ES8605772A1 - Procedimiento para preparar un polipeptido - Google Patents
Procedimiento para preparar un polipeptidoInfo
- Publication number
- ES8605772A1 ES8605772A1 ES542311A ES542311A ES8605772A1 ES 8605772 A1 ES8605772 A1 ES 8605772A1 ES 542311 A ES542311 A ES 542311A ES 542311 A ES542311 A ES 542311A ES 8605772 A1 ES8605772 A1 ES 8605772A1
- Authority
- ES
- Spain
- Prior art keywords
- image
- denotes
- agents containing
- peptides
- isolation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR UN POLIPEPTIDO DE FORMULA (I). CONSISTE EN EFECTUAR LA SINTESIS EN FASE SOLIDA DE MODO ESCALONADO EN RESINA DE POLIESTIRENO RETICULADO TRANSVERSALMENTE CON 1% DE DIVINILBENCENO. EN LA FORMULA (I) F M F 0-50; N F 0-100; R ES EL HIDROGENO FENOLICO O UN GRUPO ESTER FENOLICO; X REPRESENTA RADICALES IGUALES O DISTINTOS DE A-AMINOACIDOS PRESENTES EN LA NATURALEZA; Y SIGNIFICA VAL, ILE, THR, LEU O PHE; R SIGNIFICA HIDROGENO, SO3H O PO3H2. DE APLICACION COMO INHIBIDOR DE COAGULACION DE SANGRE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3414593 | 1984-04-18 | ||
DE19843438296 DE3438296A1 (de) | 1984-04-18 | 1984-10-19 | Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8605772A1 true ES8605772A1 (es) | 1985-12-16 |
ES542311A0 ES542311A0 (es) | 1985-12-16 |
Family
ID=25820510
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES542311A Granted ES542311A0 (es) | 1984-04-18 | 1985-04-16 | Procedimiento para preparar un polipeptido |
ES542310A Granted ES542310A0 (es) | 1984-04-18 | 1985-04-16 | Procedimiento para preparar un polipeptido |
ES542309A Expired ES8605770A1 (es) | 1984-04-18 | 1985-04-16 | Procedimiento para obtener un polipeptido purificado |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES542310A Granted ES542310A0 (es) | 1984-04-18 | 1985-04-16 | Procedimiento para preparar un polipeptido |
ES542309A Expired ES8605770A1 (es) | 1984-04-18 | 1985-04-16 | Procedimiento para obtener un polipeptido purificado |
Country Status (18)
Country | Link |
---|---|
US (1) | US4668662A (es) |
EP (1) | EP0158986B1 (es) |
JP (1) | JP2552263B2 (es) |
KR (1) | KR930000054B1 (es) |
AR (1) | AR242800A1 (es) |
AU (1) | AU580295B2 (es) |
CA (1) | CA1271298A (es) |
DE (2) | DE3438296A1 (es) |
DK (1) | DK171824B1 (es) |
ES (3) | ES542311A0 (es) |
FI (1) | FI851521L (es) |
GR (1) | GR850942B (es) |
HU (1) | HU198085B (es) |
IE (1) | IE60581B1 (es) |
IL (1) | IL74948A (es) |
NO (1) | NO851535L (es) |
PT (1) | PT80301B (es) |
ZA (1) | ZA852854B (es) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3342139A1 (de) * | 1983-11-22 | 1985-05-30 | Ciba-Geigy Ag, Basel | Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel |
EP0168342B1 (de) * | 1984-06-14 | 1991-07-03 | Ciba-Geigy Ag | Verfahren zur Herstellung von Thrombin-Inhibitoren |
DE3506992A1 (de) * | 1985-02-27 | 1986-08-28 | Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn | Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten |
ES2055149T3 (es) * | 1985-04-11 | 1994-08-16 | Hoechst Ag | Derivado de hirudina. |
DE3738541A1 (de) * | 1987-11-13 | 1989-05-24 | Hoechst Ag | Verfahren zur isolierung und reinigung von hirudin |
