE (1) DE3888754T2 (xx)
DK (1) DK172152B1 (xx)
ES (1) ES2063011T3 (xx)
FI (1) FI90237C (xx)
HK (1) HK1000802A1 (xx)
IE (1) IE62787B1 (xx)
NO (1) NO171979C (xx)
NZ (1) NZ225870A (xx)
PH (1) PH25460A (xx)
PT (1) PT88289B (xx)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0207420B1 (en) * 1985-06-26 1992-05-06 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives
IN166416B (xx) * 1985-09-18 1990-05-05 Pfizer
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
ATE58538T1 (de) * 1986-07-04 1990-12-15 Chemie Linz Gmbh 4-chinolon-3-carbonsaeurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
MY105136A (en) * 1988-04-27 1994-08-30 Daiichi Seiyaku Co Optically active pyridonecarboxylic acid derivatives.
ATE117685T1 (de) * 1988-05-19 1995-02-15 Chugai Pharmaceutical Co Ltd Chinoloncarbonsäure-derivate.
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
AU618823B2 (en) * 1988-07-20 1992-01-09 Sankyo Company Limited 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use
IL91648A (en) * 1988-09-22 1997-03-18 Abbott Lab Amino acid quinoline and naphthyridine derivatives, their preparation and pharmaceutical compositions containing them
US5057520A (en) * 1989-03-24 1991-10-15 Abbott Laboratories 7-(peptidylpyrolidinyl)naphthyridine antibacterial compounds
US5057523A (en) * 1988-09-22 1991-10-15 Abbott Laboratories Dipeptide quinolone derivatives
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
EP0997466A1 (en) * 1988-10-24 2000-05-03 PROCTER & GAMBLE PHARMACEUTICALS, INC. Novel antimicrobial lactam-quinolones
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
US4916141A (en) * 1989-03-28 1990-04-10 Warner-Lambert Company (S)-7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
CA2012681A1 (en) * 1989-03-31 1990-09-30 Masayasu Okuhira Quinolone derivatives, preparation processes thereof, and antibacterial agents containing the same
DE3910920A1 (de) * 1989-04-05 1990-10-11 Bayer Ag Enantiomerenreine 7-(3-amino-1-pyrrolidinyl)-chinolon- und -naphthyridoncarbonsaeuren
US5164402A (en) * 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
WO1991004972A1 (en) * 1989-10-06 1991-04-18 Pfizer Inc. 1,4-dihydro-4-oxo-3-quinoline derivatives as selectively toxic mammalian antibacterial agents
US5385913A (en) * 1989-10-06 1995-01-31 Pfizer Inc. 1,4-dihydro-4-oxo-3-quinoline derivatives as selectively toxic mammalian antibacterial agents
US5084276A (en) * 1990-01-05 1992-01-28 Abbott Laboratories Quinolone carboxylic acid compositions with polymeric additive to reduce vein irritation
ES2147721T3 (es) 1990-04-18 2000-10-01 Procter & Gamble Pharma Quinolonil lactamas antimicrobianas.
AU6367690A (en) * 1990-07-10 1992-05-21 Hokuriku Pharmaceutical Co. Ltd. Optically active thiazetoquinoline-3-carboxylic acid compound, method for preparation thereof, and a pharmaceutical composition comprising the same
US5342846A (en) * 1990-12-05 1994-08-30 Synphar Laboratories, Inc. 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents
