DK171824B1 - Blodkoagulationsinhiberende hirudinderivater, fremgangsmåde til deres udvinding, deres anvendelse samt middel indeholdende dem - Google Patents

Blodkoagulationsinhiberende hirudinderivater, fremgangsmåde til deres udvinding, deres anvendelse samt middel indeholdende dem Download PDF

Info

Publication number
DK171824B1
DK171824B1 DK173985A DK173985A DK171824B1 DK 171824 B1 DK171824 B1 DK 171824B1 DK 173985 A DK173985 A DK 173985A DK 173985 A DK173985 A DK 173985A DK 171824 B1 DK171824 B1 DK 171824B1
Authority
DK
Denmark
Prior art keywords
gly
cys
glu
hirudin
derivative
Prior art date
Application number
DK173985A
Other languages
Danish (da)
English (en)
Other versions
DK173985D0 (da
DK173985A (da
Inventor
Dominique Tripier
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK173985D0 publication Critical patent/DK173985D0/da
Publication of DK173985A publication Critical patent/DK173985A/da
Application granted granted Critical
Publication of DK171824B1 publication Critical patent/DK171824B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK173985A 1984-04-18 1985-04-17 Blodkoagulationsinhiberende hirudinderivater, fremgangsmåde til deres udvinding, deres anvendelse samt middel indeholdende dem DK171824B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3414593 1984-04-18
DE3414593 1984-04-18
DE19843438296 DE3438296A1 (de) 1984-04-18 1984-10-19 Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3438296 1984-10-19

Publications (3)

Publication Number Publication Date
DK173985D0 DK173985D0 (da) 1985-04-17
DK173985A DK173985A (da) 1985-10-19
DK171824B1 true DK171824B1 (da) 1997-06-23

Family

ID=25820510

Family Applications (1)

Application Number Title Priority Date Filing Date
DK173985A DK171824B1 (da) 1984-04-18 1985-04-17 Blodkoagulationsinhiberende hirudinderivater, fremgangsmåde til deres udvinding, deres anvendelse samt middel indeholdende dem

Country Status (18)