EP0209061B1 (de) * | 1985-07-17 | 1994-01-12 | Hoechst Aktiengesellschaft | Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel |
GB8530631D0 (en) | 1985-12-12 | 1986-01-22 | Ciba Geigy Ag | Thrombin inhibitors |
US5789540A (en) * | 1987-01-23 | 1998-08-04 | Merrell Pharmaceuticals Inc. | Anticoagulant peptides |
US6005071A (en) * | 1987-01-23 | 1999-12-21 | Merrell Pharmaceuticals Inc. | Anticoagulant peptides |
PT87083B (pt) * | 1987-03-28 | 1992-07-31 | Boehringer Ingelheim Int | Processo para a preparacao de uma proteina anticoagulante vascular, de adn que codifica para esta proteina e de composicoes farmaceuticas que a contem |
US5236898A (en) * | 1987-05-21 | 1993-08-17 | Merrell Dow Pharmaceuticals Inc. | Cyclic anticoagulant peptides |
US5192745A (en) * | 1987-05-21 | 1993-03-09 | Merrell Dow Pharmaceuticals Inc. | Cyclic anticoagulant peptides |
US5256559A (en) * | 1988-03-04 | 1993-10-26 | Biogen, Inc. | Methods and compositions for inhibiting platelet aggregation |
US4971953A (en) * | 1988-05-10 | 1990-11-20 | Merrell Dow Pharmaceuticals | Anticoagulant peptide alcohols |
NZ228995A (en) * | 1988-05-10 | 1992-03-26 | Merrell Dow Pharma | Hirudin peptide derivatives and pharmaceutical compositions |
WO1989011290A1 (en) * | 1988-05-27 | 1989-11-30 | Magainin Sciences, Inc. | Amphiphilic peptides and use thereof |
US5114921A (en) * | 1988-05-27 | 1992-05-19 | The Children's Hospital Of Philadelphia | Amphiphilic peptides and use thereof |
DE3819078A1 (de) * | 1988-06-04 | 1989-12-07 | Hoechst Ag | Amblyommin, ein neuer wirkstoff fuer die antikoagulationstherapie |
DE3819079A1 (de) * | 1988-06-04 | 1989-12-07 | Hoechst Ag | Hirudin-derivate mit verzoegerter wirkung |
ES2052062T3 (es) * | 1988-06-11 | 1994-07-01 | Ciba Geigy Ag | Nuevos polipeptidos con actividad anticoagulante. |
US5268296A (en) * | 1988-06-11 | 1993-12-07 | Ciba-Geigy Corporation | DNA vector and recombinant host cell for production of hirullin P6 and P18 |
US5167960A (en) * | 1988-08-03 | 1992-12-01 | New England Deaconess Hospital Corporation | Hirudin-coated biocompatible substance |
US5112615A (en) * | 1988-08-03 | 1992-05-12 | New England Deaconess Hospital Corporation | Soluble hirudin conjugates |
DE3835815A1 (de) * | 1988-10-21 | 1990-04-26 | Hoechst Ag | Neue isohirudine |
US4861865A (en) * | 1989-01-23 | 1989-08-29 | Washington University | Novel antithrombin peptide |
US5254535A (en) * | 1989-04-17 | 1993-10-19 | The Children's Hospital Of Pennsylvania | Composition and treatment with biologically active peptides and antibiotic |
US5179196A (en) * | 1989-05-04 | 1993-01-12 | Sri International | Purification of proteins employing ctap-iii fusions |
US5192747A (en) * | 1989-10-03 | 1993-03-09 | Merrell Dow Pharmaceuticals Inc. | Anticoagulant peptides |
DE3939801A1 (de) * | 1989-12-01 | 1991-06-06 | Basf Ag | Neue proteine und ihre herstellung |
US5792831A (en) * | 1990-02-08 | 1998-08-11 | Magainin Pharmaceuticals Inc. | Analogues of magainin peptides containing D-amino acids |
JPH07504152A (ja) * | 1990-02-08 | 1995-05-11 | マゲイニン ファーマスーティカルズ, インコーポレーテッド | 生物活性ペプチドおよび標的細胞、ウイルス、あるいはウイルス感染細胞の成長を抑制する方法 |