CA2058640A1 (en) * 1991-01-25 1992-07-26 Richard R. Scherschlicht Tricyclic pyridone derivative
ZA92804B (en) 1991-02-06 1992-12-30 Igen Inc Methods and apparatus for improved luminescence assays
FR2673426B1 (fr) * 1991-03-01 1993-07-16 Bouchara Sa Nouvelles quinolones, leur procede de preparation et les compositions en refermant.
FR2676445B1 (fr) * 1991-05-16 1995-02-03 Esteve Labor Dr Derives de pyridone amino acide azetidinyl substitues, leur preparation et leur application en tant que medicaments.
WO1992021659A1 (en) * 1991-05-28 1992-12-10 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivative
US5177217A (en) * 1992-04-27 1993-01-05 Warner-Lambert Company Process for the manufacture of (S)-3-amino-1-substituted-pyrrolidines
FR2692577B1 (fr) * 1992-05-26 1996-02-02 Bouchara Sa Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant.
US5290794A (en) * 1992-10-27 1994-03-01 Warner Lambert Co. Soluble calcium lactate antibacterial complexes as non-irritating parenteral forms
WO1994025464A1 (en) * 1993-04-24 1994-11-10 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and process for preparing the same
KR950018003A (ko) * 1993-12-09 1995-07-22 스미스클라인 비참 피엘씨 신규한 퀴놀론 유도체 및 그의 제조 방법
NZ287550A (en) * 1994-07-18 1998-01-26 Ube Industries 8-trifluoromethylquinolinecarboxylic acid derivatives; medicaments
US5602254A (en) * 1995-05-26 1997-02-11 Warner-Lambert Company Method for making quinoline carboxylic acids or naphthyridine carboxylic acids in free base form
DE69622715T2 (de) * 1995-06-15 2002-11-14 Pfizer Inc., New York Verfahren zur herstellung von derivaten der ein peptid enthaltenden azabizylo-naphtyridin-carbonsäure
JP4057088B2 (ja) * 1996-04-22 2008-03-05 株式会社カネカ ピロリジン誘導体の製造方法
JP3448305B2 (ja) * 1996-11-28 2003-09-22 湧永製薬株式会社 新規ピリドンカルボン酸誘導体又はその塩及びこれを有効成分とする医薬
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
SE0003795D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Pharmaceutically useful compounds
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
WO2003099815A1 (en) 2002-05-28 2003-12-04 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
JP5255183B2 (ja) 2003-09-04 2013-08-07 ウォックハート リミテッド ベンゾキノリジン−２−カルボン酸アルギニン塩四水和物
JPWO2005035493A1 (ja) * 2003-10-08 2006-12-21 帝人ファーマ株式会社 アミノピロリジン誘導体の製造方法および中間体化合物
KR100939347B1 (ko) 2005-07-20 2010-01-29 (주)카이로드 광학적으로 순수한 (ｓ)-3-히드록시 피롤리딘의 제조방법
CN101239937B (zh) * 2007-02-07 2010-05-19 上海雅本化学有限公司 一种光学活性r-(-)-1-苄氧羰基-3-氨基吡咯烷及其盐酸盐的制备方法
AU2008276512A1 (en) * 2007-07-17 2009-01-22 Amgen Inc. Thiadiazole modulators of PKB
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
CN101983187A (zh) * 2008-04-02 2011-03-02 株式会社钟化 (s)-3-(1-氰基-1，1-二苯基甲基)吡咯烷的制备方法
WO2010058429A1 (en) 2008-11-24 2010-05-27 Council Of Scientific & Industrial Research A process for the preparation of optically active n-benzyl-3 hydroxypyrrolidines
EP4382529A1 (en) 2022-12-07 2024-06-12 Bayer Consumer Care AG A process for preparing pure (3s)-pyrrolidin-3-ol and pure (3s)-pyrrolidin-3-ol hydrochloride