Country Link
US (1) US4668662A (it)
EP (1) EP0158986B1 (it)
JP (1) JP2552263B2 (it)
KR (1) KR930000054B1 (it)
AR (1) AR242800A1 (it)
AU (1) AU580295B2 (it)
CA (1) CA1271298A (it)
DE (2) DE3438296A1 (it)
DK (1) DK171824B1 (it)
ES (3) ES542309A0 (it)
FI (1) FI851521L (it)
GR (1) GR850942B (it)
HU (1) HU198085B (it)
IE (1) IE60581B1 (it)
IL (1) IL74948A (it)
NO (1) NO851535L (it)
PT (1) PT80301B (it)
ZA (1) ZA852854B (it)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
ATE64956T1 (de) * 1984-06-14 1991-07-15 Ciba Geigy Ag Verfahren zur herstellung von thrombininhibitoren.
DE3506992A1 (de) * 1985-02-27 1986-08-28 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
EP0324712B1 (de) * 1985-04-11 1993-04-07 Hoechst Aktiengesellschaft Hirudin-Derivat
DE3738541A1 (de) * 1987-11-13 1989-05-24 Hoechst Ag Verfahren zur isolierung und reinigung von hirudin
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
GB8530631D0 (en) 1985-12-12 1986-01-22 Ciba Geigy Ag Thrombin inhibitors
US5789540A (en) * 1987-01-23 1998-08-04 Merrell Pharmaceuticals Inc. Anticoagulant peptides
US6005071A (en) * 1987-01-23 1999-12-21 Merrell Pharmaceuticals Inc. Anticoagulant peptides
PT87083B (pt) * 1987-03-28 1992-07-31 Boehringer Ingelheim Int Processo para a preparacao de uma proteina anticoagulante vascular, de adn que codifica para esta proteina e de composicoes farmaceuticas que a contem
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5192745A (en) * 1987-05-21 1993-03-09 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5256559A (en) * 1988-03-04 1993-10-26 Biogen, Inc. Methods and compositions for inhibiting platelet aggregation
US4971953A (en) * 1988-05-10 1990-11-20 Merrell Dow Pharmaceuticals Anticoagulant peptide alcohols
NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
US5114921A (en) * 1988-05-27 1992-05-19 The Children's Hospital Of Philadelphia Amphiphilic peptides and use thereof
KR900701295A (ko) * 1988-05-27 1990-12-01 원본미기재 양극성 펩타이드류와 그것에 관한 용도
DE3819079A1 (de) * 1988-06-04 1989-12-07 Hoechst Ag Hirudin-derivate mit verzoegerter wirkung
DE3819078A1 (de) * 1988-06-04 1989-12-07 Hoechst Ag Amblyommin, ein neuer wirkstoff fuer die antikoagulationstherapie
ES2052062T3 (es) * 1988-06-11 1994-07-01 Ciba Geigy Ag Nuevos polipeptidos con actividad anticoagulante.
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
US5112615A (en) * 1988-08-03 1992-05-12 New England Deaconess Hospital Corporation Soluble hirudin conjugates
US5167960A (en) * 1988-08-03 1992-12-01 New England Deaconess Hospital Corporation Hirudin-coated biocompatible substance
DE3835815A1 (de) * 1988-10-21 1990-04-26 Hoechst Ag Neue isohirudine
US4861865A (en) * 1989-01-23 1989-08-29 Washington University Novel antithrombin peptide
US5254535A (en) * 1989-04-17 1993-10-19 The Children's Hospital Of Pennsylvania Composition and treatment with biologically active peptides and antibiotic
US5179196A (en) * 1989-05-04 1993-01-12 Sri International Purification of proteins employing ctap-iii fusions
US5192747A (en) * 1989-10-03 1993-03-09 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
DE3939801A1 (de) * 1989-12-01 1991-06-06 Basf Ag Neue proteine und ihre herstellung
US5459237A (en) * 1990-02-08 1995-10-17 Magainin Pharmaceuticals Inc. Peptide compositions and uses therefor
JPH07504152A (ja) * 1990-02-08 1995-05-11 マゲイニン　ファーマスーティカルズ，　インコーポレーテッド 生物活性ペプチドおよび標的細胞、ウイルス、あるいはウイルス感染細胞の成長を抑制する方法
US5792831A (en) * 1990-02-08 1998-08-11 Magainin Pharmaceuticals Inc. Analogues of magainin peptides containing D-amino acids
AU641215B2 (en) * 1990-02-13 1993-09-16 Merrell Dow Pharmaceuticals Inc. Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
DE4009268A1 (de) * 1990-03-22 1991-09-26 Consortium Elektrochem Ind Sekretion von hirudinderivaten
EP0533795A4 (en) * 1990-05-14 1993-10-20 Magainin Sciences, Inc. Composition of and treatment with biologically active peptides having d-amino acid residues
JPH05507718A (ja) * 1990-06-27 1993-11-04 マゲイニン　サイエンセズ　インコーポレーテッド 生物活性ペプチドおよびｄｎａギラーゼを阻害する抗生物質よりなる組成物と治療法
US5208220A (en) * 1990-06-27 1993-05-04 Magainin Pharmaceuticals, Inc. Composition and treatment with biologically active peptides and antibiotics which inhibit DNA gyrase
CA2086243C (en) * 1990-07-24 2001-10-02 John L. Krstenansky Anticoagulant peptides
US5574012A (en) * 1990-07-24 1996-11-12 Merrell Pharmaceuticals Inc. Analogs of hirudin having anti-platelet activity
US5118790A (en) * 1990-07-24 1992-06-02 Sri International Analogs of hirudin
US6514730B1 (en) * 1991-03-21 2003-02-04 Consortium für elektrochemische Industrie GmbH Secretion of hirudin derivatives
WO1993007892A1 (en) * 1991-10-16 1993-04-29 The Children's Hospital Of Philadelphia Composition and treatment with biologically active peptides and antibiotic
DE4140381A1 (de) * 1991-12-07 1993-06-09 Hoechst Ag, 6230 Frankfurt, De Neue synthetische isohirudine mit verbesserter stabilitaet
DE69432983T2 (de) * 1993-06-11 2004-04-29 Merrell Pharmaceuticals Inc., Cincinnati Trifunktionelle antithrombin-und antiplättchenpeptide
NZ270194A (en) * 1994-01-07 1996-05-28 Ciba Geigy Ag Hirustasin, a serine protease inhibitor from hirudo medicinalis
GB9401447D0 (en) 1994-01-26 1994-03-23 Ciba Geigy Ag Pharmaceutical compositions
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
DE19529997C1 (de) 1995-08-16 1997-04-10 Hoechst Ag Verfahren zur Inaktivierung von Carboxypeptidase Y in hirudinhaltigen Kulturbrühen
DE19543737A1 (de) * 1995-11-24 1997-05-28 Hoechst Ag Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices
DE19544233A1 (de) 1995-11-28 1997-06-05 Hoechst Ag Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten
DE69625623T2 (de) 1996-01-31 2003-11-06 Sumitomo Bakelite Co. Ltd., Tokio/Tokyo Verfahren zur Herstellung von in Epoxyharz eingekapselter Halbleitervorrichtung
DE19607239A1 (de) 1996-02-27 1997-08-28 Behringwerke Ag Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung
US7795205B2 (en) * 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
CN101095697A (zh) * 2006-06-28 2008-01-02 李振国 水蛭和/或地龙分子量5800道尔顿以下的提取物
US9056118B2 (en) * 2007-06-26 2015-06-16 Mudanjiang Youbo Pharmaceutical Co., Ltd. Extract for preventing of treating thrombotic diseases
US20110220575A1 (en) * 2008-11-19 2011-09-15 Nandu Deorkar New chromatographic media based on phenoxy alkyl and alkoxy-or phenoxy-phenyl alkyl ligands