US5459237A (en) * | 1990-02-08 | 1995-10-17 | Magainin Pharmaceuticals Inc. | Peptide compositions and uses therefor |
AU641215B2 (en) * | 1990-02-13 | 1993-09-16 | Merrell Dow Pharmaceuticals Inc. | Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin |
DE4009268A1 (de) * | 1990-03-22 | 1991-09-26 | Consortium Elektrochem Ind | Sekretion von hirudinderivaten |
WO1991017760A1 (en) * | 1990-05-14 | 1991-11-28 | Magainin Sciences Inc. | Composition of and treatment with biologically active peptides having d-amino acid residues |
JPH05507718A (ja) * | 1990-06-27 | 1993-11-04 | マゲイニン サイエンセズ インコーポレーテッド | 生物活性ペプチドおよびdnaギラーゼを阻害する抗生物質よりなる組成物と治療法 |
US5208220A (en) * | 1990-06-27 | 1993-05-04 | Magainin Pharmaceuticals, Inc. | Composition and treatment with biologically active peptides and antibiotics which inhibit DNA gyrase |
US5574012A (en) * | 1990-07-24 | 1996-11-12 | Merrell Pharmaceuticals Inc. | Analogs of hirudin having anti-platelet activity |
US5118790A (en) * | 1990-07-24 | 1992-06-02 | Sri International | Analogs of hirudin |
AU648096B2 (en) * | 1990-07-24 | 1994-04-14 | Merrell Dow Pharmaceuticals Inc. | Anticoagulant peptides |
US6514730B1 (en) * | 1991-03-21 | 2003-02-04 | Consortium für elektrochemische Industrie GmbH | Secretion of hirudin derivatives |
AU2901692A (en) * | 1991-10-16 | 1993-05-21 | Children's Hospital Of Philadelphia, The | Composition and treatment with biologically active peptides and antibiotic |
DE4140381A1 (de) * | 1991-12-07 | 1993-06-09 | Hoechst Ag, 6230 Frankfurt, De | Neue synthetische isohirudine mit verbesserter stabilitaet |
KR100330465B1 (ko) * | 1993-06-11 | 2002-11-23 | 메렐 파마슈티칼스 인크. | 삼관능성항트롬빈및항혈소판펩티드 |
NZ270194A (en) * | 1994-01-07 | 1996-05-28 | Ciba Geigy Ag | Hirustasin, a serine protease inhibitor from hirudo medicinalis |
GB9401447D0 (en) | 1994-01-26 | 1994-03-23 | Ciba Geigy Ag | Pharmaceutical compositions |
DE4404168A1 (de) * | 1994-02-10 | 1995-08-17 | Hoechst Ag | Hirudinderivate und Verfahren zu deren Herstellung |
DE19529997C1 (de) * | 1995-08-16 | 1997-04-10 | Hoechst Ag | Verfahren zur Inaktivierung von Carboxypeptidase Y in hirudinhaltigen Kulturbrühen |
DE19543737A1 (de) * | 1995-11-24 | 1997-05-28 | Hoechst Ag | Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices |
DE19544233A1 (de) | 1995-11-28 | 1997-06-05 | Hoechst Ag | Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten |
EP0787569B1 (en) | 1996-01-31 | 2002-10-02 | Sumitomo Bakelite Company Limited | Method of producing epoxy resin-encapsulated semiconductor device |
DE19607239A1 (de) | 1996-02-27 | 1997-08-28 | Behringwerke Ag | Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung |
US7795205B2 (en) | 2004-04-12 | 2010-09-14 | Canyon Pharmaceuticals, Inc. | Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor |
CN101095697A (zh) * | 2006-06-28 | 2008-01-02 | 李振国 | 水蛭和/或地龙分子量5800道尔顿以下的提取物 |
US9056118B2 (en) * | 2007-06-26 | 2015-06-16 | Mudanjiang Youbo Pharmaceutical Co., Ltd. | Extract for preventing of treating thrombotic diseases |