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5630964A (en) * 1979-08-22 1981-03-28 Kyorin Pharmaceut Co Ltd Novel substituted quinolinecarboxylic acid and its preparation
JPS58174367A (ja) * 1982-04-07 1983-10-13 Tanabe Seiyaku Co Ltd キノリン誘導体及びその製法
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
DE3306771A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS60126271A (ja) * 1983-12-09 1985-07-05 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
ZA85853B (en) * 1984-02-17 1986-09-24 Warner Lambert Co Antibacterial agents
JPS60178867A (ja) * 1984-02-24 1985-09-12 Dai Ichi Seiyaku Co Ltd ジハロゲノキノリン誘導体
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
JPS60250573A (ja) * 1984-05-25 1985-12-11 富士通株式会社 電気接続用ソケツト
JPS61205258A (ja) * 1985-03-08 1986-09-11 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
US4657913A (en) * 1985-04-18 1987-04-14 Warner-Lambert Company Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
JPS62469A (ja) * 1985-06-27 1987-01-06 Dainippon Pharmaceut Co Ltd 新規キノロン誘導体、そのエステルおよびその塩
US4668680A (en) * 1985-12-12 1987-05-26 Warner-Lambert Company 5-amino-6,8-difluoroquinolones as antibacterial agents

Also Published As

Publication number Publication date
CA1339216C (en) 1997-08-05
US4851418A (en) 1989-07-25
FI90237B (fi) 1993-09-30
PH25460A (en) 1991-07-01
KR0120389B1 (ko) 1997-11-04
FI883807A (fi) 1989-02-22
IE882363L (en) 1989-02-21
JP2679818B2 (ja) 1997-11-19
EP0304087A2 (en) 1989-02-22
NO171979B (no) 1993-02-15
PT88289A (pt) 1989-09-14
AU608881B2 (en) 1991-04-18
FI90237C (fi) 1994-01-10
NZ225870A (en) 1990-12-21
NO883722L (no) 1989-02-22
FI883807A0 (fi) 1988-08-17
DK467388A (da) 1989-02-22
EP0304087B1 (en) 1994-03-30
NO883722D0 (no) 1988-08-19
KR890003704A (ko) 1989-04-17
NO171979C (no) 1993-05-26
ES2063011T3 (es) 1995-01-01
EP0304087A3 (en) 1989-10-25
AU2062988A (en) 1989-02-23
DK467388D0 (da) 1988-08-19
DE3888754D1 (de) 1994-05-05
JPH01125371A (ja) 1989-05-17
PT88289B (pt) 1995-03-31
DE3888754T2 (de) 1994-07-14
HK1000802A1 (en) 1998-05-01
IE62787B1 (en) 1995-02-22

Similar Documents

Publication Publication Date Title
DK172152B1 (da) Quinolon- og naphthyridinderivater
KR900003494B1 (ko) 항균성 카복실산류
KR900004995B1 (ko) 항균성 카복실산류
HU196986B (en) Process for producing new naphtiridine- and quinoline-carboxylic acids of antibacterial activity and pharmaceutical compositions containing them
US5091384A (en) Anti-bacterial quinolone- and naphthyridone-carboxylic acid compounds
CZ289076B6 (cs) Enantiomery derivátů kyseliny chinolonkarboxylové a nafthyridonkarboxylové
EP0202763B1 (en) 5,6-difluoronaphthyridines and 5,6,8-trifluoro-quinolines as antibacterial agents
US4771055A (en) 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids
EP0266576A2 (en) 1-Tert-alkyl-substituted naphthyridine and quinoline carboxylic acids as antibacterial agents
US4954507A (en) 1-tertiary-alkyl-substituted naphthyridine carboxylic acid antibacterial agents
US5527910A (en) Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
US4617308A (en) 7-substituted amino-1-aryl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and derivatives thereof as antibacterial agents
JP2817907B2 (ja) 抗菌剤製造用の中間体
US4923879A (en) 1,8-Naphthyridines and their use as antibacterial agents
US4965273A (en) Certain 1-tertiary-butyl-naphthyridone carboxylic acid derivatives anti-bacterial agents
AU617181B2 (en) Quinolonecarboxylic acids
US4962108A (en) Antibacterial quinoline compounds
US4968799A (en) Antibacterial agents
US4992546A (en) Process for preparing 6,8-diazabicyclo[3.2.2]nonane derivatives
JPH07300472A (ja) 新規キノロンカルボン酸誘導体およびその製造方法
FI91636C (fi) Menetelmä antibakteeristen kinoloniyhdisteiden valmistamiseksi
KR100359151B1 (ko) 2환성 아미노기로 치환된 피리돈카르복실산 유도체, 그의 에스테르 및 그의 염 및 이들의 중간체인 2환성 아민
IE19970856A1 (en) 7-(1-Pyrrolidinyl)-3-quinolone and naphthyridone carboxylic acid derivatives, method for their preparation and for substituted mono- and bicyclic pyrrolidine intermediates, and their antibacterial and feed additive compositions
PH26729A (en) Benzoxazines useful as antibacterial preparation thereof and pharmaceutical composition containing them

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

Country of ref document: DK