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
CA1341417C (fr) * 1984-03-27 2003-01-21 Paul Tolstoshev Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
DE3429430A1 (de) * 1984-08-10 1986-02-20 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens

Also Published As

Publication number Publication date
JP2552263B2 (ja) 1996-11-06
PT80301A (de) 1985-05-01
FI851521A0 (fi) 1985-04-16
ES8605771A1 (es) 1985-12-16
ES542310A0 (es) 1985-12-16
ZA852854B (en) 1985-11-27
IE60581B1 (en) 1994-07-27
DE3438296A1 (de) 1985-11-07
DE3587576D1 (de) 1993-10-21
HUT37806A (en) 1986-02-28
AR242800A1 (es) 1993-05-31
HU198085B (en) 1989-07-28
NO851535L (no) 1985-10-21
IE850983L (en) 1985-10-18
EP0158986A2 (de) 1985-10-23
FI851521L (fi) 1985-10-19
ES8605772A1 (es) 1985-12-16
AU580295B2 (en) 1989-01-12
CA1271298A (en) 1990-07-03
DK173985D0 (da) 1985-04-17
US4668662A (en) 1987-05-26
PT80301B (de) 1987-02-10
ES8605770A1 (es) 1985-12-16
EP0158986B1 (de) 1993-09-15
KR930000054B1 (ko) 1993-01-06
IL74948A (en) 1989-09-10
DK173985A (da) 1985-10-19
JPS60233098A (ja) 1985-11-19
GR850942B (it) 1985-11-25
ES542309A0 (es) 1985-12-16
AU4136485A (en) 1985-10-24
ES542311A0 (es) 1985-12-16
IL74948A0 (en) 1985-08-30
KR850007801A (ko) 1985-12-09
EP0158986A3 (en) 1988-09-21

Similar Documents

Publication Publication Date Title
DK171824B1 (da) Blodkoagulationsinhiberende hirudinderivater, fremgangsmåde til deres udvinding, deres anvendelse samt middel indeholdende dem
DK173509B1 (da) Polypeptider med blodkoaguleringshæmmende virkning, deres fremstilling eller udvinding samt midler med indhold deraf
US4636489A (en) Modified protease inhibitors, process for their preparation, and pharmaceutical compositions prepared therefrom
RU2050160C1 (ru) Полипептид, полученный из ткани или секрета пиявок hirudinaria manillensis, специфически ингибирующий тромбин
JPH0475240B2 (it)
NO163959B (no) Fremgangsm te for utvinning og rensing av et polype
CA1137467A (en) Process for the preparation of somatostatin
US5322926A (en) Isohirudins
JP2871031B2 (ja) 新規なペプチド及びアンジオテンシン変換酵素阻害剤
JP3893579B2 (ja) 新規なテトラペプチドおよびアンジオテンシン変換酵素阻害剤
JP2007182414A (ja) 新規なかつお節ペプチド、ｌ−バリル−ｌ−プロリン及び血圧降下剤
JP3465923B2 (ja) 新規ペプチド、それを製造する方法及び用途
JP2678180B2 (ja) 新規なテトラペプチドおよびアンジオテンシン変換酵素 阻害剤
JP2003267994A (ja) 新規なペプチドおよびアンジオテンシン変換酵素阻害剤
JP3465921B2 (ja) 新規ペプチド、それを製造する方法及び用途
JP3885214B2 (ja) 新規なヘクサペプチドおよびアンジオテンシン変換酵素阻害剤
JP3709425B2 (ja) 新規なトリペプチドおよびアンジオテンシン変換酵素阻害剤
JP3474610B2 (ja) 新規ペプチド、それを製造する方法及び用途
JP2951428B2 (ja) 新規ペプチド、その製造法及び用途
JP3465922B2 (ja) 新規ペプチド、それを製造する方法及び用途
JPH1036391A (ja) 新規なペプチドおよびアンジオテンシン変換酵素阻害剤
JPH05331190A (ja) 新規ペプチド及びその製造方法
JP3465920B2 (ja) 新規ペプチド、それを製造する方法及び用途
DE3601032A1 (de) Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
B1 Patent granted (law 1993)
PUP Patent expired