CN102215953A (zh) * | 2008-11-19 | 2011-10-12 | 安万托特性材料股份有限公司 | 基于苯氧基烷基和烷氧基-或苯氧基-苯基烷基配体的新色谱介质 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3342139A1 (de) * | 1983-11-22 | 1985-05-30 | Ciba-Geigy Ag, Basel | Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel |
EP0158564B1 (fr) * | 1984-03-27 | 1992-07-15 | Transgene S.A. | Vecteurs d'expression de l'hirudine, cellules transformées et procédé de préparation de l'hirudine |
DE3429430A1 (de) * | 1984-08-10 | 1986-02-20 | Hoechst Ag, 6230 Frankfurt | Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens |
-
1984
- 1984-10-19 DE DE19843438296 patent/DE3438296A1/de not_active Withdrawn
-
1985
- 1985-04-11 HU HU851341A patent/HU198085B/hu not_active IP Right Cessation
- 1985-04-12 DE DE85104445T patent/DE3587576D1/de not_active Expired - Lifetime
- 1985-04-12 EP EP85104445A patent/EP0158986B1/de not_active Expired - Lifetime
- 1985-04-16 ES ES542311A patent/ES542311A0/es active Granted
- 1985-04-16 ES ES542310A patent/ES542310A0/es active Granted
- 1985-04-16 ES ES542309A patent/ES8605770A1/es not_active Expired
- 1985-04-16 AR AR85300094A patent/AR242800A1/es active
- 1985-04-16 FI FI851521A patent/FI851521L/fi not_active Application Discontinuation
- 1985-04-17 CA CA000479344A patent/CA1271298A/en not_active Expired - Lifetime
- 1985-04-17 ZA ZA852854A patent/ZA852854B/xx unknown
- 1985-04-17 IE IE98385A patent/IE60581B1/en not_active IP Right Cessation
- 1985-04-17 IL IL74948A patent/IL74948A/xx not_active IP Right Cessation
- 1985-04-17 DK DK173985A patent/DK171824B1/da not_active IP Right Cessation
- 1985-04-17 GR GR850942A patent/GR850942B/el unknown
- 1985-04-17 KR KR1019850002581A patent/KR930000054B1/ko not_active IP Right Cessation
- 1985-04-17 PT PT80301A patent/PT80301B/pt not_active IP Right Cessation
- 1985-04-17 JP JP60080430A patent/JP2552263B2/ja not_active Expired - Lifetime
- 1985-04-17 NO NO851535A patent/NO851535L/no unknown
- 1985-04-17 AU AU41364/85A patent/AU580295B2/en not_active Expired
- 1985-04-17 US US06/724,332 patent/US4668662A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE3587576D1 (de) | 1993-10-21 |
ES8605771A1 (es) | 1985-12-16 |
ES542309A0 (es) | 1985-12-16 |
PT80301A (de) | 1985-05-01 |
JPS60233098A (ja) | 1985-11-19 |
ES8605770A1 (es) | 1985-12-16 |
HU198085B (en) | 1989-07-28 |
DK171824B1 (da) | 1997-06-23 |
FI851521L (fi) | 1985-10-19 |
AU580295B2 (en) | 1989-01-12 |
NO851535L (no) | 1985-10-21 |
AU4136485A (en) | 1985-10-24 |
KR930000054B1 (ko) | 1993-01-06 |
IL74948A0 (en) | 1985-08-30 |
IE60581B1 (en) | 1994-07-27 |
ES542310A0 (es) | 1985-12-16 |
FI851521A0 (fi) | 1985-04-16 |
DK173985D0 (da) | 1985-04-17 |
HUT37806A (en) | 1986-02-28 |
IL74948A (en) | 1989-09-10 |
EP0158986B1 (de) | 1993-09-15 |
KR850007801A (ko) | 1985-12-09 |
US4668662A (en) | 1987-05-26 |
EP0158986A3 (en) | 1988-09-21 |
DK173985A (da) | 1985-10-19 |
PT80301B (de) | 1987-02-10 |
CA1271298A (en) | 1990-07-03 |
AR242800A1 (es) | 1993-05-31 |
JP2552263B2 (ja) | 1996-11-06 |
ES542311A0 (es) | 1985-12-16 |
ZA852854B (en) | 1985-11-27 |
EP0158986A2 (de) | 1985-10-23 |
GR850942B (es) | 1985-11-25 |
DE3438296A1 (de) | 1985-11-07 |
IE850983L (en) | 1985-10-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed |
Effective date: 19960506 |